CU23778B7 - Pirrolopirazoles, inhibidores potentes de quinasa - Google Patents

Pirrolopirazoles, inhibidores potentes de quinasa

Info

Publication number
CU23778B7
CU23778B7 CU20070160A CU20070160A CU23778B7 CU 23778 B7 CU23778 B7 CU 23778B7 CU 20070160 A CU20070160 A CU 20070160A CU 20070160 A CU20070160 A CU 20070160A CU 23778 B7 CU23778 B7 CU 23778B7
Authority
CU
Cuba
Prior art keywords
pirrolopirazoles
powerful
inhibitors
formula
quinasa
Prior art date
Application number
CU20070160A
Other languages
English (en)
Other versions
CU20070160A7 (es
Inventor
Anle Yang
Junhu Zhang
Haitao Li
Chuangxing Guo
Liming Dong
Djamal Bouzida
Yufeng Hong
Joseph Timothy Marakovits
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20070160A7 publication Critical patent/CU20070160A7/es
Publication of CU23778B7 publication Critical patent/CU23778B7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Se proporcionan compuestos de pirrolo-pirazol de fórmula I, composiciones que incluyen estos compuestos y procedimientos de su uso. Los compuestos preferidos de fórmula I tienen actividad como inhibidores de proteína cinasa, incluyendo como inhibidores de PAK4. ESPACIO PARA FÓRMULA
CU20070160A 2005-01-10 2007-07-09 Pirrolopirazoles, inhibidores potentes de quinasa CU23778B7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64290005P 2005-01-10 2005-01-10
US73377005P 2005-11-04 2005-11-04

Publications (2)

Publication Number Publication Date
CU20070160A7 CU20070160A7 (es) 2009-03-16
CU23778B7 true CU23778B7 (es) 2012-02-15

Family

ID=36463340

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070160A CU23778B7 (es) 2005-01-10 2007-07-09 Pirrolopirazoles, inhibidores potentes de quinasa

Country Status (30)

Country Link
US (2) US8067591B2 (es)
EP (1) EP1838718B1 (es)
JP (1) JP4250195B2 (es)
KR (1) KR100919343B1 (es)
CN (1) CN101115760B (es)
AP (1) AP2007004061A0 (es)
AT (1) ATE512972T1 (es)
AU (1) AU2005323797B2 (es)
BR (1) BRPI0518509A2 (es)
CA (1) CA2593428C (es)
CU (1) CU23778B7 (es)
CY (1) CY1111752T1 (es)
DK (1) DK1838718T3 (es)
EA (1) EA011815B1 (es)
ES (1) ES2365245T3 (es)
GE (1) GEP20094785B (es)
HK (1) HK1114380A1 (es)
HR (1) HRP20110485T1 (es)
IL (1) IL184275A0 (es)
MA (1) MA29141B1 (es)
MX (1) MX2007008385A (es)
NO (1) NO20073859L (es)
NZ (1) NZ556273A (es)
PL (1) PL1838718T3 (es)
PT (1) PT1838718E (es)
RS (1) RS51891B (es)
SI (1) SI1838718T1 (es)
TN (1) TNSN07254A1 (es)
WO (1) WO2006072831A1 (es)
ZA (1) ZA200705628B (es)

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CN101646673B (zh) * 2007-02-07 2014-06-25 辉瑞大药厂 作为pkc抑制剂的3-氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物
US8183255B2 (en) * 2007-02-07 2012-05-22 Pfizer, Inc. N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors
WO2008125945A2 (en) 2007-04-12 2008-10-23 Pfizer Inc. 3-amido-pyrrolo [3, 4-c] pyrazole-5 (1h, 4h, 6h) carbaldehyde derivatives as inhibitors of protein kinase c
EP2175933B1 (en) * 2007-07-25 2012-08-22 Bristol-Myers Squibb Company Triazine kinase inhibitors
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JPWO2009130900A1 (ja) * 2008-04-24 2011-08-11 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
US20120283296A1 (en) * 2009-10-06 2012-11-08 Afraxis, Inc. Pyrrolopyrazoles for treating cns disorders
KR101483215B1 (ko) * 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
MX2013005507A (es) 2010-11-17 2013-07-17 Hoffmann La Roche Metodos para tratamiento de tumores.
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013113791A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113716A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113781A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds i
WO2013113773A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113720A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
EP2809659A1 (en) 2012-02-03 2014-12-10 Basf Se Fungicidal pyrimidine compounds
WO2013113776A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113778A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113782A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113719A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds ii
AR089884A1 (es) 2012-02-03 2014-09-24 Basf Se Compuestos fungicidas de pirimidina
WO2013135671A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
WO2013135672A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
WO2013135745A1 (en) 2012-03-16 2013-09-19 F. Hoffmann-La Roche Ag Methods of treating melanoma with pak1 inhibitors
BR112015005982A2 (pt) 2012-09-19 2017-07-04 Novartis Ag di-hidropirrolidino-pirimidinas como inibidores de quinase
HUE031877T2 (en) * 2012-10-15 2017-08-28 Pfizer Ireland Pharmaceuticals A method for producing voriconazole and its analogues
WO2015036058A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
US10273252B2 (en) 2015-06-15 2019-04-30 Ube Industries, Ltd. Substituted dihydropyrrolopyrazole derivative
CN104926735A (zh) * 2015-06-16 2015-09-23 上海合全药物研发有限公司 4-氯-5-氟-2-甲基嘧啶的工业化制备方法
CA3008171A1 (en) 2015-12-22 2017-06-29 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
WO2017144546A1 (en) 2016-02-23 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
CA3041563C (en) 2016-11-22 2023-10-31 Dana-Farber Cancer Institute, Inc. Pyrimidin-2-amine derivatives and pharmaceutical compositions thereof useful as inhibitors of cyclin-dependent kinase 12 (cdk12)
CA3066939A1 (en) 2017-06-21 2018-12-27 SHY Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
EP3781168A4 (en) * 2018-04-16 2022-10-05 The Regents of the University of California PAK4 INHIBITORS AND METHODS OF USE
WO2020212484A1 (en) 2019-04-17 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
JP2023506768A (ja) 2019-12-12 2023-02-20 ティン セラピューティックス エルエルシー 聴覚損失の予防及び治療のための組成物及び方法
WO2021198511A1 (en) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of sars-cov-2 infection
CN111454278B (zh) * 2020-05-15 2021-03-19 四川大学 Pak1抑制剂及其合成和在制备抗肿瘤药物中的应用
WO2022008597A1 (en) 2020-07-08 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of infectious diseases
JP2024507433A (ja) * 2020-12-31 2024-02-20 シノハブ ファーマシューティカルズ カンパニー リミテッド プラスミン阻害剤、そのための調製方法及びその応用

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US3526633A (en) 1968-03-06 1970-09-01 American Cyanamid Co Substituted 2,4,5,6-tetrahydropyrrolo(3,4-c)pyrazoles
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US6013500A (en) 1998-05-21 2000-01-11 The Trustees Of Columbia University In The City Of New York PAK4, a novel gene encoding a serine/threonine kinase
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Also Published As

Publication number Publication date
ES2365245T3 (es) 2011-09-27
AU2005323797A1 (en) 2006-07-13
EP1838718A1 (en) 2007-10-03
DK1838718T3 (da) 2011-07-25
EA011815B1 (ru) 2009-06-30
GEP20094785B (en) 2009-09-25
NO20073859L (no) 2007-10-03
BRPI0518509A2 (pt) 2008-11-25
CU20070160A7 (es) 2009-03-16
NZ556273A (en) 2010-01-29
EA200701257A1 (ru) 2007-12-28
PL1838718T3 (pl) 2011-10-31
US8067591B2 (en) 2011-11-29
ZA200705628B (en) 2008-11-26
CA2593428C (en) 2012-04-17
US20100222342A1 (en) 2010-09-02
RS51891B (en) 2012-02-29
SI1838718T1 (sl) 2011-08-31
PT1838718E (pt) 2011-08-17
JP4250195B2 (ja) 2009-04-08
CN101115760B (zh) 2010-11-03
TNSN07254A1 (en) 2008-12-31
CN101115760A (zh) 2008-01-30
WO2006072831A1 (en) 2006-07-13
CY1111752T1 (el) 2015-10-07
EP1838718B1 (en) 2011-06-15
MA29141B1 (fr) 2008-01-02
US20120264751A1 (en) 2012-10-18
KR20070096007A (ko) 2007-10-01
HK1114380A1 (en) 2008-10-31
ATE512972T1 (de) 2011-07-15
AP2007004061A0 (en) 2007-08-31
HRP20110485T1 (hr) 2011-07-31
JP2008526826A (ja) 2008-07-24
CA2593428A1 (en) 2006-07-13
IL184275A0 (en) 2007-10-31
AU2005323797B2 (en) 2009-07-09
MX2007008385A (es) 2007-08-21
US8530652B2 (en) 2013-09-10
KR100919343B1 (ko) 2009-09-25

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