SG11201505999VA - 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity - Google Patents

6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity

Info

Publication number
SG11201505999VA
SG11201505999VA SG11201505999VA SG11201505999VA SG11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA SG 11201505999V A SG11201505999V A SG 11201505999VA
Authority
SG
Singapore
Prior art keywords
imidazol
pyrimidin
piperidin
modulators
kinase activity
Prior art date
Application number
SG11201505999VA
Inventor
Ruoxi Lan
Xiaoling Chen
Yufang Xiao
Bayard R Huck
Andreas Goutopoulos
Original Assignee
Merck Patent Gmbh
Ruoxi Lan
Xiaoling Chen
Yufang Xiao
Bayard R Huck
Andreas Goutopoulos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R Huck, Andreas Goutopoulos filed Critical Merck Patent Gmbh
Publication of SG11201505999VA publication Critical patent/SG11201505999VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201505999VA 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity SG11201505999VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776440P 2013-03-11 2013-03-11
PCT/US2014/022479 WO2014143612A1 (en) 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity

Publications (1)

Publication Number Publication Date
SG11201505999VA true SG11201505999VA (en) 2015-08-28

Family

ID=50440836

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201505999VA SG11201505999VA (en) 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
SG10201900954SA SG10201900954SA (en) 2013-03-11 2014-03-10 Heterocycles as Modulators of Kinase Activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201900954SA SG10201900954SA (en) 2013-03-11 2014-03-10 Heterocycles as Modulators of Kinase Activity

Country Status (17)

Country Link
US (2) US9458134B2 (en)
EP (1) EP2970201B1 (en)
JP (1) JP6483656B2 (en)
KR (1) KR20150124957A (en)
CN (1) CN105209454A (en)
AR (1) AR095202A1 (en)
AU (1) AU2014228385B2 (en)
BR (1) BR112015021324A2 (en)
CA (1) CA2902755C (en)
ES (1) ES2746756T3 (en)
HK (1) HK1218756A1 (en)
IL (1) IL240875B (en)
MX (1) MX370448B (en)
RU (1) RU2674261C2 (en)
SG (2) SG11201505999VA (en)
WO (1) WO2014143612A1 (en)
ZA (1) ZA201505749B (en)

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* Cited by examiner, † Cited by third party
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WO2014143612A1 (en) * 2013-03-11 2014-09-18 Merck Patent Gmbh 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
EP3105224A1 (en) * 2014-02-11 2016-12-21 Merck Patent GmbH Pyrimidine imidazole amines as modulators of kinase activity
EP3125935B1 (en) * 2014-04-03 2019-10-23 Merck Patent GmbH Combinations of cancer therapeutics
TWI732187B (en) * 2016-05-20 2021-07-01 日商大鵬藥品工業股份有限公司 Novel 5H-pyrrolo[2, 3-d]pyrimidine-6(7H)-one derivative
CN110922354B (en) * 2019-12-12 2023-05-02 丽水绿氟科技有限公司 Chemical resolution preparation method of 1-R-3-haloperidol-4-carboxylic acid and product thereof
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment

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TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7754722B2 (en) * 2002-09-20 2010-07-13 Merck Serono Sa Piperazine derivatives and methods of use
AU2004230841A1 (en) 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
WO2005033086A1 (en) 2003-09-30 2005-04-14 Irm Llc Compounds and compositions as protein kinase inhibitors
CA2541989C (en) 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
KR20060117329A (en) 2003-11-21 2006-11-16 노파르티스 아게 1h-imidazoquinoline derivatives as protein kinase inhibitors
TR200808208T1 (en) 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Suppression of an immune response or treatment of a proliferative disease
GB0403606D0 (en) * 2004-02-18 2004-03-24 Novartis Ag Organic compounds
WO2005117909A2 (en) 2004-04-23 2005-12-15 Exelixis, Inc. Kinase modulators and methods of use
CA2590961C (en) 2004-12-28 2013-11-26 Exelixis, Inc. [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
EP1902032A1 (en) 2005-06-22 2008-03-26 Astex Therapeutics Limited Pharmaceutical compounds
AR064416A1 (en) * 2006-12-21 2009-04-01 Cancer Rec Tech Ltd DERIVATIVES OF PURINE, PIRIDINE AND PYRIMIDINE CONDENSED WITH HETEROCICLES, MODULATORS OF PKA AND / OR PKB, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES.
UA99284C2 (en) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані P70 s6 kinase inhibitors
KR20110075015A (en) * 2008-11-11 2011-07-05 일라이 릴리 앤드 캄파니 P70 s6 kinase inhibitor and egfr inhibitor combination therapy
AR074072A1 (en) * 2008-11-11 2010-12-22 Lilly Co Eli COMPOSITE OF IMIDAZOL -PIPERIDIN -PIRROL-PIRIMIDIN-6-ONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MULTIFORM GLIOBLASTOMA
BRPI0921840A2 (en) * 2008-11-11 2018-10-09 Lilly Co Eli product comprising the p70 s6 kinase inhibitor compound and mtor inhibitor, p70 s6 kinase inhibitor compound and use thereof
DK2396307T3 (en) 2009-02-11 2015-01-12 Merck Patent Gmbh NOVEL AMINO-azaheterocyclic carboxamides
EA020151B1 (en) * 2009-10-23 2014-09-30 Эли Лилли Энд Компани Akt inhibitors and pharmaceutical compositions comprising them
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CA2803387C (en) * 2010-07-29 2017-12-05 Bayard R. Huck Cyclic amine azaheterocyclic carboxamides
JP5897590B2 (en) 2010-11-24 2016-03-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Quinazoline carboxamidoazetidine
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JP6162694B2 (en) * 2011-07-18 2017-07-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Benzamides
MX347241B (en) * 2011-09-12 2017-04-20 Merck Patent Gmbh Aminopyrimidine derivatives for use as modulators of kinase activity.
SI2755965T1 (en) * 2011-09-12 2017-12-29 Merck Patent Gmbh Novel imidazole amines as modulators of kinase activity
PT2794571T (en) * 2011-12-22 2017-02-07 Merck Patent Gmbh Novel heterocyclic carboxamides as modulators of kinase activity
US10227357B2 (en) * 2012-09-06 2019-03-12 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
JP6280130B2 (en) * 2012-11-16 2018-02-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Novel imidazole-piperidinyl derivatives as modulators of kinase activity
WO2014143612A1 (en) * 2013-03-11 2014-09-18 Merck Patent Gmbh 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
EP3105224A1 (en) * 2014-02-11 2016-12-21 Merck Patent GmbH Pyrimidine imidazole amines as modulators of kinase activity
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor

Also Published As

Publication number Publication date
IL240875B (en) 2020-08-31
ES2746756T3 (en) 2020-03-06
US20160016936A1 (en) 2016-01-21
WO2014143612A1 (en) 2014-09-18
MX2015011660A (en) 2015-12-16
US20160361316A1 (en) 2016-12-15
JP2016512509A (en) 2016-04-28
CA2902755C (en) 2021-02-16
MX370448B (en) 2019-12-13
SG10201900954SA (en) 2019-02-27
RU2015143160A (en) 2017-04-18
JP6483656B2 (en) 2019-03-13
HK1218756A1 (en) 2017-03-10
RU2015143160A3 (en) 2018-03-01
AR095202A1 (en) 2015-09-30
KR20150124957A (en) 2015-11-06
AU2014228385B2 (en) 2018-08-09
EP2970201A1 (en) 2016-01-20
US9867826B2 (en) 2018-01-16
CA2902755A1 (en) 2014-09-18
CN105209454A (en) 2015-12-30
EP2970201B1 (en) 2019-06-19
ZA201505749B (en) 2017-01-25
US9458134B2 (en) 2016-10-04
RU2674261C2 (en) 2018-12-06
BR112015021324A2 (en) 2017-07-18
IL240875A0 (en) 2015-10-29
AU2014228385A1 (en) 2015-08-20

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