PL1851217T3 - Pochodne podstawionej pirydo[2,3-d]pirymidyny użyteczne jako leki do leczenia zaburzeń autoimmunologicznych - Google Patents
Pochodne podstawionej pirydo[2,3-d]pirymidyny użyteczne jako leki do leczenia zaburzeń autoimmunologicznychInfo
- Publication number
- PL1851217T3 PL1851217T3 PL06707117T PL06707117T PL1851217T3 PL 1851217 T3 PL1851217 T3 PL 1851217T3 PL 06707117 T PL06707117 T PL 06707117T PL 06707117 T PL06707117 T PL 06707117T PL 1851217 T3 PL1851217 T3 PL 1851217T3
- Authority
- PL
- Poland
- Prior art keywords
- treatment
- disorders
- pyrimidine derivatives
- medicines
- autoimmune disorders
- Prior art date
Links
- 159000000018 pyrido[2,3-d]pyrimidines Chemical class 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pregnancy & Childbirth (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0503506.8A GB0503506D0 (en) | 2005-02-21 | 2005-02-21 | Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| PCT/EP2006/001539 WO2006087229A1 (en) | 2005-02-21 | 2006-02-21 | Substituted pyrido (2 , 3-d) pyrimidine derivatives useful as medicines for the treatment of autoimmune disorders |
| EP06707117A EP1851217B1 (en) | 2005-02-21 | 2006-02-21 | Substituted pyrido[2,3-d]pyrimidine derivatives useful as medicines for the treatment of autoimmune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1851217T3 true PL1851217T3 (pl) | 2009-07-31 |
Family
ID=34401023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06707117T PL1851217T3 (pl) | 2005-02-21 | 2006-02-21 | Pochodne podstawionej pirydo[2,3-d]pirymidyny użyteczne jako leki do leczenia zaburzeń autoimmunologicznych |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20080312227A1 (pl) |
| EP (1) | EP1851217B1 (pl) |
| JP (1) | JP2008530167A (pl) |
| KR (1) | KR20070112174A (pl) |
| CN (1) | CN101203514A (pl) |
| AT (1) | ATE422496T1 (pl) |
| AU (1) | AU2006215700A1 (pl) |
| BR (1) | BRPI0606844A2 (pl) |
| CA (1) | CA2598465A1 (pl) |
| DE (1) | DE602006005136D1 (pl) |
| DK (1) | DK1851217T3 (pl) |
| ES (1) | ES2318723T3 (pl) |
| GB (1) | GB0503506D0 (pl) |
| HR (1) | HRP20090208T1 (pl) |
| IL (1) | IL185289A0 (pl) |
| MX (1) | MX2007010156A (pl) |
| NO (1) | NO20074207L (pl) |
| PL (1) | PL1851217T3 (pl) |
| PT (1) | PT1851217E (pl) |
| RU (1) | RU2007135053A (pl) |
| SI (1) | SI1851217T1 (pl) |
| WO (1) | WO2006087229A1 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006135993A1 (en) * | 2005-06-24 | 2006-12-28 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c. |
| WO2008009077A2 (en) * | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| US8338435B2 (en) * | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10144736B2 (en) * | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| WO2008077650A1 (en) * | 2006-12-26 | 2008-07-03 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| MX2011008505A (es) | 2009-02-12 | 2012-10-15 | Merck Serono Sa | 2-morfolino-pirido[3,2-d]pirimidinas. |
| AU2014250836C1 (en) | 2013-04-12 | 2019-01-17 | Asana Biosciences, Llc | Quinazolines and azaquinazolines as dual inhibitors of RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways |
| CN103694255A (zh) * | 2014-01-09 | 2014-04-02 | 华中师范大学 | 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用 |
| GB201416186D0 (en) | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| CA2978188C (en) | 2015-03-04 | 2020-05-12 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| WO2018045144A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| GB201809458D0 (en) | 2018-06-08 | 2018-07-25 | Crt Pioneer Fund Lp | Salt form |
| GB201809460D0 (en) | 2018-06-08 | 2018-07-25 | Crt Pioneer Fund Lp | Salt form |
| AU2019344868B2 (en) | 2018-09-19 | 2024-06-27 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | TLR8 agonist |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| CN113801114B (zh) * | 2020-06-11 | 2022-11-18 | 江苏恒瑞医药股份有限公司 | 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用 |
| CA3187514A1 (en) | 2020-07-28 | 2022-02-03 | Andrew BELFIELD | Fused bicyclic raf inhibitors and methods for use thereof |
| KR102487604B1 (ko) * | 2020-11-06 | 2023-01-12 | 에스케이케미칼 주식회사 | 히드로플루메티아지드를 유효성분으로 포함하는 TNF-α 관련 질환 예방 또는 치료용 조성물 |
| WO2022161461A1 (zh) * | 2021-01-29 | 2022-08-04 | 江苏先声药业有限公司 | Sos1抑制剂及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818819A (en) * | 1986-10-20 | 1989-04-04 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
| US5223503A (en) * | 1991-04-29 | 1993-06-29 | Eli Lilly And Company | 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents |
-
2005
- 2005-02-21 GB GBGB0503506.8A patent/GB0503506D0/en not_active Ceased
-
2006
- 2006-02-21 CN CNA2006800054787A patent/CN101203514A/zh active Pending
- 2006-02-21 EP EP06707117A patent/EP1851217B1/en active Active
- 2006-02-21 CA CA002598465A patent/CA2598465A1/en not_active Abandoned
- 2006-02-21 US US11/816,086 patent/US20080312227A1/en not_active Abandoned
- 2006-02-21 PT PT06707117T patent/PT1851217E/pt unknown
- 2006-02-21 BR BRPI0606844-8A patent/BRPI0606844A2/pt not_active Application Discontinuation
- 2006-02-21 MX MX2007010156A patent/MX2007010156A/es not_active Application Discontinuation
- 2006-02-21 AT AT06707117T patent/ATE422496T1/de not_active IP Right Cessation
- 2006-02-21 PL PL06707117T patent/PL1851217T3/pl unknown
- 2006-02-21 SI SI200630255T patent/SI1851217T1/sl unknown
- 2006-02-21 AU AU2006215700A patent/AU2006215700A1/en not_active Abandoned
- 2006-02-21 DE DE602006005136T patent/DE602006005136D1/de not_active Expired - Fee Related
- 2006-02-21 ES ES06707117T patent/ES2318723T3/es active Active
- 2006-02-21 DK DK06707117T patent/DK1851217T3/da active
- 2006-02-21 JP JP2007555544A patent/JP2008530167A/ja not_active Withdrawn
- 2006-02-21 KR KR1020077020966A patent/KR20070112174A/ko not_active Application Discontinuation
- 2006-02-21 RU RU2007135053/04A patent/RU2007135053A/ru not_active Application Discontinuation
- 2006-02-21 WO PCT/EP2006/001539 patent/WO2006087229A1/en active Application Filing
-
2007
- 2007-08-15 IL IL185289A patent/IL185289A0/en unknown
- 2007-08-16 NO NO20074207A patent/NO20074207L/no not_active Application Discontinuation
-
2009
- 2009-04-08 HR HR20090208T patent/HRP20090208T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL185289A0 (en) | 2008-02-09 |
| DK1851217T3 (da) | 2009-03-23 |
| EP1851217B1 (en) | 2009-02-11 |
| KR20070112174A (ko) | 2007-11-22 |
| US20080312227A1 (en) | 2008-12-18 |
| MX2007010156A (es) | 2008-02-19 |
| HRP20090208T1 (en) | 2009-05-31 |
| DE602006005136D1 (de) | 2009-03-26 |
| WO2006087229A1 (en) | 2006-08-24 |
| ATE422496T1 (de) | 2009-02-15 |
| PT1851217E (pt) | 2009-05-14 |
| CN101203514A (zh) | 2008-06-18 |
| SI1851217T1 (sl) | 2009-06-30 |
| ES2318723T3 (es) | 2009-05-01 |
| BRPI0606844A2 (pt) | 2009-07-21 |
| EP1851217A1 (en) | 2007-11-07 |
| RU2007135053A (ru) | 2009-03-27 |
| GB0503506D0 (en) | 2005-03-30 |
| AU2006215700A1 (en) | 2006-08-24 |
| JP2008530167A (ja) | 2008-08-07 |
| CA2598465A1 (en) | 2006-08-24 |
| NO20074207L (no) | 2007-10-26 |
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