TN2009000085A1 - Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3 - Google Patents

Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3

Info

Publication number
TN2009000085A1
TN2009000085A1 TN2009000085A TN2009000085A TN2009000085A1 TN 2009000085 A1 TN2009000085 A1 TN 2009000085A1 TN 2009000085 A TN2009000085 A TN 2009000085A TN 2009000085 A TN2009000085 A TN 2009000085A TN 2009000085 A1 TN2009000085 A1 TN 2009000085A1
Authority
TN
Tunisia
Prior art keywords
inhibitors
pyrido
pyrimidinone derivatives
derivatives
pyrimidinone
Prior art date
Application number
TN2009000085A
Other languages
English (en)
Inventor
Hengmiao Cheng
Dilip 2Bhumralkar
Klaus Ruprecht Dress
Jacqui Elizabeth Hoffman
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Michael Bruno Plewe
Khanh Tuan Tran
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TN2009000085A1 publication Critical patent/TN2009000085A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des dérivés de 4-méthylpyridopyrimidinone nouveaux de formule (I). leurs sels, leur synthèse, et leur utilisation comme inhibiteurs de la phosphoinositide -3- kinase alpha (PI3-ka).
TN2009000085A 2006-09-15 2009-03-13 Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3 TN2009000085A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (fr) 2006-09-15 2007-09-03 Composés de pyrido (2, 3-d) pyrimidin0ne et leur utilisation en tant qu'inhibiteurs de pi3

Publications (1)

Publication Number Publication Date
TN2009000085A1 true TN2009000085A1 (fr) 2010-08-19

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2009000085A TN2009000085A1 (fr) 2006-09-15 2009-03-13 Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3

Country Status (42)

Country Link
US (3) US7696213B2 (fr)
EP (1) EP2074122B9 (fr)
JP (1) JP4718637B2 (fr)
KR (1) KR101099926B1 (fr)
CN (1) CN101573358B (fr)
AP (1) AP2710A (fr)
AR (1) AR062785A1 (fr)
AT (1) ATE514695T1 (fr)
AU (1) AU2007297212B8 (fr)
BR (1) BRPI0716749B8 (fr)
CA (1) CA2663401C (fr)
CL (1) CL2007002682A1 (fr)
CR (1) CR10662A (fr)
CU (1) CU23783B7 (fr)
CY (1) CY1111911T1 (fr)
DK (1) DK2074122T5 (fr)
DO (1) DOP2009000039A (fr)
EA (1) EA016388B1 (fr)
ES (1) ES2366489T3 (fr)
GE (1) GEP20115306B (fr)
GT (1) GT200700077A (fr)
HK (1) HK1138589A1 (fr)
HN (1) HN2007000267A (fr)
HR (1) HRP20110621T2 (fr)
IL (1) IL197243A (fr)
MA (1) MA30709B1 (fr)
ME (1) MEP8009A (fr)
MX (1) MX2009002927A (fr)
MY (1) MY146420A (fr)
NI (1) NI200900032A (fr)
NO (1) NO342357B1 (fr)
NZ (1) NZ575167A (fr)
PE (1) PE20080670A1 (fr)
PL (1) PL2074122T3 (fr)
PT (1) PT2074122E (fr)
RS (2) RS51927B (fr)
SI (1) SI2074122T1 (fr)
TN (1) TN2009000085A1 (fr)
TW (1) TWI334353B (fr)
UY (1) UY30588A1 (fr)
WO (1) WO2008032162A1 (fr)
ZA (1) ZA200901477B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008032162A1 (fr) 2006-09-15 2008-03-20 Pfizer Products Inc. Composés de pyrido (2, 3-d) pyrimidin0ne et leur utilisation en tant qu'inhibiteurs de pi3
JP2010523670A (ja) * 2007-04-10 2010-07-15 エクセリクシス， インク． Ｐｉ３ｋアルファのピリドピリミジノン阻害剤を使用した治療方法
EA018964B1 (ru) * 2007-04-11 2013-12-30 Экселиксис, Инк. СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА
US20110105521A1 (en) * 2008-07-11 2011-05-05 Novartis Ag Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway
AU2009282567B2 (en) 2008-08-20 2014-10-02 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AU2009282574B2 (en) * 2008-08-20 2014-08-21 Merck Sharp & Dohme Corp. Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
TW201019939A (en) 2008-08-20 2010-06-01 Schering Corp Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AU2009282571B2 (en) 2008-08-20 2014-12-11 Merck Sharp & Dohme Corp. Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AR073524A1 (es) * 2008-09-30 2010-11-10 Exelixis Inc Piridopirimidinonas inhibidores de pi3k a y m tor
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
ES2530545T3 (es) 2010-12-16 2015-03-03 Hoffmann La Roche Compuestos tricíclicos inhibidores de la PI3K y métodos de uso
US8664230B2 (en) * 2011-03-17 2014-03-04 The Asan Foundation Pyridopyrimidine derivatives and use thereof
TW201306842A (zh) * 2011-06-15 2013-02-16 Exelixis Inc 使用ｐｉ３ｋ／ｍｔｏｒ吡啶並嘧啶酮抑制劑及苯達莫司汀及／或利妥昔單抗治療惡性血液疾病之組合療法
WO2013066483A1 (fr) 2011-08-31 2013-05-10 Novartis Ag Combinaisons synergiques d'inhibiteurs de pi3k et de mek
CN104829609B (zh) * 2014-02-11 2016-08-03 北大方正集团有限公司 取代的吡啶并嘧啶化合物及其制备方法和应用
CN105294682B (zh) 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
CN105330699B (zh) * 2014-08-13 2018-12-04 山东汇睿迪生物技术有限公司 一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
KR20170058432A (ko) 2014-10-10 2017-05-26 화이자 인코포레이티드 상승 효과적 아우리스타틴 조합
SI3302565T1 (sl) 2015-06-04 2020-02-28 Pfizer Inc. Trdne farmacevtske oblike palbocikliba
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP2019519593A (ja) 2016-07-06 2019-07-11 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法
MD3497103T2 (ro) 2016-08-15 2021-08-31 Pfizer Inhibitori de piridopirimidinonă CDK2/4/6
WO2019157516A1 (fr) 2018-02-12 2019-08-15 resTORbio, Inc. Polythérapies
CN112423843B (zh) 2018-06-15 2023-11-28 詹森药业有限公司 雷帕霉素类似物和其用途
US20220220103A1 (en) * 2018-12-28 2022-07-14 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
WO2020140055A1 (fr) * 2018-12-28 2020-07-02 Spv Therapeutics Inc. Inhibiteurs de kinases cycline-dépendantes
US11583538B2 (en) 2019-04-08 2023-02-21 Venenum Biodesign, LLC Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
CA3163680A1 (fr) 2019-12-05 2021-06-10 David John O'neill Analogues de la rapamycine et leurs utilisations
WO2021139775A1 (fr) * 2020-01-10 2021-07-15 江苏先声药业有限公司 Composé de pyridone et son application
WO2022075974A1 (fr) * 2020-10-06 2022-04-14 Venenum Biodesign, LLC Inhibiteurs cycliques de trex1
WO2022109001A1 (fr) 2020-11-18 2022-05-27 Deciphera Pharmaceuticals, Llc Inhibiteurs des kinases gcn2 et perk et leurs méthodes d'utilisation
WO2023092104A1 (fr) * 2021-11-18 2023-05-25 Onconova Therapeutics, Inc. Méthodes et compositions pour traitement du cancer

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264437A (en) * 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
CN1085666C (zh) 1994-11-14 2002-05-29 沃尼尔·朗伯公司 用于抑制蛋白质酪氨酸激酶介导的细胞增殖的6－芳基吡啶并[2,3－d]嘧啶和1,5－二氮杂萘
CN1177960A (zh) * 1995-03-10 1998-04-01 圣诺菲药品有限公司 6－取代的吡唑并[3,4－d]嘧啶－4－酮及其组合物和使用方法
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5925761A (en) 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
DE69839338T2 (de) 1997-02-05 2008-07-10 Warner-Lambert Company Llc Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation
US6498163B1 (en) 1997-02-05 2002-12-24 Warner-Lambert Company Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
GB9904932D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
CA2394525A1 (fr) 2000-01-27 2001-08-02 Warner-Lambert Company Derives de pyridopyrimidinone destines au traitement de maladies maladie neurodegenerative
BR0109056A (pt) 2000-03-06 2003-06-03 Warner Lambert Co Inibidores da cinase de tirosina de 5-alquilpirido[2,3-d]pirimidinas
CN100345830C (zh) 2000-04-27 2007-10-31 安斯泰来制药有限公司 稠合杂芳基衍生物
KR100540623B1 (ko) 2001-02-26 2006-01-11 다나베 세이야꾸 가부시키가이샤 피리도피리미딘 또는 나프틸리딘 유도체
US7019002B2 (en) * 2001-12-11 2006-03-28 Pharmacia & Upjohn, S.P.A. Pyridopyrimidinones derivatives as telomerase inhibitors
NZ534069A (en) 2002-01-22 2007-03-30 Warner Lambert Co 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones to be used to treat neurodegenerative disorders, viruses and cancer
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
AU2003225072A1 (en) 2002-04-19 2003-11-03 Smithkline Beecham Corporation Novel compounds
KR20050006221A (ko) 2002-05-06 2005-01-15 제네랩스 테크놀로지스, 인코포레이티드 Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
JP2004083587A (ja) 2002-08-06 2004-03-18 Tanabe Seiyaku Co Ltd 医薬組成物
US7098332B2 (en) * 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
JP2004203751A (ja) 2002-12-24 2004-07-22 Pfizer Inc 置換６，６−ヘテロ二環式誘導体
US20050009849A1 (en) 2003-01-03 2005-01-13 Veach Darren R. Pyridopyrimidine kinase inhibitors
WO2004089930A1 (fr) 2003-04-02 2004-10-21 Imclone Systems Incorporated Derives de 4- fluoroquinolone et leur utilisation comme inhibiteurs de kinase
EP1624900A4 (fr) 2003-05-20 2007-05-02 Univ California Procedes permettant de lier des agents a des plaques beta-amyloides
NZ544609A (en) 2003-07-11 2008-07-31 Warner Lambert Co Isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
CA2533626A1 (fr) 2003-07-22 2005-02-03 Janssen Pharmaceutica, N.V. Derives de quinolinone en tant qu'inhibiteurs de c-fms kinase
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
PL1713806T3 (pl) 2004-02-14 2013-09-30 Irm Llc Związki i kompozycje jako inhibitory kinaz białkowych
CA2555724A1 (fr) 2004-02-18 2005-09-09 Warner-Lambert Company Llc 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
CA2561516A1 (fr) 2004-03-30 2005-10-13 Pfizer Products Inc. Combinaisons d'inhibiteurs de transduction de signaux
WO2005105097A2 (fr) 2004-04-28 2005-11-10 Gpc Biotech Ag Derives de pyridopyrimidine
JP2007536370A (ja) * 2004-05-04 2007-12-13 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 療法薬としてのピロリル置換ピリド［２，３−ｄ］ピリミジン−７−オンおよびその誘導体
JP2008501677A (ja) 2004-06-04 2008-01-24 ファイザー・プロダクツ・インク 異常な細胞増殖を治療する方法
EP1786817A1 (fr) 2004-08-26 2007-05-23 Boehringer Ingelheim International GmbH Pteridinones en tant que inhibiteurs de plk (polo like kinase)
CA2585091C (fr) 2004-11-03 2016-07-19 University Of Kansas Analogues de novobiocine en tant qu'agents anticancereux
US7767687B2 (en) 2004-12-13 2010-08-03 Biogen Idec Ma Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
US20060142312A1 (en) 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
CN102746298A (zh) * 2005-10-07 2012-10-24 埃克塞里艾克西斯公司 PI3Kα的吡啶并嘧啶酮抑制剂
KR101538412B1 (ko) * 2005-10-07 2015-07-22 엑셀리시스, 인코포레이티드 ＰＩ３Ｋα의 피리도피리미디논 억제제
EP1872922A1 (fr) * 2006-06-27 2008-01-02 Nederlandse Organisatie voor Toegepast-Natuuurwetenschappelijk Onderzoek TNO Procédé et dispositif de fabrication d'un article en matière plastique
JP2010500994A (ja) 2006-08-16 2010-01-14 エグゼリクシス， インコーポレイテッド Ｐｉ３ｋおよびｍｅｋモジュレーターを使用する方法
WO2008032162A1 (fr) 2006-09-15 2008-03-20 Pfizer Products Inc. Composés de pyrido (2, 3-d) pyrimidin0ne et leur utilisation en tant qu'inhibiteurs de pi3
EP2527330A1 (fr) * 2007-03-14 2012-11-28 Exelixis, Inc. Inhibiteurs de la voie Hedgehog
EA018964B1 (ru) 2007-04-11 2013-12-30 Экселиксис, Инк. СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА
AR073524A1 (es) 2008-09-30 2010-11-10 Exelixis Inc Piridopirimidinonas inhibidores de pi3k a y m tor
JP2013525308A (ja) * 2010-04-16 2013-06-20 キュリス，インコーポレイテッド Ｋ−ｒａｓ変異を有する癌の治療

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Publication number Publication date
CN101573358A (zh) 2009-11-04
NI200900032A (es) 2010-05-14
CU23783B7 (es) 2012-02-15
MEP8009A (en) 2011-12-20
NO342357B1 (no) 2018-05-14
HK1138589A1 (en) 2010-08-27
ZA200901477B (en) 2010-07-28
CA2663401C (fr) 2011-07-12
US20080090801A1 (en) 2008-04-17
IL197243A (en) 2013-07-31
PL2074122T3 (pl) 2011-10-31
MY146420A (en) 2012-08-15
EA016388B1 (ru) 2012-04-30
RS20090104A (en) 2010-06-30
DK2074122T5 (da) 2014-03-17
AU2007297212B2 (en) 2011-04-14
CN101573358B (zh) 2012-05-30
JP4718637B2 (ja) 2011-07-06
CY1111911T1 (el) 2015-11-04
CU20090040A7 (es) 2011-07-11
NZ575167A (en) 2010-10-29
SI2074122T1 (sl) 2011-10-28
TW200820972A (en) 2008-05-16
PT2074122E (pt) 2011-08-24
US20100137279A1 (en) 2010-06-03
PE20080670A1 (es) 2008-06-14
AU2007297212A1 (en) 2008-03-20
EP2074122B1 (fr) 2011-06-29
AP2710A (en) 2013-07-30
BRPI0716749B1 (pt) 2020-10-06
CR10662A (es) 2009-04-17
DOP2009000039A (es) 2015-12-15
WO2008032162A8 (fr) 2009-03-26
BRPI0716749B8 (pt) 2021-05-25
UY30588A1 (es) 2008-05-02
DK2074122T3 (da) 2011-08-15
NO20091141L (no) 2009-03-31
ATE514695T1 (de) 2011-07-15
EP2074122B9 (fr) 2013-09-11
ES2366489T3 (es) 2011-10-20
ES2366489T9 (es) 2013-12-27
AP2009004790A0 (en) 2009-04-30
CA2663401A1 (fr) 2008-03-20
HRP20110621T2 (hr) 2013-12-06
EP2074122A1 (fr) 2009-07-01
JP2010503653A (ja) 2010-02-04
MX2009002927A (es) 2009-03-31
TWI334353B (en) 2010-12-11
US8633204B2 (en) 2014-01-21
GEP20115306B (fr) 2011-10-10
IL197243A0 (en) 2009-12-24
EA200970207A1 (ru) 2009-08-28
MA30709B1 (fr) 2009-09-01
US7696213B2 (en) 2010-04-13
RS51927B (en) 2012-02-29
WO2008032162A1 (fr) 2008-03-20
CL2007002682A1 (es) 2008-04-04
KR20090040389A (ko) 2009-04-23
HRP20110621T1 (en) 2011-09-30
BRPI0716749A2 (pt) 2014-02-18
US20120309775A1 (en) 2012-12-06
AU2007297212B8 (en) 2011-04-28
GT200700077A (es) 2009-08-03
KR101099926B1 (ko) 2011-12-28
US8273755B2 (en) 2012-09-25
HN2007000267A (es) 2011-02-25
AR062785A1 (es) 2008-12-03

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