ATE28639T1 - Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung. - Google Patents
Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung.Info
- Publication number
- ATE28639T1 ATE28639T1 AT84401824T AT84401824T ATE28639T1 AT E28639 T1 ATE28639 T1 AT E28639T1 AT 84401824 T AT84401824 T AT 84401824T AT 84401824 T AT84401824 T AT 84401824T AT E28639 T1 ATE28639 T1 AT E28639T1
- Authority
- AT
- Austria
- Prior art keywords
- atoms
- branched
- phenylacetamide
- alkynyloxy
- piperazine
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8314720A FR2552083B1 (fr) | 1983-09-15 | 1983-09-15 | Derives de (alkynyloxy-3 hydroxy-2-propyl)-4 piperazinyl-1 n-phenyl acetamide, leur preparation et leur application en therapeutique |
| EP84401824A EP0143016B1 (de) | 1983-09-15 | 1984-09-14 | Derivate von 4-(3-Alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-N-phenylacetamid, ihre Herstellung und ihre therapeutische Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE28639T1 true ATE28639T1 (de) | 1987-08-15 |
Family
ID=9292262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84401824T ATE28639T1 (de) | 1983-09-15 | 1984-09-14 | Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0143016B1 (de) |
| JP (1) | JPS60142972A (de) |
| KR (1) | KR850002477A (de) |
| AT (1) | ATE28639T1 (de) |
| AU (1) | AU572888B2 (de) |
| DE (1) | DE3465085D1 (de) |
| DK (1) | DK439384A (de) |
| ES (2) | ES8602724A1 (de) |
| FI (1) | FI77243C (de) |
| FR (1) | FR2552083B1 (de) |
| GR (1) | GR80359B (de) |
| HU (1) | HU192994B (de) |
| PT (1) | PT79214B (de) |
| ZA (1) | ZA846937B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552023B2 (en) | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
| NZ520782A (en) * | 2000-02-22 | 2004-03-26 | Cv Therapeutics Inc | Substituted piperazine compounds that are partial fatty acid oxidation inhibitors |
| US6451798B2 (en) | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
| US6677336B2 (en) | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| CA2682384C (en) * | 2007-03-30 | 2016-05-10 | Council Of Scientific And Industrial Research | Benzophenone hybrids as potential anticancer agents and a process for the preparation thereof |
| JP6077344B2 (ja) * | 2013-03-12 | 2017-02-08 | 花王株式会社 | ピペラジン誘導体を含む漂白剤組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2173869B1 (de) * | 1972-04-13 | 1975-12-26 | Cerm Cent Europ Rech Mauvernay | |
| US3951979A (en) * | 1972-04-13 | 1976-04-20 | Roland Yves Mauvernary | New amino propanediol derivatives |
| FR2403330A1 (fr) * | 1977-06-16 | 1979-04-13 | Fabre Sa Pierre | Nouveaux derives de benzoyl-2-chloro-4-glycinanilides substitues, leur procede de preparation et leur application en tant que medicaments |
-
1983
- 1983-09-15 FR FR8314720A patent/FR2552083B1/fr not_active Expired
-
1984
- 1984-09-04 ZA ZA846937A patent/ZA846937B/xx unknown
- 1984-09-10 AU AU32861/84A patent/AU572888B2/en not_active Ceased
- 1984-09-13 ES ES535899A patent/ES8602724A1/es not_active Expired
- 1984-09-13 GR GR80359A patent/GR80359B/el unknown
- 1984-09-13 JP JP59192411A patent/JPS60142972A/ja active Pending
- 1984-09-14 DE DE8484401824T patent/DE3465085D1/de not_active Expired
- 1984-09-14 KR KR1019840005613A patent/KR850002477A/ko not_active Withdrawn
- 1984-09-14 AT AT84401824T patent/ATE28639T1/de not_active IP Right Cessation
- 1984-09-14 HU HU843473A patent/HU192994B/hu not_active IP Right Cessation
- 1984-09-14 DK DK439384A patent/DK439384A/da not_active Application Discontinuation
- 1984-09-14 PT PT79214A patent/PT79214B/pt unknown
- 1984-09-14 EP EP84401824A patent/EP0143016B1/de not_active Expired
- 1984-09-14 FI FI843617A patent/FI77243C/fi not_active IP Right Cessation
-
1985
- 1985-07-05 ES ES544919A patent/ES8607265A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HUT35253A (en) | 1985-06-28 |
| KR850002477A (ko) | 1985-05-13 |
| DK439384A (da) | 1985-03-16 |
| ES544919A0 (es) | 1986-05-16 |
| DK439384D0 (da) | 1984-09-14 |
| PT79214B (en) | 1986-08-22 |
| EP0143016A1 (de) | 1985-05-29 |
| ES535899A0 (es) | 1985-12-01 |
| ES8602724A1 (es) | 1985-12-01 |
| FR2552083B1 (fr) | 1986-05-09 |
| ZA846937B (en) | 1985-04-24 |
| DE3465085D1 (en) | 1987-09-03 |
| GR80359B (en) | 1985-01-11 |
| FI843617L (fi) | 1985-03-16 |
| JPS60142972A (ja) | 1985-07-29 |
| AU572888B2 (en) | 1988-05-19 |
| EP0143016B1 (de) | 1987-07-29 |
| FI843617A0 (fi) | 1984-09-14 |
| ES8607265A1 (es) | 1986-05-16 |
| FR2552083A1 (fr) | 1985-03-22 |
| PT79214A (en) | 1984-10-01 |
| FI77243B (fi) | 1988-10-31 |
| AU3286184A (en) | 1985-03-21 |
| FI77243C (fi) | 1989-02-10 |
| HU192994B (en) | 1987-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |