ES2054806T3 - Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas. - Google Patents
Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas.Info
- Publication number
- ES2054806T3 ES2054806T3 ES88305408T ES88305408T ES2054806T3 ES 2054806 T3 ES2054806 T3 ES 2054806T3 ES 88305408 T ES88305408 T ES 88305408T ES 88305408 T ES88305408 T ES 88305408T ES 2054806 T3 ES2054806 T3 ES 2054806T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- substituted
- ergolins
- cyclloalkylamides
- 8beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ESTA INVENCION FACILITA (8 BETA)-1-ALQUIL-6-ERGOLINAS (SUSTITUIDA)-8-CARBOXAMIDAS DE LA FORMULA (I) DONDE R1 ES ALQUILO C1-C4; R2 ES ARILO O ALQUILO C1-C4 DE CADENA LINEAL; R3 ES HIDROGENO O ALQUILO C1-C4 DE CADENA LINEAL; R4 ES HIDROGENO, ALQUILO C1-C4, HIDROXI O ALCOXI C1-C4, M ES 0,1,2 O 3 O UNA SAL FARMACEUTICAMENTE ACEPTABLE DELOS MISMOS. LOS COMPUESTOS SON UTILES PARA BLOQUEAR LOS RECEPTORES 5HT2 DE LOS MAMIFEROS QUE TENGAN UN EXCESO DE SEROTINA CENTRAL O PERIFERICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6228587A | 1987-06-15 | 1987-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2054806T3 true ES2054806T3 (es) | 1994-08-16 |
Family
ID=22041482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88305408T Expired - Lifetime ES2054806T3 (es) | 1987-06-15 | 1988-06-14 | Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0296748B1 (es) |
JP (1) | JP2653835B2 (es) |
KR (1) | KR960010454B1 (es) |
CN (1) | CN1019451B (es) |
AT (1) | ATE87921T1 (es) |
AU (1) | AU613641B2 (es) |
CA (1) | CA1339661C (es) |
DE (1) | DE3880022T2 (es) |
DK (1) | DK322588A (es) |
EG (1) | EG18586A (es) |
ES (1) | ES2054806T3 (es) |
HK (1) | HK77693A (es) |
HU (2) | HU203344B (es) |
IE (1) | IE61884B1 (es) |
IL (1) | IL86725A (es) |
MX (1) | MX11866A (es) |
NZ (1) | NZ225022A (es) |
PH (1) | PH24309A (es) |
PT (1) | PT87716B (es) |
SU (1) | SU1597103A3 (es) |
UA (1) | UA6022A1 (es) |
ZA (1) | ZA884222B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4902691A (en) * | 1988-12-19 | 1990-02-20 | Eli Lilly And Company | Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors |
IT1232692B (it) * | 1989-08-04 | 1992-03-04 | Poli Ind Chimica Spa | Derivati ergolinici con attivita' dopaminergica |
US5043341A (en) * | 1990-04-11 | 1991-08-27 | Eli Lilly And Company | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides |
US5141944A (en) * | 1990-04-11 | 1992-08-25 | Eli Lilly And Company | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides |
JPH11503757A (ja) * | 1995-04-18 | 1999-03-30 | イーライ・リリー・アンド・カンパニー | 5−ht▲下7▼レセプターにおいて生理学的および病理学的機能を生じるエルゴリン化合物の使用方法 |
US5880134A (en) * | 1996-03-20 | 1999-03-09 | Eli Lilly And Company | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor |
EP0961148B1 (en) | 1998-05-26 | 2010-07-21 | Canon Kabushiki Kaisha | Camera with focus detecting device |
EP2515654A4 (en) | 2009-12-23 | 2013-04-24 | Map Pharmaceuticals Inc | NEW ERGOLINANALOGA |
CN102775402B (zh) * | 2011-05-13 | 2015-08-26 | 上海现代制药股份有限公司 | 一种制备二氢麦角酸的中间体及其制备方法 |
KR20140042868A (ko) | 2011-06-23 | 2014-04-07 | 맵 파마슈티컬스, 인코포레이티드 | 신규한 플루오로에르골린 유사체 |
EP2793580A4 (en) | 2011-12-19 | 2015-05-20 | Map Pharmaceuticals Inc | NEW DERIVATIVES OF ISO-ERGOLINE |
AU2012355983A1 (en) | 2011-12-21 | 2015-01-22 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH386441A (de) * | 1961-02-17 | 1965-01-15 | Sandoz Ag | Verfahren zur Herstellung von am Indolstickstoff substituierten Derivaten der Lysergsäure-Reihe |
GB982737A (en) * | 1961-05-08 | 1965-02-10 | Westminster Bank Ltd | Improvements in or relating to lysergic acid compounds |
GB996062A (en) * | 1961-07-13 | 1965-06-23 | Westminster Bank Ltd | Improvements in or relating to lysergic acid compounds |
-
1988
- 1988-06-13 MX MX1186688A patent/MX11866A/es unknown
- 1988-06-13 PH PH37059A patent/PH24309A/en unknown
- 1988-06-13 ZA ZA884222A patent/ZA884222B/xx unknown
- 1988-06-13 CA CA000569291A patent/CA1339661C/en not_active Expired - Fee Related
- 1988-06-13 EG EG332/88A patent/EG18586A/xx active
- 1988-06-13 IL IL86725A patent/IL86725A/xx not_active IP Right Cessation
- 1988-06-14 JP JP63146689A patent/JP2653835B2/ja not_active Expired - Lifetime
- 1988-06-14 NZ NZ225022A patent/NZ225022A/xx unknown
- 1988-06-14 KR KR1019880007099A patent/KR960010454B1/ko not_active IP Right Cessation
- 1988-06-14 DE DE8888305408T patent/DE3880022T2/de not_active Expired - Fee Related
- 1988-06-14 CN CN88103627A patent/CN1019451B/zh not_active Expired
- 1988-06-14 SU SU884355904A patent/SU1597103A3/ru active
- 1988-06-14 PT PT87716A patent/PT87716B/pt not_active IP Right Cessation
- 1988-06-14 AT AT88305408T patent/ATE87921T1/de not_active IP Right Cessation
- 1988-06-14 UA UA4355904A patent/UA6022A1/uk unknown
- 1988-06-14 IE IE178888A patent/IE61884B1/en unknown
- 1988-06-14 AU AU17652/88A patent/AU613641B2/en not_active Ceased
- 1988-06-14 ES ES88305408T patent/ES2054806T3/es not_active Expired - Lifetime
- 1988-06-14 DK DK322588A patent/DK322588A/da not_active Application Discontinuation
- 1988-06-14 EP EP88305408A patent/EP0296748B1/en not_active Expired - Lifetime
- 1988-06-14 HU HU883047A patent/HU203344B/hu not_active IP Right Cessation
-
1993
- 1993-08-05 HK HK776/93A patent/HK77693A/xx not_active IP Right Cessation
-
1995
- 1995-06-22 HU HU95P/P00405P patent/HU211235A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
CN1019451B (zh) | 1992-12-16 |
AU613641B2 (en) | 1991-08-08 |
JPS6416781A (en) | 1989-01-20 |
KR890000482A (ko) | 1989-03-14 |
CN1030586A (zh) | 1989-01-25 |
NZ225022A (en) | 1990-07-26 |
MX11866A (es) | 1993-12-01 |
JP2653835B2 (ja) | 1997-09-17 |
EP0296748A1 (en) | 1988-12-28 |
ZA884222B (en) | 1990-02-28 |
ATE87921T1 (de) | 1993-04-15 |
SU1597103A3 (ru) | 1990-09-30 |
HU203344B (en) | 1991-07-29 |
IL86725A (en) | 1993-01-14 |
EG18586A (en) | 1993-08-30 |
CA1339661C (en) | 1998-02-10 |
PH24309A (en) | 1990-05-29 |
HUT47271A (en) | 1989-02-28 |
IE881788L (en) | 1988-12-15 |
HK77693A (en) | 1993-08-13 |
UA6022A1 (uk) | 1994-12-29 |
PT87716A (pt) | 1988-07-01 |
IE61884B1 (en) | 1994-11-30 |
DE3880022T2 (de) | 1993-08-19 |
IL86725A0 (en) | 1988-11-30 |
DE3880022D1 (de) | 1993-05-13 |
EP0296748B1 (en) | 1993-04-07 |
AU1765288A (en) | 1988-12-15 |
DK322588D0 (da) | 1988-06-14 |
KR960010454B1 (ko) | 1996-08-01 |
PT87716B (pt) | 1992-10-30 |
HU211235A9 (en) | 1995-11-28 |
DK322588A (da) | 1989-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0378518T3 (da) | Adenosinderivater med farmaceutisk aktivitet som antihypertensiva | |
PT918776E (pt) | Sintese total de acilfulvenos antitumorais | |
ES2054806T3 (es) | Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas. | |
ES2094772T3 (es) | Derivados de imidazonaftiridinas. | |
HK1004750A1 (en) | Bicyclic sulfonamide derivatives and their preparation their use and formulations containing them | |
GR3001955T3 (en) | N-phenethylaminoalkyl-benzamide anti-arrhythmia agents | |
GR3005444T3 (es) | ||
DK0420224T3 (da) | Anthihepatopatisk middel | |
EP0555479A4 (es) | ||
PT99043A (pt) | Processo para a preparacao de composicoes biocidas contendo derivados de 4,5-polimetileno-4-isotiazolin-3-onas | |
FI901277A0 (fi) | 2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ. | |
FI872997A (fi) | Amidderivat. | |
FR2598914B1 (fr) | Composition prophylactique et curative pour l'arteriosclerose | |
ES2143974T3 (es) | Analogos de prostaglandina i. | |
ES2053808T3 (es) | Nuevos compuestos azolicos. | |
FI821872A0 (fi) | N-/2-(2-amino-2-fenyletyl)fenyl/-2,2-dimetyl-propanamid och dess derivat samt foerfarande foer derasframstaellning | |
ATE100449T1 (de) | 1,3-dioxolan-benzoesaeure und derivate davon. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 296748 Country of ref document: ES |