TN2009000085A1 - Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3 - Google Patents

Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3

Info

Publication number
TN2009000085A1
TN2009000085A1 TN2009000085A TN2009000085A TN2009000085A1 TN 2009000085 A1 TN2009000085 A1 TN 2009000085A1 TN 2009000085 A TN2009000085 A TN 2009000085A TN 2009000085 A TN2009000085 A TN 2009000085A TN 2009000085 A1 TN2009000085 A1 TN 2009000085A1
Authority
TN
Tunisia
Prior art keywords
inhibitors
pyrido
pyrimidinone derivatives
derivatives
pyrimidinone
Prior art date
Application number
TN2009000085A
Other languages
English (en)
Inventor
Hengmiao Cheng
Dilip 2Bhumralkar
Klaus Ruprecht Dress
Jacqui Elizabeth Hoffman
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Michael Bruno Plewe
Khanh Tuan Tran
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TN2009000085A1 publication Critical patent/TN2009000085A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des dérivés de 4-méthylpyridopyrimidinone nouveaux de formule (I). leurs sels, leur synthèse, et leur utilisation comme inhibiteurs de la phosphoinositide -3- kinase alpha (PI3-ka).
TN2009000085A 2006-09-15 2009-03-13 Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3 TN2009000085A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (fr) 2006-09-15 2007-09-03 Composés de pyrido (2, 3-d) pyrimidin0ne et leur utilisation en tant qu'inhibiteurs de pi3

Publications (1)

Publication Number Publication Date
TN2009000085A1 true TN2009000085A1 (fr) 2010-08-19

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2009000085A TN2009000085A1 (fr) 2006-09-15 2009-03-13 Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3

Country Status (42)

Country Link
US (3) US7696213B2 (fr)
EP (1) EP2074122B9 (fr)
JP (1) JP4718637B2 (fr)
KR (1) KR101099926B1 (fr)
CN (1) CN101573358B (fr)
AP (1) AP2710A (fr)
AR (1) AR062785A1 (fr)
AT (1) ATE514695T1 (fr)
AU (1) AU2007297212B8 (fr)
BR (1) BRPI0716749B8 (fr)
CA (1) CA2663401C (fr)
CL (1) CL2007002682A1 (fr)
CR (1) CR10662A (fr)
CU (1) CU23783B7 (fr)
CY (1) CY1111911T1 (fr)
DK (1) DK2074122T5 (fr)
DO (1) DOP2009000039A (fr)
EA (1) EA016388B1 (fr)
ES (1) ES2366489T3 (fr)
GE (1) GEP20115306B (fr)
GT (1) GT200700077A (fr)
HK (1) HK1138589A1 (fr)
HN (1) HN2007000267A (fr)
HR (1) HRP20110621T2 (fr)
IL (1) IL197243A (fr)
MA (1) MA30709B1 (fr)
ME (1) MEP8009A (fr)
MX (1) MX2009002927A (fr)
MY (1) MY146420A (fr)
NI (1) NI200900032A (fr)
NO (1) NO342357B1 (fr)
NZ (1) NZ575167A (fr)
PE (1) PE20080670A1 (fr)
PL (1) PL2074122T3 (fr)
PT (1) PT2074122E (fr)
RS (2) RS20090104A (fr)
SI (1) SI2074122T1 (fr)
TN (1) TN2009000085A1 (fr)
TW (1) TWI334353B (fr)
UY (1) UY30588A1 (fr)
WO (1) WO2008032162A1 (fr)
ZA (1) ZA200901477B (fr)

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Also Published As

Publication number Publication date
CN101573358A (zh) 2009-11-04
US8273755B2 (en) 2012-09-25
AP2009004790A0 (en) 2009-04-30
AU2007297212B2 (en) 2011-04-14
IL197243A0 (en) 2009-12-24
KR20090040389A (ko) 2009-04-23
PT2074122E (pt) 2011-08-24
ATE514695T1 (de) 2011-07-15
US20100137279A1 (en) 2010-06-03
AU2007297212B8 (en) 2011-04-28
NZ575167A (en) 2010-10-29
CL2007002682A1 (es) 2008-04-04
BRPI0716749B8 (pt) 2021-05-25
TW200820972A (en) 2008-05-16
SI2074122T1 (sl) 2011-10-28
CU20090040A7 (es) 2011-07-11
UY30588A1 (es) 2008-05-02
BRPI0716749A2 (pt) 2014-02-18
MEP8009A (en) 2011-12-20
NI200900032A (es) 2010-05-14
CR10662A (es) 2009-04-17
WO2008032162A1 (fr) 2008-03-20
CA2663401A1 (fr) 2008-03-20
EA200970207A1 (ru) 2009-08-28
MA30709B1 (fr) 2009-09-01
ES2366489T3 (es) 2011-10-20
DK2074122T3 (da) 2011-08-15
TWI334353B (en) 2010-12-11
US7696213B2 (en) 2010-04-13
AP2710A (en) 2013-07-30
GT200700077A (es) 2009-08-03
JP2010503653A (ja) 2010-02-04
HK1138589A1 (en) 2010-08-27
HRP20110621T2 (hr) 2013-12-06
PL2074122T3 (pl) 2011-10-31
DOP2009000039A (es) 2015-12-15
RS51927B (en) 2012-02-29
AU2007297212A1 (en) 2008-03-20
KR101099926B1 (ko) 2011-12-28
US20080090801A1 (en) 2008-04-17
HN2007000267A (es) 2011-02-25
ZA200901477B (en) 2010-07-28
GEP20115306B (fr) 2011-10-10
EP2074122A1 (fr) 2009-07-01
US20120309775A1 (en) 2012-12-06
MY146420A (en) 2012-08-15
EP2074122B9 (fr) 2013-09-11
DK2074122T5 (da) 2014-03-17
PE20080670A1 (es) 2008-06-14
CA2663401C (fr) 2011-07-12
CN101573358B (zh) 2012-05-30
HRP20110621T1 (en) 2011-09-30
ES2366489T9 (es) 2013-12-27
EP2074122B1 (fr) 2011-06-29
RS20090104A (en) 2010-06-30
NO20091141L (no) 2009-03-31
AR062785A1 (es) 2008-12-03
WO2008032162A8 (fr) 2009-03-26
NO342357B1 (no) 2018-05-14
JP4718637B2 (ja) 2011-07-06
BRPI0716749B1 (pt) 2020-10-06
EA016388B1 (ru) 2012-04-30
US8633204B2 (en) 2014-01-21
MX2009002927A (es) 2009-03-31
CU23783B7 (es) 2012-02-15
CY1111911T1 (el) 2015-11-04
IL197243A (en) 2013-07-31

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