CR10601A - Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt - Google Patents
Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa aktInfo
- Publication number
- CR10601A CR10601A CR10601A CR10601A CR10601A CR 10601 A CR10601 A CR 10601A CR 10601 A CR10601 A CR 10601A CR 10601 A CR10601 A CR 10601A CR 10601 A CR10601 A CR 10601A
- Authority
- CR
- Costa Rica
- Prior art keywords
- inhibitors
- akt
- cinasa
- pyrimidins
- cyclopenta
- Prior art date
Links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
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- Pulmonology (AREA)
- Reproductive Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Diabetes (AREA)
- Obesity (AREA)
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Abstract
La presente invencion proporciona compuestos de la Formula I, incluyendo tautomeros, enantiomeros reducidos, diastereomeros, solvatos, metabolitos, sales y profarmacos farmaceuticamente aceptables de los mismos. Formula (I). Tambien se proporcionan metodos para utilizar los compuestos de esta invencion como inhibidores de la proteina cinasa AKT y para el tratamiento de enfermedades hiperproliferativas tales como cancer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81876206P | 2006-07-06 | 2006-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10601A true CR10601A (es) | 2009-02-20 |
Family
ID=38686844
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10601A CR10601A (es) | 2006-07-06 | 2009-02-05 | Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt |
CR20140215A CR20140215A (es) | 2006-07-06 | 2014-05-09 | Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20140215A CR20140215A (es) | 2006-07-06 | 2014-05-09 | Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt |
Country Status (32)
Country | Link |
---|---|
US (3) | US8003651B2 (es) |
EP (1) | EP2049500B1 (es) |
JP (3) | JP5268904B2 (es) |
KR (2) | KR20150041164A (es) |
CN (2) | CN103288753A (es) |
AR (1) | AR061844A1 (es) |
AT (1) | ATE523499T1 (es) |
AU (1) | AU2007269052B2 (es) |
BR (1) | BRPI0713555A2 (es) |
CA (1) | CA2656618C (es) |
CL (1) | CL2007001992A1 (es) |
CO (1) | CO6160229A2 (es) |
CR (2) | CR10601A (es) |
CY (1) | CY1112142T1 (es) |
DK (1) | DK2049500T3 (es) |
ES (1) | ES2372955T3 (es) |
HK (1) | HK1126758A1 (es) |
HR (1) | HRP20110882T1 (es) |
IL (1) | IL196051A (es) |
MA (1) | MA30952B1 (es) |
MX (1) | MX2008016203A (es) |
MY (1) | MY147628A (es) |
NO (1) | NO20090580L (es) |
NZ (1) | NZ573979A (es) |
PL (1) | PL2049500T3 (es) |
PT (1) | PT2049500E (es) |
RS (1) | RS52210B (es) |
RU (1) | RU2481336C2 (es) |
SI (1) | SI2049500T1 (es) |
TW (1) | TWI428335B (es) |
UA (1) | UA99597C2 (es) |
WO (1) | WO2008006032A1 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
SI2054418T1 (sl) * | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji |
CN103288753A (zh) | 2006-07-06 | 2013-09-11 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶 |
CA2656566C (en) | 2006-07-06 | 2014-06-17 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
AU2014201211B2 (en) * | 2006-07-06 | 2016-04-14 | Array Biopharma Inc. | Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
TWI450720B (zh) | 2007-07-05 | 2014-09-01 | Array Biopharma Inc | 作為akt蛋白質激酶抑制劑之嘧啶環戊烷 |
KR20150091196A (ko) | 2007-07-05 | 2015-08-07 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제로서의 피리미딜 시클로펜탄 |
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