AP2710A - Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors - Google Patents

Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors

Info

Publication number
AP2710A
AP2710A AP2009004790A AP2009004790A AP2710A AP 2710 A AP2710 A AP 2710A AP 2009004790 A AP2009004790 A AP 2009004790A AP 2009004790 A AP2009004790 A AP 2009004790A AP 2710 A AP2710 A AP 2710A
Authority
AP
ARIPO
Prior art keywords
pyrido
inhibitors
pyrimidinone compounds
pyrimidinone
compounds
Prior art date
Application number
AP2009004790A
Other languages
English (en)
Other versions
AP2009004790A0 (en
Inventor
Dilip Bhumralkar
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2009004790A0 publication Critical patent/AP2009004790A0/xx
Application granted granted Critical
Publication of AP2710A publication Critical patent/AP2710A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
AP2009004790A 2006-09-15 2007-09-03 Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors AP2710A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (en) 2006-09-15 2007-09-03 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors

Publications (2)

Publication Number Publication Date
AP2009004790A0 AP2009004790A0 (en) 2009-04-30
AP2710A true AP2710A (en) 2013-07-30

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2009004790A AP2710A (en) 2006-09-15 2007-09-03 Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors

Country Status (42)

Country Link
US (3) US7696213B2 (xx)
EP (1) EP2074122B9 (xx)
JP (1) JP4718637B2 (xx)
KR (1) KR101099926B1 (xx)
CN (1) CN101573358B (xx)
AP (1) AP2710A (xx)
AR (1) AR062785A1 (xx)
AT (1) ATE514695T1 (xx)
AU (1) AU2007297212B8 (xx)
BR (1) BRPI0716749B8 (xx)
CA (1) CA2663401C (xx)
CL (1) CL2007002682A1 (xx)
CR (1) CR10662A (xx)
CU (1) CU23783B7 (xx)
CY (1) CY1111911T1 (xx)
DK (1) DK2074122T5 (xx)
DO (1) DOP2009000039A (xx)
EA (1) EA016388B1 (xx)
ES (1) ES2366489T3 (xx)
GE (1) GEP20115306B (xx)
GT (1) GT200700077A (xx)
HK (1) HK1138589A1 (xx)
HN (1) HN2007000267A (xx)
HR (1) HRP20110621T2 (xx)
IL (1) IL197243A (xx)
MA (1) MA30709B1 (xx)
ME (1) MEP8009A (xx)
MX (1) MX2009002927A (xx)
MY (1) MY146420A (xx)
NI (1) NI200900032A (xx)
NO (1) NO342357B1 (xx)
NZ (1) NZ575167A (xx)
PE (1) PE20080670A1 (xx)
PL (1) PL2074122T3 (xx)
PT (1) PT2074122E (xx)
RS (2) RS51927B (xx)
SI (1) SI2074122T1 (xx)
TN (1) TN2009000085A1 (xx)
TW (1) TWI334353B (xx)
UY (1) UY30588A1 (xx)
WO (1) WO2008032162A1 (xx)
ZA (1) ZA200901477B (xx)

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CN104829609B (zh) * 2014-02-11 2016-08-03 北大方正集团有限公司 取代的吡啶并嘧啶化合物及其制备方法和应用
CN105294681B (zh) 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
CN105330699B (zh) * 2014-08-13 2018-12-04 山东汇睿迪生物技术有限公司 一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
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BR112017025398A2 (pt) 2015-06-04 2018-08-07 Pfizer Inc. formas de dosagem sólidas de palbociclib
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US10919877B2 (en) 2016-07-06 2021-02-16 The Regents Of The University Of Michigan Multifunctional inhibitors of MEK/PI3K and mTOR/MEK/PI3K biological pathways and therapeutic methods using the same
CN109803968A (zh) 2016-08-15 2019-05-24 辉瑞公司 吡啶并嘧啶酮cdk2/4/6抑制剂
CN110049783A (zh) * 2016-12-14 2019-07-23 塔弗达治疗有限公司 Hsp90-靶向缀合物及其制剂
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CN114901664B (zh) * 2020-01-10 2024-07-02 南京再明医药有限公司 吡啶酮化合物及应用
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CN118678960A (zh) * 2021-11-18 2024-09-20 安可诺瓦治疗公司 用于治疗癌症的方法和组合物

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Also Published As

Publication number Publication date
US20100137279A1 (en) 2010-06-03
US20080090801A1 (en) 2008-04-17
HRP20110621T2 (hr) 2013-12-06
ES2366489T3 (es) 2011-10-20
TWI334353B (en) 2010-12-11
WO2008032162A8 (en) 2009-03-26
MX2009002927A (es) 2009-03-31
MEP8009A (en) 2011-12-20
BRPI0716749A2 (pt) 2014-02-18
MY146420A (en) 2012-08-15
AU2007297212B2 (en) 2011-04-14
UY30588A1 (es) 2008-05-02
CA2663401C (en) 2011-07-12
WO2008032162A1 (en) 2008-03-20
NI200900032A (es) 2010-05-14
CU20090040A7 (es) 2011-07-11
CR10662A (es) 2009-04-17
CY1111911T1 (el) 2015-11-04
JP4718637B2 (ja) 2011-07-06
AR062785A1 (es) 2008-12-03
NZ575167A (en) 2010-10-29
AU2007297212B8 (en) 2011-04-28
AP2009004790A0 (en) 2009-04-30
BRPI0716749B1 (pt) 2020-10-06
US8633204B2 (en) 2014-01-21
JP2010503653A (ja) 2010-02-04
CU23783B7 (es) 2012-02-15
ES2366489T9 (es) 2013-12-27
TW200820972A (en) 2008-05-16
DOP2009000039A (es) 2015-12-15
CN101573358A (zh) 2009-11-04
EA200970207A1 (ru) 2009-08-28
DK2074122T3 (da) 2011-08-15
ATE514695T1 (de) 2011-07-15
PL2074122T3 (pl) 2011-10-31
BRPI0716749B8 (pt) 2021-05-25
AU2007297212A1 (en) 2008-03-20
CA2663401A1 (en) 2008-03-20
NO342357B1 (no) 2018-05-14
IL197243A (en) 2013-07-31
HK1138589A1 (en) 2010-08-27
EP2074122B1 (en) 2011-06-29
GEP20115306B (xx) 2011-10-10
GT200700077A (es) 2009-08-03
HN2007000267A (es) 2011-02-25
PE20080670A1 (es) 2008-06-14
MA30709B1 (fr) 2009-09-01
RS51927B (en) 2012-02-29
CN101573358B (zh) 2012-05-30
EA016388B1 (ru) 2012-04-30
CL2007002682A1 (es) 2008-04-04
TN2009000085A1 (fr) 2010-08-19
RS20090104A (xx) 2010-06-30
PT2074122E (pt) 2011-08-24
US8273755B2 (en) 2012-09-25
US7696213B2 (en) 2010-04-13
EP2074122B9 (en) 2013-09-11
ZA200901477B (en) 2010-07-28
IL197243A0 (en) 2009-12-24
DK2074122T5 (da) 2014-03-17
HRP20110621T1 (en) 2011-09-30
EP2074122A1 (en) 2009-07-01
US20120309775A1 (en) 2012-12-06
SI2074122T1 (sl) 2011-10-28
NO20091141L (no) 2009-03-31
KR101099926B1 (ko) 2011-12-28
KR20090040389A (ko) 2009-04-23

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