DK235690A - Platin(ii)-komplekser, deres fremstilling og anvendelse som antitumormidler - Google Patents
Platin(ii)-komplekser, deres fremstilling og anvendelse som antitumormidler Download PDFInfo
- Publication number
- DK235690A DK235690A DK235690A DK235690A DK235690A DK 235690 A DK235690 A DK 235690A DK 235690 A DK235690 A DK 235690A DK 235690 A DK235690 A DK 235690A DK 235690 A DK235690 A DK 235690A
- Authority
- DK
- Denmark
- Prior art keywords
- platin
- complexes
- preparation
- antitumor agents
- chem
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002690 malonic acid derivatives Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8820074A IT1216687B (it) | 1988-04-01 | 1988-04-01 | Complessi di platino (ii), loro preparazione e impiego come antitumorali. |
| PCT/EP1989/000330 WO1989009218A1 (en) | 1988-04-01 | 1989-03-25 | Platinum(ii) complexes, their preparation and use as anti-tumour agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK235690A true DK235690A (da) | 1990-09-28 |
| DK235690D0 DK235690D0 (da) | 1990-09-28 |
Family
ID=11163596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK235690A DK235690D0 (da) | 1988-04-01 | 1990-09-28 | Platin(ii)-komplekser, deres fremstilling og anvendelse som antitumormidler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5104895A (da) |
| EP (2) | EP0415939A1 (da) |
| JP (1) | JPH03503529A (da) |
| AT (1) | ATE99315T1 (da) |
| AU (1) | AU633817B2 (da) |
| DE (1) | DE68911745T2 (da) |
| DK (1) | DK235690D0 (da) |
| ES (1) | ES2061756T3 (da) |
| HU (1) | HU206220B (da) |
| IT (1) | IT1216687B (da) |
| WO (1) | WO1989009218A1 (da) |
| ZA (1) | ZA892398B (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1238693B (it) * | 1990-02-16 | 1993-09-01 | Montedipe Srl | Mescole a base di polimeri vinilaromatici ad elevate caratteristiche meccaniche |
| EP0550385A1 (de) * | 1991-12-19 | 1993-07-07 | Ciba-Geigy Ag | Peroral zu verabreichende pharmazeutische Zusammensetzungen, die Methandiphosphonsäure-Derivate und 18-Krone-6 Ether enthalten |
| US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
| US7166733B2 (en) * | 2000-01-04 | 2007-01-23 | Access Pharmaceuticals, Inc. | O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes |
| US7138520B2 (en) * | 2003-01-13 | 2006-11-21 | Massachusetts Institute Of Technology | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same |
| WO2005027895A2 (en) | 2003-09-15 | 2005-03-31 | Ordway Research Institute | Thyroid hormone analogs and methods of use in angiogenesis |
| US9198887B2 (en) | 2003-09-15 | 2015-12-01 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use |
| US8071134B2 (en) * | 2003-09-15 | 2011-12-06 | Ordway Research Institute, Inc. | Thyroid hormone analogs and methods of use |
| US8668926B1 (en) | 2003-09-15 | 2014-03-11 | Shaker A. Mousa | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof |
| EA018427B1 (ru) * | 2003-12-16 | 2013-07-30 | Нектар Терапьютикс | Химически модифицированный налоксон |
| US20100047338A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| CN101203278A (zh) * | 2005-04-19 | 2008-06-18 | 默克专利股份有限公司 | 紫外线保护 |
| US10130686B2 (en) | 2005-09-15 | 2018-11-20 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders |
| US9220788B2 (en) * | 2009-06-17 | 2015-12-29 | Nanopharmaceuticals Llc | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
| US20090022806A1 (en) * | 2006-12-22 | 2009-01-22 | Mousa Shaker A | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof |
| US9498536B2 (en) | 2005-09-15 | 2016-11-22 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders |
| WO2007035612A2 (en) | 2005-09-16 | 2007-03-29 | Ordway Research Institute, Inc. | Polyphenol conjugates as rgd-binding compounds and methods of use |
| WO2008140507A2 (en) * | 2006-12-22 | 2008-11-20 | Clf Medical Technology Acceleration Program, Inc. | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| WO2010075332A1 (en) * | 2008-12-23 | 2010-07-01 | Charitable Leadership Foundation | Small molecule ligands of the integrin rgd recognition site and methods of use |
| AU2010210422A1 (en) | 2009-02-05 | 2011-08-18 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens |
| WO2010120506A1 (en) * | 2009-03-31 | 2010-10-21 | Ordway Research Institute, Inc. | Combination treatment of cancer with cetuximab and tetrac |
| US8802240B2 (en) | 2011-01-06 | 2014-08-12 | Nanopharmaceuticals Llc | Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| WO2015023710A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| WO2015074050A1 (en) | 2013-11-18 | 2015-05-21 | Nanopharmaceuticals Llc | Methods for screening patients for resistance to angioinhibition, treatment and prophylaxis thereof |
| AU2017279536A1 (en) | 2016-06-07 | 2018-12-20 | Nanopharmaceuticals, Llc | Non-cleavable polymer conjugated with αvβ3 integrin thyroid antagonists |
| US11351137B2 (en) | 2018-04-11 | 2022-06-07 | Nanopharmaceuticals Llc | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| US10328043B1 (en) | 2018-04-11 | 2019-06-25 | Nanopharmaceuticals, Llc. | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| US10961204B1 (en) | 2020-04-29 | 2021-03-30 | Nanopharmaceuticals Llc | Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors |
| US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL67789A (en) * | 1983-01-31 | 1986-09-30 | Yissum Res Dev Co | Amino-substituted malonato platinum(ii)complexes and method for their preparation |
| US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
| GB2163163B (en) * | 1984-01-23 | 1987-10-07 | Inst Obschei I Neoorganichesko | Blended carboxylate complexes of platinum |
| GB8416048D0 (en) * | 1984-06-22 | 1984-07-25 | Johnson Matthey Plc | Anti-tumour compounds of platinum |
| DE3582961D1 (de) * | 1984-06-27 | 1991-07-04 | Johnson Matthey Plc | Platinkoordinationsverbindungen. |
| EP0169645A1 (en) * | 1984-06-27 | 1986-01-29 | Johnson Matthey Public Limited Company | Platinum co-ordination compounds |
| DE3432320A1 (de) * | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
| US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
| US4737589A (en) * | 1985-08-27 | 1988-04-12 | Nippon Kayaku Kabushiki Kaisha | Platinum Complexes |
| JPS62207283A (ja) * | 1986-03-07 | 1987-09-11 | Yoshinori Kitani | 新規な白金錯体 |
| DE3630497A1 (de) * | 1986-09-08 | 1988-03-10 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| JPS63203692A (ja) * | 1987-02-19 | 1988-08-23 | Nippon Kayaku Co Ltd | 新規白金錯体 |
| US4882447A (en) * | 1987-02-20 | 1989-11-21 | Tanabe Seiyaku Co., Ltd. | Novel organic platinum complex and process for the preparation thereof |
| IL85595A0 (en) * | 1987-03-06 | 1988-08-31 | Tanabe Seiyaku Co | Organic platinum complex and its preparation |
| US4904809A (en) * | 1987-09-25 | 1990-02-27 | Ss Pharmaceutical Co., Ltd. | Platinum complex |
| EP0376076A1 (en) * | 1988-12-27 | 1990-07-04 | Ss Pharmaceutical Co., Ltd. | Novel platinum complex |
| JP2740919B2 (ja) * | 1989-03-30 | 1998-04-15 | 塩野義製薬株式会社 | 白金錯体およびこれらを有効成分として含有する抗腫瘍剤 |
| US4994591A (en) * | 1989-06-02 | 1991-02-19 | The Research Foundation Of State University Of Ny | Platinum complexes derived from b-silyamines |
-
1988
- 1988-04-01 IT IT8820074A patent/IT1216687B/it active
-
1989
- 1989-03-25 DE DE68911745T patent/DE68911745T2/de not_active Expired - Fee Related
- 1989-03-25 ES ES89105369T patent/ES2061756T3/es not_active Expired - Lifetime
- 1989-03-25 AU AU32927/89A patent/AU633817B2/en not_active Expired - Fee Related
- 1989-03-25 EP EP89903737A patent/EP0415939A1/en active Pending
- 1989-03-25 HU HU892555A patent/HU206220B/hu not_active IP Right Cessation
- 1989-03-25 JP JP1503437A patent/JPH03503529A/ja active Pending
- 1989-03-25 EP EP89105369A patent/EP0341409B1/en not_active Expired - Lifetime
- 1989-03-25 WO PCT/EP1989/000330 patent/WO1989009218A1/en not_active Ceased
- 1989-03-25 AT AT89105369T patent/ATE99315T1/de not_active IP Right Cessation
- 1989-03-31 ZA ZA892398A patent/ZA892398B/xx unknown
-
1990
- 1990-09-28 DK DK235690A patent/DK235690D0/da not_active Application Discontinuation
- 1990-11-05 US US07/585,118 patent/US5104895A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HU892555D0 (en) | 1991-03-28 |
| ZA892398B (en) | 1989-11-29 |
| ES2061756T3 (es) | 1994-12-16 |
| DE68911745T2 (de) | 1994-05-19 |
| EP0341409B1 (en) | 1993-12-29 |
| WO1989009218A1 (en) | 1989-10-05 |
| IT1216687B (it) | 1990-03-08 |
| AU633817B2 (en) | 1993-02-11 |
| HUT55401A (en) | 1991-05-28 |
| AU3292789A (en) | 1989-10-16 |
| ATE99315T1 (de) | 1994-01-15 |
| IT8820074A0 (it) | 1988-04-01 |
| JPH03503529A (ja) | 1991-08-08 |
| EP0341409A1 (en) | 1989-11-15 |
| HU206220B (en) | 1992-09-28 |
| DK235690D0 (da) | 1990-09-28 |
| US5104895A (en) | 1992-04-14 |
| DE68911745D1 (de) | 1994-02-10 |
| EP0415939A1 (en) | 1991-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |