ATE115952T1 - Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel. - Google Patents

Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel.

Info

Publication number
ATE115952T1
ATE115952T1 AT89311135T AT89311135T ATE115952T1 AT E115952 T1 ATE115952 T1 AT E115952T1 AT 89311135 T AT89311135 T AT 89311135T AT 89311135 T AT89311135 T AT 89311135T AT E115952 T1 ATE115952 T1 AT E115952T1
Authority
AT
Austria
Prior art keywords
pyrimidindone
derivatives
production
agents containing
containing same
Prior art date
Application number
AT89311135T
Other languages
English (en)
Inventor
Tsutomu Katakami
Tatsuro Yokoyama
Michihiko Miyamoto
Haruki H- Nyuraifu Kanaza Mori
Kanazawa-Ku
Nobuya Kawauchi
Tadahito Nobori
Kunio Sannohe
Joji Kamiya
Masaaki Ishii
Kanji Yoshihara
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Application granted granted Critical
Publication of ATE115952T1 publication Critical patent/ATE115952T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT89311135T 1988-10-29 1989-10-27 Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel. ATE115952T1 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP27199288 1988-10-29
JP30684088 1988-12-06
JP30684188 1988-12-06
JP9641789 1989-04-18
JP9641889 1989-04-18
JP9641689 1989-04-18
JP22927289 1989-09-06
JP01246318 1989-09-25
JP24631789 1989-09-25

Publications (1)

Publication Number Publication Date
ATE115952T1 true ATE115952T1 (de) 1995-01-15

Family

ID=27577291

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89311135T ATE115952T1 (de) 1988-10-29 1989-10-27 Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel.

Country Status (12)

Country Link
US (1) US5008267A (de)
EP (1) EP0369627B1 (de)
KR (1) KR920002307B1 (de)
AT (1) ATE115952T1 (de)
AU (1) AU613805B2 (de)
DE (1) DE68920125T2 (de)
DK (1) DK170203B1 (de)
ES (1) ES2066000T3 (de)
FI (1) FI95245C (de)
HU (1) HU210780B (de)
NO (1) NO174711C (de)
NZ (1) NZ231165A (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308848A (en) * 1989-10-24 1994-05-03 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione derivatives and antiarrythmic agents containing the same
JPH03173885A (ja) * 1989-12-01 1991-07-29 Mitsui Toatsu Chem Inc ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤
JPH0413669A (ja) * 1990-04-27 1992-01-17 Mitsui Toatsu Chem Inc 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤
DE4032766A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
EP0640341A1 (de) * 1993-08-27 1995-03-01 Mitsui Toatsu Chemicals, Incorporated Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren
EP0697407B1 (de) 1994-08-19 1997-06-25 MITSUI TOATSU CHEMICALS, Inc. Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
WO1996017831A1 (de) * 1994-12-07 1996-06-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Uracilderivate
EP0722732A1 (de) * 1995-01-24 1996-07-24 Mitsui Toatsu Chemicals, Inc. Pyrimidindionderivate enthaltendes Arzneimittel mit verlängerter Wirkstoffabgabe
DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6750342B1 (en) * 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6906068B1 (en) 1999-05-19 2005-06-14 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6458952B1 (en) * 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6664255B1 (en) * 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
AU2001243598A1 (en) 2000-03-13 2001-09-24 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
US6875791B2 (en) 2000-04-05 2005-04-05 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
AU2001251315A1 (en) * 2000-04-05 2001-10-23 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
US20040171616A9 (en) 2000-04-17 2004-09-02 South Michael S. Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2002042272A2 (en) * 2000-11-20 2002-05-30 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
ATE442363T1 (de) * 2001-08-02 2009-09-15 Sumitomo Chemical Co Verfahren zur herstellung von pyridinverbindungen
US20040068113A1 (en) * 2001-11-20 2004-04-08 South Michael S. Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
PT1778236E (pt) 2004-07-02 2010-10-19 Corcept Therapeutics Inc Moduladores do receptor de glucocorticóide de pirimidina modificada
AU2012231265B2 (en) 2011-03-18 2016-07-07 Corcept Therapeutics, Inc. Pyrimidine cyclohexyl glucocorticoid receptor modulators
CN102617486B (zh) * 2012-03-01 2014-04-16 江西吉翔医药化工有限公司 一种6-氯-1,3-二甲基脲嘧啶的制备方法
CN103288751B (zh) * 2013-06-03 2016-04-20 四川百利药业有限责任公司 一种高纯度盐酸尼非卡兰的制备方法
UA117929C2 (uk) 2013-06-21 2018-10-25 Міокардіа, Інк. Сполуки піримідиндіону, спрямовані проти станів серцево-судинної системи
IL278936B1 (en) 2018-06-04 2024-10-01 Corcept Therapeutics Inc Pyrimidine cyclophenyl glucocorticoid and mineralocorticoid receptor modulators
WO2020151605A1 (zh) * 2019-01-25 2020-07-30 青岛吉澳医药科技有限公司 氘代苯甲氨嘧啶二酮衍生物及其用途
CA3158745A1 (en) 2019-12-11 2021-06-17 Corcept Therapeutics Incorporated Methods of treating antipsychotic-induced weight gain with miricorilant
WO2021226260A1 (en) 2020-05-06 2021-11-11 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
CA3202353A1 (en) 2020-12-21 2022-06-30 Jeffrey Mark Dener Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787103A (fr) * 1971-08-04 1973-02-02 Pfizer Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
DE2329399A1 (de) * 1973-06-08 1975-01-02 Wuelfing J A Fa 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
LU77339A1 (de) * 1977-05-16 1979-01-19
JPH01175937A (ja) * 1987-12-28 1989-07-12 Mitsui Toatsu Chem Inc 不整脈治療剤

Also Published As

Publication number Publication date
NZ231165A (en) 1992-02-25
DK535789D0 (da) 1989-10-27
NO894299D0 (no) 1989-10-27
US5008267A (en) 1991-04-16
DK535789A (da) 1990-04-30
HUT52764A (en) 1990-08-28
KR920002307B1 (ko) 1992-03-21
NO894299L (no) 1990-04-30
DE68920125D1 (de) 1995-02-02
FI895121A0 (fi) 1989-10-27
DK170203B1 (da) 1995-06-12
DE68920125T2 (de) 1995-08-03
AU613805B2 (en) 1991-08-08
HU895468D0 (en) 1990-01-28
HU210780B (en) 1995-07-28
KR900006300A (ko) 1990-05-07
EP0369627A2 (de) 1990-05-23
NO174711B (no) 1994-03-14
FI95245B (fi) 1995-09-29
FI95245C (fi) 1996-01-10
EP0369627A3 (en) 1990-12-12
NO174711C (no) 1994-06-22
ES2066000T3 (es) 1995-03-01
AU4386989A (en) 1990-05-31
EP0369627B1 (de) 1994-12-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time