ATE512972T1 - Pyrrolopyrazole als wirksame kinaseinhibitoren - Google Patents

Pyrrolopyrazole als wirksame kinaseinhibitoren

Info

Publication number
ATE512972T1
ATE512972T1 AT05850734T AT05850734T ATE512972T1 AT E512972 T1 ATE512972 T1 AT E512972T1 AT 05850734 T AT05850734 T AT 05850734T AT 05850734 T AT05850734 T AT 05850734T AT E512972 T1 ATE512972 T1 AT E512972T1
Authority
AT
Austria
Prior art keywords
pyrrolopyrazoles
kinase inhibitors
effective kinase
effective
inhibitors
Prior art date
Application number
AT05850734T
Other languages
English (en)
Inventor
Djamal Bouzida
Liming Dong
Chuangxing Guo
Yufeng Hong
Haitao Li
Joseph T Marakovits
Anle Yang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE512972T1 publication Critical patent/ATE512972T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AT05850734T 2005-01-10 2005-12-28 Pyrrolopyrazole als wirksame kinaseinhibitoren ATE512972T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64290005P 2005-01-10 2005-01-10
US73377005P 2005-11-04 2005-11-04
PCT/IB2005/003975 WO2006072831A1 (en) 2005-01-10 2005-12-28 Pyrrolopyrazoles, potent kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE512972T1 true ATE512972T1 (de) 2011-07-15

Family

ID=36463340

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05850734T ATE512972T1 (de) 2005-01-10 2005-12-28 Pyrrolopyrazole als wirksame kinaseinhibitoren

Country Status (29)

Country Link
US (2) US8067591B2 (de)
EP (1) EP1838718B1 (de)
JP (1) JP4250195B2 (de)
KR (1) KR100919343B1 (de)
CN (1) CN101115760B (de)
AP (1) AP2007004061A0 (de)
AT (1) ATE512972T1 (de)
AU (1) AU2005323797B2 (de)
BR (1) BRPI0518509A2 (de)
CA (1) CA2593428C (de)
CU (1) CU23778B7 (de)
CY (1) CY1111752T1 (de)
DK (1) DK1838718T3 (de)
EA (1) EA011815B1 (de)
ES (1) ES2365245T3 (de)
GE (1) GEP20094785B (de)
HR (1) HRP20110485T1 (de)
IL (1) IL184275A0 (de)
MA (1) MA29141B1 (de)
MX (1) MX2007008385A (de)
NO (1) NO20073859L (de)
NZ (1) NZ556273A (de)
PL (1) PL1838718T3 (de)
PT (1) PT1838718E (de)
RS (1) RS51891B (de)
SI (1) SI1838718T1 (de)
TN (1) TNSN07254A1 (de)
WO (1) WO2006072831A1 (de)
ZA (1) ZA200705628B (de)

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UA96618C2 (en) * 2007-02-07 2011-11-25 Пфайзер Инк. 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors
WO2008096260A1 (en) 2007-02-07 2008-08-14 Pfizer Inc. 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors
CN104370914B (zh) * 2007-04-12 2018-09-07 辉瑞大药厂 作为蛋白酶c抑制剂的3-酰氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物
JP5282091B2 (ja) * 2007-07-25 2013-09-04 ブリストル−マイヤーズ スクイブ カンパニー トリアジンキナーゼ阻害剤
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
WO2009130900A1 (ja) * 2008-04-24 2009-10-29 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
EP2145891A1 (de) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substierte 5-Carboxy-Oxadiazin-Chinolon-Derivate, ihre Herstellung und ihre Anwendung als antibakterielle Mittel
EP2485727A4 (de) * 2009-10-06 2013-05-01 Afraxis Inc Pyrrolopyrazole zur behandlung von zns-erkrankungen
KR101483215B1 (ko) * 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
BR112013012175A2 (pt) 2010-11-17 2019-09-24 Hoffmann La Roche combinação, coadministração, uso e método
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WO2013113719A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds ii
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AR089884A1 (es) 2012-02-03 2014-09-24 Basf Se Compuestos fungicidas de pirimidina
WO2013113778A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113782A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113781A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds i
WO2013113776A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
IN2014DN07224A (de) 2012-02-03 2015-04-24 Basf Se
WO2013113716A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113773A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013135672A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
JP2015512891A (ja) 2012-03-13 2015-04-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 殺菌性ピリミジン化合物
BR112014020173A8 (pt) * 2012-03-16 2017-07-11 Hoffmann La Roche Métodos para o tratamento de um melanoma, utilizações de um inibidor, composições, conjunto, método de inibição, método de identificação, método de ajuste do tratamento e invenção
BR112015005982A2 (pt) 2012-09-19 2017-07-04 Novartis Ag di-hidropirrolidino-pirimidinas como inibidores de quinase
EP2906555B1 (de) * 2012-10-15 2016-12-14 Pfizer Ireland Pharmaceuticals Verfahren zur herstellung von voriconazol und analogen davon
CN105722833A (zh) 2013-09-16 2016-06-29 巴斯夫欧洲公司 杀真菌的嘧啶化合物
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2016105528A2 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
HK1246645A1 (zh) 2015-03-27 2018-09-14 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
EP3309163A4 (de) * 2015-06-15 2019-01-09 UBE Industries, Ltd. Substituiertes dihydropyrrolopyrazolderivat
CN104926735A (zh) * 2015-06-16 2015-09-23 上海合全药物研发有限公司 4-氯-5-氟-2-甲基嘧啶的工业化制备方法
AU2016378723B2 (en) 2015-12-22 2021-09-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
WO2017144546A1 (en) 2016-02-23 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
JP7258748B2 (ja) 2016-11-22 2023-04-17 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ１２（ｃｄｋ１２）の阻害剤およびその使用
MX2019014875A (es) 2017-06-21 2021-01-29 SHY Therapeutics LLC Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.
US20210161943A1 (en) * 2018-04-16 2021-06-03 The Regents Of The University Of California Pak4 inhibitors and methods of use
US12187701B2 (en) 2018-06-25 2025-01-07 Dana-Farber Cancer Institute, Inc. Taire family kinase inhibitors and uses thereof
US12391705B2 (en) 2018-12-19 2025-08-19 Shy Therapeutics, Llc Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
CA3124422A1 (en) * 2018-12-28 2020-07-02 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 and uses thereof
EP3956446A1 (de) 2019-04-17 2022-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und zusammensetzungen zur behandlung von durch nlrp3-inflammasom vermittelten il-1-beta-abhängigen erkrankungen
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
WO2021198511A1 (en) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of sars-cov-2 infection
CN111454278B (zh) * 2020-05-15 2021-03-19 四川大学 Pak1抑制剂及其合成和在制备抗肿瘤药物中的应用
WO2022008597A1 (en) 2020-07-08 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of infectious diseases
EP4273135A4 (de) * 2020-12-31 2024-11-20 Scinnohub Pharmaceutical Co., Ltd Plasmininhibitor sowie herstellungsverfahren dafür und anwendung davon
WO2024261302A1 (en) 2023-06-22 2024-12-26 Institut National de la Santé et de la Recherche Médicale Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders
WO2025078334A1 (en) 2023-10-09 2025-04-17 Institut National de la Santé et de la Recherche Médicale Combination of pak1 inhibitors and clk inhibitors for preventing resistance to chemotherapy in patients suffering from acute myeloid leukemia

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Also Published As

Publication number Publication date
US8530652B2 (en) 2013-09-10
EA011815B1 (ru) 2009-06-30
CN101115760B (zh) 2010-11-03
DK1838718T3 (da) 2011-07-25
GEP20094785B (en) 2009-09-25
HRP20110485T1 (hr) 2011-07-31
NO20073859L (no) 2007-10-03
EP1838718B1 (de) 2011-06-15
AP2007004061A0 (en) 2007-08-31
EA200701257A1 (ru) 2007-12-28
NZ556273A (en) 2010-01-29
WO2006072831A1 (en) 2006-07-13
KR100919343B1 (ko) 2009-09-25
CN101115760A (zh) 2008-01-30
AU2005323797B2 (en) 2009-07-09
AU2005323797A1 (en) 2006-07-13
BRPI0518509A2 (pt) 2008-11-25
SI1838718T1 (sl) 2011-08-31
ES2365245T3 (es) 2011-09-27
PL1838718T3 (pl) 2011-10-31
MX2007008385A (es) 2007-08-21
CA2593428A1 (en) 2006-07-13
MA29141B1 (fr) 2008-01-02
CU23778B7 (es) 2012-02-15
JP2008526826A (ja) 2008-07-24
TNSN07254A1 (en) 2008-12-31
IL184275A0 (en) 2007-10-31
KR20070096007A (ko) 2007-10-01
PT1838718E (pt) 2011-08-17
HK1114380A1 (en) 2008-10-31
EP1838718A1 (de) 2007-10-03
ZA200705628B (en) 2008-11-26
US20120264751A1 (en) 2012-10-18
RS51891B (sr) 2012-02-29
US8067591B2 (en) 2011-11-29
CU20070160A7 (es) 2009-03-16
US20100222342A1 (en) 2010-09-02
CY1111752T1 (el) 2015-10-07
JP4250195B2 (ja) 2009-04-08
CA2593428C (en) 2012-04-17

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