IT1216687B - Complessi di platino (ii), loro preparazione e impiego come antitumorali. - Google Patents
Complessi di platino (ii), loro preparazione e impiego come antitumorali.Info
- Publication number
- IT1216687B IT1216687B IT8820074A IT2007488A IT1216687B IT 1216687 B IT1216687 B IT 1216687B IT 8820074 A IT8820074 A IT 8820074A IT 2007488 A IT2007488 A IT 2007488A IT 1216687 B IT1216687 B IT 1216687B
- Authority
- IT
- Italy
- Prior art keywords
- complexes
- platinum
- preparation
- chem
- residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8820074A IT1216687B (it) | 1988-04-01 | 1988-04-01 | Complessi di platino (ii), loro preparazione e impiego come antitumorali. |
HU892555A HU206220B (en) | 1988-04-01 | 1989-03-25 | Process for producing platinum(ii) complexes and pharmaceutical compositions comprising such compounds as active ingredient |
ES89105369T ES2061756T3 (es) | 1988-04-01 | 1989-03-25 | Complejos de platino (ii), su preparacion y uso como agentes anti-tumor. |
AU32927/89A AU633817B2 (en) | 1988-04-01 | 1989-03-25 | Platinum(ii) complexes, their preparation and use as anti-tumour agents |
DE68911745T DE68911745T2 (de) | 1988-04-01 | 1989-03-25 | Platin(II)-Komplexe, Verfahren zu ihrer Herstellung und Anwendung als Antitumormittel. |
EP89903737A EP0415939A1 (en) | 1988-04-01 | 1989-03-25 | Platinum(ii) complexes, their preparation and use as anti-tumour agents |
JP1503437A JPH03503529A (ja) | 1988-04-01 | 1989-03-25 | 白金(2)錯体、その製造法および抗腫瘍剤としての利用 |
AT89105369T ATE99315T1 (de) | 1988-04-01 | 1989-03-25 | Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel. |
PCT/EP1989/000330 WO1989009218A1 (en) | 1988-04-01 | 1989-03-25 | Platinum(ii) complexes, their preparation and use as anti-tumour agents |
EP89105369A EP0341409B1 (en) | 1988-04-01 | 1989-03-25 | Platinum (II) complexes, their preparation and use as antitumour agents |
ZA892398A ZA892398B (en) | 1988-04-01 | 1989-03-31 | Platinum(ii)complexes,their preparations and use as anti-tumour agents |
DK235690A DK235690A (da) | 1988-04-01 | 1990-09-28 | Platin(ii)-komplekser, deres fremstilling og anvendelse som antitumormidler |
US07/585,118 US5104895A (en) | 1988-04-01 | 1990-11-05 | Platinum(ii) complexes, their preparation and use as anti-tumor agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8820074A IT1216687B (it) | 1988-04-01 | 1988-04-01 | Complessi di platino (ii), loro preparazione e impiego come antitumorali. |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8820074A0 IT8820074A0 (it) | 1988-04-01 |
IT1216687B true IT1216687B (it) | 1990-03-08 |
Family
ID=11163596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8820074A IT1216687B (it) | 1988-04-01 | 1988-04-01 | Complessi di platino (ii), loro preparazione e impiego come antitumorali. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5104895A (it) |
EP (2) | EP0341409B1 (it) |
JP (1) | JPH03503529A (it) |
AT (1) | ATE99315T1 (it) |
AU (1) | AU633817B2 (it) |
DE (1) | DE68911745T2 (it) |
DK (1) | DK235690A (it) |
ES (1) | ES2061756T3 (it) |
HU (1) | HU206220B (it) |
IT (1) | IT1216687B (it) |
WO (1) | WO1989009218A1 (it) |
ZA (1) | ZA892398B (it) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1238693B (it) * | 1990-02-16 | 1993-09-01 | Montedipe Srl | Mescole a base di polimeri vinilaromatici ad elevate caratteristiche meccaniche |
EP0550385A1 (de) * | 1991-12-19 | 1993-07-07 | Ciba-Geigy Ag | Peroral zu verabreichende pharmazeutische Zusammensetzungen, die Methandiphosphonsäure-Derivate und 18-Krone-6 Ether enthalten |
US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
US7166733B2 (en) * | 2000-01-04 | 2007-01-23 | Access Pharmaceuticals, Inc. | O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes |
US7138520B2 (en) * | 2003-01-13 | 2006-11-21 | Massachusetts Institute Of Technology | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same |
US8668926B1 (en) | 2003-09-15 | 2014-03-11 | Shaker A. Mousa | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof |
US8071134B2 (en) * | 2003-09-15 | 2011-12-06 | Ordway Research Institute, Inc. | Thyroid hormone analogs and methods of use |
US9198887B2 (en) | 2003-09-15 | 2015-12-01 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use |
EP2335694B1 (en) | 2003-09-15 | 2018-06-13 | NanoPharmaceuticals LLC | Thyroid hormone analogs and methods of use |
CN102895666B (zh) * | 2003-12-16 | 2015-08-19 | 尼克塔治疗公司 | 化学改性的小分子 |
US20100047338A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
US8268293B2 (en) * | 2005-04-19 | 2012-09-18 | Merck Patent Gmbh | UV protection |
US10130686B2 (en) | 2005-09-15 | 2018-11-20 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders |
US9498536B2 (en) | 2005-09-15 | 2016-11-22 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders |
US20090022806A1 (en) * | 2006-12-22 | 2009-01-22 | Mousa Shaker A | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof |
WO2007035612A2 (en) | 2005-09-16 | 2007-03-29 | Ordway Research Institute, Inc. | Polyphenol conjugates as rgd-binding compounds and methods of use |
EP2120913B1 (en) * | 2006-12-22 | 2015-01-21 | NanoPharmaceuticals LLC | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
US20100159021A1 (en) * | 2008-12-23 | 2010-06-24 | Paul Davis | Small Molecule Ligands of the Integrin RGD Recognition Site and Methods of Use |
CA2761389A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
US9180107B2 (en) * | 2009-03-31 | 2015-11-10 | Nanopharmaceuticals Llc | Combination treatment of cancer with cetuximab and tetrac |
CA2765792C (en) * | 2009-06-17 | 2017-03-28 | Ordway Research Institute, Inc. | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
US8802240B2 (en) | 2011-01-06 | 2014-08-12 | Nanopharmaceuticals Llc | Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells |
EP4066841A1 (en) | 2013-03-14 | 2022-10-05 | University of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
AU2014306698A1 (en) | 2013-08-12 | 2016-01-28 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
WO2015074050A1 (en) | 2013-11-18 | 2015-05-21 | Nanopharmaceuticals Llc | Methods for screening patients for resistance to angioinhibition, treatment and prophylaxis thereof |
WO2017214299A1 (en) | 2016-06-07 | 2017-12-14 | Nanopharmaceuticals, Llc | NON-CLEAVABLE POLYMER CONJUGATED WITH αvβ3 INTEGRIN THYROID ANTAGONISTS |
US10328043B1 (en) | 2018-04-11 | 2019-06-25 | Nanopharmaceuticals, Llc. | Composition and method for dual targeting in treatment of neuroendocrine tumors |
US11351137B2 (en) | 2018-04-11 | 2022-06-07 | Nanopharmaceuticals Llc | Composition and method for dual targeting in treatment of neuroendocrine tumors |
US10961204B1 (en) | 2020-04-29 | 2021-03-30 | Nanopharmaceuticals Llc | Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors |
US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL67789A (en) * | 1983-01-31 | 1986-09-30 | Yissum Res Dev Co | Amino-substituted malonato platinum(ii)complexes and method for their preparation |
US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
CH665421A5 (de) * | 1984-01-23 | 1988-05-13 | Inst Obschei I Neoorganichesko | Gemischte karboxylatokomplexe von platin (ii) und verfahren zu ihrer herstellung. |
GB8416048D0 (en) * | 1984-06-22 | 1984-07-25 | Johnson Matthey Plc | Anti-tumour compounds of platinum |
DE3582961D1 (de) * | 1984-06-27 | 1991-07-04 | Johnson Matthey Plc | Platinkoordinationsverbindungen. |
EP0169645A1 (en) * | 1984-06-27 | 1986-01-29 | Johnson Matthey Public Limited Company | Platinum co-ordination compounds |
DE3432320A1 (de) * | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
US4737589A (en) * | 1985-08-27 | 1988-04-12 | Nippon Kayaku Kabushiki Kaisha | Platinum Complexes |
JPS62207283A (ja) * | 1986-03-07 | 1987-09-11 | Yoshinori Kitani | 新規な白金錯体 |
DE3630497A1 (de) * | 1986-09-08 | 1988-03-10 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
JPS63203692A (ja) * | 1987-02-19 | 1988-08-23 | Nippon Kayaku Co Ltd | 新規白金錯体 |
EP0284197A1 (en) * | 1987-02-20 | 1988-09-28 | Tanabe Seiyaku Co., Ltd. | Novel organic platinum complex and process for the preparation thereof |
IL85595A0 (en) * | 1987-03-06 | 1988-08-31 | Tanabe Seiyaku Co | Organic platinum complex and its preparation |
US4904809A (en) * | 1987-09-25 | 1990-02-27 | Ss Pharmaceutical Co., Ltd. | Platinum complex |
EP0376076A1 (en) * | 1988-12-27 | 1990-07-04 | Ss Pharmaceutical Co., Ltd. | Novel platinum complex |
JP2740919B2 (ja) * | 1989-03-30 | 1998-04-15 | 塩野義製薬株式会社 | 白金錯体およびこれらを有効成分として含有する抗腫瘍剤 |
US4994591A (en) * | 1989-06-02 | 1991-02-19 | The Research Foundation Of State University Of Ny | Platinum complexes derived from b-silyamines |
-
1988
- 1988-04-01 IT IT8820074A patent/IT1216687B/it active
-
1989
- 1989-03-25 DE DE68911745T patent/DE68911745T2/de not_active Expired - Fee Related
- 1989-03-25 HU HU892555A patent/HU206220B/hu not_active IP Right Cessation
- 1989-03-25 ES ES89105369T patent/ES2061756T3/es not_active Expired - Lifetime
- 1989-03-25 JP JP1503437A patent/JPH03503529A/ja active Pending
- 1989-03-25 AU AU32927/89A patent/AU633817B2/en not_active Expired - Fee Related
- 1989-03-25 WO PCT/EP1989/000330 patent/WO1989009218A1/en not_active Application Discontinuation
- 1989-03-25 AT AT89105369T patent/ATE99315T1/de not_active IP Right Cessation
- 1989-03-25 EP EP89105369A patent/EP0341409B1/en not_active Expired - Lifetime
- 1989-03-25 EP EP89903737A patent/EP0415939A1/en active Pending
- 1989-03-31 ZA ZA892398A patent/ZA892398B/xx unknown
-
1990
- 1990-09-28 DK DK235690A patent/DK235690A/da not_active Application Discontinuation
- 1990-11-05 US US07/585,118 patent/US5104895A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK235690D0 (da) | 1990-09-28 |
EP0415939A1 (en) | 1991-03-13 |
EP0341409A1 (en) | 1989-11-15 |
JPH03503529A (ja) | 1991-08-08 |
ES2061756T3 (es) | 1994-12-16 |
IT8820074A0 (it) | 1988-04-01 |
DE68911745T2 (de) | 1994-05-19 |
HU206220B (en) | 1992-09-28 |
ATE99315T1 (de) | 1994-01-15 |
AU633817B2 (en) | 1993-02-11 |
DK235690A (da) | 1990-09-28 |
ZA892398B (en) | 1989-11-29 |
AU3292789A (en) | 1989-10-16 |
HUT55401A (en) | 1991-05-28 |
US5104895A (en) | 1992-04-14 |
EP0341409B1 (en) | 1993-12-29 |
WO1989009218A1 (en) | 1989-10-05 |
HU892555D0 (en) | 1991-03-28 |
DE68911745D1 (de) | 1994-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950427 |