PT1851217E - Derivados de pirido[2,3-d]pirimidina substituída úteis a título de medicamentos para o tratamento de patologias autoimunes - Google Patents
Derivados de pirido[2,3-d]pirimidina substituída úteis a título de medicamentos para o tratamento de patologias autoimunes Download PDFInfo
- Publication number
- PT1851217E PT1851217E PT06707117T PT06707117T PT1851217E PT 1851217 E PT1851217 E PT 1851217E PT 06707117 T PT06707117 T PT 06707117T PT 06707117 T PT06707117 T PT 06707117T PT 1851217 E PT1851217 E PT 1851217E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- disorders
- pyrimidine derivatives
- medicines
- autoimmune disorders
- Prior art date
Links
- 159000000018 pyrido[2,3-d]pyrimidines Chemical class 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0503506.8A GB0503506D0 (en) | 2005-02-21 | 2005-02-21 | Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1851217E true PT1851217E (pt) | 2009-05-14 |
Family
ID=34401023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06707117T PT1851217E (pt) | 2005-02-21 | 2006-02-21 | Derivados de pirido[2,3-d]pirimidina substituída úteis a título de medicamentos para o tratamento de patologias autoimunes |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20080312227A1 (pt) |
| EP (1) | EP1851217B1 (pt) |
| JP (1) | JP2008530167A (pt) |
| KR (1) | KR20070112174A (pt) |
| CN (1) | CN101203514A (pt) |
| AT (1) | ATE422496T1 (pt) |
| AU (1) | AU2006215700A1 (pt) |
| BR (1) | BRPI0606844A2 (pt) |
| CA (1) | CA2598465A1 (pt) |
| DE (1) | DE602006005136D1 (pt) |
| DK (1) | DK1851217T3 (pt) |
| ES (1) | ES2318723T3 (pt) |
| GB (1) | GB0503506D0 (pt) |
| HR (1) | HRP20090208T1 (pt) |
| IL (1) | IL185289A0 (pt) |
| MX (1) | MX2007010156A (pt) |
| NO (1) | NO20074207L (pt) |
| PL (1) | PL1851217T3 (pt) |
| PT (1) | PT1851217E (pt) |
| RU (1) | RU2007135053A (pt) |
| SI (1) | SI1851217T1 (pt) |
| WO (1) | WO2006087229A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2612788A1 (en) | 2005-06-24 | 2006-12-28 | Steven Cesar Alfons De Jonghe | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c |
| US8338435B2 (en) * | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| WO2008009079A2 (en) * | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| US8673929B2 (en) * | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| TW200840584A (en) | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| WO2008077650A1 (en) * | 2006-12-26 | 2008-07-03 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| AU2010213014B2 (en) | 2009-02-12 | 2016-02-25 | Merck Serono S.A. | 2-morpholino-pyrido[3,2-d]pyrimidines |
| WO2014169167A1 (en) | 2013-04-12 | 2014-10-16 | Asana Biosciences, Llc | Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways |
| CN103694255A (zh) * | 2014-01-09 | 2014-04-02 | 华中师范大学 | 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用 |
| GB201416186D0 (en) | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| SI3097102T1 (en) | 2015-03-04 | 2018-02-28 | Gilead Sciences, Inc. | A TOOL RECEPTOR MODULING 4,6-DIAMINO-PYRIDO (3,2-D) PYRIMIDINE COMPOUNDS |
| US10370342B2 (en) | 2016-09-02 | 2019-08-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| ES2826748T3 (es) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll |
| GB201809458D0 (en) | 2018-06-08 | 2018-07-25 | Crt Pioneer Fund Lp | Salt form |
| GB201809460D0 (en) | 2018-06-08 | 2018-07-25 | Crt Pioneer Fund Lp | Salt form |
| WO2020057604A1 (zh) | 2018-09-19 | 2020-03-26 | 正大天晴药业集团股份有限公司 | Tlr8激动剂 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| CN113801114B (zh) * | 2020-06-11 | 2022-11-18 | 江苏恒瑞医药股份有限公司 | 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用 |
| AU2021314955A1 (en) | 2020-07-28 | 2023-03-30 | Jazz Pharmaceuticals Ireland Limited | Fused bicyclic Raf inhibitors and methods for use thereof |
| KR102487604B1 (ko) * | 2020-11-06 | 2023-01-12 | 에스케이케미칼 주식회사 | 히드로플루메티아지드를 유효성분으로 포함하는 TNF-α 관련 질환 예방 또는 치료용 조성물 |
| WO2022161461A1 (zh) * | 2021-01-29 | 2022-08-04 | 江苏先声药业有限公司 | Sos1抑制剂及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818819A (en) * | 1986-10-20 | 1989-04-04 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
| US5223503A (en) * | 1991-04-29 | 1993-06-29 | Eli Lilly And Company | 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents |
-
2005
- 2005-02-21 GB GBGB0503506.8A patent/GB0503506D0/en not_active Ceased
-
2006
- 2006-02-21 EP EP06707117A patent/EP1851217B1/en active Active
- 2006-02-21 DK DK06707117T patent/DK1851217T3/da active
- 2006-02-21 AU AU2006215700A patent/AU2006215700A1/en not_active Abandoned
- 2006-02-21 JP JP2007555544A patent/JP2008530167A/ja not_active Withdrawn
- 2006-02-21 US US11/816,086 patent/US20080312227A1/en not_active Abandoned
- 2006-02-21 SI SI200630255T patent/SI1851217T1/sl unknown
- 2006-02-21 CA CA002598465A patent/CA2598465A1/en not_active Abandoned
- 2006-02-21 PL PL06707117T patent/PL1851217T3/pl unknown
- 2006-02-21 KR KR1020077020966A patent/KR20070112174A/ko not_active Application Discontinuation
- 2006-02-21 ES ES06707117T patent/ES2318723T3/es active Active
- 2006-02-21 MX MX2007010156A patent/MX2007010156A/es not_active Application Discontinuation
- 2006-02-21 PT PT06707117T patent/PT1851217E/pt unknown
- 2006-02-21 RU RU2007135053/04A patent/RU2007135053A/ru not_active Application Discontinuation
- 2006-02-21 AT AT06707117T patent/ATE422496T1/de not_active IP Right Cessation
- 2006-02-21 CN CNA2006800054787A patent/CN101203514A/zh active Pending
- 2006-02-21 DE DE602006005136T patent/DE602006005136D1/de not_active Expired - Fee Related
- 2006-02-21 BR BRPI0606844-8A patent/BRPI0606844A2/pt not_active Application Discontinuation
- 2006-02-21 WO PCT/EP2006/001539 patent/WO2006087229A1/en active Application Filing
-
2007
- 2007-08-15 IL IL185289A patent/IL185289A0/en unknown
- 2007-08-16 NO NO20074207A patent/NO20074207L/no not_active Application Discontinuation
-
2009
- 2009-04-08 HR HR20090208T patent/HRP20090208T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006215700A1 (en) | 2006-08-24 |
| HRP20090208T1 (en) | 2009-05-31 |
| BRPI0606844A2 (pt) | 2009-07-21 |
| KR20070112174A (ko) | 2007-11-22 |
| US20080312227A1 (en) | 2008-12-18 |
| SI1851217T1 (sl) | 2009-06-30 |
| IL185289A0 (en) | 2008-02-09 |
| DK1851217T3 (da) | 2009-03-23 |
| CA2598465A1 (en) | 2006-08-24 |
| ES2318723T3 (es) | 2009-05-01 |
| CN101203514A (zh) | 2008-06-18 |
| ATE422496T1 (de) | 2009-02-15 |
| JP2008530167A (ja) | 2008-08-07 |
| EP1851217A1 (en) | 2007-11-07 |
| DE602006005136D1 (de) | 2009-03-26 |
| WO2006087229A1 (en) | 2006-08-24 |
| RU2007135053A (ru) | 2009-03-27 |
| GB0503506D0 (en) | 2005-03-30 |
| EP1851217B1 (en) | 2009-02-11 |
| NO20074207L (no) | 2007-10-26 |
| MX2007010156A (es) | 2008-02-19 |
| PL1851217T3 (pl) | 2009-07-31 |
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