SG11201505999VA - 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity - Google Patents

6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity

Info

Publication number
SG11201505999VA
SG11201505999VA SG11201505999VA SG11201505999VA SG11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA
Authority
SG
Singapore
Prior art keywords
imidazol
pyrimidin
piperidin
modulators
kinase activity
Prior art date
Application number
SG11201505999VA
Inventor
Ruoxi Lan
Xiaoling Chen
Yufang Xiao
Bayard R Huck
Andreas Goutopoulos
Original Assignee
Merck Patent Gmbh
Ruoxi Lan
Xiaoling Chen
Yufang Xiao
Bayard R Huck
Andreas Goutopoulos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R Huck, Andreas Goutopoulos filed Critical Merck Patent Gmbh
Publication of SG11201505999VA publication Critical patent/SG11201505999VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201505999VA 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity SG11201505999VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776440P 2013-03-11 2013-03-11
PCT/US2014/022479 WO2014143612A1 (en) 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity

Publications (1)

Publication Number Publication Date
SG11201505999VA true SG11201505999VA (en) 2015-08-28

Family

ID=50440836

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201505999VA SG11201505999VA (en) 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
SG10201900954SA SG10201900954SA (en) 2013-03-11 2014-03-10 Heterocycles as Modulators of Kinase Activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201900954SA SG10201900954SA (en) 2013-03-11 2014-03-10 Heterocycles as Modulators of Kinase Activity

Country Status (17)

Country Link
US (2) US9458134B2 (en)
EP (1) EP2970201B1 (en)
JP (1) JP6483656B2 (en)
KR (1) KR20150124957A (en)
CN (1) CN105209454A (en)
AR (1) AR095202A1 (en)
AU (1) AU2014228385B2 (en)
BR (1) BR112015021324A2 (en)
CA (1) CA2902755C (en)
ES (1) ES2746756T3 (en)
HK (1) HK1218756A1 (en)
IL (1) IL240875B (en)
MX (1) MX370448B (en)
RU (1) RU2674261C2 (en)
SG (2) SG11201505999VA (en)
WO (1) WO2014143612A1 (en)
ZA (1) ZA201505749B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015021324A2 (en) * 2013-03-11 2017-07-18 Merck Patent Gmbh 6- [4- (1h-imidazol-2-yl) piperidin-1-yl] pyrimidin-4-amine derivatives as kinase activity modulators
BR112016015285A8 (en) * 2014-02-11 2020-06-09 Merck Patent Gmbh pyrimidine imidazole amines as modulators of kinase activity, their uses and their preparation process, pharmaceutical composition, and kit
BR112016020135A8 (en) * 2014-04-03 2021-07-06 Merck Patent Gmbh compound mixture, its uses, pharmaceutical composition, and set (kit)
SG11201810360YA (en) * 2016-05-20 2018-12-28 Taiho Pharmaceutical Co Ltd Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative
CN110922354B (en) * 2019-12-12 2023-05-02 丽水绿氟科技有限公司 Chemical resolution preparation method of 1-R-3-haloperidol-4-carboxylic acid and product thereof
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
EP1542993B1 (en) * 2002-09-20 2012-12-19 Merck Serono SA Piperazine derivatives and methods of use
US7547794B2 (en) 2003-04-03 2009-06-16 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
CN100412066C (en) 2003-09-30 2008-08-20 Irm责任有限公司 Compounds and compositions as protein kinase inhibitors
CA2541989C (en) 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
RU2006121646A (en) 2003-11-21 2008-01-10 Новартис АГ (CH) 1H-IMIDAZOCHINOLINE DERIVATIVES AS PROTEINKINASE INHIBITORS
BRPI0417498A (en) 2003-12-09 2007-05-29 Us Gov Health & Human Serv method for suppressing an immune response in an individual; method of inhibiting cell proliferation; method of treating a proliferative disorder in an individual; method for selecting an immunosuppressive or antiproliferative agent; pharmaceutical composition and vascular stent
GB0403606D0 (en) * 2004-02-18 2004-03-24 Novartis Ag Organic compounds
EP1750727A2 (en) 2004-04-23 2007-02-14 Exelixis, Inc. Kinase modulators and methods of use
WO2006071819A1 (en) 2004-12-28 2006-07-06 Exelixis, Inc. [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
EP1902032A1 (en) 2005-06-22 2008-03-26 Astex Therapeutics Limited Pharmaceutical compounds
AR064416A1 (en) 2006-12-21 2009-04-01 Cancer Rec Tech Ltd DERIVATIVES OF PURINE, PIRIDINE AND PYRIMIDINE CONDENSED WITH HETEROCICLES, MODULATORS OF PKA AND / OR PKB, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES.
UA99284C2 (en) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані P70 s6 kinase inhibitors
AU2009314335B2 (en) * 2008-11-11 2013-09-12 Eli Lilly And Company P70 S6 kinase inhibitor and mTOR inhibitor combination therapy
JP2012508240A (en) * 2008-11-11 2012-04-05 イーライ リリー アンド カンパニー Combination therapy of P70S6 kinase inhibitor and EGFR inhibitor
AR074072A1 (en) 2008-11-11 2010-12-22 Lilly Co Eli COMPOSITE OF IMIDAZOL -PIPERIDIN -PIRROL-PIRIMIDIN-6-ONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MULTIFORM GLIOBLASTOMA
MY160468A (en) 2009-02-11 2017-03-15 Merck Patent Gmbh Novel amino azaheterocyclic carboxamides
BR112012011328A2 (en) * 2009-10-23 2016-11-22 Lilly Co Eli akt inhibitors
UA110113C2 (en) 2010-07-29 2015-11-25 BICYCLIC AZAGETEROCYCLIC CARBOXAMIDES
CA2803387C (en) 2010-07-29 2017-12-05 Bayard R. Huck Cyclic amine azaheterocyclic carboxamides
BR112013012488B1 (en) 2010-11-24 2021-08-31 Merck Patent Gmbh Quinazoline carboxamide azetidines, their uses and their manufacturing process, pharmaceutical composition, and kit
EA031153B1 (en) * 2011-06-10 2018-11-30 Мерк Патент Гмбх Use of pyrimidine compounds with btk inhibitory activity
WO2013012848A1 (en) * 2011-07-18 2013-01-24 Merck Patent Gmbh Benzamides
SG10201606301YA (en) 2011-09-12 2016-09-29 Merck Patent Gmbh Novel imidazole amines as modulators of kinase activity
AU2012308681B2 (en) * 2011-09-12 2017-07-13 Merck Patent Gmbh Aminopyrimidine derivatives for use as modulators of kinase activity
HUE032918T2 (en) * 2011-12-22 2017-11-28 Merck Patent Gmbh Novel heterocyclic carboxamides as modulators of kinase activity
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CA2890345A1 (en) * 2012-11-16 2014-05-22 Merck Patent Gmbh Imidazol-piperidinyl derivatives as modulators of kinase activity
BR112015021324A2 (en) * 2013-03-11 2017-07-18 Merck Patent Gmbh 6- [4- (1h-imidazol-2-yl) piperidin-1-yl] pyrimidin-4-amine derivatives as kinase activity modulators
BR112016015285A8 (en) * 2014-02-11 2020-06-09 Merck Patent Gmbh pyrimidine imidazole amines as modulators of kinase activity, their uses and their preparation process, pharmaceutical composition, and kit
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor

Also Published As

Publication number Publication date
EP2970201B1 (en) 2019-06-19
CA2902755A1 (en) 2014-09-18
MX2015011660A (en) 2015-12-16
AU2014228385B2 (en) 2018-08-09
JP2016512509A (en) 2016-04-28
ES2746756T3 (en) 2020-03-06
MX370448B (en) 2019-12-13
US9458134B2 (en) 2016-10-04
AR095202A1 (en) 2015-09-30
KR20150124957A (en) 2015-11-06
CA2902755C (en) 2021-02-16
US20160361316A1 (en) 2016-12-15
US9867826B2 (en) 2018-01-16
RU2674261C2 (en) 2018-12-06
IL240875A0 (en) 2015-10-29
AU2014228385A1 (en) 2015-08-20
RU2015143160A (en) 2017-04-18
IL240875B (en) 2020-08-31
JP6483656B2 (en) 2019-03-13
HK1218756A1 (en) 2017-03-10
CN105209454A (en) 2015-12-30
US20160016936A1 (en) 2016-01-21
WO2014143612A1 (en) 2014-09-18
RU2015143160A3 (en) 2018-03-01
BR112015021324A2 (en) 2017-07-18
EP2970201A1 (en) 2016-01-20
SG10201900954SA (en) 2019-02-27
ZA201505749B (en) 2017-01-25

Similar Documents

Publication Publication Date Title
HUS2200010I1 (en) Fused heterocyclic compounds as protein kinase inhibitors
HK1253099A1 (en) Heterocyclic amides as kinase inhibitors
SG11201600062RA (en) Pyrimidine derivatives as kinase inhibitors
HK1207642A1 (en) Novel fused pyridine derivatives useful as c-met tyrosine kinase inhibitors c-met
ZA201505749B (en) 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
HK1258911A1 (en) Substituted pyridine derivatives useful as c-fms kinase inhibitors
HK1212975A1 (en) Thiazole derivatives as inhibitors of brutons tyrosine kinase
EP2968331A4 (en) Pyrimidine compounds as kinase inhibitors
IL274874A (en) Substituted dialkyl(oxido)-lamda 4-sulfanylidene nicotinamide derivatives as kinase inhibitors
IL235935A0 (en) Substituted picolinamide kinase inhibitors