BR112016002970A2 - biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio - Google Patents

biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio

Info

Publication number
BR112016002970A2
BR112016002970A2 BR112016002970A BR112016002970A BR112016002970A2 BR 112016002970 A2 BR112016002970 A2 BR 112016002970A2 BR 112016002970 A BR112016002970 A BR 112016002970A BR 112016002970 A BR112016002970 A BR 112016002970A BR 112016002970 A2 BR112016002970 A2 BR 112016002970A2
Authority
BR
Brazil
Prior art keywords
treatment
androgen
biomarkers
neoplastic disorders
prostate cancer
Prior art date
Application number
BR112016002970A
Other languages
English (en)
Inventor
Zoubeidi Amina
Jacoby Douglas
Corey Eva
Ferrante Karen
Njar Vincent
Original Assignee
Tokai Pharmaceuticals Inc
Univ Maryland
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokai Pharmaceuticals Inc, Univ Maryland, Univ Washington filed Critical Tokai Pharmaceuticals Inc
Publication of BR112016002970A2 publication Critical patent/BR112016002970A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

1/1 resumo “biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio” são aqui descritos métodos e composições para o tratamento de câncer da próstata em um indivíduo em necessidade deste. o câncer da próstata pode ser um câncer da próstata resistente à castração e um resistente ao antagonista de receptor androgênico. os métodos podem compreender a administração ao indivíduo de um inibidor de cyp17-liase de fórmula ii.
BR112016002970A 2013-08-12 2014-08-12 biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio BR112016002970A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361865038P 2013-08-12 2013-08-12
US201461990570P 2014-05-08 2014-05-08
US201462002110P 2014-05-22 2014-05-22
PCT/US2014/050793 WO2015023710A1 (en) 2013-08-12 2014-08-12 Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Publications (1)

Publication Number Publication Date
BR112016002970A2 true BR112016002970A2 (pt) 2017-09-12

Family

ID=52468645

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002970A BR112016002970A2 (pt) 2013-08-12 2014-08-12 biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio

Country Status (13)

Country Link
US (2) US9808472B2 (pt)
EP (1) EP3033088A4 (pt)
JP (1) JP2016528252A (pt)
KR (1) KR20160058774A (pt)
CN (1) CN105636594A (pt)
AU (1) AU2014306698A1 (pt)
BR (1) BR112016002970A2 (pt)
CA (1) CA2920317A1 (pt)
IL (1) IL243419A0 (pt)
MX (1) MX2016001901A (pt)
RU (1) RU2016104643A (pt)
SG (1) SG11201600525XA (pt)
WO (1) WO2015023710A1 (pt)

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CA2721506C (en) 2008-04-16 2019-09-17 Jun Luo Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants
CA2904170A1 (en) 2013-03-14 2014-09-25 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
AU2014306698A1 (en) 2013-08-12 2016-01-28 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
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WO2016033114A1 (en) 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
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ES2839128T3 (es) * 2014-12-05 2021-07-05 Aragon Pharmaceuticals Inc Composiciones anticancerosas
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EP3532642B1 (en) * 2016-10-27 2021-12-08 The General Hospital Corporation Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers
WO2018217237A1 (en) * 2017-05-26 2018-11-29 Genyous Biomed International Combination therapy for cancer using botanical compositions and enzalutamide
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WO2019023651A2 (en) 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
WO2019023654A2 (en) * 2017-07-28 2019-01-31 Massachusetts Institute Of Technology DISCOVERING SMALL MOLECULES TARGETING THE ANDROGEN RECEPTOR AND USES THEREOF
CN107375276B (zh) * 2017-07-28 2021-03-16 广东工业大学 一种药物组合物及其应用
EP3697398A1 (en) * 2017-10-16 2020-08-26 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
CN107722101A (zh) * 2017-11-03 2018-02-23 郑州大学 甾体吡啶类衍生物及其制备方法和应用
CN112687354B (zh) * 2019-01-29 2022-07-12 杭州纽安津生物科技有限公司 针对靶向药物PI3K、AKT、mTOR通路的激酶抑制剂的多肽疫苗组合及其设计方法
RU2731002C1 (ru) * 2019-10-22 2020-08-26 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения рака предстательной железы
KR102543618B1 (ko) * 2021-05-27 2023-06-13 사회복지법인 삼성생명공익재단 전립선암의 엔잘루타미드 저항성 예측용 신규 바이오마커 및 이의 용도
CN114113633A (zh) * 2021-12-27 2022-03-01 复旦大学 用于前列腺癌危险度诊断和疗效评估的分子指标、试剂盒

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