DK170203B1 - Pyrimidindionderivater, fremgangsmåde til fremstilling heraf og antiarrhythmika omfattende samme - Google Patents
Pyrimidindionderivater, fremgangsmåde til fremstilling heraf og antiarrhythmika omfattende samme Download PDFInfo
- Publication number
- DK170203B1 DK170203B1 DK535789A DK535789A DK170203B1 DK 170203 B1 DK170203 B1 DK 170203B1 DK 535789 A DK535789 A DK 535789A DK 535789 A DK535789 A DK 535789A DK 170203 B1 DK170203 B1 DK 170203B1
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- dimethyl
- pyrimidinedione
- group
- nitrophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27199288 | 1988-10-29 | ||
| JP27199288 | 1988-10-29 | ||
| JP30684188 | 1988-12-06 | ||
| JP30684188 | 1988-12-06 | ||
| JP30684088 | 1988-12-06 | ||
| JP30684088 | 1988-12-06 | ||
| JP9641689 | 1989-04-18 | ||
| JP9641789 | 1989-04-18 | ||
| JP9641889 | 1989-04-18 | ||
| JP9641889 | 1989-04-18 | ||
| JP9641789 | 1989-04-18 | ||
| JP9641689 | 1989-04-18 | ||
| JP22927289 | 1989-09-06 | ||
| JP22927289 | 1989-09-06 | ||
| JP24631789 | 1989-09-25 | ||
| JP24631889 | 1989-09-25 | ||
| JP01246318 | 1989-09-25 | ||
| JP24631789 | 1989-09-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK535789D0 DK535789D0 (da) | 1989-10-27 |
| DK535789A DK535789A (da) | 1990-04-30 |
| DK170203B1 true DK170203B1 (da) | 1995-06-12 |
Family
ID=27577291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK535789A DK170203B1 (da) | 1988-10-29 | 1989-10-27 | Pyrimidindionderivater, fremgangsmåde til fremstilling heraf og antiarrhythmika omfattende samme |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5008267A (de) |
| EP (1) | EP0369627B1 (de) |
| KR (1) | KR920002307B1 (de) |
| AT (1) | ATE115952T1 (de) |
| AU (1) | AU613805B2 (de) |
| DE (1) | DE68920125T2 (de) |
| DK (1) | DK170203B1 (de) |
| ES (1) | ES2066000T3 (de) |
| FI (1) | FI95245C (de) |
| HU (1) | HU210780B (de) |
| NO (1) | NO174711C (de) |
| NZ (1) | NZ231165A (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308848A (en) * | 1989-10-24 | 1994-05-03 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione derivatives and antiarrythmic agents containing the same |
| JPH03173885A (ja) * | 1989-12-01 | 1991-07-29 | Mitsui Toatsu Chem Inc | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 |
| JPH0413669A (ja) * | 1990-04-27 | 1992-01-17 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤 |
| DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
| EP0640341A1 (de) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren |
| DE69500377T2 (de) | 1994-08-19 | 1997-10-09 | Mitsui Toatsu Chemicals | Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen |
| DE59509727D1 (de) * | 1994-12-07 | 2001-11-22 | Byk Gulden Lomberg Chem Fab | Uracilderivate |
| EP0722732A1 (de) * | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Pyrimidindionderivate enthaltendes Arzneimittel mit verlängerter Wirkstoffabgabe |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6653316B1 (en) * | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
| US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| US6693121B2 (en) | 2000-04-05 | 2004-02-17 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| AU2001249870A1 (en) * | 2000-04-05 | 2001-10-23 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| WO2001079155A2 (en) * | 2000-04-17 | 2001-10-25 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| WO2002042272A2 (en) * | 2000-11-20 | 2002-05-30 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| MXPA04001041A (es) * | 2001-08-02 | 2004-05-27 | Sumitomo Chemical Co | Procedimiento para producir compuestos de piridina. |
| US20040068113A1 (en) * | 2001-11-20 | 2004-04-08 | South Michael S. | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| NZ552984A (en) | 2004-07-02 | 2010-06-25 | Corcept Therapeutics Inc | Modified pyrimidine glucocorticoid receptor modulators |
| AU2012231265B2 (en) | 2011-03-18 | 2016-07-07 | Corcept Therapeutics, Inc. | Pyrimidine cyclohexyl glucocorticoid receptor modulators |
| CN102617486B (zh) * | 2012-03-01 | 2014-04-16 | 江西吉翔医药化工有限公司 | 一种6-氯-1,3-二甲基脲嘧啶的制备方法 |
| CN103288751B (zh) * | 2013-06-03 | 2016-04-20 | 四川百利药业有限责任公司 | 一种高纯度盐酸尼非卡兰的制备方法 |
| LT3010910T (lt) | 2013-06-21 | 2020-03-10 | MyoKardia, Inc. | Pirimidindiono junginiai, skirti širdies ligoms |
| WO2019236487A1 (en) | 2018-06-04 | 2019-12-12 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
| WO2020151605A1 (zh) * | 2019-01-25 | 2020-07-30 | 青岛吉澳医药科技有限公司 | 氘代苯甲氨嘧啶二酮衍生物及其用途 |
| US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| CA3182272A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| CA3202353A1 (en) | 2020-12-21 | 2022-06-30 | Jeffrey Mark Dener | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787103A (fr) * | 1971-08-04 | 1973-02-02 | Pfizer | Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant |
| DE2329399A1 (de) * | 1973-06-08 | 1975-01-02 | Wuelfing J A Fa | 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| LU77339A1 (de) * | 1977-05-16 | 1979-01-19 | ||
| JPH01175937A (ja) * | 1987-12-28 | 1989-07-12 | Mitsui Toatsu Chem Inc | 不整脈治療剤 |
-
1989
- 1989-10-24 US US07/425,730 patent/US5008267A/en not_active Expired - Lifetime
- 1989-10-26 NZ NZ231165A patent/NZ231165A/en unknown
- 1989-10-27 AU AU43869/89A patent/AU613805B2/en not_active Expired
- 1989-10-27 DK DK535789A patent/DK170203B1/da not_active IP Right Cessation
- 1989-10-27 AT AT89311135T patent/ATE115952T1/de not_active IP Right Cessation
- 1989-10-27 FI FI895121A patent/FI95245C/fi active IP Right Grant
- 1989-10-27 HU HU895468A patent/HU210780B/hu unknown
- 1989-10-27 ES ES89311135T patent/ES2066000T3/es not_active Expired - Lifetime
- 1989-10-27 NO NO894299A patent/NO174711C/no unknown
- 1989-10-27 EP EP89311135A patent/EP0369627B1/de not_active Expired - Lifetime
- 1989-10-27 DE DE68920125T patent/DE68920125T2/de not_active Expired - Lifetime
- 1989-10-28 KR KR1019890015569A patent/KR920002307B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ231165A (en) | 1992-02-25 |
| ES2066000T3 (es) | 1995-03-01 |
| AU613805B2 (en) | 1991-08-08 |
| ATE115952T1 (de) | 1995-01-15 |
| DE68920125D1 (de) | 1995-02-02 |
| DE68920125T2 (de) | 1995-08-03 |
| FI895121A0 (fi) | 1989-10-27 |
| HU895468D0 (en) | 1990-01-28 |
| EP0369627B1 (de) | 1994-12-21 |
| FI95245C (fi) | 1996-01-10 |
| HUT52764A (en) | 1990-08-28 |
| EP0369627A3 (en) | 1990-12-12 |
| DK535789D0 (da) | 1989-10-27 |
| NO174711C (no) | 1994-06-22 |
| FI95245B (fi) | 1995-09-29 |
| DK535789A (da) | 1990-04-30 |
| KR920002307B1 (ko) | 1992-03-21 |
| NO174711B (no) | 1994-03-14 |
| US5008267A (en) | 1991-04-16 |
| NO894299L (no) | 1990-04-30 |
| NO894299D0 (no) | 1989-10-27 |
| HU210780B (en) | 1995-07-28 |
| EP0369627A2 (de) | 1990-05-23 |
| AU4386989A (en) | 1990-05-31 |
| KR900006300A (ko) | 1990-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |