DK439384A - DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE - Google Patents

DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE Download PDF

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Publication number
DK439384A
DK439384A DK439384A DK439384A DK439384A DK 439384 A DK439384 A DK 439384A DK 439384 A DK439384 A DK 439384A DK 439384 A DK439384 A DK 439384A DK 439384 A DK439384 A DK 439384A
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DK
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Prior art keywords
atoms
branched
phenylacetamide
alkynyloxy
piperazin
Prior art date
Application number
DK439384A
Other languages
Danish (da)
Other versions
DK439384D0 (en
Inventor
Michel Combourieu
Jean-Claude Laigle
Jean-Francois Reyjal
Marie-Paule Landes
Original Assignee
Cerm Cent Europ Rech Mauvernay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerm Cent Europ Rech Mauvernay filed Critical Cerm Cent Europ Rech Mauvernay
Publication of DK439384D0 publication Critical patent/DK439384D0/en
Publication of DK439384A publication Critical patent/DK439384A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Compounds of the formula : see diagramm : EP0143016,P9,F1 wherein R1 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R2 and R3 represent separately a phenyl radical, an alkyl radical linear or branched having 1-6 C atoms, or together with the carbon atom to which they are bounded a cycloalkyl radical of 5 to 7 C atoms ; R4 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R5 represents an alkyl radical linear or branched having 1-6 C atoms or phenyl radical optionally substituted by a halogen atom ; X represents hydrogen or halogen atom, and pharmaceutically acceptable addition salts thereof.
DK439384A 1983-09-15 1984-09-14 DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE DK439384A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8314720A FR2552083B1 (en) 1983-09-15 1983-09-15 (ALKYNYLOXY-3 HYDROXY-2-PROPYL) -4 PIPERAZINYL-1 N-PHENYL ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
DK439384D0 DK439384D0 (en) 1984-09-14
DK439384A true DK439384A (en) 1985-03-16

Family

ID=9292262

Family Applications (1)

Application Number Title Priority Date Filing Date
DK439384A DK439384A (en) 1983-09-15 1984-09-14 DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE

Country Status (14)

Country Link
EP (1) EP0143016B1 (en)
JP (1) JPS60142972A (en)
KR (1) KR850002477A (en)
AT (1) ATE28639T1 (en)
AU (1) AU572888B2 (en)
DE (1) DE3465085D1 (en)
DK (1) DK439384A (en)
ES (2) ES8602724A1 (en)
FI (1) FI77243C (en)
FR (1) FR2552083B1 (en)
GR (1) GR80359B (en)
HU (1) HU192994B (en)
PT (1) PT79214B (en)
ZA (1) ZA846937B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
US6677336B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
EP1259493A2 (en) * 2000-02-22 2002-11-27 Cv Therapeutics, Inc. Substituted piperazine compounds
US6451798B2 (en) 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2682384C (en) * 2007-03-30 2016-05-10 Council Of Scientific And Industrial Research Benzophenone hybrids as potential anticancer agents and a process for the preparation thereof
JP6077344B2 (en) * 2013-03-12 2017-02-08 花王株式会社 Bleach composition comprising a piperazine derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2173869B1 (en) * 1972-04-13 1975-12-26 Cerm Cent Europ Rech Mauvernay
US3951979A (en) * 1972-04-13 1976-04-20 Roland Yves Mauvernary New amino propanediol derivatives
FR2403330A1 (en) * 1977-06-16 1979-04-13 Fabre Sa Pierre NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
EP0143016A1 (en) 1985-05-29
EP0143016B1 (en) 1987-07-29
PT79214B (en) 1986-08-22
KR850002477A (en) 1985-05-13
PT79214A (en) 1984-10-01
FR2552083A1 (en) 1985-03-22
JPS60142972A (en) 1985-07-29
ATE28639T1 (en) 1987-08-15
AU3286184A (en) 1985-03-21
AU572888B2 (en) 1988-05-19
FI77243C (en) 1989-02-10
FR2552083B1 (en) 1986-05-09
FI843617L (en) 1985-03-16
FI77243B (en) 1988-10-31
HU192994B (en) 1987-08-28
HUT35253A (en) 1985-06-28
ES535899A0 (en) 1985-12-01
ES8607265A1 (en) 1986-05-16
ZA846937B (en) 1985-04-24
GR80359B (en) 1985-01-11
FI843617A0 (en) 1984-09-14
DK439384D0 (en) 1984-09-14
DE3465085D1 (en) 1987-09-03
ES8602724A1 (en) 1985-12-01
ES544919A0 (en) 1986-05-16

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AHB Application shelved due to non-payment