ES2032430T3 - Un procedimiento para la preparacion de nuevos complejos amina-platino ammina-aliciclicos que muestran potentes actividades antitumorales. - Google Patents

Un procedimiento para la preparacion de nuevos complejos amina-platino ammina-aliciclicos que muestran potentes actividades antitumorales.

Info

Publication number
ES2032430T3
ES2032430T3 ES198787118819T ES87118819T ES2032430T3 ES 2032430 T3 ES2032430 T3 ES 2032430T3 ES 198787118819 T ES198787118819 T ES 198787118819T ES 87118819 T ES87118819 T ES 87118819T ES 2032430 T3 ES2032430 T3 ES 2032430T3
Authority
ES
Spain
Prior art keywords
alicyclic
complexes
procedure
preparation
tumor activities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787118819T
Other languages
English (en)
Inventor
Tetsushi Totani
Katsutoshi Aono
Yasuko Adachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2032430T3 publication Critical patent/ES2032430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System

Abstract

SE PRESENTA UN COMPUESTO DE FORMULA (I) DONDE R ES ALQUILO C1-C5, HIDROXI, CARBOXI, ALCOXI C1-C5, HALOGENO U OXO; M ES UN ENTERO DE 2 A 7; X E Y ES, CADA UNO, UN LIGANDO DE CLORO O NITRATO, O BIEN, TOMADOS JUNTOS, FORMAN (II), (III) O (IV) (DONDE R1 ES HIDROGENO, ALQUILO C1-C5, HIDROXIMETILO, HALOGENOMETILO O FENILO; R2 ES HIDROGENO O ALQUILO C1-C5; Y N ES UN ENTERO DE 2 A 5). ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTITUMORALES.
ES198787118819T 1986-12-18 1987-12-18 Un procedimiento para la preparacion de nuevos complejos amina-platino ammina-aliciclicos que muestran potentes actividades antitumorales. Expired - Lifetime ES2032430T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30352986 1986-12-18

Publications (1)

Publication Number Publication Date
ES2032430T3 true ES2032430T3 (es) 1993-02-16

Family

ID=17922086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787118819T Expired - Lifetime ES2032430T3 (es) 1986-12-18 1987-12-18 Un procedimiento para la preparacion de nuevos complejos amina-platino ammina-aliciclicos que muestran potentes actividades antitumorales.

Country Status (8)

Country Link
US (1) US4902797A (es)
EP (1) EP0273315B1 (es)
KR (1) KR900003457B1 (es)
AT (1) ATE73814T1 (es)
CA (1) CA1327039C (es)
DE (1) DE3777583D1 (es)
ES (1) ES2032430T3 (es)
GR (1) GR3004629T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970324A (en) * 1985-12-24 1990-11-13 Hoeschele James D Aminoalkyl-substituted azetidine platinum(II) complexes
JPH01294683A (ja) * 1988-02-04 1989-11-28 Kanebo Ltd 新規白金錯体および該化合物を有効成分とする抗腫瘍剤並びに該化合物製造用中間体
DE3834098A1 (de) * 1988-10-07 1990-04-19 Behringwerke Ag Cis-platin-komplexe mit einem 1,3-diaminopropan-derivat als liganden, verfahren zu ihrer herstellung und diese verbindung enthaltende pharmazeutische mittel
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
CZ288406B6 (en) * 1998-05-27 2001-06-13 Lachema Np Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6806289B1 (en) * 2000-07-14 2004-10-19 Stephen J. Lippard Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
ATE457992T1 (de) * 2001-08-23 2010-03-15 Yissum Res Dev Co Platinkomplexe und deren verwendung in der therapie
EP1536864A2 (en) * 2002-09-11 2005-06-08 Board Of Regents The University Of Texas System Platinum complexes as antitumor agents in combination with biochemical modulation
ES2257178B1 (es) * 2004-09-30 2007-08-16 Universidad Autonoma De Madrid Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral.
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
CN101809024A (zh) * 2007-07-16 2010-08-18 铂雅制药公司 吡铂的口服制剂
EP2249644A4 (en) * 2008-02-08 2012-05-30 Poniard Pharmaceuticals Inc PICOPLATIN AND AMRUBICIN USEFUL IN THE TREATMENT OF LUNG CANCER

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123198A (en) * 1981-01-23 1982-07-31 Shionogi & Co Ltd Novel platinum complex
HU193809B (en) * 1984-09-12 1987-12-28 Chugai Pharmaceutical Co Ltd Process for producing new platinum complexes

Also Published As

Publication number Publication date
KR880007552A (ko) 1988-08-27
EP0273315B1 (en) 1992-03-18
EP0273315A1 (en) 1988-07-06
ATE73814T1 (de) 1992-04-15
DE3777583D1 (de) 1992-04-23
GR3004629T3 (es) 1993-04-28
CA1327039C (en) 1994-02-15
US4902797A (en) 1990-02-20
KR900003457B1 (ko) 1990-05-19

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