MA29141B1 - Pyrrolopyrazoles, servant de puissants inhibiteurs de kinases - Google Patents

Pyrrolopyrazoles, servant de puissants inhibiteurs de kinases

Info

Publication number
MA29141B1
MA29141B1 MA30059A MA30059A MA29141B1 MA 29141 B1 MA29141 B1 MA 29141B1 MA 30059 A MA30059 A MA 30059A MA 30059 A MA30059 A MA 30059A MA 29141 B1 MA29141 B1 MA 29141B1
Authority
MA
Morocco
Prior art keywords
kinases
pyrrolopyrazoles
inhibitors
powerful inhibitors
compounds
Prior art date
Application number
MA30059A
Other languages
English (en)
Inventor
Djamal Bouzida
Liming Dong
Chuangxing Guo
Yufeng Hong
Haitao Li
Joseph Timothy Marakovits
Anle Yang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA29141B1 publication Critical patent/MA29141B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'INVENTION DES COMPOSÉS DE PYRROLOPYRAZOLES DE FORMULE (I), DES COMPOSITIONS COMPRENANT LESDITS COMPOSÉS, AINSI QUE LEURS MÉTHODES D'UTILISATION. LES COMPOSÉS PRÉFÉRÉS DE FORMULE I PRÉSENTENT UNE ACTIVITÉ EN TANT QU'INHIBITEURS DE PROTÉINES KINASES, NOTAMMENT EN TANT QU'INHIBITEURS DE PAK4.
MA30059A 2005-01-10 2007-07-10 Pyrrolopyrazoles, servant de puissants inhibiteurs de kinases MA29141B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64290005P 2005-01-10 2005-01-10
US73377005P 2005-11-04 2005-11-04

Publications (1)

Publication Number Publication Date
MA29141B1 true MA29141B1 (fr) 2008-01-02

Family

ID=36463340

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30059A MA29141B1 (fr) 2005-01-10 2007-07-10 Pyrrolopyrazoles, servant de puissants inhibiteurs de kinases

Country Status (30)

Country Link
US (2) US8067591B2 (fr)
EP (1) EP1838718B1 (fr)
JP (1) JP4250195B2 (fr)
KR (1) KR100919343B1 (fr)
CN (1) CN101115760B (fr)
AP (1) AP2007004061A0 (fr)
AT (1) ATE512972T1 (fr)
AU (1) AU2005323797B2 (fr)
BR (1) BRPI0518509A2 (fr)
CA (1) CA2593428C (fr)
CU (1) CU23778B7 (fr)
CY (1) CY1111752T1 (fr)
DK (1) DK1838718T3 (fr)
EA (1) EA011815B1 (fr)
ES (1) ES2365245T3 (fr)
GE (1) GEP20094785B (fr)
HK (1) HK1114380A1 (fr)
HR (1) HRP20110485T1 (fr)
IL (1) IL184275A0 (fr)
MA (1) MA29141B1 (fr)
MX (1) MX2007008385A (fr)
NO (1) NO20073859L (fr)
NZ (1) NZ556273A (fr)
PL (1) PL1838718T3 (fr)
PT (1) PT1838718E (fr)
RS (1) RS51891B (fr)
SI (1) SI1838718T1 (fr)
TN (1) TNSN07254A1 (fr)
WO (1) WO2006072831A1 (fr)
ZA (1) ZA200705628B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101029167B1 (ko) * 2005-12-21 2011-04-12 화이자 프로덕츠 인크. 강력한 키나제 억제제인 카르보닐아미노 피롤로피라졸
CN101646673B (zh) * 2007-02-07 2014-06-25 辉瑞大药厂 作为pkc抑制剂的3-氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物
AP2009004958A0 (en) * 2007-02-07 2009-08-31 Pfizer 3-amino-pyrrolo [3,4-C] pyrazole - 5 (1H, 4H, 6H) carbaldehyde derivatives as PKC inhibitors
CA2683695C (fr) * 2007-04-12 2013-06-18 Pfizer Inc. Nouveaux derives de 3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h.6h) carbaldehyde
WO2009015254A1 (fr) * 2007-07-25 2009-01-29 Bristol-Myers Squibb Company Inhibiteurs de triazine kinase
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
JPWO2009130900A1 (ja) * 2008-04-24 2011-08-11 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
EP2145891A1 (fr) 2008-07-09 2010-01-20 Vetoquinol S.A. Dérivés de 9-substitués-5-carboxy-oxadiazino-quinolone, leur préparation et leur application en tant qu'antibactériens
US20120283296A1 (en) * 2009-10-06 2012-11-08 Afraxis, Inc. Pyrrolopyrazoles for treating cns disorders
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
RU2013126036A (ru) 2010-11-17 2014-12-27 Ф. Хоффманн-Ля Рош Аг Способ лечения опухолей
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
WO2013113720A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
AU2013214353A1 (en) 2012-02-03 2014-08-21 Basf Se Fungicidal pyrimidine compounds
WO2013113781A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides i
WO2013113716A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
WO2013113782A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
WO2013113778A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
IN2014DN07220A (fr) 2012-02-03 2015-04-24 Basf Se
WO2013113776A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
WO2013113773A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés fongicides de pyrimidine
WO2013113719A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides ii
WO2013113788A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
WO2013135672A1 (fr) 2012-03-13 2013-09-19 Basf Se Composés de pyrimidine fongicides
JP2015512891A (ja) 2012-03-13 2015-04-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 殺菌性ピリミジン化合物
KR20140135198A (ko) * 2012-03-16 2014-11-25 에프. 호프만-라 로슈 아게 Pak1 억제제로 흑색종을 치료하는 방법
WO2014047020A1 (fr) 2012-09-19 2014-03-27 Novartis Ag Dihydropyrrolidinopyrimidines comme inhibiteurs de kinase
DK2906555T3 (en) * 2012-10-15 2017-02-06 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogs thereof
WO2015036058A1 (fr) 2013-09-16 2015-03-19 Basf Se Composés pyrimidines fongicides
WO2015036059A1 (fr) 2013-09-16 2015-03-19 Basf Se Composés fongicides de pyrimidine
US10273252B2 (en) 2015-06-15 2019-04-30 Ube Industries, Ltd. Substituted dihydropyrrolopyrazole derivative
CN104926735A (zh) * 2015-06-16 2015-09-23 上海合全药物研发有限公司 4-氯-5-氟-2-甲基嘧啶的工业化制备方法
WO2017112777A1 (fr) 2015-12-22 2017-06-29 SHY Therapeutics LLC Composés pour le traitement du cancer et de maladies inflammatoires
WO2017144546A1 (fr) 2016-02-23 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement d'un carcinome de rhinopharyngite
CA3041563C (fr) 2016-11-22 2023-10-31 Dana-Farber Cancer Institute, Inc. Derives de pyrimidine-2-amine et compositions pharmaceutiques connexes utiles comme inhibiteurs de kinase 12 dependante des cyclines (cdk12)
KR20200041294A (ko) 2017-06-21 2020-04-21 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
CA3097543A1 (fr) * 2018-04-16 2019-10-24 The Regents Of The University Of California Inhibiteurs de pak4 et procedes d'utilisation
WO2020212484A1 (fr) 2019-04-17 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions de traitement de troubles dépendants de il-1beta mediés par inflamasome nlrp3
WO2021198511A1 (fr) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pour le traitement d'une infection par sars-cov-2
CN111454278B (zh) * 2020-05-15 2021-03-19 四川大学 Pak1抑制剂及其合成和在制备抗肿瘤药物中的应用
WO2022008597A1 (fr) 2020-07-08 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et composition pharmaceutique pour le traitement de maladies infectieuses
CA3203896A1 (fr) * 2020-12-31 2022-07-07 Anle Yang Inhibiteur de plasmine, son procede de preparation et son application

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423414A (en) * 1966-01-13 1969-01-21 Ciba Geigy Corp Pyrazolopyridines
US3526633A (en) * 1968-03-06 1970-09-01 American Cyanamid Co Substituted 2,4,5,6-tetrahydropyrrolo(3,4-c)pyrazoles
US3947467A (en) * 1973-08-02 1976-03-30 Eli Lilly And Company 3-(5-Nitro-2-imidazolyl) pyrazoles
JPS5163193A (ja) 1974-11-26 1976-06-01 Yoshitomi Pharmaceutical Tetorahidoropirazoropirijinkagobutsuno seizoho
US6013500A (en) * 1998-05-21 2000-01-11 The Trustees Of Columbia University In The City Of New York PAK4, a novel gene encoding a serine/threonine kinase
ES2349762T3 (es) * 2000-08-10 2011-01-11 Pfizer Italia S.R.L. Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
MXPA05000945A (es) * 2002-07-25 2005-05-16 Pharmacia Italia Spa Biciclo-pirazoles activos como inhibidores de la cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
UA81790C2 (uk) * 2002-12-19 2008-02-11 Фармация Италия С.П.А. Заміщені піролопіразольні похідні як інгібітори кінази
US7141568B2 (en) * 2003-07-09 2006-11-28 Pfizer Italia S.R.L. Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
KR100919343B1 (ko) 2009-09-25
NO20073859L (no) 2007-10-03
JP4250195B2 (ja) 2009-04-08
WO2006072831A1 (fr) 2006-07-13
DK1838718T3 (da) 2011-07-25
KR20070096007A (ko) 2007-10-01
MX2007008385A (es) 2007-08-21
JP2008526826A (ja) 2008-07-24
ZA200705628B (en) 2008-11-26
ATE512972T1 (de) 2011-07-15
US20120264751A1 (en) 2012-10-18
EP1838718B1 (fr) 2011-06-15
CA2593428C (fr) 2012-04-17
CU20070160A7 (es) 2009-03-16
TNSN07254A1 (en) 2008-12-31
AU2005323797B2 (en) 2009-07-09
NZ556273A (en) 2010-01-29
US8530652B2 (en) 2013-09-10
EA200701257A1 (ru) 2007-12-28
BRPI0518509A2 (pt) 2008-11-25
CN101115760A (zh) 2008-01-30
AU2005323797A1 (en) 2006-07-13
CU23778B7 (es) 2012-02-15
HK1114380A1 (en) 2008-10-31
GEP20094785B (en) 2009-09-25
HRP20110485T1 (hr) 2011-07-31
PT1838718E (pt) 2011-08-17
EP1838718A1 (fr) 2007-10-03
SI1838718T1 (sl) 2011-08-31
ES2365245T3 (es) 2011-09-27
US20100222342A1 (en) 2010-09-02
CN101115760B (zh) 2010-11-03
RS51891B (en) 2012-02-29
PL1838718T3 (pl) 2011-10-31
CY1111752T1 (el) 2015-10-07
US8067591B2 (en) 2011-11-29
IL184275A0 (en) 2007-10-31
AP2007004061A0 (en) 2007-08-31
EA011815B1 (ru) 2009-06-30
CA2593428A1 (fr) 2006-07-13

Similar Documents

Publication Publication Date Title
MA29141B1 (fr) Pyrrolopyrazoles, servant de puissants inhibiteurs de kinases
MA30076B1 (fr) Carbonylaminopyrrolopyrazoles servant de puissants inhibiteurs de kinases.
TNSN05208A1 (fr) Composes aminoheteroaryliques servant d'inhibiteurs de proteine-kinases
MA30784B1 (fr) Derives phenyliques et utilisation de ceux-ci en tant qu'immunomodulateurs.
MA27467A1 (fr) Quinolones anti-microbiens, leurs compositions et utilisations
JO3181B1 (ar) مشتقات كمحول ثاني الكيل البايردينيل - أحادي الفينيل كأنزيم ثنائي استرات الفوسفود
NO20070557L (no) Ftalazinderivater som PARP-inhibitorer
ATE433447T1 (de) Pyrimiidinverbindungen
NO20041493L (no) Kjemiske forbindelser.
MA31433B1 (fr) Inhibiteurs de la p70 s6 kinase
NO20071078L (no) Antivirale forbindelser
NO20070866L (no) Antivirale forbindelser.
NO20070529L (no) Kinazolindionderivater som parp-inhibitorer
BR0313176A (pt) Composições de pirazol úteis como inibidores de gsk-3
MY153424A (en) Modulators of indoleamine 2,3-dioxygenase and methods of using the same
DE602004013563D1 (de) Rantagonisten
NO20065051L (no) Bazedoksifenacetat faste dispersjonsfomuleringer
TW200738281A (en) Bazedoxifene acetate formulations
EA201000494A1 (ru) Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4
MA32150B1 (fr) Inhibiteurs heterocycliques de la stearoyl-coa desaturase
MA29723B1 (fr) Composes
MA32173B1 (fr) Derives de pyridin-2-yle utilises comme agents immunomodulateurs
DE60141636D1 (de) Phospholipidderivate von valproinsäure und ihre kombinationen
MX2010007543A (es) Inhibidores de iap.
MA31526B1 (fr) Nouveaux herbicides