ATE73814T1 - Ammine-n-heterocyclische platinkomplexe und antitumormittel. - Google Patents
Ammine-n-heterocyclische platinkomplexe und antitumormittel.Info
- Publication number
- ATE73814T1 ATE73814T1 AT87118819T AT87118819T ATE73814T1 AT E73814 T1 ATE73814 T1 AT E73814T1 AT 87118819 T AT87118819 T AT 87118819T AT 87118819 T AT87118819 T AT 87118819T AT E73814 T1 ATE73814 T1 AT E73814T1
- Authority
- AT
- Austria
- Prior art keywords
- antitumor agents
- ammine
- heterocyclic
- platinum complexes
- alkyl
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical class [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004970 halomethyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- -1 hydroxy, carboxy Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30352986 | 1986-12-18 | ||
| EP87118819A EP0273315B1 (de) | 1986-12-18 | 1987-12-18 | Ammine-N-heterocyclische Platinkomplexe und Antitumormittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE73814T1 true ATE73814T1 (de) | 1992-04-15 |
Family
ID=17922086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87118819T ATE73814T1 (de) | 1986-12-18 | 1987-12-18 | Ammine-n-heterocyclische platinkomplexe und antitumormittel. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4902797A (de) |
| EP (1) | EP0273315B1 (de) |
| KR (1) | KR900003457B1 (de) |
| AT (1) | ATE73814T1 (de) |
| CA (1) | CA1327039C (de) |
| DE (1) | DE3777583D1 (de) |
| ES (1) | ES2032430T3 (de) |
| GR (1) | GR3004629T3 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970324A (en) * | 1985-12-24 | 1990-11-13 | Hoeschele James D | Aminoalkyl-substituted azetidine platinum(II) complexes |
| JPH01294683A (ja) * | 1988-02-04 | 1989-11-28 | Kanebo Ltd | 新規白金錯体および該化合物を有効成分とする抗腫瘍剤並びに該化合物製造用中間体 |
| DE3834098A1 (de) * | 1988-10-07 | 1990-04-19 | Behringwerke Ag | Cis-platin-komplexe mit einem 1,3-diaminopropan-derivat als liganden, verfahren zu ihrer herstellung und diese verbindung enthaltende pharmazeutische mittel |
| GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
| CZ288406B6 (en) * | 1998-05-27 | 2001-06-13 | Lachema Np | Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| US6806289B1 (en) * | 2000-07-14 | 2004-10-19 | Stephen J. Lippard | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same |
| WO2003017998A1 (en) * | 2001-08-23 | 2003-03-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Platinum complexes and their use in cancer treatment |
| EP1536864A2 (de) * | 2002-09-11 | 2005-06-08 | Board Of Regents The University Of Texas System | Platin-komplexe als antitumorale mittel in kombination mit biochemischer modulation |
| ES2257178B1 (es) * | 2004-09-30 | 2007-08-16 | Universidad Autonoma De Madrid | Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral. |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| EP2178893A4 (de) * | 2007-07-16 | 2012-09-19 | Poniard Pharmaceuticals Inc | Orale formulierungen für picoplatin |
| CN102014624A (zh) * | 2008-02-08 | 2011-04-13 | 帕纳德制药公司 | 治疗肺癌的吡铂和氨柔比星 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57123198A (en) * | 1981-01-23 | 1982-07-31 | Shionogi & Co Ltd | Novel platinum complex |
| HU193809B (en) * | 1984-09-12 | 1987-12-28 | Chugai Pharmaceutical Co Ltd | Process for producing new platinum complexes |
-
1987
- 1987-12-18 US US07/135,061 patent/US4902797A/en not_active Expired - Fee Related
- 1987-12-18 DE DE8787118819T patent/DE3777583D1/de not_active Expired - Fee Related
- 1987-12-18 ES ES198787118819T patent/ES2032430T3/es not_active Expired - Lifetime
- 1987-12-18 CA CA000554853A patent/CA1327039C/en not_active Expired - Fee Related
- 1987-12-18 KR KR1019870014490A patent/KR900003457B1/ko not_active IP Right Cessation
- 1987-12-18 AT AT87118819T patent/ATE73814T1/de not_active IP Right Cessation
- 1987-12-18 EP EP87118819A patent/EP0273315B1/de not_active Expired - Lifetime
-
1992
- 1992-05-18 GR GR920400958T patent/GR3004629T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3777583D1 (de) | 1992-04-23 |
| EP0273315B1 (de) | 1992-03-18 |
| ES2032430T3 (es) | 1993-02-16 |
| EP0273315A1 (de) | 1988-07-06 |
| KR880007552A (ko) | 1988-08-27 |
| US4902797A (en) | 1990-02-20 |
| CA1327039C (en) | 1994-02-15 |
| GR3004629T3 (de) | 1993-04-28 |
| KR900003457B1 (ko) | 1990-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |