KR880007552A - 암민-지환식아민-백금 착화합물 및 항 종양제 - Google Patents

암민-지환식아민-백금 착화합물 및 항 종양제 Download PDF

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KR880007552A
KR880007552A KR870014490A KR870014490A KR880007552A KR 880007552 A KR880007552 A KR 880007552A KR 870014490 A KR870014490 A KR 870014490A KR 870014490 A KR870014490 A KR 870014490A KR 880007552 A KR880007552 A KR 880007552A
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South Korea
Prior art keywords
alkyl
ammine
antitumor agents
integer
hydrogen
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KR870014490A
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English (en)
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KR900003457B1 (ko
Inventor
데쓰시 도따니
가쓰도시 아오노
야스꼬 아다찌
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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Publication of KR880007552A publication Critical patent/KR880007552A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

암민-지환식아민-백금 착화합물 및 항 종양제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기식(Ⅰ)로 표시되는 화합물 :
    (상기식에서 R은 C1∼C5알킬, 히드록시, 카르복시, C1∼C5알콕시, 할로겐 또는 옥소이고 ; m은 2∼7의 정수이고 ; X및 Y는 각각 염소 또는 니트레이토 리간드이거나 또는 함께 -OCOCH(R1)O-, OCOCOO-,또는를 형성하는데 ; 여기서, R1은 수소, C1∼C5알킬, 히드록시메틸, 할로메틸 또는 페닐이고 ; R2는 수소 또는 C1∼C5알킬이고 ; n은 2∼5의 정수임).
  2. 제1항에 있어서, (암민)(글리콜레이토-0.0′)(피페리딘)백금(Ⅱ)인 화합물.
  3. 제1항에 특허청구된 화합물의 약리학적 유효량과 약학적으로 허용되는 담체, 희석제 및/또는 부형제로 이루어진 약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870014490A 1986-12-18 1987-12-18 암민-지환식아민-백금 착화합물 및 항종양제 KR900003457B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61-303529 1986-12-18
JP303529/86 1986-12-18
JP30352986 1986-12-18

Publications (2)

Publication Number Publication Date
KR880007552A true KR880007552A (ko) 1988-08-27
KR900003457B1 KR900003457B1 (ko) 1990-05-19

Family

ID=17922086

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870014490A KR900003457B1 (ko) 1986-12-18 1987-12-18 암민-지환식아민-백금 착화합물 및 항종양제

Country Status (8)

Country Link
US (1) US4902797A (ko)
EP (1) EP0273315B1 (ko)
KR (1) KR900003457B1 (ko)
AT (1) ATE73814T1 (ko)
CA (1) CA1327039C (ko)
DE (1) DE3777583D1 (ko)
ES (1) ES2032430T3 (ko)
GR (1) GR3004629T3 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970324A (en) * 1985-12-24 1990-11-13 Hoeschele James D Aminoalkyl-substituted azetidine platinum(II) complexes
JPH01294683A (ja) * 1988-02-04 1989-11-28 Kanebo Ltd 新規白金錯体および該化合物を有効成分とする抗腫瘍剤並びに該化合物製造用中間体
DE3834098A1 (de) * 1988-10-07 1990-04-19 Behringwerke Ag Cis-platin-komplexe mit einem 1,3-diaminopropan-derivat als liganden, verfahren zu ihrer herstellung und diese verbindung enthaltende pharmazeutische mittel
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
CZ288406B6 (en) * 1998-05-27 2001-06-13 Lachema Np Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6806289B1 (en) * 2000-07-14 2004-10-19 Stephen J. Lippard Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
CA2456348A1 (en) * 2001-08-23 2003-03-06 Yechezkel Barenholz Platinum complexes and their uses in therapy
US7271161B2 (en) * 2002-09-11 2007-09-18 Board Of Regents, The University Of Texas System Platinum complexes as antitumor agents in combination with biochemical modulation
ES2257178B1 (es) * 2004-09-30 2007-08-16 Universidad Autonoma De Madrid Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral.
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
WO2009011861A1 (en) * 2007-07-16 2009-01-22 Poniard Pharmaceuticals, Inc. Oral formulations for picoplatin
WO2009099634A2 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Picoplatin and amrubicin to treat lung cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123198A (en) * 1981-01-23 1982-07-31 Shionogi & Co Ltd Novel platinum complex
HU193809B (en) * 1984-09-12 1987-12-28 Chugai Pharmaceutical Co Ltd Process for producing new platinum complexes

Also Published As

Publication number Publication date
EP0273315B1 (en) 1992-03-18
US4902797A (en) 1990-02-20
ATE73814T1 (de) 1992-04-15
CA1327039C (en) 1994-02-15
EP0273315A1 (en) 1988-07-06
GR3004629T3 (ko) 1993-04-28
ES2032430T3 (es) 1993-02-16
KR900003457B1 (ko) 1990-05-19
DE3777583D1 (de) 1992-04-23

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