MA30709B1 - Derives de pyrido (2, 3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3. - Google Patents

Derives de pyrido (2, 3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3.

Info

Publication number
MA30709B1
MA30709B1 MA31707A MA31707A MA30709B1 MA 30709 B1 MA30709 B1 MA 30709B1 MA 31707 A MA31707 A MA 31707A MA 31707 A MA31707 A MA 31707A MA 30709 B1 MA30709 B1 MA 30709B1
Authority
MA
Morocco
Prior art keywords
inhibitors
pyrido
pyrimidinone derivatives
pyrimidinone
derivatives
Prior art date
Application number
MA31707A
Other languages
English (en)
Inventor
Hengmiao Cheng
Dilip Bhumralkar
Klaus Ruprecht Dress
Jacqui Elizabeth Hoffman
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Michael Bruno Plewe
Khanh Tuan Tran
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA30709B1 publication Critical patent/MA30709B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

CETTE INVENTION CONCERNE DES NOUVEAUX COMPOSÉS DE 4-METHYLPYRIDOPYRIMIDINONE REPRÉSENTÉS PAR LA FORMULE (I), ET DES SELS DE CEUX-CI, LEUR SYNTHÈSE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PHOSPHOINOSITIDE 3-KINASE ALPHA (PI3- KA).
MA31707A 2006-09-15 2009-03-13 Derives de pyrido (2, 3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3. MA30709B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30

Publications (1)

Publication Number Publication Date
MA30709B1 true MA30709B1 (fr) 2009-09-01

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31707A MA30709B1 (fr) 2006-09-15 2009-03-13 Derives de pyrido (2, 3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3.

Country Status (42)

Country Link
US (3) US7696213B2 (fr)
EP (1) EP2074122B9 (fr)
JP (1) JP4718637B2 (fr)
KR (1) KR101099926B1 (fr)
CN (1) CN101573358B (fr)
AP (1) AP2710A (fr)
AR (1) AR062785A1 (fr)
AT (1) ATE514695T1 (fr)
AU (1) AU2007297212B8 (fr)
BR (1) BRPI0716749B8 (fr)
CA (1) CA2663401C (fr)
CL (1) CL2007002682A1 (fr)
CR (1) CR10662A (fr)
CU (1) CU23783B7 (fr)
CY (1) CY1111911T1 (fr)
DK (1) DK2074122T5 (fr)
DO (1) DOP2009000039A (fr)
EA (1) EA016388B1 (fr)
ES (1) ES2366489T3 (fr)
GE (1) GEP20115306B (fr)
GT (1) GT200700077A (fr)
HK (1) HK1138589A1 (fr)
HN (1) HN2007000267A (fr)
HR (1) HRP20110621T2 (fr)
IL (1) IL197243A (fr)
MA (1) MA30709B1 (fr)
ME (1) MEP8009A (fr)
MX (1) MX2009002927A (fr)
MY (1) MY146420A (fr)
NI (1) NI200900032A (fr)
NO (1) NO342357B1 (fr)
NZ (1) NZ575167A (fr)
PE (1) PE20080670A1 (fr)
PL (1) PL2074122T3 (fr)
PT (1) PT2074122E (fr)
RS (2) RS51927B (fr)
SI (1) SI2074122T1 (fr)
TN (1) TN2009000085A1 (fr)
TW (1) TWI334353B (fr)
UY (1) UY30588A1 (fr)
WO (1) WO2008032162A1 (fr)
ZA (1) ZA200901477B (fr)

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EP2331511A1 (fr) 2008-08-20 2011-06-15 Schering Corporation Dérivés de pyridine et de pyrimidine à substitution éthylyle et leur utilisation dans le traitement d infections virales
CA2734486A1 (fr) 2008-08-20 2010-02-25 Southern Research Institute Derives de pyridine et pyrimidine substituees et leur utilisation dans le traitement d'infections virales
UY32153A (es) * 2008-09-30 2011-04-29 Exelixis Inc Inhibidores de piridomidinona de pi13ka(alfa) y mtor
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EP3636283A1 (fr) 2015-06-04 2020-04-15 Pfizer Inc Formes galéniques solides de palbociclib
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Also Published As

Publication number Publication date
PL2074122T3 (pl) 2011-10-31
US20120309775A1 (en) 2012-12-06
KR20090040389A (ko) 2009-04-23
AP2009004790A0 (en) 2009-04-30
AP2710A (en) 2013-07-30
TW200820972A (en) 2008-05-16
US8633204B2 (en) 2014-01-21
EA200970207A1 (ru) 2009-08-28
HRP20110621T1 (en) 2011-09-30
CN101573358A (zh) 2009-11-04
NO342357B1 (no) 2018-05-14
GT200700077A (es) 2009-08-03
MY146420A (en) 2012-08-15
PT2074122E (pt) 2011-08-24
CN101573358B (zh) 2012-05-30
RS20090104A (en) 2010-06-30
JP2010503653A (ja) 2010-02-04
SI2074122T1 (sl) 2011-10-28
NI200900032A (es) 2010-05-14
KR101099926B1 (ko) 2011-12-28
GEP20115306B (fr) 2011-10-10
CA2663401A1 (fr) 2008-03-20
US8273755B2 (en) 2012-09-25
HK1138589A1 (en) 2010-08-27
DK2074122T5 (da) 2014-03-17
RS51927B (en) 2012-02-29
US20100137279A1 (en) 2010-06-03
AU2007297212B2 (en) 2011-04-14
IL197243A0 (en) 2009-12-24
CL2007002682A1 (es) 2008-04-04
MEP8009A (en) 2011-12-20
TN2009000085A1 (fr) 2010-08-19
BRPI0716749A2 (pt) 2014-02-18
NZ575167A (en) 2010-10-29
ES2366489T9 (es) 2013-12-27
ZA200901477B (en) 2010-07-28
EP2074122A1 (fr) 2009-07-01
EA016388B1 (ru) 2012-04-30
IL197243A (en) 2013-07-31
CR10662A (es) 2009-04-17
DK2074122T3 (da) 2011-08-15
EP2074122B9 (fr) 2013-09-11
WO2008032162A8 (fr) 2009-03-26
CU20090040A7 (es) 2011-07-11
BRPI0716749B8 (pt) 2021-05-25
MX2009002927A (es) 2009-03-31
JP4718637B2 (ja) 2011-07-06
UY30588A1 (es) 2008-05-02
CY1111911T1 (el) 2015-11-04
EP2074122B1 (fr) 2011-06-29
ATE514695T1 (de) 2011-07-15
TWI334353B (en) 2010-12-11
US7696213B2 (en) 2010-04-13
HRP20110621T2 (hr) 2013-12-06
PE20080670A1 (es) 2008-06-14
CU23783B7 (es) 2012-02-15
CA2663401C (fr) 2011-07-12
US20080090801A1 (en) 2008-04-17
WO2008032162A1 (fr) 2008-03-20
BRPI0716749B1 (pt) 2020-10-06
DOP2009000039A (es) 2015-12-15
AU2007297212B8 (en) 2011-04-28
HN2007000267A (es) 2011-02-25
NO20091141L (no) 2009-03-31
AR062785A1 (es) 2008-12-03
AU2007297212A1 (en) 2008-03-20
ES2366489T3 (es) 2011-10-20

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