EP2557923A4 - Treatment of cancers having k-ras mutations - Google Patents

Treatment of cancers having k-ras mutations

Info

Publication number
EP2557923A4
EP2557923A4 EP11769663.3A EP11769663A EP2557923A4 EP 2557923 A4 EP2557923 A4 EP 2557923A4 EP 11769663 A EP11769663 A EP 11769663A EP 2557923 A4 EP2557923 A4 EP 2557923A4
Authority
EP
European Patent Office
Prior art keywords
cancers
treatment
ras mutations
ras
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11769663.3A
Other languages
German (de)
French (fr)
Other versions
EP2557923A1 (en
Inventor
Rudi Bao
Chengjung Lai
Changgeng Qian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of EP2557923A1 publication Critical patent/EP2557923A1/en
Publication of EP2557923A4 publication Critical patent/EP2557923A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP11769663.3A 2010-04-16 2011-04-15 Treatment of cancers having k-ras mutations Withdrawn EP2557923A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32491210P 2010-04-16 2010-04-16
PCT/US2011/032683 WO2011130628A1 (en) 2010-04-16 2011-04-15 Treatment of cancers having k-ras mutations

Publications (2)

Publication Number Publication Date
EP2557923A1 EP2557923A1 (en) 2013-02-20
EP2557923A4 true EP2557923A4 (en) 2013-10-23

Family

ID=44799046

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11769663.3A Withdrawn EP2557923A4 (en) 2010-04-16 2011-04-15 Treatment of cancers having k-ras mutations

Country Status (6)

Country Link
EP (1) EP2557923A4 (en)
JP (1) JP2013525308A (en)
CN (1) CN102970868A (en)
AU (1) AU2011239537A1 (en)
CA (1) CA2795952A1 (en)
WO (1) WO2011130628A1 (en)

Families Citing this family (27)

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EA016388B1 (en) * 2006-09-15 2012-04-30 Пфайзер Продактс Инк. Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors
MX2011007326A (en) 2009-01-08 2011-10-19 Curis Inc Phosphoinositide 3-kinase inhibitors with a zinc binding moiety.
PT2694075T (en) 2011-04-01 2016-07-11 Curis Inc Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
ES2575143T3 (en) * 2011-11-23 2016-06-24 Cancer Research Technology Limited Atypical protein kinase C thienopyridine inhibitors
US8940742B2 (en) * 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3053926B1 (en) * 2013-09-30 2018-08-08 Shanghai Yingli Pharmaceutical Co. Ltd. Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
EP3054952B1 (en) * 2013-10-08 2022-10-26 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer
KR20220140042A (en) * 2013-11-15 2022-10-17 온코슈틱스 인코포레이티드 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, salts thereof and methods of use
CN103601745B (en) * 2013-11-26 2017-01-18 大连联化化学有限公司 Preparation method of commonly used acetamidopyridine boronic acid pinacol ester
PT3125898T (en) * 2014-03-31 2020-04-01 Scripps Research Inst Pharmacophore for trail induction
CN104131034B (en) * 2014-06-19 2017-04-05 中山大学 A kind of chimeric vector and its preparation method and application
CN107205392B (en) 2015-01-30 2020-06-09 巴斯夫欧洲公司 Herbicidal phenylpyrimidines
WO2016169417A1 (en) * 2015-04-21 2016-10-27 成都金瑞长青生物科技有限公司 Purinyl-n-hydroxyl pyrimidine formamide derivatives, preparation method therefor and use thereof
CN105037345B (en) * 2015-06-09 2019-01-25 天津渤海职业技术学院 Antitumoral compounds, preparation method and use
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
CA3034010A1 (en) 2016-08-24 2018-03-01 Arqule, Inc. Amino-pyrrolopyrimidinone compounds and methods of use thereof
EP3521290A4 (en) * 2016-09-29 2020-04-22 Daiichi Sankyo Company, Limited Crystals of [2-(1-methyl-1h-pyrazol-4-yl)-6-(morpholin-4-yl)-9h-purin-8-yl][4-(morpholin-4-yl)piperidin-1-yl]methanone and pharmaceutically acceptable salt thereof
CN118206529A (en) 2017-09-04 2024-06-18 C4医药公司 Dihydrobenzimidazolone
US11351156B2 (en) 2017-10-13 2022-06-07 Inserm Combination treatment of pancreatic cancer
MX2020011991A (en) * 2018-05-10 2021-04-12 Univ Louisville Res Found Inc Inhibitors of the ras oncoprotein, methods of making and methods of use thereof.
EP3849554A4 (en) 2018-09-11 2022-06-01 Curis, Inc. Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety
JP7407461B2 (en) * 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー Compounds that interact with the RAS superfamily for the treatment of cancer, inflammatory diseases, RAS diseases, and fibrotic diseases
EP3935050A4 (en) 2019-03-06 2023-01-04 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment
AU2021280893A1 (en) 2020-05-08 2023-01-05 Halia Therapeutics, Inc. Inhibitors of NEK7 kinase
EP4161511A4 (en) * 2020-06-04 2024-07-17 Pillai Universal Llc Novel small molecules for targeted degradation of untargetable kras in cancer therapy
CN113735830B (en) * 2021-10-11 2024-08-20 成都自豪药业有限公司 Hydroxamic acid derivative and application thereof
WO2024041519A1 (en) * 2022-08-24 2024-02-29 上海璎黎药业有限公司 Morpholinyl quinazoline compound, and pharmaceutical composition and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006097449A1 (en) * 2005-03-15 2006-09-21 Menarini International Operations Luxembourg S.A. N-hydroxyamides omega-substituted with tricyclic groups as histone deacetylase inhibitors, their preparation and use in pharmaceutical formulations
WO2008076447A2 (en) * 2006-12-15 2008-06-26 Ordway Research Institute Treatments of therapy-resistant diseases comprising drug combinations
WO2009129335A2 (en) * 2008-04-15 2009-10-22 Pharmacyclics, Inc. Selective inhibitors of histone deacetylase
WO2009155659A1 (en) * 2008-06-27 2009-12-30 The University Of Queensland Combination therapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101507182B1 (en) * 2006-12-07 2015-03-30 제넨테크, 인크. Phosphoinositide 3-kinase inhibitor compounds and methods of use
WO2008100985A2 (en) * 2007-02-15 2008-08-21 Novartis Ag Combination of lbh589 with other therapeutic agents for treating cancer
MX2011007326A (en) * 2009-01-08 2011-10-19 Curis Inc Phosphoinositide 3-kinase inhibitors with a zinc binding moiety.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006097449A1 (en) * 2005-03-15 2006-09-21 Menarini International Operations Luxembourg S.A. N-hydroxyamides omega-substituted with tricyclic groups as histone deacetylase inhibitors, their preparation and use in pharmaceutical formulations
WO2008076447A2 (en) * 2006-12-15 2008-06-26 Ordway Research Institute Treatments of therapy-resistant diseases comprising drug combinations
WO2009129335A2 (en) * 2008-04-15 2009-10-22 Pharmacyclics, Inc. Selective inhibitors of histone deacetylase
WO2009155659A1 (en) * 2008-06-27 2009-12-30 The University Of Queensland Combination therapy

Non-Patent Citations (14)

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Title
CHIA-WEI CHOU ET AL: "HDAC Inhibition Decreases the Expression of EGFR in Colorectal Cancer Cells", PLOS ONE, vol. 6, no. 3, 25 March 2011 (2011-03-25), pages e18087, XP055078579, DOI: 10.1371/journal.pone.0018087 *
DENLINGER ET AL: "Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 130, no. 5, 1 November 2005 (2005-11-01), pages 1422 - 1429, XP005127283, ISSN: 0022-5223, DOI: 10.1016/J.JTCVS.2005.06.051 *
E LOPEZ-CRAPEZ ET AL: "Rapid and large-scale method to detect K-ras gene mutations in tumor samples", CLINICAL CHEMISTRY, 1 January 1997 (1997-01-01), pages 936 - 942, XP055078570, Retrieved from the Internet <URL:http://www.clinchem.org/content/43/6/936.full.pdf+html> [retrieved on 20130910] *
FRANKLIN WILBUR A ET AL: "KRAS Mutation Comparison of Testing Methods and Tissue Sampling Techniques in Colon Cance", JOURNAL OF MOLECULAR DIAGNOSTICS,THE, AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 12, no. 1, 1 January 2010 (2010-01-01), pages 43 - 50, XP009168344, ISSN: 1525-1578 *
G. J. RIELY ET AL: "KRAS Mutations in Non-Small Cell Lung Cancer", PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY, vol. 6, no. 2, 15 April 2009 (2009-04-15), pages 201 - 205, XP055024772, ISSN: 1546-3222, DOI: 10.1513/pats.200809-107LC *
JEET GANDHI ET AL: "Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 4, no. 2, 24 February 2009 (2009-02-24), pages E4576 - 1, XP002677508, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0004576 *
KRYPUY MICHAEL ET AL: "High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 6, no. 1, 21 December 2006 (2006-12-21), pages 295, XP021023081, ISSN: 1471-2407, DOI: 10.1186/1471-2407-6-295 *
M A LEA ET AL: "Induction of Differentiation of Colon Cancer Cells by Combined Inhibition of Kinases and Histone Deacetylase", ANTICANCER RESEARCH, vol. 27, 1 January 2007 (2007-01-01), pages 741 - 748, XP055079030 *
N SUNAGA ET AL: "Knockdown of Oncogenic KRAS in Non-Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy", MOLECULAR CANCER THERAPEUTICS, vol. 10, 1 January 2011 (2011-01-01), pages 336 - 346, XP055079048 *
PERGOLIZZI ROBERT G ET AL: "Mutational status of codons 12 and 13 of the N- and K-ras genes in tissue and cell lines derived from primary and metastatic prostate carcinomas", CANCER INVESTIGATION, vol. 11, no. 1, 1993, pages 25 - 32, XP008164834, ISSN: 0735-7907 *
REDDY G K: "EARLY CLINICAL DATA AND POTENTIAL CLINICAL UTILITY OF NOVEL HISTONE DEACETYLASE INHIBITORS IN PROSTATE CANCER", CLINICAL PROSTATE CANCER, CANCER INFORMATION GROUP, DALLAS, TX, US, vol. 4, no. 2, 1 January 2005 (2005-01-01), pages 83 - 85, XP009079218, ISSN: 1540-0352 *
See also references of WO2011130628A1 *
WANG QINGDING ET AL: "Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH JUN 2002, vol. 8, no. 6, June 2002 (2002-06-01), pages 1940 - 1947, XP055079069, ISSN: 1078-0432 *
YU X-D ET AL: "Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells", CANCER JOURNAL, JONES AND BARTLETT PUBLISHERS, US, vol. 13, no. 2, 1 March 2007 (2007-03-01), pages 105 - 113, XP008111377, ISSN: 1528-9117 *

Also Published As

Publication number Publication date
CN102970868A (en) 2013-03-13
CA2795952A1 (en) 2011-10-20
EP2557923A1 (en) 2013-02-20
AU2011239537A1 (en) 2012-11-15
WO2011130628A1 (en) 2011-10-20
JP2013525308A (en) 2013-06-20

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