AU572888B2 - 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives - Google Patents

4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives

Info

Publication number
AU572888B2
AU572888B2 AU32861/84A AU3286184A AU572888B2 AU 572888 B2 AU572888 B2 AU 572888B2 AU 32861/84 A AU32861/84 A AU 32861/84A AU 3286184 A AU3286184 A AU 3286184A AU 572888 B2 AU572888 B2 AU 572888B2
Authority
AU
Australia
Prior art keywords
atoms
phenyl
branched
alkyl radical
alkynyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU32861/84A
Other versions
AU3286184A (en
Inventor
Michel Combourieu
Jean-Claude Laigle
Marie-Paule Landes
Jean-Francois Reyjal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riom Laboratoires Cerm "rl-Cerm" Sa
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of AU3286184A publication Critical patent/AU3286184A/en
Application granted granted Critical
Publication of AU572888B2 publication Critical patent/AU572888B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Compounds of the formula : see diagramm : EP0143016,P9,F1 wherein R1 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R2 and R3 represent separately a phenyl radical, an alkyl radical linear or branched having 1-6 C atoms, or together with the carbon atom to which they are bounded a cycloalkyl radical of 5 to 7 C atoms ; R4 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R5 represents an alkyl radical linear or branched having 1-6 C atoms or phenyl radical optionally substituted by a halogen atom ; X represents hydrogen or halogen atom, and pharmaceutically acceptable addition salts thereof.
AU32861/84A 1983-09-15 1984-09-10 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives Ceased AU572888B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8314720 1983-09-15
FR8314720A FR2552083B1 (en) 1983-09-15 1983-09-15 (ALKYNYLOXY-3 HYDROXY-2-PROPYL) -4 PIPERAZINYL-1 N-PHENYL ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
AU3286184A AU3286184A (en) 1985-03-21
AU572888B2 true AU572888B2 (en) 1988-05-19

Family

ID=9292262

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32861/84A Ceased AU572888B2 (en) 1983-09-15 1984-09-10 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives

Country Status (14)

Country Link
EP (1) EP0143016B1 (en)
JP (1) JPS60142972A (en)
KR (1) KR850002477A (en)
AT (1) ATE28639T1 (en)
AU (1) AU572888B2 (en)
DE (1) DE3465085D1 (en)
DK (1) DK439384A (en)
ES (2) ES8602724A1 (en)
FI (1) FI77243C (en)
FR (1) FR2552083B1 (en)
GR (1) GR80359B (en)
HU (1) HU192994B (en)
PT (1) PT79214B (en)
ZA (1) ZA846937B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451798B2 (en) 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
EP1259493A2 (en) * 2000-02-22 2002-11-27 Cv Therapeutics, Inc. Substituted piperazine compounds
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
US6677336B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
EP2142506B1 (en) * 2007-03-30 2013-10-16 Council of Scientific & Industrial Research Novel benzophenone hybrids as potential anticancer agents and a process for the preparation thereof
JP6077344B2 (en) * 2013-03-12 2017-02-08 花王株式会社 Bleach composition comprising a piperazine derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951979A (en) * 1972-04-13 1976-04-20 Roland Yves Mauvernary New amino propanediol derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2173869B1 (en) * 1972-04-13 1975-12-26 Cerm Cent Europ Rech Mauvernay
FR2403330A1 (en) * 1977-06-16 1979-04-13 Fabre Sa Pierre NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951979A (en) * 1972-04-13 1976-04-20 Roland Yves Mauvernary New amino propanediol derivatives

Also Published As

Publication number Publication date
HUT35253A (en) 1985-06-28
DK439384A (en) 1985-03-16
FI843617A0 (en) 1984-09-14
JPS60142972A (en) 1985-07-29
PT79214A (en) 1984-10-01
FI843617L (en) 1985-03-16
FI77243C (en) 1989-02-10
GR80359B (en) 1985-01-11
FI77243B (en) 1988-10-31
ES535899A0 (en) 1985-12-01
FR2552083A1 (en) 1985-03-22
AU3286184A (en) 1985-03-21
ES8602724A1 (en) 1985-12-01
PT79214B (en) 1986-08-22
KR850002477A (en) 1985-05-13
ZA846937B (en) 1985-04-24
DK439384D0 (en) 1984-09-14
HU192994B (en) 1987-08-28
DE3465085D1 (en) 1987-09-03
ES544919A0 (en) 1986-05-16
ES8607265A1 (en) 1986-05-16
FR2552083B1 (en) 1986-05-09
EP0143016A1 (en) 1985-05-29
EP0143016B1 (en) 1987-07-29
ATE28639T1 (en) 1987-08-15

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