ATE292462T1 - Behandlung von asthma anhand von mek-inhibitoren - Google Patents

Behandlung von asthma anhand von mek-inhibitoren

Info

Publication number
ATE292462T1
ATE292462T1 AT99968153T AT99968153T ATE292462T1 AT E292462 T1 ATE292462 T1 AT E292462T1 AT 99968153 T AT99968153 T AT 99968153T AT 99968153 T AT99968153 T AT 99968153T AT E292462 T1 ATE292462 T1 AT E292462T1
Authority
AT
Austria
Prior art keywords
treatment
asthma
mek inhibitors
administering
patient
Prior art date
Application number
AT99968153T
Other languages
English (en)
Inventor
Alexander James Bridges
David Thomas Dudley
James Leslie Mobley
Alan Robert Saltiel
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE292462T1 publication Critical patent/ATE292462T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
AT99968153T 1999-01-07 1999-12-21 Behandlung von asthma anhand von mek-inhibitoren ATE292462T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11508699P 1999-01-07 1999-01-07
PCT/US1999/030419 WO2000040235A2 (en) 1999-01-07 1999-12-21 Treatment of asthma with mek inhibitors

Publications (1)

Publication Number Publication Date
ATE292462T1 true ATE292462T1 (de) 2005-04-15

Family

ID=22359251

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99968153T ATE292462T1 (de) 1999-01-07 1999-12-21 Behandlung von asthma anhand von mek-inhibitoren

Country Status (9)

Country Link
US (2) US6696440B1 (de)
EP (1) EP1140062B1 (de)
JP (1) JP2002534380A (de)
AT (1) ATE292462T1 (de)
AU (1) AU2483000A (de)
BR (1) BR9916785A (de)
CA (1) CA2350234A1 (de)
DE (1) DE69924641D1 (de)
WO (1) WO2000040235A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345051B2 (en) 2000-01-31 2008-03-18 Genaera Corporation Mucin synthesis inhibitors
PT1255544E (pt) 2000-01-31 2007-06-15 Genaera Corp Inibidores da síntese da mucina.
CN1219753C (zh) 2000-07-19 2005-09-21 沃尼尔·朗伯公司 4－碘苯氨基苯氧肟酸的氧合酯
EP1344525A4 (de) 2000-12-22 2005-05-25 Ishihara Sangyo Kaisha Anilinderivate oder ihre salze und diese enthaltende zytokinproduktion-inhibitoren
NZ518726A (en) 2001-05-09 2004-06-25 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
DOP2003000556A (es) * 2002-01-23 2003-10-31 Warner Lambert Co Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico.
US7235537B2 (en) * 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
CA2542210A1 (en) 2003-10-21 2005-05-06 Warner-Lambert Company Llc Polymorphic form of n-[(r)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
JP4768628B2 (ja) 2003-11-19 2011-09-07 アレイ バイオファーマ、インコーポレイテッド Ｍｅｋの二環系阻害剤及びその使用方法
AU2004293026B2 (en) 2003-11-21 2012-01-19 Array Biopharma Inc. AKT protein kinase inhibitors
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
EP1737475A4 (de) * 2004-03-19 2009-08-05 Xiu-Min Li Pflanzliche therapie zur behandlung von asthma
PL1761528T3 (pl) 2004-06-11 2008-05-30 Japan Tobacco Inc Pochodne 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pirydo[2,3-D]pirymidyny i związki pokrewne do leczenia raka
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
SG177981A1 (en) * 2005-05-18 2012-02-28 Array Biopharma Inc 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases
PL1934174T3 (pl) 2005-10-07 2011-09-30 Exelixis Inc Azetydyny jako inhibitory w leczeniu chorób proliferacyjnych
AU2006306991A1 (en) 2005-10-28 2007-05-03 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
WO2008006039A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA99597C2 (ru) 2006-07-06 2012-09-10 Еррей Біофарма Інк. Пиримидилциклопентаны как ингибиторы акт протеинкиназ
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
CN101605540A (zh) 2006-12-14 2009-12-16 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
CA2692502C (en) 2007-07-05 2016-03-01 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
EP2173723B3 (de) 2007-07-05 2014-11-19 Array Biopharma Inc. Pyrimidylcyclopentane als inhibitoren der akt-proteinkinase
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
NZ586418A (en) 2007-12-19 2012-09-28 Cancer Rec Tech Ltd Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
WO2009089459A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
KR101624752B1 (ko) 2008-01-09 2016-05-26 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄
BRPI0908708A2 (pt) 2008-03-17 2019-09-24 Scripps Research Inst métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desdiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de células tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de célula tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, composição, e, kit
WO2010051933A2 (en) 2008-11-10 2010-05-14 Bayer Schering Pharma Aktiengesellschaft Substituted sulphonamido phenoxybenzamides
CA2777430A1 (en) 2009-10-21 2011-04-28 Bayer Pharma Aktiengesellschaft Substituted benzosulphonamides
EP2491015A1 (de) 2009-10-21 2012-08-29 Bayer Pharma Aktiengesellschaft Substituierte benzosulfonamide
WO2011047796A1 (en) 2009-10-21 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Substituted halophenoxybenzamide derivatives
BR112012018415A2 (pt) 2010-02-01 2020-08-04 Cancer Research Technology Limited composto, composição, métodos de preparar uma composição e de tratamento, e, uso de um composto.
CN103221043B (zh) 2010-08-05 2016-04-06 卡斯西部储备大学 用于治疗神经元连接发育障碍的erk抑制剂
JP2013542214A (ja) 2010-10-29 2013-11-21 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換フェノキシピリジン類
CN114164167A (zh) 2010-12-22 2022-03-11 菲特治疗公司 用于单细胞分选与增强ipsc重新编程的细胞培养平台
TR201815685T4 (tr) 2011-04-01 2018-11-21 Genentech Inc Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları.
CA2844699C (en) 2011-04-01 2019-05-07 Genentech, Inc. Combinations of akt inhibitor compounds and abiraterone, and methods of use
NZ706723A (en) 2012-10-12 2018-07-27 Exelixis Inc Novel process for making compounds for use in the treatment of cancer
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
EP3604499A1 (de) 2014-03-04 2020-02-05 Fate Therapeutics, Inc. Verbesserte neuprogrammierungsverfahren und zellkulturplattformen
CA3001917A1 (en) 2015-10-16 2017-04-20 Fate Therapeutics, Inc. Platform for the induction & maintenance of ground state pluripotency

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525625A (en) * 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
US6143728A (en) * 1996-11-15 2000-11-07 The Picower Institute For Medical Research Guanylhydrazones useful for treating diseases associated with T cell activation
AU5610398A (en) * 1997-02-28 1998-09-18 Warner-Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
JP4621355B2 (ja) * 1999-01-13 2011-01-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ベンゾ複素環およびｍｅｋ阻害剤としてのその使用

Also Published As

Publication number Publication date
CA2350234A1 (en) 2000-07-13
AU2483000A (en) 2000-07-24
EP1140062B1 (de) 2005-04-06
JP2002534380A (ja) 2002-10-15
US6696440B1 (en) 2004-02-24
DE69924641D1 (de) 2005-05-12
BR9916785A (pt) 2001-10-23
WO2000040235A3 (en) 2000-11-09
EP1140062A2 (de) 2001-10-10
US20040141924A1 (en) 2004-07-22
WO2000040235A2 (en) 2000-07-13

Similar Documents

Publication Publication Date Title
ATE292462T1 (de) Behandlung von asthma anhand von mek-inhibitoren
ATE241358T1 (de) Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen
NZ515567A (en) Method for treating chronic pain using MEK inhibitors
CY1109242T1 (el) Θεραπευτικοι παραγοντες χρησιμοι για θεραπεια πονου
DE60316779D1 (de) Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen
ATE395052T1 (de) Verwendung von c-kit-inhibitoren für die behandlung von typ-2-diabetes
ATE362363T1 (de) Verwendung von tnf-alpha inhibitoren zur behandlung von nervenwurzelschäden
TR200200204T2 (tr) MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.
ATE399782T1 (de) Zur behandlung von schmerzen geeignete phenylcarbonsäureamidverbindungen
MXPA05006359A (es) Tratamiento de la enfermedad a traves de inhibidores peptidos antimicrobianos.
ATE301995T1 (de) Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzen
DE602006010442D1 (de) Verwendung von benzokondensierten heterocyclischen sulfamid-derivaten zur behandlung von schmerzen
SE0104248D0 (sv) Method of treatment
CY1109037T1 (el) Πιπεραζινες χρησιμες για θεραπεια πονου
ATE382346T1 (de) Verfahren zur behandlung von krankheiten mit hsp90-hemmenden mitteln in kombination mit antimetaboliten
DE60327557D1 (de) Verwendung von spongosin (2-methoxyadenosin) zur behandlung von schmerzen, insbesondere hyperalgesie
DE69920205D1 (de) Verwendung von metall-proteinase-inhibitoren, um das wachstum der haare oder körperhaare zu induzieren und/oder zu stimulieren und/oder den haarausfall zu verlangsamen
IL165259A (en) Compounds useful in the treatment of anthrax and inhibiting lethal factor
DE69822626D1 (de) Verwendung eines nitroxids oder seiner prodrugs zur prophylaktischen und therapeutischen behandlung von krebs
ATE297739T1 (de) Endothelin-antagonisten zur behandlung von herzversagen
SE0301883D0 (sv) New use II
DE60220825D1 (de) Verwendung von norepinephrinwiederaufnahmehemmern zur behandlung von ticks
MXPA05010800A (es) Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos.
ATE291434T1 (de) Verwendung von angiotensin zur behandlung von krebsmetastasierung
DE60121978D1 (de) 7-CHLOR-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON SCHMERZEN

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties