AR073524A1 - Piridopirimidinonas inhibidores de pi3k a y m tor - Google Patents
Piridopirimidinonas inhibidores de pi3k a y m torInfo
- Publication number
- AR073524A1 AR073524A1 ARP090103759A ARP090103759A AR073524A1 AR 073524 A1 AR073524 A1 AR 073524A1 AR P090103759 A ARP090103759 A AR P090103759A AR P090103759 A ARP090103759 A AR P090103759A AR 073524 A1 AR073524 A1 AR 073524A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyridopirimidinones
- pi3k
- tor
- inhibiting
- tor inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula I opcionalmente en forma de un estereoisomero simple o mezcla de estereoisomeros del mismo, y además opcionalmente en forma de una sal aceptable para uso farmacéutico del mismo, donde R1 es tetrahidrofuranilo o tetrahidropiranilo; R2 es hidrogeno o alquilo; R3 es -NR4R4; y R4 y R4a son hidrogeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19476108P | 2008-09-30 | 2008-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR073524A1 true AR073524A1 (es) | 2010-11-10 |
Family
ID=41572575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103759A AR073524A1 (es) | 2008-09-30 | 2009-09-29 | Piridopirimidinonas inhibidores de pi3k a y m tor |
Country Status (8)
Country | Link |
---|---|
US (1) | US8101622B2 (es) |
EP (1) | EP2350070A1 (es) |
JP (1) | JP2012504628A (es) |
AR (1) | AR073524A1 (es) |
PA (1) | PA8843901A1 (es) |
TW (1) | TW201018685A (es) |
UY (1) | UY32153A (es) |
WO (1) | WO2010039740A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101538412B1 (ko) * | 2005-10-07 | 2015-07-22 | 엑셀리시스, 인코포레이티드 | PI3Kα의 피리도피리미디논 억제제 |
UA116188C2 (uk) * | 2005-10-07 | 2018-02-26 | Екселіксіс, Інк. | Інгібітори фосфатидилінозит-3-кінази і способи їх застосування |
US20100075947A1 (en) | 2006-08-16 | 2010-03-25 | Exelixis, Inc. | Methods of Using PI3K and MEK Modulators |
WO2008032162A1 (en) * | 2006-09-15 | 2008-03-20 | Pfizer Products Inc. | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors |
EP2139484B9 (en) * | 2007-04-10 | 2014-06-11 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha |
AU2008239655B2 (en) * | 2007-04-11 | 2013-06-20 | Exelixis, Inc. | Pyrido (2, 3-d) pyrimidin-7-one compounds as inhibitors of PI3k-alpha for the treatment of cancer |
US8901137B2 (en) | 2010-02-09 | 2014-12-02 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors |
JP5792819B2 (ja) | 2010-09-14 | 2015-10-14 | エクセリクシス, インク. | Pi3k−デルタの阻害剤ならびにそれらの使用法および製造法 |
JP6130305B2 (ja) * | 2011-02-23 | 2017-05-17 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
EA201391606A1 (ru) * | 2011-04-29 | 2016-01-29 | Экселиксис, Инк. | Способ лечения лимфомы посредством пиридопиримидиноновых ингибиторов pi3k/mtor |
EA201490905A1 (ru) | 2011-11-01 | 2014-11-28 | Экселиксис, Инк. | N-(3-{[(3-{[2-хлор-5-(метокси)фенил]амино}хиноксалин-2-ил)амино]сульфонил}фенил)-2-метилаланинамид как ингибитор фосфатидилинозитол-3-киназы для лечения лимфопролиферативных злокачественных заболеваний |
EP3828269B1 (en) | 2015-03-06 | 2023-05-03 | Korea Advanced Institute Of Science And Technology | Composition for prevention or treatment of intractable epilepsy comprising mtor inhibitor |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
WO2021139775A1 (zh) * | 2020-01-10 | 2021-07-15 | 江苏先声药业有限公司 | 吡啶酮化合物及应用 |
US20230165864A1 (en) * | 2020-04-30 | 2023-06-01 | Guangzhou Joyo Pharmatech Co., Ltd | Application of heterocyclic compound |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
BR9807305A (pt) | 1997-02-05 | 2000-05-02 | Warner Lambert Co | Pirido [2,3-d] pirimidinas e 4-aminopirimidinas como inibidores de proliferação celular. |
US20040224958A1 (en) | 2000-01-27 | 2004-11-11 | Booth Richard John | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease |
CA2401368A1 (en) | 2000-03-06 | 2001-09-27 | Warner-Lambert Company | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
WO2001083456A1 (fr) | 2000-04-27 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'heteroaryle condenses |
JP4166991B2 (ja) | 2001-02-26 | 2008-10-15 | 田辺三菱製薬株式会社 | ピリドピリミジンまたはナフチリジン誘導体 |
US20030100572A1 (en) * | 2001-06-21 | 2003-05-29 | Ariad Pharmaceuticals,Inc. | Novel pyridopyrimidones and uses thereof |
US7019002B2 (en) | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
DE60315826T2 (de) | 2002-04-19 | 2008-05-21 | Smithkline Beecham Corp. | Neue verbindungen |
AU2003232071A1 (en) | 2002-05-06 | 2003-11-17 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
JP2004083587A (ja) | 2002-08-06 | 2004-03-18 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
WO2004063195A1 (en) | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
WO2004089930A1 (en) | 2003-04-02 | 2004-10-21 | Imclone Systems Incorporated | 4-fluoroquinolone derivatives and their use as kinase inhibitors |
EP1624900A4 (en) | 2003-05-20 | 2007-05-02 | Univ California | METHOD OF BINDING AGENTS AT BETA AMYLOID PLAQUE |
BRPI0507852A (pt) | 2004-02-18 | 2007-07-10 | Warner Lambert Co | 2-(piridin-3-ilamino)-pirido[2,3-d]pirimidin-7-onas |
JP2007536370A (ja) * | 2004-05-04 | 2007-12-13 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 療法薬としてのピロリル置換ピリド[2,3−d]ピリミジン−7−オンおよびその誘導体 |
EP1828186A1 (en) | 2004-12-13 | 2007-09-05 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
CA2624965A1 (en) * | 2005-10-07 | 2007-04-19 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of pi3k.alpha. |
KR101538412B1 (ko) * | 2005-10-07 | 2015-07-22 | 엑셀리시스, 인코포레이티드 | PI3Kα의 피리도피리미디논 억제제 |
WO2008032162A1 (en) * | 2006-09-15 | 2008-03-20 | Pfizer Products Inc. | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors |
AU2008239596B2 (en) * | 2007-04-11 | 2013-08-15 | Exelixis, Inc. | Pyrido [2,3-D] pyrimidin-7-one compounds as inhibitors of PI3K-alpha for the treatment of cancer |
-
2009
- 2009-09-29 PA PA20098843901A patent/PA8843901A1/es unknown
- 2009-09-29 JP JP2011530150A patent/JP2012504628A/ja active Pending
- 2009-09-29 TW TW098133017A patent/TW201018685A/zh unknown
- 2009-09-29 AR ARP090103759A patent/AR073524A1/es not_active Application Discontinuation
- 2009-09-29 WO PCT/US2009/058881 patent/WO2010039740A1/en active Application Filing
- 2009-09-29 US US12/569,760 patent/US8101622B2/en not_active Expired - Fee Related
- 2009-09-29 EP EP09737495A patent/EP2350070A1/en not_active Withdrawn
- 2009-09-29 UY UY0001032153A patent/UY32153A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW201018685A (en) | 2010-05-16 |
US8101622B2 (en) | 2012-01-24 |
US20100087456A1 (en) | 2010-04-08 |
WO2010039740A1 (en) | 2010-04-08 |
PA8843901A1 (es) | 2010-05-26 |
UY32153A (es) | 2011-04-29 |
EP2350070A1 (en) | 2011-08-03 |
JP2012504628A (ja) | 2012-02-23 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |