MA31433B1 - Inhibiteurs de la p70 s6 kinase - Google Patents

Inhibiteurs de la p70 s6 kinase

Info

Publication number
MA31433B1
MA31433B1 MA32404A MA32404A MA31433B1 MA 31433 B1 MA31433 B1 MA 31433B1 MA 32404 A MA32404 A MA 32404A MA 32404 A MA32404 A MA 32404A MA 31433 B1 MA31433 B1 MA 31433B1
Authority
MA
Morocco
Prior art keywords
inhibitors
inhibitors kinase
kinase
formula
methods
Prior art date
Application number
MA32404A
Other languages
Arabic (ar)
English (en)
Inventor
Robert Dean Dally
Jianping Huang
Sajan Joseph
Timothy Alan Shepherd
Christian L Holst
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA31433B1 publication Critical patent/MA31433B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des inhibiteurs de la p70 s6 kinase de formule : des formulations pharmaceutiques comprenant ces inhibiteurs et leurs procédés d'utilisation.
MA32404A 2007-05-11 2009-12-07 Inhibiteurs de la p70 s6 kinase MA31433B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11
PCT/US2008/062143 WO2008140947A1 (fr) 2007-05-11 2008-05-01 Inhibiteurs de la p70 s6 kinase

Publications (1)

Publication Number Publication Date
MA31433B1 true MA31433B1 (fr) 2010-06-01

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32404A MA31433B1 (fr) 2007-05-11 2009-12-07 Inhibiteurs de la p70 s6 kinase

Country Status (33)

Country Link
US (2) US8093383B2 (fr)
EP (1) EP2148880B1 (fr)
JP (1) JP5503532B2 (fr)
KR (1) KR101088219B1 (fr)
CN (1) CN101679439B (fr)
AR (1) AR066344A1 (fr)
AU (1) AU2008251692B2 (fr)
BR (1) BRPI0811212A2 (fr)
CA (1) CA2687265C (fr)
CL (1) CL2008001230A1 (fr)
CO (1) CO6241109A2 (fr)
CR (1) CR11106A (fr)
DK (1) DK2148880T3 (fr)
DO (1) DOP2009000257A (fr)
EA (1) EA016445B1 (fr)
EC (1) ECSP099721A (fr)
ES (1) ES2483726T3 (fr)
GT (1) GT200900292A (fr)
HR (1) HRP20140611T1 (fr)
IL (1) IL201564A (fr)
MA (1) MA31433B1 (fr)
MX (1) MX2009012075A (fr)
MY (1) MY154898A (fr)
NZ (1) NZ580423A (fr)
PE (1) PE20090887A1 (fr)
PL (1) PL2148880T3 (fr)
PT (1) PT2148880E (fr)
RS (1) RS53451B (fr)
SI (1) SI2148880T1 (fr)
TN (1) TN2009000446A1 (fr)
TW (1) TWI423805B (fr)
UA (1) UA99284C2 (fr)
WO (1) WO2008140947A1 (fr)

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UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
US8252791B2 (en) * 2008-08-13 2012-08-28 Jenrin Discovery, Inc. Purine compounds as cannabinoid receptor blockers
WO2010056574A1 (fr) * 2008-11-11 2010-05-20 Eli Lilly And Company Thérapie combinant l'inhibiteur de p70 s6 kinase et l'inhibiteur de mtor
AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
US8334293B2 (en) 2008-11-11 2012-12-18 Eli Lilly And Company P70 S6 kinase inhibitor and EGFR inhibitor combination therapy
CA2751886C (fr) 2009-02-11 2017-08-29 Merck Patent Gmbh Nouveaux carboxamides amino-azaheterocycliques
WO2011017009A1 (fr) 2009-08-07 2011-02-10 Merck Patent Gmbh Nouveaux composés azahétérocycliques
WO2011050016A1 (fr) * 2009-10-23 2011-04-28 Eli Lilly And Company Inhibiteurs d'akt
MX2012009030A (es) 2010-02-03 2012-09-12 Signal Pharm Llc Identificacion de mutacion lkb1 como biomarcador predictivo para sensibilidad a inhibidores de tor cinasa.
EP2598497B1 (fr) 2010-07-29 2019-03-06 Merck Patent GmbH Carboxamides azahétérocycliques d'amines cycliques
UA110113C2 (xx) 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
EP2643313B9 (fr) 2010-11-24 2017-02-22 Merck Patent GmbH Quinazoline carboxamide azétidines
CN106946796B (zh) 2011-09-12 2020-05-08 默克专利有限公司 用作激酶活性调节剂的氨基嘧啶衍生物
MX346095B (es) 2011-09-12 2017-03-07 Merck Patent Gmbh Nuevas imidazol-aminas como moduladores de la actividad de cinasas.
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
WO2014078634A1 (fr) * 2012-11-16 2014-05-22 Merck Patent Gmbh Nouveaux dérivés imidazol-pipéridinyle en tant que modulateurs de l'activité kinase
AR093512A1 (es) 2012-11-16 2015-06-10 Merck Patent Gmbh Derivados heterociclicos como moduladores de la actividad de cinasas
PE20151782A1 (es) 2012-11-29 2015-12-02 Merck Patent Gmbh Derivados de azaquinolin-carboxamida
SG10201900954SA (en) * 2013-03-11 2019-02-27 Merck Patent Gmbh Heterocycles as Modulators of Kinase Activity
MX374749B (es) 2013-04-17 2025-03-06 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un analogo de citidina para tratar cancer.
NZ629230A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
NZ629332A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
CA2909579A1 (fr) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Therapie combinee comprenant un inhibiteur de la kinase tor et du n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide pour le traitement d'un cancer
EP2986322A1 (fr) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Polythérapie comprenant un inhibiteur de kinase tor et un composé de quinazolinone substitué en 5 pour le traitement du cancer
NZ629411A (en) 2013-04-17 2017-06-30 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629469A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
HK1223286A1 (zh) 2013-05-29 2017-07-28 西格诺药品有限公司 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法
WO2015134536A1 (fr) * 2014-03-04 2015-09-11 Plexxikon Inc. Composés et méthodes de modulation des kinases, et leurs indications
US9980966B2 (en) 2014-04-03 2018-05-29 Merck Patent Gmbh Combinations of cancer therapeutics
EP3131551A4 (fr) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC Formes solides comprenant 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one, et co-formateur, compositions et procédés d'utilisation de ces dernières
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
WO2016040078A1 (fr) * 2014-09-10 2016-03-17 Eli Lilly And Company Composés de phénylimidazolylpipéridyle substitués utilisés en tant qu'inhibiteurs de p70s6k1
WO2016164641A1 (fr) 2015-04-08 2016-10-13 Plexxikon Inc. Composés et méthodes de modulation des kinases, et leurs indications
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
MY198676A (en) 2017-06-22 2023-09-15 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
WO2022101459A1 (fr) 2020-11-16 2022-05-19 Merck Patent Gmbh Combinaisons d'inhibiteurs de kinase pour le traitement du cancer

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PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
JP5213229B2 (ja) * 2004-04-23 2013-06-19 エグゼリクシス， インコーポレイテッド キナーゼ調節因子および使用方法
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
ATE543821T1 (de) 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
US20090325924A1 (en) 2005-06-30 2009-12-31 Stuart Edward GPCR Agonists
JP2009536620A (ja) 2006-04-25 2009-10-15 アステックス、セラピューティックス、リミテッド 医薬組み合わせ物
US8796293B2 (en) 2006-04-25 2014-08-05 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
WO2008012635A2 (fr) 2006-07-26 2008-01-31 Pfizer Products Inc. Dérivés d'amines utiles en tant qu'agents anticancéreux
AR064416A1 (es) * 2006-12-21 2009-04-01 Cancer Rec Tech Ltd Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Also Published As

Publication number Publication date
JP2010526814A (ja) 2010-08-05
PT2148880E (pt) 2014-08-28
TW200848053A (en) 2008-12-16
EP2148880B1 (fr) 2014-05-28
AR066344A1 (es) 2009-08-12
PL2148880T3 (pl) 2014-10-31
PE20090887A1 (es) 2009-07-13
EA016445B1 (ru) 2012-05-30
CO6241109A2 (es) 2011-01-20
MY154898A (en) 2015-08-28
IL201564A (en) 2014-08-31
SI2148880T1 (sl) 2014-07-31
CA2687265C (fr) 2012-12-04
HK1140767A1 (en) 2010-10-22
EP2148880A1 (fr) 2010-02-03
RS53451B (sr) 2014-12-31
DOP2009000257A (es) 2010-03-31
WO2008140947A1 (fr) 2008-11-20
CN101679439B (zh) 2013-09-11
CR11106A (es) 2010-04-12
US20120071490A1 (en) 2012-03-22
CL2008001230A1 (es) 2009-05-22
TN2009000446A1 (en) 2011-03-31
CN101679439A (zh) 2010-03-24
CA2687265A1 (fr) 2008-11-20
KR101088219B1 (ko) 2011-11-30
MX2009012075A (es) 2009-11-19
KR20100005710A (ko) 2010-01-15
AU2008251692B2 (en) 2012-10-11
BRPI0811212A2 (pt) 2014-10-29
AU2008251692A1 (en) 2008-11-20
US8093383B2 (en) 2012-01-10
TWI423805B (zh) 2014-01-21
HRP20140611T1 (hr) 2014-08-15
JP5503532B2 (ja) 2014-05-28
DK2148880T3 (da) 2014-06-16
US20090163714A1 (en) 2009-06-25
NZ580423A (en) 2012-02-24
IL201564A0 (en) 2010-05-31
ECSP099721A (es) 2009-12-28
GT200900292A (es) 2011-06-24
UA99284C2 (ru) 2012-08-10
EA200971051A1 (ru) 2010-06-30
ES2483726T3 (es) 2014-08-07

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