HRP20090208T1 - Supstituirani derivati pirido[2,3-d]pirimidina korisni kao lijekovi za liječenje autoimunih bolesti - Google Patents

Supstituirani derivati pirido[2,3-d]pirimidina korisni kao lijekovi za liječenje autoimunih bolesti

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Publication number
HRP20090208T1
HRP20090208T1 HR20090208T HRP20090208T HRP20090208T1 HR P20090208 T1 HRP20090208 T1 HR P20090208T1 HR 20090208 T HR20090208 T HR 20090208T HR P20090208 T HRP20090208 T HR P20090208T HR P20090208 T1 HRP20090208 T1 HR P20090208T1
Authority
HR
Croatia
Prior art keywords
medicines
treatment
autoimmune disorders
pyrimidine derivatives
derivatives useful
Prior art date
Application number
HR20090208T
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English (en)
Inventor
Cesar Alfons De Jonghe Steven
Andr� Maurits Maria Herdewijn Piet
Gao Ling-Jie
Original Assignee
4 Aza Ip Nv
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Publication date
Application filed by 4 Aza Ip Nv filed Critical 4 Aza Ip Nv
Publication of HRP20090208T1 publication Critical patent/HRP20090208T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Derivat pirido(2,3-d)pirimidina koji ima opću formulu: naznačen time, što: - R1 je amino, - R2 je izabran iz grupe koju čine hidroksi, halogen, mono C1-7alkil amino; mono-arilamino; monoarilC1-7alkilamino; morfolinil; N-piperidinil; triazolil; heterocikličnom grupom supstituirani amino; C1-7 alkoksi; oksiheterociklična grupa; piperazinil ili homopiperazinil, naznačen time što je navedeni piperazinil izborno
HR20090208T 2005-02-21 2009-04-08 Supstituirani derivati pirido[2,3-d]pirimidina korisni kao lijekovi za liječenje autoimunih bolesti HRP20090208T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0503506.8A GB0503506D0 (en) 2005-02-21 2005-02-21 Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
PCT/EP2006/001539 WO2006087229A1 (en) 2005-02-21 2006-02-21 Substituted pyrido (2 , 3-d) pyrimidine derivatives useful as medicines for the treatment of autoimmune disorders

Publications (1)

Publication Number Publication Date
HRP20090208T1 true HRP20090208T1 (hr) 2009-05-31

Family

ID=34401023

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090208T HRP20090208T1 (hr) 2005-02-21 2009-04-08 Supstituirani derivati pirido[2,3-d]pirimidina korisni kao lijekovi za liječenje autoimunih bolesti

Country Status (22)

Country Link
US (1) US20080312227A1 (hr)
EP (1) EP1851217B1 (hr)
JP (1) JP2008530167A (hr)
KR (1) KR20070112174A (hr)
CN (1) CN101203514A (hr)
AT (1) ATE422496T1 (hr)
AU (1) AU2006215700A1 (hr)
BR (1) BRPI0606844A2 (hr)
CA (1) CA2598465A1 (hr)
DE (1) DE602006005136D1 (hr)
DK (1) DK1851217T3 (hr)
ES (1) ES2318723T3 (hr)
GB (1) GB0503506D0 (hr)
HR (1) HRP20090208T1 (hr)
IL (1) IL185289A0 (hr)
MX (1) MX2007010156A (hr)
NO (1) NO20074207L (hr)
PL (1) PL1851217T3 (hr)
PT (1) PT1851217E (hr)
RU (1) RU2007135053A (hr)
SI (1) SI1851217T1 (hr)
WO (1) WO2006087229A1 (hr)

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CA2612788A1 (en) * 2005-06-24 2006-12-28 Steven Cesar Alfons De Jonghe Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c
WO2008009078A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US8338435B2 (en) 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections
WO2008009079A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US8673929B2 (en) * 2006-07-20 2014-03-18 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
TW200840584A (en) 2006-12-26 2008-10-16 Gilead Sciences Inc Pyrido(3,2-d)pyrimidines useful for treating viral infections
US8637531B2 (en) * 2006-12-26 2014-01-28 Gilead Sciences, Inc. Pyrido(3,2-d)pyridmidines useful for treating viral infections
ES2570456T3 (es) 2009-02-12 2016-05-18 Merck Serono Sa 2-Morfolino-pirido[3,2-d]pirimidinas
JP6496301B2 (ja) 2013-04-12 2019-04-03 アサナ・バイオサイエンシズ，リミテッド・ライアビリティ・カンパニー Ｒａｓ／ｒａｆ／ｍｅｋ／ｅｒｋ経路およびｐｉ３ｋ／ａｋｔ／ｐｔｅｎ／ｍｔｏｒ経路の二重阻害剤としてのキナゾリンおよびアザキナゾリン
CN103694255A (zh) * 2014-01-09 2014-04-02 华中师范大学 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用
GB201416186D0 (en) 2014-09-12 2014-10-29 Redx Pharma Ltd Compounds
HUE050029T2 (hu) 2015-03-04 2020-11-30 Gilead Sciences Inc 4,6-Diamino-pirido[3,2-d]pirimidin-származékok és alkalmazásuk toll-szerû receptorok modulátoraként
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
JP6746776B2 (ja) 2016-09-02 2020-08-26 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体調節剤化合物
GB201809458D0 (en) 2018-06-08 2018-07-25 Crt Pioneer Fund Lp Salt form
GB201809460D0 (en) 2018-06-08 2018-07-25 Crt Pioneer Fund Lp Salt form
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN113801114B (zh) * 2020-06-11 2022-11-18 江苏恒瑞医药股份有限公司 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用
BR112023001557A2 (pt) 2020-07-28 2023-04-04 Jazz Pharmaceuticals Ireland Ltd Inibidores de raf bicíclicos fundidos e métodos para uso dos mesmos
KR102487604B1 (ko) * 2020-11-06 2023-01-12 에스케이케미칼 주식회사 히드로플루메티아지드를 유효성분으로 포함하는 TNF-α 관련 질환 예방 또는 치료용 조성물
WO2022161461A1 (zh) * 2021-01-29 2022-08-04 江苏先声药业有限公司 Sos1抑制剂及其制备方法和应用

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US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US5223503A (en) * 1991-04-29 1993-06-29 Eli Lilly And Company 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents

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JP2008530167A (ja) 2008-08-07
RU2007135053A (ru) 2009-03-27
NO20074207L (no) 2007-10-26
WO2006087229A1 (en) 2006-08-24
CA2598465A1 (en) 2006-08-24
CN101203514A (zh) 2008-06-18
GB0503506D0 (en) 2005-03-30
DK1851217T3 (da) 2009-03-23
US20080312227A1 (en) 2008-12-18
SI1851217T1 (sl) 2009-06-30
EP1851217B1 (en) 2009-02-11
EP1851217A1 (en) 2007-11-07
PL1851217T3 (pl) 2009-07-31
BRPI0606844A2 (pt) 2009-07-21
MX2007010156A (es) 2008-02-19
KR20070112174A (ko) 2007-11-22
ES2318723T3 (es) 2009-05-01
IL185289A0 (en) 2008-02-09
PT1851217E (pt) 2009-05-14
ATE422496T1 (de) 2009-02-15
DE602006005136D1 (de) 2009-03-26
AU2006215700A1 (en) 2006-08-24

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