ES2143974T3 - Analogos de prostaglandina i. - Google Patents

Analogos de prostaglandina i.

Info

Publication number
ES2143974T3
ES2143974T3 ES90305046T ES90305046T ES2143974T3 ES 2143974 T3 ES2143974 T3 ES 2143974T3 ES 90305046 T ES90305046 T ES 90305046T ES 90305046 T ES90305046 T ES 90305046T ES 2143974 T3 ES2143974 T3 ES 2143974T3
Authority
ES
Spain
Prior art keywords
group
prostaglandina
analogs
alkyl group
prostagrandine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90305046T
Other languages
English (en)
Inventor
Ryuzo Ueno
Ryuji Ueno
Tomio Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R Tech Ueno Ltd
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Application granted granted Critical
Publication of ES2143974T3 publication Critical patent/ES2143974T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS ANALOGOS I DE POSTAGRANDINA REPRESENTADOS POR LA FORMULA GENERAL (I) Y (II). EN DONDE R SUB 1 ES UN ATOMO DE HIDROGENO O UN GRUPO DE ALQUILO, POR LO MENOS UN R SUB 2 Y/O R'' SUB 2 SON UN ATOMO DE HALOGENO, UN GRUPO DE ALQUILO, UN GRUPO QUE CONTIENE UN GRUPO AROMATICO, UN GRUPO HIDROXILO O UN GRUPO ALCOXI SIEMPRE QUE R SUB 2 Y R'' SUB 2 NO SEAN ATOMOS DE HIDROGENO AL MISMO TIEMPO O UNA SAL DE LOS MISMOS, CUYO COMPUESTO ES BUENO COMO HIPOTENSIVOS.
ES90305046T 1988-09-16 1990-05-10 Analogos de prostaglandina i. Expired - Lifetime ES2143974T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8821817A GB2225573A (en) 1988-09-16 1988-09-16 13,14-dihydro-15-keto-PGFs
JP63286274A JPH0791218B2 (ja) 1988-09-16 1988-11-10 新規プロスタグランジンｉ類

Publications (1)

Publication Number Publication Date
ES2143974T3 true ES2143974T3 (es) 2000-06-01

Family

ID=40130684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90305046T Expired - Lifetime ES2143974T3 (es) 1988-09-16 1990-05-10 Analogos de prostaglandina i.

Country Status (9)

Country Link
EP (1) EP0455899B1 (es)
JP (1) JPH0791218B2 (es)
KR (1) KR950005777B1 (es)
AT (1) ATE189813T1 (es)
DE (1) DE69033459T2 (es)
DK (1) DK0455899T3 (es)
ES (1) ES2143974T3 (es)
GB (1) GB2225573A (es)
GR (1) GR3033353T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5107014A (en) * 1990-05-10 1992-04-21 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandin I analogue

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505386A (en) * 1965-12-29 1970-04-07 Upjohn Co Compounds related to prostaglandins
US3435053A (en) * 1966-06-06 1969-03-25 Upjohn Co Cyclopenta(b)pyrans
US4053467A (en) * 1974-07-03 1977-10-11 American Home Products Corporation Prostaglandin derivatives
DE2517771A1 (de) * 1975-04-18 1976-10-28 Schering Ag Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung
US4089885A (en) * 1976-11-05 1978-05-16 American Home Products Corporation Prostaglandin derivatives
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2
IT1113341B (it) * 1978-03-31 1986-01-20 Ono Pharmaceutical Co Analoghi della 6,9-metano-pgi2
EP0134153B1 (en) * 1983-08-19 1989-04-19 Sagami Chemical Research Center Bicyclo[3.3.0]octane derivative and preparation thereof

Also Published As

Publication number Publication date
DE69033459D1 (de) 2000-03-23
KR950005777B1 (ko) 1995-05-30
GR3033353T3 (en) 2000-09-29
DE69033459T2 (de) 2000-06-15
JPH02131446A (ja) 1990-05-21
JPH0791218B2 (ja) 1995-10-04
EP0455899B1 (en) 2000-02-16
KR910019969A (ko) 1991-12-19
DK0455899T3 (da) 2000-06-05
GB2225573A (en) 1990-06-06
EP0455899A1 (en) 1991-11-13
ATE189813T1 (de) 2000-03-15
GB8821817D0 (en) 1988-10-19

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