HRP20140611T1 - Inhibitori kinaze p70 s6 - Google Patents
Inhibitori kinaze p70 s6 Download PDFInfo
- Publication number
- HRP20140611T1 HRP20140611T1 HRP20140611AT HRP20140611T HRP20140611T1 HR P20140611 T1 HRP20140611 T1 HR P20140611T1 HR P20140611A T HRP20140611A T HR P20140611AT HR P20140611 T HRP20140611 T HR P20140611T HR P20140611 T1 HRP20140611 T1 HR P20140611T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- intended
- trifluoromethyl
- Prior art date
Links
- 108010013238 70-kDa Ribosomal Protein S6 Kinases Proteins 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- FYXRSVDHGLUMHB-UHFFFAOYSA-N 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine Chemical compound N1=C(C2CCN(CC2)C=2C=3C=NNC=3N=CN=2)N(C)C=C1C1=CC=C(F)C(C(F)(F)F)=C1 FYXRSVDHGLUMHB-UHFFFAOYSA-N 0.000 claims 1
- HDYUXDNMHBQKAU-UHFFFAOYSA-N 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.N1=C(C2CCN(CC2)C=2C=3C=NNC=3N=CN=2)N(C)C=C1C1=CC=C(F)C(C(F)(F)F)=C1 HDYUXDNMHBQKAU-UHFFFAOYSA-N 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Claims (9)
1. Spoj formule:
[image]
,
naznačen time što:
Y je CR6;
Z1 i Z2 su neovisno CR3 ili N, uz uvjet da Z1 i Z2 nisu oba N;
R1 je H ili CH3;
R3 je fenil supstituiran s prvim supstituentom, kojeg se bira između halogena i trifluormetila, i izborno je dodatno supstituiran s drugim supstituentom, gdje je navedeni drugi supstituent halogen;
R3 je vodik, halogen, C1-C4 alkil, C3-C6 cikloalkil ili C2-C6 alkinil, gdje je C2-C6 alkinil izborno supstituiran s hidroksi;
R4 i R5 su neovisno vodik ili C1-C4 alkil;
R6 je vodik;
ili njegova farmaceutski prihvatljiva sol.
2. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je Z2 N.
3. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je 4-(4-{4-[4-fluor-3-(trifluormetil)fenil]-1-metil-1H-imidazol-2-il}piperidin-1-il)-1H-pirazolo[3,4-d]pirimidin, ili njegova farmaceutski prihvatljiva sol.
4. Spoj u skladu s patentnim zahtjevom 3, naznačen time što je 4-(4-{4-[4-fluor-3-(trifluormetil)fenil]-1-metil-1H-imidazol-2-il}piperidin-1-il)-1H-pirazolo[3,4-d]pirimidin-p-toluensulfonat.
5. Farmaceutska formulacija, naznačena time što sadrži spoj u skladu s bilo kojim od patentni zahtjeva 1 do 4, ili njegovu farmaceutski prihvatljivu sol, u kombinaciji s farmaceutski prihvatljivom podlogom, razrjeđivačem ili pomoćnom tvari.
6. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 4, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u terapiji.
7. Spoj u skladu s bilo kojim od patentni zahtjeva 1 do 4, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u sprječavanju angiogeneze.
8. Spoj u skladu s bilo kojim od patentni zahtjeva 1 do 4, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju adenokarcinoma debelog crijeva.
9. Spoj u skladu s bilo kojim od patentni zahtjeva 1 do 4, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju hiperlipidemije.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91733107P | 2007-05-11 | 2007-05-11 | |
| PCT/US2008/062143 WO2008140947A1 (en) | 2007-05-11 | 2008-05-01 | P70 s6 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140611T1 true HRP20140611T1 (hr) | 2014-08-15 |
Family
ID=39765082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140611AT HRP20140611T1 (hr) | 2007-05-11 | 2014-06-26 | Inhibitori kinaze p70 s6 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US8093383B2 (hr) |
| EP (1) | EP2148880B1 (hr) |
| JP (1) | JP5503532B2 (hr) |
| KR (1) | KR101088219B1 (hr) |
| CN (1) | CN101679439B (hr) |
| AR (1) | AR066344A1 (hr) |
| AU (1) | AU2008251692B2 (hr) |
| BR (1) | BRPI0811212A2 (hr) |
| CA (1) | CA2687265C (hr) |
| CL (1) | CL2008001230A1 (hr) |
| CO (1) | CO6241109A2 (hr) |
| CR (1) | CR11106A (hr) |
| DK (1) | DK2148880T3 (hr) |
| DO (1) | DOP2009000257A (hr) |
| EA (1) | EA016445B1 (hr) |
| EC (1) | ECSP099721A (hr) |
| ES (1) | ES2483726T3 (hr) |
| GT (1) | GT200900292A (hr) |
| HK (1) | HK1140767A1 (hr) |
| HR (1) | HRP20140611T1 (hr) |
| IL (1) | IL201564A (hr) |
| MA (1) | MA31433B1 (hr) |
| MX (1) | MX2009012075A (hr) |
| MY (1) | MY154898A (hr) |
| NZ (1) | NZ580423A (hr) |
| PE (1) | PE20090887A1 (hr) |
| PL (1) | PL2148880T3 (hr) |
| PT (1) | PT2148880E (hr) |
| RS (1) | RS53451B (hr) |
| SI (1) | SI2148880T1 (hr) |
| TN (1) | TN2009000446A1 (hr) |
| TW (1) | TWI423805B (hr) |
| UA (1) | UA99284C2 (hr) |
| WO (1) | WO2008140947A1 (hr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| WO2010019762A1 (en) * | 2008-08-13 | 2010-02-18 | Jenrin Discovery | Purine compounds as cannabinoid receptor blockers |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| MX2011005002A (es) | 2008-11-11 | 2011-05-25 | Lilly Co Eli | Inhibidor de p70 s6 quinasa y terapia de combinacion de inhibidor del receptor de egfr. |
| MX2011005003A (es) * | 2008-11-11 | 2011-05-25 | Lilly Co Eli | Inhibidor de p70 s6 quinasa y terapia de combinacion de inhibidor de mtor. |
| KR101699991B1 (ko) | 2009-02-11 | 2017-01-26 | 메르크 파텐트 게엠베하 | 신규의 아미노 아자헤테로시클릭 카르복사미드 |
| EA020302B1 (ru) | 2009-08-07 | 2014-10-30 | Мерк Патент Гмбх | Новые азагетероциклические соединения |
| AU2010310786B2 (en) * | 2009-10-23 | 2014-03-27 | Eli Lilly And Company | AKT inhibitors |
| EP2992878A1 (en) | 2010-02-03 | 2016-03-09 | Signal Pharmaceuticals, LLC | Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors |
| CN103140484B (zh) | 2010-07-29 | 2015-04-22 | 默克专利有限公司 | 环状胺氮杂杂环甲酰胺 |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| US8946247B2 (en) | 2010-11-24 | 2015-02-03 | Merck Patent Gmbh | Quinazoline carboxamide azetidines |
| CN103930407B (zh) | 2011-09-12 | 2019-02-26 | 默克专利有限公司 | 用作激酶活性调节剂的氨基嘧啶衍生物 |
| CN104080782B (zh) * | 2011-09-12 | 2016-06-01 | 默克专利有限公司 | 用作激酶活性调节剂的咪唑胺 |
| EP2892534B8 (en) | 2012-09-06 | 2021-09-15 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| AU2013344552B2 (en) | 2012-11-16 | 2018-03-15 | Xiaoling Chen | Novel heterocyclic derivatives as modulators of kinase activity |
| CN110078743A (zh) | 2012-11-16 | 2019-08-02 | 默克专利有限公司 | 用作激酶活性调节剂的新颖的咪唑-哌啶基衍生物 |
| CN105793254B (zh) | 2012-11-29 | 2020-10-23 | 默克专利有限公司 | 氮杂喹唑啉羧酰胺衍生物 |
| SG11201505999VA (en) * | 2013-03-11 | 2015-08-28 | Merck Patent Gmbh | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
| CA2908353C (en) | 2013-04-17 | 2021-11-02 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| BR112015026297B1 (pt) | 2013-04-17 | 2022-08-23 | Signal Pharmaceuticals, Llc | Uso de um inibidor da quinase tor e quinazolinona 5-substituída, composição farmacêutica que os compreende, e kit |
| US9358232B2 (en) | 2013-04-17 | 2016-06-07 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
| JP6382948B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | 癌を治療するためのｔｏｒキナーゼ阻害剤及びシチジン類似体を含む組合せ療法 |
| US9937169B2 (en) | 2013-04-17 | 2018-04-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy |
| WO2014172426A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| TW201527300A (zh) | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 關於１－乙基－７－（２－甲基－６－（１Ｈ－１，２，４－三唑－３－基）吡啶－３－基）－３，４－二氫吡并［２，３－ｂ］吡－２（１Ｈ）－酮之醫藥調配物、方法、固態型式及使用方法 |
| CN113831345A (zh) | 2013-05-29 | 2021-12-24 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| WO2015134536A1 (en) * | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| SG11201608189WA (en) | 2014-04-03 | 2016-10-28 | Merck Patent Gmbh | Combinations of cancer therapeutics |
| EP3131551A4 (en) | 2014-04-16 | 2017-09-20 | Signal Pharmaceuticals, LLC | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| WO2016040078A1 (en) * | 2014-09-10 | 2016-03-17 | Eli Lilly And Company | Substituted phenyl imidazolyl piperidyl compounds as p70s6k1 inhibitors |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN106187899B (zh) * | 2016-06-28 | 2019-07-16 | 绍兴文理学院 | 一种氟代氮杂芳烃的合成方法 |
| JP7282045B2 (ja) | 2017-06-22 | 2023-05-26 | セルジーン コーポレイション | Ｂ型肝炎ウイルス感染を特徴とする肝細胞癌の治療 |
| EP4243819A1 (en) | 2020-11-16 | 2023-09-20 | Merck Patent GmbH | Kinase inhibitor combinations for cancer treatment |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| CA2563699C (en) * | 2004-04-23 | 2014-03-25 | Exelixis, Inc. | Kinase modulators and method of use |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| US7994172B2 (en) | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| JP5114395B2 (ja) | 2005-06-30 | 2013-01-09 | プロシディオン・リミテッド | Ｇｐｃｒアゴニスト |
| WO2007125310A2 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical combinations of pk inhibitors and other active agents |
| EP2043655A2 (en) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
-
2008
- 2008-01-05 UA UAA200911422A patent/UA99284C2/ru unknown
- 2008-04-23 TW TW097114908A patent/TWI423805B/zh not_active IP Right Cessation
- 2008-04-29 AR ARP080101808A patent/AR066344A1/es unknown
- 2008-04-29 CL CL2008001230A patent/CL2008001230A1/es unknown
- 2008-04-29 PE PE2008000756A patent/PE20090887A1/es not_active Application Discontinuation
- 2008-05-01 MY MYPI20094763A patent/MY154898A/en unknown
- 2008-05-01 EA EA200971051A patent/EA016445B1/ru not_active IP Right Cessation
- 2008-05-01 KR KR1020097023455A patent/KR101088219B1/ko not_active IP Right Cessation
- 2008-05-01 CN CN2008800156864A patent/CN101679439B/zh not_active Expired - Fee Related
- 2008-05-01 EP EP08747285.8A patent/EP2148880B1/en active Active
- 2008-05-01 NZ NZ580423A patent/NZ580423A/en not_active IP Right Cessation
- 2008-05-01 PL PL08747285T patent/PL2148880T3/pl unknown
- 2008-05-01 CA CA2687265A patent/CA2687265C/en not_active Expired - Fee Related
- 2008-05-01 AU AU2008251692A patent/AU2008251692B2/en not_active Ceased
- 2008-05-01 ES ES08747285.8T patent/ES2483726T3/es active Active
- 2008-05-01 BR BRPI0811212-6A2A patent/BRPI0811212A2/pt not_active IP Right Cessation
- 2008-05-01 JP JP2010507532A patent/JP5503532B2/ja not_active Expired - Fee Related
- 2008-05-01 WO PCT/US2008/062143 patent/WO2008140947A1/en active Application Filing
- 2008-05-01 MX MX2009012075A patent/MX2009012075A/es active IP Right Grant
- 2008-05-01 DK DK08747285.8T patent/DK2148880T3/da active
- 2008-05-01 PT PT87472858T patent/PT2148880E/pt unknown
- 2008-05-01 RS RS20140385A patent/RS53451B/en unknown
- 2008-05-01 SI SI200831223T patent/SI2148880T1/sl unknown
-
2009
- 2009-03-02 US US12/396,103 patent/US8093383B2/en not_active Expired - Fee Related
- 2009-10-15 IL IL201564A patent/IL201564A/en not_active IP Right Cessation
- 2009-10-28 TN TNP2009000446A patent/TN2009000446A1/fr unknown
- 2009-11-09 EC EC2009009721A patent/ECSP099721A/es unknown
- 2009-11-10 CO CO09127778A patent/CO6241109A2/es active IP Right Grant
- 2009-11-10 DO DO2009000257A patent/DOP2009000257A/es unknown
- 2009-11-10 CR CR11106A patent/CR11106A/es unknown
- 2009-11-10 GT GT200900292A patent/GT200900292A/es unknown
- 2009-12-07 MA MA32404A patent/MA31433B1/fr unknown
-
2010
- 2010-07-29 HK HK10107283.9A patent/HK1140767A1/xx not_active IP Right Cessation
-
2011
- 2011-11-30 US US13/307,560 patent/US20120071490A1/en not_active Abandoned
-
2014
- 2014-06-26 HR HRP20140611AT patent/HRP20140611T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20140611T1 (hr) | Inhibitori kinaze p70 s6 | |
| AR065556A1 (es) | Derivados de 3-(( 1,2,4) triazolo (4,3-a) piridin -7-il) benzamida | |
| NZ597533A (en) | Apoptosis signal-regulating kinase inhibitors | |
| HRP20140481T1 (hr) | SUPSTITUIRANI SPOJEVI IMIDAZO[1,2-b]PIRIDAZINA KAO INHIBITORI TRK KINAZE | |
| RU2012148133A (ru) | Комбинация, включающая ингибитор циклинзависимой киназы 4 или циклинзависимой киназы 6 (cdk4/6) и ингибитор mtor, для лечения рака | |
| BRPI0506765A (pt) | composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composição | |
| MX2020008570A (es) | Inhibidores de arginasa y sus metodos de uso. | |
| NO20076450L (no) | Heterosykliske forbindelser som nikotinsyrereseptoragonister for behandling av dyslipidemi | |
| HRP20090208T1 (hr) | Supstituirani derivati pirido[2,3-d]pirimidina korisni kao lijekovi za liječenje autoimunih bolesti | |
| WO2015058126A8 (en) | Heteroaromatic compounds useful for the treatment of prolferative diseases | |
| MX2009011964A (es) | Derivados heterociclicos pirrolo-nitrogenosos, su preparacion y uso farmaceutico. | |
| MY144655A (en) | Pyrimidine urea derivatives as kinase inhibitors | |
| RS54260B1 (en) | AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT | |
| AR092289A1 (es) | Derivados de aminoquinazolina y sus sales y metodos de uso | |
| NO20063231L (no) | Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer | |
| NO20082101L (no) | Pyrido-, pyrazo- og pyrimido-pyrimidinderivater som mTor inhibitorer | |
| NZ605528A (en) | Ip receptor agonist heterocyclic compounds | |
| SE0402735D0 (sv) | Novel compounds | |
| NO20090216L (no) | Forbindelser med CRTH2 antagonistaktivitet | |
| WO2008115098A3 (fr) | 2,3,4,5-tétrahydro-1h-pyrido[4,3-b]indoles substitués ainsi que procédés de leur fabrication et leur utilisation | |
| MXPA05013349A (es) | Derivados de 2-amino-pirimidina como inhibidores de quinasa raf. | |
| GEP20156267B (en) | 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES | |
| NO20073259L (no) | Nye 4-arylaminopyndondenvater som MEK inhibrtorer av hyperproliferende lidelser | |
| ATE553106T1 (de) | Heteroarylpyrrolopyridinone als kinaseinhibitoren | |
| HK1146049A1 (en) | Isoxazole derivatives as modulators of 11-beta-hydroxysteroid dehydrogenase type 1 |