AR061844A1 - Pirimidil-ciclopentanos como inhibidores de protein-quinasa akt - Google Patents

Pirimidil-ciclopentanos como inhibidores de protein-quinasa akt

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Publication number
AR061844A1
AR061844A1 ARP070103035A ARP070103035A AR061844A1 AR 061844 A1 AR061844 A1 AR 061844A1 AR P070103035 A ARP070103035 A AR P070103035A AR P070103035 A ARP070103035 A AR P070103035A AR 061844 A1 AR061844 A1 AR 061844A1
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
phenyl
cycloalkyl
membered
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ARP070103035A
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Array Biopharma Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR061844(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of AR061844A1 publication Critical patent/AR061844A1/es

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Abstract

También se proporcionan métodos para usar los compuestos como inhibidores de la proteína quinasa AKT y para el tratamiento de enfermedades proliferativas tales como cáncer. Reivindicacion 1: Un compuesto de la formula 1 y enantiomeros y sales del mismo, donde R1y R1a se seleccionan entre H, Me, Et, CH=CH2, CH2OH, CF3, CHF2 o CH2F; R2 y R2a se seleccionan independientemente entre H o F; R5 es H, Me, Et o CF3; A es como se muestra en formula (2); donde G es fenilo opcionalmente sustituido con uno a cuatro grupos R9 o un heteroarilo monocíclico de 5-6 miembros o bicíclico de 9 miembros opcionalmente sustituido con un halogeno; R6 y R7 son independientemente H, cicloalquil C3-6-(CH2), cicloalquil C3-6-(CH2CH2), V-(CH2)0-1 donde V es un heteroarilo de 5-6 miembros, W-(CH2)1-2 donde W es fenilo sustituido en forma opcional con F, CI, Br, I, OMe, CF3 o Me, cicloalquilo C3-6, hidroxi-cicloalquilo C3-6, fluor-cicloalquilo C3-6, CH(CH3)CH(OH)fenilo, heterociclo de 4-6 miembros opcionalmente sustituido alquilo C1-3, o C(=O)alquilo C1-3) o alquilo C1-6 opcionalmente sustituido con uno o más grupos independientemente seleccionados de OH, oxo, Oalquilo C1-6, CN, F, NH2, NHalquilo C1-6, N(alquil C1-6)2, tetrahidropiranilo, tetrahidrofuranilo, morfolinilo, oxetanilo piperidinilo, y pirrolidinilo, o R6 y R7 junto con el nitrogeno al cual están unidos forman un anillo heterocíclico de 3-6 miembros opcionalmente sustituido con uno o más grupos independientemente seleccionados de OH, halogeno, oxo, CF3, CH2CF3, CH2CH2OH, C(=O)CH3, y alquilo C1-3; Ra y Rb son H, o Ra es H y Rb y R6 junto con los átomos a los cuales están unidos forman un anillo heterocíclico de 5-6 miembros que tiene uno o dos átomos de nitrogeno en el anillo; Rc y Rd son H o Me, o Rc y Rd junto con el átomo al cual están unidos forman un anillo ciclopropilo; R8 es H, Me, u OH, o R8 y R6 junto con los átomos a los cuales están unidos forman un anillo heterocíclico de 5-6 miembros que tiene uno o dos átomos de nitrogeno en el anillo; cada R9 es de manera independiente halogeno, alquilo C1-6, cicloalquilo C3-6, O-alquilo C1-6, CF3, OCF3, Salquilo C1-6, CN, OCH2-fenilo, CH2O- fenilo, NH2, NH-alquilo C1-6, N-(alquilo C1-6)2, piperidina, pirrolidina, CH2F, CHF2, OCH2F, OCHF2, OH, SO2alquilo C1-6, C(O)NH2, C(O)NHalquilo C1-6 y C(O)N(alquilo C1-6)2 y m, n y p son independientemente 0 o 1.
ARP070103035A 2006-07-06 2007-07-06 Pirimidil-ciclopentanos como inhibidores de protein-quinasa akt AR061844A1 (es)

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US (3) US8003651B2 (es)
EP (1) EP2049500B1 (es)
JP (3) JP5268904B2 (es)
KR (2) KR20150041164A (es)
CN (2) CN101631778B (es)
AR (1) AR061844A1 (es)
AT (1) ATE523499T1 (es)
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