DE68920125D1 - Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel. - Google Patents

Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel.

Info

Publication number
DE68920125D1
DE68920125D1 DE68920125T DE68920125T DE68920125D1 DE 68920125 D1 DE68920125 D1 DE 68920125D1 DE 68920125 T DE68920125 T DE 68920125T DE 68920125 T DE68920125 T DE 68920125T DE 68920125 D1 DE68920125 D1 DE 68920125D1
Authority
DE
Germany
Prior art keywords
processes
preparation
pyrimidinedione
agents containing
antiarrhythmic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68920125T
Other languages
English (en)
Other versions
DE68920125T2 (de
Inventor
Tsutomu Katakami
Tatsuro Yokoyama
Michihiko Miyamoto
Haruki H- Mori
Nobuya Kawauchi
Tadahito Nobori
Kunio Sannohe
Joji Kamiya
Masaaki Ishii
Kanji Yoshihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Publication of DE68920125D1 publication Critical patent/DE68920125D1/de
Application granted granted Critical
Publication of DE68920125T2 publication Critical patent/DE68920125T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE68920125T 1988-10-29 1989-10-27 Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel. Expired - Lifetime DE68920125T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP27199288 1988-10-29
JP30684188 1988-12-06
JP30684088 1988-12-06
JP9641689 1989-04-18
JP9641789 1989-04-18
JP9641889 1989-04-18
JP22927289 1989-09-06
JP24631789 1989-09-25
JP01246318 1989-09-25

Publications (2)

Publication Number Publication Date
DE68920125D1 true DE68920125D1 (de) 1995-02-02
DE68920125T2 DE68920125T2 (de) 1995-08-03

Family

ID=27577291

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68920125T Expired - Lifetime DE68920125T2 (de) 1988-10-29 1989-10-27 Pyrimidindion-Derivate, Verfahren zu deren Herstellung und diese enthaltende antiarrythmische Mittel.

Country Status (12)

Country Link
US (1) US5008267A (de)
EP (1) EP0369627B1 (de)
KR (1) KR920002307B1 (de)
AT (1) ATE115952T1 (de)
AU (1) AU613805B2 (de)
DE (1) DE68920125T2 (de)
DK (1) DK170203B1 (de)
ES (1) ES2066000T3 (de)
FI (1) FI95245C (de)
HU (1) HU210780B (de)
NO (1) NO174711C (de)
NZ (1) NZ231165A (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308848A (en) * 1989-10-24 1994-05-03 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione derivatives and antiarrythmic agents containing the same
JPH03173885A (ja) * 1989-12-01 1991-07-29 Mitsui Toatsu Chem Inc ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤
JPH0413669A (ja) * 1990-04-27 1992-01-17 Mitsui Toatsu Chem Inc 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤
DE4032766A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
EP0640341A1 (de) * 1993-08-27 1995-03-01 Mitsui Toatsu Chemicals, Incorporated Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren
EP0697407B1 (de) 1994-08-19 1997-06-25 MITSUI TOATSU CHEMICALS, Inc. Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
JPH10510253A (ja) * 1994-12-07 1998-10-06 ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング ウラシル誘導体
EP0722732A1 (de) * 1995-01-24 1996-07-24 Mitsui Toatsu Chemicals, Inc. Pyrimidindionderivate enthaltendes Arzneimittel mit verlängerter Wirkstoffabgabe
DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
US6906068B1 (en) 1999-05-19 2005-06-14 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants
US6664255B1 (en) * 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6653316B1 (en) * 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) * 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6660885B2 (en) * 2000-03-13 2003-12-09 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
DE60108948T2 (de) 2000-04-05 2005-11-03 Pharmacia Corp. Polyzyclisch aryl und heteroaryl substituierte 4-pyronen verwendbar als selektive hemmung von dem koagulationsprozess
EP1268428A2 (de) 2000-04-05 2003-01-02 Pharmacia Corporation Polyzyklische aryl und heteroaryl substituierte 4-pyridon-derivate verwendbar zur selektiven hemmung der blutgerinnungskaskade
CA2405684A1 (en) * 2000-04-17 2001-10-25 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
JP2004517074A (ja) * 2000-11-20 2004-06-10 ファルマシア・コーポレーション 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類
DE60233664D1 (de) * 2001-08-02 2009-10-22 Sumitomo Chemical Co Verfahren zur herstellung von pyridinverbindungen
US20040068113A1 (en) * 2001-11-20 2004-04-08 South Michael S. Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
DK1778236T3 (da) 2004-07-02 2010-10-25 Corcept Therapeutics Inc Modificerede pyrimidin-glucocorticoid-receptor-modulatorer
SG193509A1 (en) 2011-03-18 2013-10-30 Corcept Therapeutics Inc Pyrimidine cyclohexyl glucocorticoid receptor modulators
CN102617486B (zh) * 2012-03-01 2014-04-16 江西吉翔医药化工有限公司 一种6-氯-1,3-二甲基脲嘧啶的制备方法
CN103288751B (zh) * 2013-06-03 2016-04-20 四川百利药业有限责任公司 一种高纯度盐酸尼非卡兰的制备方法
TN2015000553A1 (en) * 2013-06-21 2017-04-06 Myokardia Inc Pyrimidinedione compounds against cardiac conditions
MX2020012831A (es) 2018-06-04 2021-04-28 Corcept Therapeutics Inc Moduladores del receptor de glucocorticoide de pirimidina ciclohexenilo.
CN111116492B (zh) 2019-01-25 2021-07-09 青岛吉澳医药科技有限公司 氘代苯甲氨嘧啶二酮衍生物及其用途
CA3158745A1 (en) 2019-12-11 2021-06-17 Corcept Therapeutics Incorporated Methods of treating antipsychotic-induced weight gain with miricorilant
AU2021268944B2 (en) 2020-05-06 2024-04-18 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
JP2024503244A (ja) 2020-12-21 2024-01-25 コーセプト セラピューティクス， インコーポレイテッド ピリミジンシクロヘキシルグルココルチコイド受容体調節因子を調製する方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787103A (fr) * 1971-08-04 1973-02-02 Pfizer Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
DE2329399A1 (de) * 1973-06-08 1975-01-02 Wuelfing J A Fa 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
LU77339A1 (de) * 1977-05-16 1979-01-19
JPH01175937A (ja) * 1987-12-28 1989-07-12 Mitsui Toatsu Chem Inc 不整脈治療剤

Also Published As

Publication number Publication date
ES2066000T3 (es) 1995-03-01
US5008267A (en) 1991-04-16
DK170203B1 (da) 1995-06-12
NO174711B (no) 1994-03-14
FI95245B (fi) 1995-09-29
FI95245C (fi) 1996-01-10
EP0369627B1 (de) 1994-12-21
NO894299D0 (no) 1989-10-27
KR900006300A (ko) 1990-05-07
DE68920125T2 (de) 1995-08-03
NZ231165A (en) 1992-02-25
AU613805B2 (en) 1991-08-08
HU210780B (en) 1995-07-28
DK535789D0 (da) 1989-10-27
NO174711C (no) 1994-06-22
NO894299L (no) 1990-04-30
HUT52764A (en) 1990-08-28
DK535789A (da) 1990-04-30
EP0369627A2 (de) 1990-05-23
FI895121A0 (fi) 1989-10-27
KR920002307B1 (ko) 1992-03-21
HU895468D0 (en) 1990-01-28
EP0369627A3 (en) 1990-12-12
AU4386989A (en) 1990-05-31
ATE115952T1 (de) 1995-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP

8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE