BRPI0713555A2 - ciclopenta [d] pirimidinas como inibidores de akt protéina cinase - Google Patents
ciclopenta [d] pirimidinas como inibidores de akt protéina cinase Download PDFInfo
- Publication number
- BRPI0713555A2 BRPI0713555A2 BRPI0713555-6A BRPI0713555A BRPI0713555A2 BR PI0713555 A2 BRPI0713555 A2 BR PI0713555A2 BR PI0713555 A BRPI0713555 A BR PI0713555A BR PI0713555 A2 BRPI0713555 A2 BR PI0713555A2
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- Prior art keywords
- protein kinase
- kinase inhibitors
- cyclopenta
- pyrimidines
- akt protein
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
CICLOPENTA[D]PIRIMIDINAS COMO INIBIDORES DE AKT PROTEìNA CINASE. A presente invenção refere-se a compostos de fórmula 1, incluindo tautómeros, enantiómeros resolvidos, diastereómeros, solvatos, metabólitos, sais e pró-fármacos farmaceuticamente aceitáveis dos mesmos. Fórmula (I). São da mesma forma fornecidos métodos de utilizar os compostos desta invenção como inibidores de AKT proteína cinase e para o tratamento de doenças hiperproliferativas tais como câncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81876206P | 2006-07-06 | 2006-07-06 | |
US60/818,762 | 2006-07-06 | ||
PCT/US2007/072876 WO2008006032A1 (en) | 2006-07-06 | 2007-07-05 | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0713555A2 true BRPI0713555A2 (pt) | 2012-03-20 |
Family
ID=38686844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0713555-6A BRPI0713555A2 (pt) | 2006-07-06 | 2007-07-05 | ciclopenta [d] pirimidinas como inibidores de akt protéina cinase |
Country Status (32)
Country | Link |
---|---|
US (3) | US8003651B2 (pt) |
EP (1) | EP2049500B1 (pt) |
JP (3) | JP5268904B2 (pt) |
KR (2) | KR101527232B1 (pt) |
CN (2) | CN103288753A (pt) |
AR (1) | AR061844A1 (pt) |
AT (1) | ATE523499T1 (pt) |
AU (1) | AU2007269052B2 (pt) |
BR (1) | BRPI0713555A2 (pt) |
CA (1) | CA2656618C (pt) |
CL (1) | CL2007001992A1 (pt) |
CO (1) | CO6160229A2 (pt) |
CR (2) | CR10601A (pt) |
CY (1) | CY1112142T1 (pt) |
DK (1) | DK2049500T3 (pt) |
ES (1) | ES2372955T3 (pt) |
HK (1) | HK1126758A1 (pt) |
HR (1) | HRP20110882T1 (pt) |
IL (1) | IL196051A (pt) |
MA (1) | MA30952B1 (pt) |
MX (1) | MX2008016203A (pt) |
MY (1) | MY147628A (pt) |
NO (1) | NO20090580L (pt) |
NZ (1) | NZ573979A (pt) |
PL (1) | PL2049500T3 (pt) |
PT (1) | PT2049500E (pt) |
RS (1) | RS52210B (pt) |
RU (1) | RU2481336C2 (pt) |
SI (1) | SI2049500T1 (pt) |
TW (1) | TWI428335B (pt) |
UA (1) | UA99597C2 (pt) |
WO (1) | WO2008006032A1 (pt) |
Families Citing this family (41)
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ATE532789T1 (de) * | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
US8003651B2 (en) | 2006-07-06 | 2011-08-23 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
AU2014201211B2 (en) * | 2006-07-06 | 2016-04-14 | Array Biopharma Inc. | Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
EP2049546B1 (en) * | 2006-07-06 | 2010-12-29 | Array Biopharma, Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2009006569A1 (en) * | 2007-07-05 | 2009-01-08 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CA2692502C (en) | 2007-07-05 | 2016-03-01 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
JP5608097B2 (ja) | 2008-01-08 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピロロピリジン |
US8329709B2 (en) | 2008-01-09 | 2012-12-11 | Genentech, Inc. | 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors |
CA2711741A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
EP2247578B1 (en) * | 2008-01-09 | 2013-05-22 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
NZ586720A (en) * | 2008-01-09 | 2012-11-30 | Array Biopharma Inc | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
ES2403284T3 (es) | 2008-01-09 | 2013-05-17 | Array Biopharma, Inc. | Pirimidil ciclopentanos como inhibidores de la proteína quinasa AKT |
US20100048914A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
EP3023433A1 (en) | 2009-02-05 | 2016-05-25 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
US20100233733A1 (en) * | 2009-02-10 | 2010-09-16 | Nodality, Inc., A Delaware Corporation | Multiple mechanisms for modulation of the pi3 kinase pathway |
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