CU23778B7 - Pirrolopirazoles, inhibidores potentes de quinasa - Google Patents
Pirrolopirazoles, inhibidores potentes de quinasaInfo
- Publication number
- CU23778B7 CU23778B7 CU20070160A CU20070160A CU23778B7 CU 23778 B7 CU23778 B7 CU 23778B7 CU 20070160 A CU20070160 A CU 20070160A CU 20070160 A CU20070160 A CU 20070160A CU 23778 B7 CU23778 B7 CU 23778B7
- Authority
- CU
- Cuba
- Prior art keywords
- pirrolopirazoles
- powerful
- inhibitors
- formula
- quinasa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Se proporcionan compuestos de pirrolo-pirazol de fórmula I, composiciones que incluyen estos compuestos y procedimientos de su uso. Los compuestos preferidos de fórmula I tienen actividad como inhibidores de proteína cinasa, incluyendo como inhibidores de PAK4. ESPACIO PARA FÓRMULA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64290005P | 2005-01-10 | 2005-01-10 | |
US73377005P | 2005-11-04 | 2005-11-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20070160A7 CU20070160A7 (es) | 2009-03-16 |
CU23778B7 true CU23778B7 (es) | 2012-02-15 |
Family
ID=36463340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20070160A CU23778B7 (es) | 2005-01-10 | 2007-07-09 | Pirrolopirazoles, inhibidores potentes de quinasa |
Country Status (30)
Country | Link |
---|---|
US (2) | US8067591B2 (es) |
EP (1) | EP1838718B1 (es) |
JP (1) | JP4250195B2 (es) |
KR (1) | KR100919343B1 (es) |
CN (1) | CN101115760B (es) |
AP (1) | AP2007004061A0 (es) |
AT (1) | ATE512972T1 (es) |
AU (1) | AU2005323797B2 (es) |
BR (1) | BRPI0518509A2 (es) |
CA (1) | CA2593428C (es) |
CU (1) | CU23778B7 (es) |
CY (1) | CY1111752T1 (es) |
DK (1) | DK1838718T3 (es) |
EA (1) | EA011815B1 (es) |
ES (1) | ES2365245T3 (es) |
GE (1) | GEP20094785B (es) |
HK (1) | HK1114380A1 (es) |
HR (1) | HRP20110485T1 (es) |
IL (1) | IL184275A0 (es) |
MA (1) | MA29141B1 (es) |
MX (1) | MX2007008385A (es) |
NO (1) | NO20073859L (es) |
NZ (1) | NZ556273A (es) |
PL (1) | PL1838718T3 (es) |
PT (1) | PT1838718E (es) |
RS (1) | RS51891B (es) |
SI (1) | SI1838718T1 (es) |
TN (1) | TNSN07254A1 (es) |
WO (1) | WO2006072831A1 (es) |
ZA (1) | ZA200705628B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS53029B (en) * | 2005-12-21 | 2014-04-30 | Pfizer Products Inc. | CARBONYLAMINE PIROLOPYRAZOLES, POWERFUL KINASE INHIBITORS |
CN101646673B (zh) * | 2007-02-07 | 2014-06-25 | 辉瑞大药厂 | 作为pkc抑制剂的3-氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物 |
US8183255B2 (en) * | 2007-02-07 | 2012-05-22 | Pfizer, Inc. | N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors |
WO2008125945A2 (en) | 2007-04-12 | 2008-10-23 | Pfizer Inc. | 3-amido-pyrrolo [3, 4-c] pyrazole-5 (1h, 4h, 6h) carbaldehyde derivatives as inhibitors of protein kinase c |
EP2175933B1 (en) * | 2007-07-25 | 2012-08-22 | Bristol-Myers Squibb Company | Triazine kinase inhibitors |
FR2928150A1 (fr) | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
JPWO2009130900A1 (ja) * | 2008-04-24 | 2011-08-11 | 日本曹達株式会社 | オキシム誘導体、中間体化合物および植物病害防除剤 |
EP2145891A1 (en) | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
US20120283296A1 (en) * | 2009-10-06 | 2012-11-08 | Afraxis, Inc. | Pyrrolopyrazoles for treating cns disorders |
KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
MX2013005507A (es) | 2010-11-17 | 2013-07-17 | Hoffmann La Roche | Metodos para tratamiento de tumores. |
US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2013113791A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113781A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds i |
WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
EP2809659A1 (en) | 2012-02-03 | 2014-12-10 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113778A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113782A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113719A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds ii |
AR089884A1 (es) | 2012-02-03 | 2014-09-24 | Basf Se | Compuestos fungicidas de pirimidina |
WO2013135671A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
WO2013135672A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
WO2013135745A1 (en) | 2012-03-16 | 2013-09-19 | F. Hoffmann-La Roche Ag | Methods of treating melanoma with pak1 inhibitors |
BR112015005982A2 (pt) | 2012-09-19 | 2017-07-04 | Novartis Ag | di-hidropirrolidino-pirimidinas como inibidores de quinase |
HUE031877T2 (en) * | 2012-10-15 | 2017-08-28 | Pfizer Ireland Pharmaceuticals | A method for producing voriconazole and its analogues |
WO2015036058A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
WO2015036059A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
US10273252B2 (en) | 2015-06-15 | 2019-04-30 | Ube Industries, Ltd. | Substituted dihydropyrrolopyrazole derivative |
CN104926735A (zh) * | 2015-06-16 | 2015-09-23 | 上海合全药物研发有限公司 | 4-氯-5-氟-2-甲基嘧啶的工业化制备方法 |
CA3008171A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
WO2017144546A1 (en) | 2016-02-23 | 2017-08-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma |
CA3041563C (en) | 2016-11-22 | 2023-10-31 | Dana-Farber Cancer Institute, Inc. | Pyrimidin-2-amine derivatives and pharmaceutical compositions thereof useful as inhibitors of cyclin-dependent kinase 12 (cdk12) |
CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
EP3781168A4 (en) * | 2018-04-16 | 2022-10-05 | The Regents of the University of California | PAK4 INHIBITORS AND METHODS OF USE |
WO2020212484A1 (en) | 2019-04-17 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders |
JP2023506768A (ja) | 2019-12-12 | 2023-02-20 | ティン セラピューティックス エルエルシー | 聴覚損失の予防及び治療のための組成物及び方法 |
WO2021198511A1 (en) | 2020-04-03 | 2021-10-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of sars-cov-2 infection |
CN111454278B (zh) * | 2020-05-15 | 2021-03-19 | 四川大学 | Pak1抑制剂及其合成和在制备抗肿瘤药物中的应用 |
WO2022008597A1 (en) | 2020-07-08 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of infectious diseases |
JP2024507433A (ja) * | 2020-12-31 | 2024-02-20 | シノハブ ファーマシューティカルズ カンパニー リミテッド | プラスミン阻害剤、そのための調製方法及びその応用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3423414A (en) | 1966-01-13 | 1969-01-21 | Ciba Geigy Corp | Pyrazolopyridines |
US3526633A (en) | 1968-03-06 | 1970-09-01 | American Cyanamid Co | Substituted 2,4,5,6-tetrahydropyrrolo(3,4-c)pyrazoles |
US3947467A (en) | 1973-08-02 | 1976-03-30 | Eli Lilly And Company | 3-(5-Nitro-2-imidazolyl) pyrazoles |
JPS5163193A (ja) | 1974-11-26 | 1976-06-01 | Yoshitomi Pharmaceutical | Tetorahidoropirazoropirijinkagobutsuno seizoho |
US6013500A (en) | 1998-05-21 | 2000-01-11 | The Trustees Of Columbia University In The City Of New York | PAK4, a novel gene encoding a serine/threonine kinase |
ZA200301813B (en) | 2000-08-10 | 2004-06-22 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them. |
AU2003244649A1 (en) | 2002-07-25 | 2004-02-23 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
UA81790C2 (uk) * | 2002-12-19 | 2008-02-11 | Фармация Италия С.П.А. | Заміщені піролопіразольні похідні як інгібітори кінази |
US7141568B2 (en) | 2003-07-09 | 2006-11-28 | Pfizer Italia S.R.L. | Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
-
2005
- 2005-12-28 BR BRPI0518509-2A patent/BRPI0518509A2/pt not_active Application Discontinuation
- 2005-12-28 PL PL05850734T patent/PL1838718T3/pl unknown
- 2005-12-28 CA CA2593428A patent/CA2593428C/en not_active Expired - Fee Related
- 2005-12-28 DK DK05850734.4T patent/DK1838718T3/da active
- 2005-12-28 EA EA200701257A patent/EA011815B1/ru not_active IP Right Cessation
- 2005-12-28 RS RS20110352A patent/RS51891B/en unknown
- 2005-12-28 MX MX2007008385A patent/MX2007008385A/es active IP Right Grant
- 2005-12-28 EP EP05850734A patent/EP1838718B1/en active Active
- 2005-12-28 SI SI200531320T patent/SI1838718T1/sl unknown
- 2005-12-28 PT PT05850734T patent/PT1838718E/pt unknown
- 2005-12-28 AU AU2005323797A patent/AU2005323797B2/en not_active Ceased
- 2005-12-28 ES ES05850734T patent/ES2365245T3/es active Active
- 2005-12-28 US US11/813,658 patent/US8067591B2/en not_active Expired - Fee Related
- 2005-12-28 KR KR1020077018110A patent/KR100919343B1/ko not_active IP Right Cessation
- 2005-12-28 JP JP2007549962A patent/JP4250195B2/ja not_active Expired - Fee Related
- 2005-12-28 CN CN2005800480012A patent/CN101115760B/zh not_active Expired - Fee Related
- 2005-12-28 AT AT05850734T patent/ATE512972T1/de active
- 2005-12-28 WO PCT/IB2005/003975 patent/WO2006072831A1/en active Application Filing
- 2005-12-28 NZ NZ556273A patent/NZ556273A/en not_active IP Right Cessation
- 2005-12-28 AP AP2007004061A patent/AP2007004061A0/xx unknown
- 2005-12-28 GE GEAP200510173A patent/GEP20094785B/en unknown
-
2007
- 2007-06-28 IL IL184275A patent/IL184275A0/en unknown
- 2007-07-04 TN TNP2007000254A patent/TNSN07254A1/en unknown
- 2007-07-09 ZA ZA200705628A patent/ZA200705628B/xx unknown
- 2007-07-09 CU CU20070160A patent/CU23778B7/es not_active IP Right Cessation
- 2007-07-10 MA MA30059A patent/MA29141B1/fr unknown
- 2007-07-23 NO NO20073859A patent/NO20073859L/no not_active Application Discontinuation
-
2008
- 2008-03-19 HK HK08103173.5A patent/HK1114380A1/xx not_active IP Right Cessation
-
2011
- 2011-06-30 HR HR20110485T patent/HRP20110485T1/hr unknown
- 2011-07-20 CY CY20111100716T patent/CY1111752T1/el unknown
- 2011-10-06 US US13/267,302 patent/US8530652B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant of patent | ||
FD | Lapse (for not paying fees) |