FI843617L - 4- (2-ALKYNYLOXY-2-HYDROXIPROPYL) -PIPERAZIN-1-YL-N-PHENYL-ACETAMIDE DERIVATIVES. - Google Patents

4- (2-ALKYNYLOXY-2-HYDROXIPROPYL) -PIPERAZIN-1-YL-N-PHENYL-ACETAMIDE DERIVATIVES.

Info

Publication number
FI843617L
FI843617L FI843617A FI843617A FI843617L FI 843617 L FI843617 L FI 843617L FI 843617 A FI843617 A FI 843617A FI 843617 A FI843617 A FI 843617A FI 843617 L FI843617 L FI 843617L
Authority
FI
Finland
Prior art keywords
atoms
phenyl
branched
alkyl radical
hydroxipropyl
Prior art date
Application number
FI843617A
Other languages
Finnish (fi)
Other versions
FI77243C (en
FI843617A0 (en
FI77243B (en
Inventor
Michel Combourieu
Jean-Claude Laigle
Jean-Francois Reyjal
Marie-Paule Landes
Original Assignee
Cerm Cent Europ Rech Mauvernay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerm Cent Europ Rech Mauvernay filed Critical Cerm Cent Europ Rech Mauvernay
Publication of FI843617A0 publication Critical patent/FI843617A0/en
Publication of FI843617L publication Critical patent/FI843617L/en
Application granted granted Critical
Publication of FI77243B publication Critical patent/FI77243B/en
Publication of FI77243C publication Critical patent/FI77243C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Compounds of the formula : see diagramm : EP0143016,P9,F1 wherein R1 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R2 and R3 represent separately a phenyl radical, an alkyl radical linear or branched having 1-6 C atoms, or together with the carbon atom to which they are bounded a cycloalkyl radical of 5 to 7 C atoms ; R4 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R5 represents an alkyl radical linear or branched having 1-6 C atoms or phenyl radical optionally substituted by a halogen atom ; X represents hydrogen or halogen atom, and pharmaceutically acceptable addition salts thereof.
FI843617A 1983-09-15 1984-09-14 Process for the preparation of therapeutically useful 4- (3-alkynylox i-2-hydroxypropyl) piperazin-1-yl-N-phenylacetamide derivatives. FI77243C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8314720A FR2552083B1 (en) 1983-09-15 1983-09-15 (ALKYNYLOXY-3 HYDROXY-2-PROPYL) -4 PIPERAZINYL-1 N-PHENYL ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR8314720 1983-09-15

Publications (4)

Publication Number Publication Date
FI843617A0 FI843617A0 (en) 1984-09-14
FI843617L true FI843617L (en) 1985-03-16
FI77243B FI77243B (en) 1988-10-31
FI77243C FI77243C (en) 1989-02-10

Family

ID=9292262

Family Applications (1)

Application Number Title Priority Date Filing Date
FI843617A FI77243C (en) 1983-09-15 1984-09-14 Process for the preparation of therapeutically useful 4- (3-alkynylox i-2-hydroxypropyl) piperazin-1-yl-N-phenylacetamide derivatives.

Country Status (14)

Country Link
EP (1) EP0143016B1 (en)
JP (1) JPS60142972A (en)
KR (1) KR850002477A (en)
AT (1) ATE28639T1 (en)
AU (1) AU572888B2 (en)
DE (1) DE3465085D1 (en)
DK (1) DK439384A (en)
ES (2) ES8602724A1 (en)
FI (1) FI77243C (en)
FR (1) FR2552083B1 (en)
GR (1) GR80359B (en)
HU (1) HU192994B (en)
PT (1) PT79214B (en)
ZA (1) ZA846937B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
US6451798B2 (en) 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
NZ520782A (en) * 2000-02-22 2004-03-26 Cv Therapeutics Inc Substituted piperazine compounds that are partial fatty acid oxidation inhibitors
US6677336B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2682384C (en) * 2007-03-30 2016-05-10 Council Of Scientific And Industrial Research Benzophenone hybrids as potential anticancer agents and a process for the preparation thereof
JP6077344B2 (en) * 2013-03-12 2017-02-08 花王株式会社 Bleach composition comprising a piperazine derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2173869B1 (en) * 1972-04-13 1975-12-26 Cerm Cent Europ Rech Mauvernay
US3951979A (en) * 1972-04-13 1976-04-20 Roland Yves Mauvernary New amino propanediol derivatives
FR2403330A1 (en) * 1977-06-16 1979-04-13 Fabre Sa Pierre NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
DK439384D0 (en) 1984-09-14
KR850002477A (en) 1985-05-13
FR2552083A1 (en) 1985-03-22
JPS60142972A (en) 1985-07-29
ATE28639T1 (en) 1987-08-15
HUT35253A (en) 1985-06-28
ES535899A0 (en) 1985-12-01
PT79214A (en) 1984-10-01
ES544919A0 (en) 1986-05-16
ES8602724A1 (en) 1985-12-01
FI77243C (en) 1989-02-10
DE3465085D1 (en) 1987-09-03
DK439384A (en) 1985-03-16
AU572888B2 (en) 1988-05-19
FI843617A0 (en) 1984-09-14
HU192994B (en) 1987-08-28
EP0143016B1 (en) 1987-07-29
FI77243B (en) 1988-10-31
AU3286184A (en) 1985-03-21
PT79214B (en) 1986-08-22
FR2552083B1 (en) 1986-05-09
ES8607265A1 (en) 1986-05-16
EP0143016A1 (en) 1985-05-29
ZA846937B (en) 1985-04-24
GR80359B (en) 1985-01-11

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: RIOM LABORATOIRES - C.E.R.M.