KR850002477A - 4-(3-알키닐옥시-2-하이드록시-프로필)-피퍼라진-1-일-n-페닐-아세트아미드 유도체의 제조방법 - Google Patents

4-(3-알키닐옥시-2-하이드록시-프로필)-피퍼라진-1-일-n-페닐-아세트아미드 유도체의 제조방법 Download PDF

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Publication number
KR850002477A
KR850002477A KR1019840005613A KR840005613A KR850002477A KR 850002477 A KR850002477 A KR 850002477A KR 1019840005613 A KR1019840005613 A KR 1019840005613A KR 840005613 A KR840005613 A KR 840005613A KR 850002477 A KR850002477 A KR 850002477A
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South Korea
Prior art keywords
phenyl
lower alkyl
formula
hydrogen
radical
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KR1019840005613A
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English (en)
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꽁부리외 미쉘 (외 3)
Original Assignee
쟝 미쉘 바르네리아
리농 라보 라뜨와 쎄. 에. 에르. 엠 에르엘-세르 쏘시에떼 아노뉨
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Application filed by 쟝 미쉘 바르네리아, 리농 라보 라뜨와 쎄. 에. 에르. 엠 에르엘-세르 쏘시에떼 아노뉨 filed Critical 쟝 미쉘 바르네리아
Publication of KR850002477A publication Critical patent/KR850002477A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

4-(3-알키닐옥시-2-하이드록시-프로필)-피퍼라진-1-일-N-페닐-아세트아미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기식(A) 또는 그염과 하기식(D)에 따른 적당히 치환된 N-페닐-할로게노아세트아미드가 알카리물질 존재하에서 반응되는 것을 특징으로 하는 하기식(I)의 화합물을 제조하는 방법.
  2. 제1항에 있어서, 칼륨카보네이트 또는 트리에틸아민이 알카리물질로 사용되는 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 하기식(C) 또는 그염과 하기식 (D)가 무수물 유기용매내에서 반응하는 것을 특징으로 하는 방법.
  4. 활성성분으로서 적어도 하나의 하기식(I)화합물을 적당한 부형제와 혼합하여 포함하는 것을 특징으로 하는 심장질환치료에 특히 유용한 약학적 조성물.
    여기서, R1은 수소 또는 저급알킬라디칼, R2와 R3는 각각 페닐라디칼 또는 저급알킬라디칼이며 이것이 부착되어 있는 탄소원자는 사이크로알킬 라디칼이고, R4는 수소 또는 저급알킬라디칼, R5는 할로겐원자에 의해 임의로 치환된 저급알킬라디칼 또는 페닐라디칼이고, X는 수소 또는 할로겐원자와 약학적으로 허용되는 산부가염이며, "Hal"는 할로겐 특히 염소 또는 브롬이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840005613A 1983-09-15 1984-09-14 4-(3-알키닐옥시-2-하이드록시-프로필)-피퍼라진-1-일-n-페닐-아세트아미드 유도체의 제조방법 KR850002477A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8314720 1983-09-15
FR8314720A FR2552083B1 (fr) 1983-09-15 1983-09-15 Derives de (alkynyloxy-3 hydroxy-2-propyl)-4 piperazinyl-1 n-phenyl acetamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
KR850002477A true KR850002477A (ko) 1985-05-13

Family

ID=9292262

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005613A KR850002477A (ko) 1983-09-15 1984-09-14 4-(3-알키닐옥시-2-하이드록시-프로필)-피퍼라진-1-일-n-페닐-아세트아미드 유도체의 제조방법

Country Status (14)

Country Link
EP (1) EP0143016B1 (ko)
JP (1) JPS60142972A (ko)
KR (1) KR850002477A (ko)
AT (1) ATE28639T1 (ko)
AU (1) AU572888B2 (ko)
DE (1) DE3465085D1 (ko)
DK (1) DK439384A (ko)
ES (2) ES535899A0 (ko)
FI (1) FI77243C (ko)
FR (1) FR2552083B1 (ko)
GR (1) GR80359B (ko)
HU (1) HU192994B (ko)
PT (1) PT79214B (ko)
ZA (1) ZA846937B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451798B2 (en) 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
US6677336B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
EP1259493A2 (en) * 2000-02-22 2002-11-27 Cv Therapeutics, Inc. Substituted piperazine compounds
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2008120235A1 (en) * 2007-03-30 2008-10-09 Council Of Scientific & Industrial Research Novel benzophenone hybrids as potential anticancer agents and a process for the preparation thereof
JP6077344B2 (ja) * 2013-03-12 2017-02-08 花王株式会社 ピペラジン誘導体を含む漂白剤組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2173869B1 (ko) * 1972-04-13 1975-12-26 Cerm Cent Europ Rech Mauvernay
US3951979A (en) * 1972-04-13 1976-04-20 Roland Yves Mauvernary New amino propanediol derivatives
FR2403330A1 (fr) * 1977-06-16 1979-04-13 Fabre Sa Pierre Nouveaux derives de benzoyl-2-chloro-4-glycinanilides substitues, leur procede de preparation et leur application en tant que medicaments

Also Published As

Publication number Publication date
PT79214A (en) 1984-10-01
AU3286184A (en) 1985-03-21
FI843617A0 (fi) 1984-09-14
FI77243B (fi) 1988-10-31
PT79214B (en) 1986-08-22
DE3465085D1 (en) 1987-09-03
ES8602724A1 (es) 1985-12-01
JPS60142972A (ja) 1985-07-29
EP0143016B1 (fr) 1987-07-29
ATE28639T1 (de) 1987-08-15
DK439384A (da) 1985-03-16
HU192994B (en) 1987-08-28
ZA846937B (en) 1985-04-24
GR80359B (en) 1985-01-11
EP0143016A1 (fr) 1985-05-29
FI843617L (fi) 1985-03-16
DK439384D0 (da) 1984-09-14
ES544919A0 (es) 1986-05-16
FI77243C (fi) 1989-02-10
AU572888B2 (en) 1988-05-19
FR2552083B1 (fr) 1986-05-09
HUT35253A (en) 1985-06-28
FR2552083A1 (fr) 1985-03-22
ES8607265A1 (es) 1986-05-16
ES535899A0 (es) 1985-12-01

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