ES2066000T3 - Compuestos derivados de pirimidinediona, metodo de produccion de los mismos y agentes antirritmicos que los contienen. - Google Patents
Compuestos derivados de pirimidinediona, metodo de produccion de los mismos y agentes antirritmicos que los contienen.Info
- Publication number
- ES2066000T3 ES2066000T3 ES89311135T ES89311135T ES2066000T3 ES 2066000 T3 ES2066000 T3 ES 2066000T3 ES 89311135 T ES89311135 T ES 89311135T ES 89311135 T ES89311135 T ES 89311135T ES 2066000 T3 ES2066000 T3 ES 2066000T3
- Authority
- ES
- Spain
- Prior art keywords
- pyrimidinediona
- antirhythmic
- production
- compounds derived
- agents containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
UN COMPUESTO DERIVADO DE PIRIMIDIONA TIENE UNA ESTRUCTURA BASICA EN LA CUAL UNA PARTE DE GRUPO FENILO Y UNA PARTE DE PIRIMIDINADIONA ESTAN ENLAZADOS POR UNA ESTRUCTURA COMPRENDIENDO UNA CADENA DE ALQUILO CONTENIENDO AL MENOS DOS ATOMOS DE NITROGENO. LOS DERIVADOS DE PIRIMIDINADIONA SE USAN PARA UN TRATAMIENTO MEDICO DE ARRITMIAS CARDIACAS. LA FORMULA GENERAL ES (1)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27199288 | 1988-10-29 | ||
JP30684188 | 1988-12-06 | ||
JP30684088 | 1988-12-06 | ||
JP9641889 | 1989-04-18 | ||
JP9641789 | 1989-04-18 | ||
JP9641689 | 1989-04-18 | ||
JP22927289 | 1989-09-06 | ||
JP24631789 | 1989-09-25 | ||
JP01246318 | 1989-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2066000T3 true ES2066000T3 (es) | 1995-03-01 |
Family
ID=27577291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89311135T Expired - Lifetime ES2066000T3 (es) | 1988-10-29 | 1989-10-27 | Compuestos derivados de pirimidinediona, metodo de produccion de los mismos y agentes antirritmicos que los contienen. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5008267A (es) |
EP (1) | EP0369627B1 (es) |
KR (1) | KR920002307B1 (es) |
AT (1) | ATE115952T1 (es) |
AU (1) | AU613805B2 (es) |
DE (1) | DE68920125T2 (es) |
DK (1) | DK170203B1 (es) |
ES (1) | ES2066000T3 (es) |
FI (1) | FI95245C (es) |
HU (1) | HU210780B (es) |
NO (1) | NO174711C (es) |
NZ (1) | NZ231165A (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308848A (en) * | 1989-10-24 | 1994-05-03 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione derivatives and antiarrythmic agents containing the same |
JPH03173885A (ja) * | 1989-12-01 | 1991-07-29 | Mitsui Toatsu Chem Inc | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 |
JPH0413669A (ja) * | 1990-04-27 | 1992-01-17 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤 |
DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
EP0640341A1 (en) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Sustained release pharmaceutical composition and process for producing same |
EP0697407B1 (en) | 1994-08-19 | 1997-06-25 | MITSUI TOATSU CHEMICALS, Inc. | Pyrimidinedione derivatives and antiarrhythmic compositions containing same |
EP0796251B1 (de) * | 1994-12-07 | 2001-10-17 | Byk Gulden Lomberg Chemische Fabrik GmbH | Uracilderivate |
EP0722732A1 (en) * | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Long-acting drug formulation containing pyrimidinedione derivatives |
DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) * | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6852761B2 (en) | 2000-03-13 | 2005-02-08 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
CA2405306A1 (en) * | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
ATE289299T1 (de) * | 2000-04-05 | 2005-03-15 | Pharmacia Corp | Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess |
AU2001253363A1 (en) * | 2000-04-17 | 2001-10-30 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
JP2004517074A (ja) * | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
ES2331513T3 (es) * | 2001-08-02 | 2010-01-07 | Sumitomo Chemical Company, Limited | Procedimiento para la produccion de compuestos de piridina. |
US20040068113A1 (en) * | 2001-11-20 | 2004-04-08 | South Michael S. | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
PT1778236E (pt) | 2004-07-02 | 2010-10-19 | Corcept Therapeutics Inc | Moduladores do receptor de glucocorticóide de pirimidina modificada |
JP6039587B2 (ja) | 2011-03-18 | 2016-12-07 | コーセプト セラピューティクス, インコーポレイテッド | ピリミジンシクロヘキシルグルココルチコイドレセプター調節因子 |
CN102617486B (zh) * | 2012-03-01 | 2014-04-16 | 江西吉翔医药化工有限公司 | 一种6-氯-1,3-二甲基脲嘧啶的制备方法 |
CN103288751B (zh) * | 2013-06-03 | 2016-04-20 | 四川百利药业有限责任公司 | 一种高纯度盐酸尼非卡兰的制备方法 |
CN105473576B (zh) | 2013-06-21 | 2018-10-30 | 迈奥卡迪亚公司 | 针对心脏病症的嘧啶二酮化合物 |
CA3102099C (en) | 2018-06-04 | 2023-09-26 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
CN111116492B (zh) * | 2019-01-25 | 2021-07-09 | 青岛吉澳医药科技有限公司 | 氘代苯甲氨嘧啶二酮衍生物及其用途 |
CN114929229A (zh) | 2019-12-11 | 2022-08-19 | 科赛普特治疗学股份有限公司 | 用米立可兰治疗抗精神病药导致的体重增加的方法 |
AU2021268944B2 (en) | 2020-05-06 | 2024-04-18 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
KR20230124020A (ko) | 2020-12-21 | 2023-08-24 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 피리미딘 시클로헥실 글루코코르티코이드 수용체 조절제의제조 방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE787103A (fr) * | 1971-08-04 | 1973-02-02 | Pfizer | Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant |
DE2329399A1 (de) * | 1973-06-08 | 1975-01-02 | Wuelfing J A Fa | 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
LU77339A1 (es) * | 1977-05-16 | 1979-01-19 | ||
JPH01175937A (ja) * | 1987-12-28 | 1989-07-12 | Mitsui Toatsu Chem Inc | 不整脈治療剤 |
-
1989
- 1989-10-24 US US07/425,730 patent/US5008267A/en not_active Expired - Lifetime
- 1989-10-26 NZ NZ231165A patent/NZ231165A/en unknown
- 1989-10-27 DE DE68920125T patent/DE68920125T2/de not_active Expired - Lifetime
- 1989-10-27 FI FI895121A patent/FI95245C/fi active IP Right Grant
- 1989-10-27 DK DK535789A patent/DK170203B1/da not_active IP Right Cessation
- 1989-10-27 AU AU43869/89A patent/AU613805B2/en not_active Expired
- 1989-10-27 NO NO894299A patent/NO174711C/no unknown
- 1989-10-27 EP EP89311135A patent/EP0369627B1/en not_active Expired - Lifetime
- 1989-10-27 AT AT89311135T patent/ATE115952T1/de not_active IP Right Cessation
- 1989-10-27 ES ES89311135T patent/ES2066000T3/es not_active Expired - Lifetime
- 1989-10-27 HU HU895468A patent/HU210780B/hu unknown
- 1989-10-28 KR KR1019890015569A patent/KR920002307B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK535789D0 (da) | 1989-10-27 |
EP0369627A3 (en) | 1990-12-12 |
AU613805B2 (en) | 1991-08-08 |
HUT52764A (en) | 1990-08-28 |
DE68920125D1 (de) | 1995-02-02 |
NO894299D0 (no) | 1989-10-27 |
EP0369627A2 (en) | 1990-05-23 |
NZ231165A (en) | 1992-02-25 |
DK170203B1 (da) | 1995-06-12 |
HU895468D0 (en) | 1990-01-28 |
NO174711C (no) | 1994-06-22 |
ATE115952T1 (de) | 1995-01-15 |
AU4386989A (en) | 1990-05-31 |
HU210780B (en) | 1995-07-28 |
DE68920125T2 (de) | 1995-08-03 |
FI895121A0 (fi) | 1989-10-27 |
FI95245C (fi) | 1996-01-10 |
EP0369627B1 (en) | 1994-12-21 |
NO174711B (no) | 1994-03-14 |
FI95245B (fi) | 1995-09-29 |
DK535789A (da) | 1990-04-30 |
KR900006300A (ko) | 1990-05-07 |
US5008267A (en) | 1991-04-16 |
NO894299L (no) | 1990-04-30 |
KR920002307B1 (ko) | 1992-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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