BRPI0915901A2 - combinação de (a) um inibidor de fosfoinositídeo 3-quinase e (b) um modulador da via ras/raf/mek - Google Patents
combinação de (a) um inibidor de fosfoinositídeo 3-quinase e (b) um modulador da via ras/raf/mekInfo
- Publication number
- BRPI0915901A2 BRPI0915901A2 BRPI0915901A BRPI0915901A BRPI0915901A2 BR PI0915901 A2 BRPI0915901 A2 BR PI0915901A2 BR PI0915901 A BRPI0915901 A BR PI0915901A BR PI0915901 A BRPI0915901 A BR PI0915901A BR PI0915901 A2 BRPI0915901 A2 BR PI0915901A2
- Authority
- BR
- Brazil
- Prior art keywords
- phosphoinositide
- raf
- ras
- combination
- kinase inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08160218 | 2008-07-11 | ||
PCT/US2009/050192 WO2010006225A1 (en) | 2008-07-11 | 2009-07-10 | Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0915901A2 true BRPI0915901A2 (pt) | 2015-10-27 |
Family
ID=39739487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0915901A BRPI0915901A2 (pt) | 2008-07-11 | 2009-07-10 | combinação de (a) um inibidor de fosfoinositídeo 3-quinase e (b) um modulador da via ras/raf/mek |
Country Status (11)
Country | Link |
---|---|
US (3) | US20110105521A1 (pt) |
EP (1) | EP2310050A1 (pt) |
JP (2) | JP2011527703A (pt) |
KR (1) | KR20110028651A (pt) |
CN (1) | CN102089007B (pt) |
AU (1) | AU2009268469B2 (pt) |
BR (1) | BRPI0915901A2 (pt) |
CA (1) | CA2729914A1 (pt) |
MX (2) | MX2011000440A (pt) |
RU (2) | RU2508110C2 (pt) |
WO (1) | WO2010006225A1 (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2579810C (en) | 2004-09-17 | 2012-01-24 | Eisai R&D Management Co., Ltd. | Stable pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide |
US9006240B2 (en) | 2005-08-02 | 2015-04-14 | Eisai R&D Management Co., Ltd. | Method for assay on the effect of vascularization inhibitor |
RU2448708C3 (ru) | 2006-05-18 | 2017-09-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое средство против рака щитовидной железы |
CA2729914A1 (en) | 2008-07-11 | 2010-01-14 | Novartis Ag | Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway |
KR20120096869A (ko) * | 2009-05-15 | 2012-08-31 | 노파르티스 아게 | 포스포이노시티드 3-키나제 억제제 및 항당뇨병 화합물의 조합물 |
WO2012061683A2 (en) * | 2010-11-05 | 2012-05-10 | Glaxosmithkline Llc | Methods for treating cancer |
WO2012066451A1 (en) * | 2010-11-15 | 2012-05-24 | Pfizer Inc. | Prognostic and predictive gene signature for colon cancer |
US20130231346A1 (en) * | 2010-11-17 | 2013-09-05 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods of treating cancer |
EP2640860A4 (en) * | 2010-11-19 | 2014-06-04 | Univ California | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING B-RAF HEMMER RESISTANT MELANOMES |
TR201815685T4 (tr) | 2011-04-01 | 2018-11-21 | Genentech Inc | Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları. |
JP6021805B2 (ja) * | 2011-04-18 | 2016-11-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療剤 |
EP3444363B1 (en) | 2011-06-03 | 2020-11-25 | Eisai R&D Management Co., Ltd. | Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
CN103842030B (zh) * | 2011-08-01 | 2018-07-31 | 霍夫曼-拉罗奇有限公司 | 使用pd-1轴结合拮抗剂和mek抑制剂治疗癌症的方法 |
KR20140072028A (ko) * | 2011-08-31 | 2014-06-12 | 노파르티스 아게 | Pi3k- 및 mek-억제제의 상승작용적 조합물 |
US20140341916A1 (en) * | 2011-10-28 | 2014-11-20 | Genentech, Inc. | Therapeutic combinations and methods of treating melanoma |
EA201490879A1 (ru) * | 2011-10-28 | 2014-08-29 | Дженентек, Инк. | Терапевтические комбинации и способы лечения меланомы |
WO2013082511A1 (en) | 2011-12-02 | 2013-06-06 | Genentech, Inc. | Methods for overcoming tumor resistance to vegf antagonists |
WO2013106683A1 (en) * | 2012-01-11 | 2013-07-18 | Duke University | Methods of treating and preventing cancer by disrupting the binding of copper in the map kinase pathway |
WO2013109142A1 (en) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Combined pdk and mapk/erk pathway inhibition in neoplasia |
AR091876A1 (es) | 2012-07-26 | 2015-03-04 | Novartis Ag | Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas |
WO2014022680A1 (en) | 2012-08-02 | 2014-02-06 | Genentech, Inc. | Anti-etbr antibodies and immunoconjugates |
CN104717979A (zh) | 2012-08-02 | 2015-06-17 | 基因泰克公司 | 抗etbr抗体和免疫偶联物 |
WO2014028566A1 (en) * | 2012-08-16 | 2014-02-20 | Novartis Ag | Combination of pi3k inhibitor and c-met inhibitor |
CA2889866A1 (en) | 2012-12-21 | 2014-06-26 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
WO2014108837A1 (en) * | 2013-01-09 | 2014-07-17 | Glaxosmithkline Intellectual Property (No.2) Limited | Combination |
EP2968345B1 (en) * | 2013-03-13 | 2017-12-13 | The Regents of The University of Michigan | Dual mek/pi3k inhibitors and their application in the treatment of cancer diseases |
WO2014160358A1 (en) * | 2013-03-14 | 2014-10-02 | Thomas Cooper Woods | Use of mir-221 and 222 lowering agents to prevent cardiovascular disease in diabetic subjects |
US9522130B2 (en) | 2013-03-14 | 2016-12-20 | Thomas Cooper Woods | Use of miR-221 and 222 lowering agents to prevent cardiovascular disease in diabetic subjects |
JP2016516682A (ja) * | 2013-03-15 | 2016-06-09 | サノフイ | 癌細胞の耐性を克服するための、pi3kベータ阻害剤およびraf阻害剤を含む抗腫瘍組成物 |
JP6411379B2 (ja) | 2013-05-14 | 2018-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する子宮内膜がん対象の応答性を予測及び評価するためのバイオマーカー |
WO2014203152A1 (en) * | 2013-06-18 | 2014-12-24 | Novartis Ag | Pharmaceutical combinations |
US9227969B2 (en) | 2013-08-14 | 2016-01-05 | Novartis Ag | Compounds and compositions as inhibitors of MEK |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
US9629851B2 (en) | 2013-09-20 | 2017-04-25 | Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis | ROCK in combination with MAPK pathway |
EP3052493A4 (en) * | 2013-10-03 | 2017-06-14 | Millennium Pharmaceuticals, Inc. | Enhanced treatment regimens using pi3k inhibitors |
WO2015156674A2 (en) | 2014-04-10 | 2015-10-15 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
PL3169361T3 (pl) | 2014-07-15 | 2019-11-29 | Hoffmann La Roche | Kompozycje do leczenia nowotworu z użyciem związków antagonistycznych wiązania osi pd-1 i inhibitorów mek |
LT3524595T (lt) | 2014-08-28 | 2022-09-26 | Eisai R&D Management Co., Ltd. | Aukšto grynumo chinolino darinys ir jo gamybos būdas |
RS65049B1 (sr) | 2015-02-25 | 2024-02-29 | Eisai R&D Man Co Ltd | Metoda za suzbijanje gorčine derivata kinolina |
WO2016140717A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
KR20160129609A (ko) | 2015-04-30 | 2016-11-09 | 삼성전자주식회사 | Braf 저해제를 포함하는 세포 또는 개체의 노화를 감소시키기 위한 조성물 및 그의 용도 |
WO2016204193A1 (ja) | 2015-06-16 | 2016-12-22 | 株式会社PRISM Pharma | 抗がん剤 |
JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
CN107802838A (zh) * | 2017-09-25 | 2018-03-16 | 石河子大学 | PLCE1抑制剂与NF‑κB通路抑制剂联合在制备治疗食管鳞癌的药物中的应用 |
CN110760582A (zh) * | 2019-07-10 | 2020-02-07 | 中山大学 | 二甲双胍在治疗kras突变型结直肠癌中的应用 |
CN114053416A (zh) * | 2021-10-11 | 2022-02-18 | 中山大学附属第一医院 | Pi3k抑制剂在制备用于治疗对flt3抑制剂耐药的药物中的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2192861C1 (ru) * | 2001-06-29 | 2002-11-20 | Новосибирский институт биоорганической химии СО РАН | Композиция для антибластической терапии |
US20030133903A1 (en) | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of prostate cancers and methods of making and using the same |
US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7378423B2 (en) * | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
MY149960A (en) | 2005-05-18 | 2013-11-15 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
TW200804345A (en) * | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
WO2008032162A1 (en) * | 2006-09-15 | 2008-03-20 | Pfizer Products Inc. | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors |
CA2729914A1 (en) | 2008-07-11 | 2010-01-14 | Novartis Ag | Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway |
UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
MX345155B (es) | 2009-10-12 | 2017-01-18 | F Hoffmann-La Roche Ag * | Combinaciones de un inhibidor de pi3k y un inhibidor de mek. |
-
2009
- 2009-07-10 CA CA 2729914 patent/CA2729914A1/en not_active Abandoned
- 2009-07-10 MX MX2011000440A patent/MX2011000440A/es active IP Right Grant
- 2009-07-10 CN CN2009801265844A patent/CN102089007B/zh not_active Withdrawn - After Issue
- 2009-07-10 JP JP2011517641A patent/JP2011527703A/ja active Pending
- 2009-07-10 BR BRPI0915901A patent/BRPI0915901A2/pt not_active IP Right Cessation
- 2009-07-10 WO PCT/US2009/050192 patent/WO2010006225A1/en active Application Filing
- 2009-07-10 EP EP20090795223 patent/EP2310050A1/en not_active Withdrawn
- 2009-07-10 US US13/003,581 patent/US20110105521A1/en not_active Abandoned
- 2009-07-10 MX MX2013005357A patent/MX336723B/es unknown
- 2009-07-10 AU AU2009268469A patent/AU2009268469B2/en not_active Ceased
- 2009-07-10 RU RU2011104570/15A patent/RU2508110C2/ru not_active IP Right Cessation
- 2009-07-10 KR KR1020117003118A patent/KR20110028651A/ko not_active Application Discontinuation
-
2013
- 2013-07-05 RU RU2013131004/15A patent/RU2013131004A/ru not_active Application Discontinuation
- 2013-10-30 US US14/066,734 patent/US20140057904A1/en not_active Abandoned
-
2014
- 2014-09-08 JP JP2014181858A patent/JP5931982B2/ja active Active
- 2014-12-19 US US14/576,314 patent/US9241939B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MX336723B (es) | 2016-01-28 |
CN102089007B (zh) | 2013-05-15 |
MX2011000440A (es) | 2011-02-24 |
WO2010006225A1 (en) | 2010-01-14 |
RU2011104570A (ru) | 2012-08-20 |
CN102089007A (zh) | 2011-06-08 |
KR20110028651A (ko) | 2011-03-21 |
US20110105521A1 (en) | 2011-05-05 |
CA2729914A1 (en) | 2010-01-14 |
AU2009268469B2 (en) | 2013-02-28 |
US20150105417A1 (en) | 2015-04-16 |
RU2508110C2 (ru) | 2014-02-27 |
US9241939B2 (en) | 2016-01-26 |
RU2013131004A (ru) | 2015-01-10 |
JP2015007110A (ja) | 2015-01-15 |
JP2011527703A (ja) | 2011-11-04 |
US20140057904A1 (en) | 2014-02-27 |
JP5931982B2 (ja) | 2016-06-08 |
EP2310050A1 (en) | 2011-04-20 |
AU2009268469A1 (en) | 2010-01-14 |
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