NO20082101L - Pyrido-, pyrazo- og pyrimido-pyrimidinderivater som mTor inhibitorer - Google Patents
Pyrido-, pyrazo- og pyrimido-pyrimidinderivater som mTor inhibitorerInfo
- Publication number
- NO20082101L NO20082101L NO20082101A NO20082101A NO20082101L NO 20082101 L NO20082101 L NO 20082101L NO 20082101 A NO20082101 A NO 20082101A NO 20082101 A NO20082101 A NO 20082101A NO 20082101 L NO20082101 L NO 20082101L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- group
- alkyl group
- rog
- rer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Det tilveiebringes en forbindelse med formel I: hvor: én eller to av X, Xog Xer N og den andre er CH; Rer valgt fra halogen, OR, SR, NRR, NRC(=0)R, NRS0R, en eventuelt substituert C.o heteroarylgruppe eller en eventuelt substituert C.o arylgruppe, hvor Rog Rer valgt fra H, en eventuelt substituert C.arylgruppe, en eventuelt substituert C.heteroarylgruppe eller en eventuelt substituert Ci .7 alkylgruppe;og Rer uavhengig valgt fra H, en eventuelt substituert C.alkylgruppe, en eventuelt substituert C5.20 heteroarylgruppe, en eventuelt substituert C.arylgruppe ellerog Rsammen med nitrogenet hvortil de er bundet danner en heterocyklisk ring inneholdende mellom 3 og 8 ringatomer; Rer valgt fra H, en eventuelt substituert C.arylgruppe, en eventuelt substituert C.heteroarylgruppe, en eventuelt substituert C.alkylgruppe eller NR, hvorog Rer uavhengig valgt fra H, en eventuelt substituert C.alkylgruppe, en eventuelt substituert C5.20 heteroarylgruppe, en eventuelt substituert C.arylgruppe eller Rog Rsammen med nitrogenet hvor til de er bundet danner en heterocyklisk ring inneholdende mellom 3 og 8 ringatomer; Rer valgt fra H, en eventuelt substituert C.arylgruppe, en eventuelt substituert C5.20 heteroarylgruppe eller en eventuelt substituert Ci.alkylgruppe; Rog Rer valgt fra H og en C-alkylgruppe;og R, sammen med nitrogenet hvor til de er bundet, danner en heterocyklisk ring inneholdende mellom 3 og 8 ringatomer; Rer valgt fra H, halogen, OR, SR, NRR, en eventuelt substituert C5.20 heteroarylgruppe og en eventuelt substituert C.arylgruppe, hvor Rog Rer valgt fra H, en eventuelt substituert C.arylgruppe, en eventuelt substituert C.heteroarylgruppe eller en eventuelt substituert C.alkylgruppe;; Rog R6 er uavhengig valgt fra H, en eventuelt substituert C.alkylgruppe, en eventuelt substituert C.heteroarylgruppe og en eventuelt substituert C.arylgruppe ellerog Rsammen med nitrogenet hvortil de er bundet danner en heterocyklisk ring inneholdende mellom 3 og 8 ringatomer eller et farmasøytisk akseptabelt salt derav, med det forbehold at når Rer usubstituert morfolino, Rog Rsammen med nitrogenatomet som de er bundet til danner en usubstituert morfolino og Rer usubstituert fenyl og Xer CH, da er Xikke N og Xer ikke CH eller Xer ikke CH og Xer ikke N og nårer usubstituert piperidinyl, Rra og Rsammen med nitrogenatomet som de er bundet til danner en usubstituert piperidinyl og Rer usubstituert fenyl og Xer CH, da er Xikke CH og Xer ikke N. Det er også gitt fremgangsmåter for fremstilling av en forbindelse med formelen 1 og anvendelse av en forbindelse med formelen 1 som et medikament og ved behandling av kreft.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73890205P | 2005-11-22 | 2005-11-22 | |
GB0524047A GB0524047D0 (en) | 2005-11-25 | 2005-11-25 | Compounds |
US82330806P | 2006-08-23 | 2006-08-23 | |
US82330906P | 2006-08-23 | 2006-08-23 | |
PCT/GB2006/004327 WO2007060404A1 (en) | 2005-11-22 | 2006-11-20 | PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20082101L true NO20082101L (no) | 2008-08-15 |
NO341055B1 NO341055B1 (no) | 2017-08-14 |
Family
ID=37533284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082101A NO341055B1 (no) | 2005-11-22 | 2008-05-06 | Pyridopyrimidinforbindelser og anvendelse derav,samt farmasøytisk preparat. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20080194546A1 (no) |
EP (1) | EP1954699B1 (no) |
JP (1) | JP5161102B2 (no) |
KR (1) | KR101464384B1 (no) |
AR (1) | AR057626A1 (no) |
AU (1) | AU2006318948B2 (no) |
CA (1) | CA2628920C (no) |
EC (1) | ECSP088536A (no) |
HK (1) | HK1124039A1 (no) |
HR (1) | HRP20120963T1 (no) |
IL (1) | IL191196A (no) |
NO (1) | NO341055B1 (no) |
PL (1) | PL1954699T3 (no) |
TW (1) | TWI452047B (no) |
UY (1) | UY29938A1 (no) |
WO (1) | WO2007060404A1 (no) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006330924B2 (en) * | 2005-12-21 | 2012-03-15 | Abbvie Inc. | Anti-viral compounds |
WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
CN101558067B (zh) * | 2006-08-23 | 2014-05-28 | 库多斯药物有限公司 | 作为mtor抑制剂的2-甲基吗啉吡啶并、吡唑并和嘧啶并-嘧啶衍生物 |
MX2009001946A (es) * | 2006-08-23 | 2009-03-05 | Kudos Pharm Ltd | Derivados de 2-metilmorfolin-pirido-, pirazo- y pirimido- pirimidina como inhibidores de mtor. |
US8236950B2 (en) | 2006-12-20 | 2012-08-07 | Abbott Laboratories | Anti-viral compounds |
WO2009039140A1 (en) * | 2007-09-17 | 2009-03-26 | Smithkline Beecham Corporation | Pyridopyrimidine derivatives as pi3 kinase inhibitors |
CA2702315A1 (en) * | 2007-10-15 | 2009-04-23 | Astrazeneca Ab | Combination 059 |
WO2009079797A1 (en) | 2007-12-26 | 2009-07-02 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP2262504A1 (en) * | 2008-02-21 | 2010-12-22 | AstraZeneca AB | Combination therapy 238 |
EP2303875B1 (en) | 2008-06-20 | 2012-11-28 | AstraZeneca AB | Compositions with and process for methylmorpholin-subsituted pyrido[2,3-d]pyrimidines |
EP3023426A1 (en) | 2008-07-17 | 2016-05-25 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
ES2432821T3 (es) * | 2008-07-31 | 2013-12-05 | Genentech, Inc. | Compuestos de pirimidina, composiciones y métodos de utilización |
WO2010049481A1 (en) * | 2008-10-31 | 2010-05-06 | Novartis Ag | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
CA2781210A1 (en) | 2009-11-18 | 2011-05-26 | Novartis Ag | Methods and compositions for treating solid tumors and other malignancies |
WO2011067348A2 (en) | 2009-12-03 | 2011-06-09 | Novartis Ag | Mek inhibitor salts and solvates thereof |
WO2011067356A2 (en) | 2009-12-03 | 2011-06-09 | Novartis Ag | Polymorphs of a mek inhibitor |
UA110697C2 (uk) | 2010-02-03 | 2016-02-10 | Сігнал Фармасьютікалз, Елелсі | ЗАСТОСУВАННЯ ІНГІБІТОРІВ TOR-КІНАЗИ ДЛЯ ЛІКУВАННЯ ПУХЛИННИХ ЗАХВОРЮВАНЬ У ПАЦІЄНТА ЗІ ЗНИЖЕНИМ РІВНЕМ БІЛКА pAMPK ТА/АБО АКТИВНОСТІ AMPK |
BR112012019635A2 (pt) * | 2010-02-22 | 2016-05-03 | Hoffmann La Roche | compostos inibidores de pirido[3,2-d] pirimidina pi3k delta e métodos de uso |
BR112012024585A2 (pt) | 2010-03-30 | 2016-05-31 | Novartis Ag | inibidores de pkc para o tratamento de linfomade células b tendo sinalização do receptor de células b ativas crônicas |
CA2794952C (en) | 2010-04-01 | 2018-05-15 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
MX2012011912A (es) | 2010-04-13 | 2012-11-16 | Novartis Ag | Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclia (cdk4/6) y un inhibidor de mtor para tratar cancer. |
KR20130048293A (ko) | 2010-06-25 | 2013-05-09 | 노파르티스 아게 | 단백질 키나제 억제제로서의 헤테로아릴 화합물 및 조성물 |
WO2012099581A1 (en) | 2011-01-19 | 2012-07-26 | Takeda Pharmaceutical Company Limited | Dihydrofuropyrimidine compounds |
CA2843887A1 (en) | 2011-08-03 | 2013-02-07 | Signal Pharmaceuticals, Llc | Identification of gene expression profile as a predictive biomarker for lkb1 status |
CN102911172A (zh) * | 2011-08-04 | 2013-02-06 | 上海恒瑞医药有限公司 | 杂芳基并嘧啶类衍生物、其制备方法和用途 |
CN103374021B (zh) * | 2012-04-21 | 2015-10-28 | 通化济达医药有限公司 | 含有锌结合基的吡啶并嘧啶类HDAC和mTOR抑制剂 |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
AU2013352261B2 (en) | 2012-11-29 | 2018-05-10 | Merck Patent Gmbh | Azaquinazoline carboxamide derivatives |
EP2986322A1 (en) | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
CA2908830C (en) | 2013-04-17 | 2021-12-07 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
US9937169B2 (en) | 2013-04-17 | 2018-04-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy |
TW201521725A (zh) | 2013-04-17 | 2015-06-16 | Signal Pharm Llc | 使用tor激酶抑制劑組合療法以治療癌症之方法 |
PE20160041A1 (es) | 2013-04-17 | 2016-01-28 | Signal Pharm Llc | FORMULACIONES FARMACEUTICAS, PROCESO, FORMAS SOLIDAS Y METODOS DE USO RELACIONADOS CON 1-ETIL-7-(2-METIL-6-(1H-1,2,4-TRIAZOL-3-IL)PIRIDIN-3-IL)-3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA |
JP6382948B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ,エルエルシー | 癌を治療するためのtorキナーゼ阻害剤及びシチジン類似体を含む組合せ療法 |
TWI631950B (zh) | 2013-04-17 | 2018-08-11 | 標誌製藥公司 | 藉二氫吡𠯤并吡𠯤治療癌症 |
EP3003313A1 (en) | 2013-05-29 | 2016-04-13 | Signal Pharmaceuticals, LLC | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
JP2017511367A (ja) | 2014-04-16 | 2017-04-20 | シグナル ファーマシューティカルズ,エルエルシー | 1−エチル−7−(2−メチル−6−(1H−1,2,4−トリアゾール−3−イル)ピリジン−3−イル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン及び共形成物を含む固体形態、その組成物及び使用方法 |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
TWI656121B (zh) * | 2014-08-04 | 2019-04-11 | 德商拜耳製藥公司 | 2-(嗎啉-4-基)-1,7-萘啶 |
CN106008559B (zh) * | 2015-03-25 | 2020-10-16 | 中国科学院上海药物研究所 | 取代吡啶并嘧啶类化合物的合成工艺 |
WO2018144791A1 (en) * | 2017-02-03 | 2018-08-09 | Millennium Pharmaceuticals, Inc. | Combination of vps34 inhibitors and mtor inhibitors |
CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
CN111315750B (zh) | 2017-11-06 | 2022-12-23 | 南京明德新药研发有限公司 | 作为mTORC1/2双激酶抑制剂的吡啶并嘧啶类化合物 |
WO2021133509A1 (en) * | 2019-12-27 | 2021-07-01 | Angex Pharmaceutical, Inc. | Heterocyclic compounds as mtor inhibitors |
WO2024057013A1 (en) * | 2022-09-12 | 2024-03-21 | Exscientia Ai Limited | Nlrp3 modulators |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2940972A (en) * | 1957-06-27 | 1960-06-14 | Thomae Gmbh Dr K | Tri-and tetra-substituted pteridine derivatives |
US4560685A (en) * | 1984-06-18 | 1985-12-24 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | 2-Piperazino-pteridines useful as antithrombotics and antimetastatics |
DE3445298A1 (de) * | 1984-12-12 | 1986-06-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
US5990117A (en) * | 1998-04-15 | 1999-11-23 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives |
EP1481970B1 (de) * | 1999-09-07 | 2006-03-22 | Syngenta Participations AG | Neue Herbizide |
DE60144322D1 (de) * | 2000-04-27 | 2011-05-12 | Astellas Pharma Inc | Kondensierte heteroarylderivate |
US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
GB0428475D0 (en) * | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
-
2006
- 2006-11-20 KR KR1020087015084A patent/KR101464384B1/ko active IP Right Grant
- 2006-11-20 EP EP06808609A patent/EP1954699B1/en active Active
- 2006-11-20 CA CA2628920A patent/CA2628920C/en active Active
- 2006-11-20 JP JP2008541809A patent/JP5161102B2/ja active Active
- 2006-11-20 AU AU2006318948A patent/AU2006318948B2/en not_active Ceased
- 2006-11-20 PL PL06808609T patent/PL1954699T3/pl unknown
- 2006-11-20 WO PCT/GB2006/004327 patent/WO2007060404A1/en active Application Filing
- 2006-11-21 UY UY29938A patent/UY29938A1/es not_active Application Discontinuation
- 2006-11-22 AR ARP060105124A patent/AR057626A1/es not_active Application Discontinuation
- 2006-11-22 TW TW095143285A patent/TWI452047B/zh not_active IP Right Cessation
-
2007
- 2007-08-21 US US11/842,927 patent/US20080194546A1/en not_active Abandoned
-
2008
- 2008-05-01 IL IL191196A patent/IL191196A/en active IP Right Grant
- 2008-05-06 NO NO20082101A patent/NO341055B1/no not_active IP Right Cessation
- 2008-06-16 EC EC2008008536A patent/ECSP088536A/es unknown
- 2008-12-10 HK HK08113443.8A patent/HK1124039A1/xx not_active IP Right Cessation
-
2012
- 2012-11-27 HR HRP20120963TT patent/HRP20120963T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
CA2628920C (en) | 2015-12-29 |
AU2006318948B2 (en) | 2011-02-24 |
EP1954699A1 (en) | 2008-08-13 |
EP1954699B1 (en) | 2012-09-19 |
NO341055B1 (no) | 2017-08-14 |
TW200738706A (en) | 2007-10-16 |
AR057626A1 (es) | 2007-12-05 |
KR20080070079A (ko) | 2008-07-29 |
CA2628920A1 (en) | 2007-05-31 |
JP5161102B2 (ja) | 2013-03-13 |
TWI452047B (zh) | 2014-09-11 |
ECSP088536A (es) | 2008-07-30 |
HRP20120963T1 (hr) | 2012-12-31 |
WO2007060404A1 (en) | 2007-05-31 |
KR101464384B1 (ko) | 2014-11-21 |
IL191196A (en) | 2016-02-29 |
PL1954699T3 (pl) | 2013-01-31 |
AU2006318948A1 (en) | 2007-05-31 |
UY29938A1 (es) | 2007-06-29 |
JP2009516727A (ja) | 2009-04-23 |
HK1124039A1 (en) | 2009-07-03 |
US20080194546A1 (en) | 2008-08-14 |
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