KR880007552A - 암민-지환식아민-백금 착화합물 및 항 종양제 - Google Patents
암민-지환식아민-백금 착화합물 및 항 종양제 Download PDFInfo
- Publication number
- KR880007552A KR880007552A KR870014490A KR870014490A KR880007552A KR 880007552 A KR880007552 A KR 880007552A KR 870014490 A KR870014490 A KR 870014490A KR 870014490 A KR870014490 A KR 870014490A KR 880007552 A KR880007552 A KR 880007552A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- ammine
- antitumor agents
- integer
- hydrogen
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- -1 hydroxy, carboxy Chemical group 0.000 claims abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 2
- 239000000460 chlorine Substances 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000004970 halomethyl group Chemical group 0.000 claims abstract 2
- 150000002431 hydrogen Chemical class 0.000 claims abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract 2
- 239000003446 ligand Substances 0.000 claims abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 하기식(Ⅰ)로 표시되는 화합물 :(상기식에서 R은 C1∼C5알킬, 히드록시, 카르복시, C1∼C5알콕시, 할로겐 또는 옥소이고 ; m은 2∼7의 정수이고 ; X및 Y는 각각 염소 또는 니트레이토 리간드이거나 또는 함께 -OCOCH(R1)O-, OCOCOO-,또는를 형성하는데 ; 여기서, R1은 수소, C1∼C5알킬, 히드록시메틸, 할로메틸 또는 페닐이고 ; R2는 수소 또는 C1∼C5알킬이고 ; n은 2∼5의 정수임).
- 제1항에 있어서, (암민)(글리콜레이토-0.0′)(피페리딘)백금(Ⅱ)인 화합물.
- 제1항에 특허청구된 화합물의 약리학적 유효량과 약학적으로 허용되는 담체, 희석제 및/또는 부형제로 이루어진 약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61-303529 | 1986-12-18 | ||
| JP30352986 | 1986-12-18 | ||
| JP303529/86 | 1986-12-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880007552A true KR880007552A (ko) | 1988-08-27 |
| KR900003457B1 KR900003457B1 (ko) | 1990-05-19 |
Family
ID=17922086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019870014490A KR900003457B1 (ko) | 1986-12-18 | 1987-12-18 | 암민-지환식아민-백금 착화합물 및 항종양제 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4902797A (ko) |
| EP (1) | EP0273315B1 (ko) |
| KR (1) | KR900003457B1 (ko) |
| AT (1) | ATE73814T1 (ko) |
| CA (1) | CA1327039C (ko) |
| DE (1) | DE3777583D1 (ko) |
| ES (1) | ES2032430T3 (ko) |
| GR (1) | GR3004629T3 (ko) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970324A (en) * | 1985-12-24 | 1990-11-13 | Hoeschele James D | Aminoalkyl-substituted azetidine platinum(II) complexes |
| JPH01294683A (ja) * | 1988-02-04 | 1989-11-28 | Kanebo Ltd | 新規白金錯体および該化合物を有効成分とする抗腫瘍剤並びに該化合物製造用中間体 |
| DE3834098A1 (de) * | 1988-10-07 | 1990-04-19 | Behringwerke Ag | Cis-platin-komplexe mit einem 1,3-diaminopropan-derivat als liganden, verfahren zu ihrer herstellung und diese verbindung enthaltende pharmazeutische mittel |
| GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
| CZ288406B6 (en) * | 1998-05-27 | 2001-06-13 | Lachema Np | Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| US6806289B1 (en) * | 2000-07-14 | 2004-10-19 | Stephen J. Lippard | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same |
| DE60235375D1 (de) * | 2001-08-23 | 2010-04-01 | Yissum Res Dev Co | Platinkomplexe und deren verwendung in der therapie |
| WO2004024062A2 (en) * | 2002-09-11 | 2004-03-25 | Board Of Regents, The University Of Texas System | Platinum complexes as antitumor agents in combination with biochemical modulation |
| ES2257178B1 (es) * | 2004-09-30 | 2007-08-16 | Universidad Autonoma De Madrid | Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral. |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| CN101809024A (zh) * | 2007-07-16 | 2010-08-18 | 铂雅制药公司 | 吡铂的口服制剂 |
| US20110053879A1 (en) * | 2008-02-08 | 2011-03-03 | Poniard Pharmaceuticals, Inc. | Picoplatin and amrubicin to treat lung cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57123198A (en) * | 1981-01-23 | 1982-07-31 | Shionogi & Co Ltd | Novel platinum complex |
| HU193809B (en) * | 1984-09-12 | 1987-12-28 | Chugai Pharmaceutical Co Ltd | Process for producing new platinum complexes |
-
1987
- 1987-12-18 US US07/135,061 patent/US4902797A/en not_active Expired - Fee Related
- 1987-12-18 AT AT87118819T patent/ATE73814T1/de not_active IP Right Cessation
- 1987-12-18 KR KR1019870014490A patent/KR900003457B1/ko not_active IP Right Cessation
- 1987-12-18 ES ES198787118819T patent/ES2032430T3/es not_active Expired - Lifetime
- 1987-12-18 CA CA000554853A patent/CA1327039C/en not_active Expired - Fee Related
- 1987-12-18 DE DE8787118819T patent/DE3777583D1/de not_active Expired - Fee Related
- 1987-12-18 EP EP87118819A patent/EP0273315B1/en not_active Expired - Lifetime
-
1992
- 1992-05-18 GR GR920400958T patent/GR3004629T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1327039C (en) | 1994-02-15 |
| ES2032430T3 (es) | 1993-02-16 |
| EP0273315A1 (en) | 1988-07-06 |
| GR3004629T3 (ko) | 1993-04-28 |
| EP0273315B1 (en) | 1992-03-18 |
| DE3777583D1 (de) | 1992-04-23 |
| ATE73814T1 (de) | 1992-04-15 |
| US4902797A (en) | 1990-02-20 |
| KR900003457B1 (ko) | 1990-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 19941230 Year of fee payment: 6 |
|
| LAPS | Lapse due to unpaid annual fee |