PT1268463E - 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao - Google Patents
4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacaoInfo
- Publication number
- PT1268463E PT1268463E PT01923149T PT01923149T PT1268463E PT 1268463 E PT1268463 E PT 1268463E PT 01923149 T PT01923149 T PT 01923149T PT 01923149 T PT01923149 T PT 01923149T PT 1268463 E PT1268463 E PT 1268463E
- Authority
- PT
- Portugal
- Prior art keywords
- polycyclic
- cascade
- heteroaryl
- substituted
- coagulacao
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19491500P | 2000-04-05 | 2000-04-05 | |
US25215700P | 2000-11-20 | 2000-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1268463E true PT1268463E (pt) | 2005-05-31 |
Family
ID=26890524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT01923149T PT1268463E (pt) | 2000-04-05 | 2001-04-04 | 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao |
Country Status (10)
Country | Link |
---|---|
US (4) | US6875791B2 (pt) |
EP (1) | EP1268463B1 (pt) |
JP (1) | JP2004505014A (pt) |
AT (1) | ATE289299T1 (pt) |
AU (1) | AU2001249870A1 (pt) |
CA (1) | CA2405561A1 (pt) |
DE (1) | DE60108948T2 (pt) |
ES (1) | ES2236211T3 (pt) |
PT (1) | PT1268463E (pt) |
WO (1) | WO2001077097A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001068605A1 (en) | 2000-03-13 | 2001-09-20 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
US6875791B2 (en) | 2000-04-05 | 2005-04-05 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
EP1351686A2 (en) * | 2000-11-20 | 2003-10-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
WO2003093242A2 (en) | 2001-10-03 | 2003-11-13 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
CA2462305A1 (en) | 2001-10-03 | 2003-04-10 | Michael S. South | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
US8753124B2 (en) * | 2009-02-15 | 2014-06-17 | Cheryl Lynn Evans | Method and apparatus for prescribing and preparing a reproducible and customized dysphagia diet |
WO2015085238A1 (en) * | 2013-12-05 | 2015-06-11 | The Regents Of The University Of California, A California Corporation | Inhibitors of lpxc |
Family Cites Families (63)
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JPS5910541A (ja) * | 1982-07-09 | 1984-01-20 | Takeda Chem Ind Ltd | キノン化合物 |
JPS60255749A (ja) * | 1984-05-31 | 1985-12-17 | Univ Nagoya | キノン誘導体 |
US5304658A (en) * | 1984-08-01 | 1994-04-19 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
IL81264A (en) * | 1986-01-30 | 1990-11-05 | Takeda Chemical Industries Ltd | Quinone derivatives,their production and pharmaceutical compositions containing them |
DE3826846A1 (de) | 1988-08-06 | 1990-02-08 | Goedecke Ag | Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US5008267A (en) | 1988-10-29 | 1991-04-16 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same |
JPH05501886A (ja) * | 1990-06-29 | 1993-04-08 | ジ・アップジョン・カンパニー | 抗アテローム性動脈硬化症性および抗血栓性2―アミノ―6―フェニル―4h―ピラン―4―オン類 |
GB9216272D0 (en) | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
WO1993021214A1 (en) | 1992-04-16 | 1993-10-28 | Zeneca Limited | Alpha-aminoboronic acid peptides and their use as elastase inhibitors |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US6011158A (en) | 1994-12-13 | 2000-01-04 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
ATE217321T1 (de) | 1994-12-13 | 2002-05-15 | Corvas Int Inc | Aromatische heterocyclische derivate als enzyminhibitoren |
WO1996033974A1 (fr) | 1995-04-27 | 1996-10-31 | The Green Cross Corporation | Composes heterocycliques amides et leur utilisation medicinale |
US5612378A (en) | 1995-06-06 | 1997-03-18 | 3-Dimensional Pharmaceuticals, Inc. | Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors |
US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
CA2224437A1 (en) | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Pyridinone-thrombin inhibitors |
JP2921606B2 (ja) | 1995-11-08 | 1999-07-19 | ケーニツヒ ウント バウエル−アルバート アクチエンゲゼルシヤフト | 折り装置 |
EP0923372A4 (en) | 1996-02-22 | 2001-09-05 | Merck & Co Inc | PYRIDINONE THROMBINE INHIBITORS |
JP3140790B2 (ja) | 1996-04-23 | 2001-03-05 | メルク エンド カンパニー インコーポレーテッド | ピラジノン系トロンビン阻害薬 |
US5668289A (en) * | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
EP0934305A4 (en) | 1996-08-29 | 2001-04-11 | Merck & Co Inc | INTEGRINE ANTAGONISTS |
WO1998009987A1 (en) | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
CN1169791C (zh) | 1996-09-06 | 2004-10-06 | 日本化药株式会社 | 新颖的乙酰胺衍生物和蛋白酶抑制剂 |
AU725403B2 (en) | 1996-09-13 | 2000-10-12 | Merck & Co., Inc. | Thrombin inhibitors |
US5872138A (en) * | 1996-09-13 | 1999-02-16 | Merck & Co., Inc. | Thrombin inhibitors |
CA2268264A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
AU743735B2 (en) | 1996-10-11 | 2002-02-07 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
US5869487A (en) * | 1996-10-24 | 1999-02-09 | Merck & Co., Inc. | Pyrido 3,4-B!pyrazines for use as thrombin inhibitors |
JP2001502691A (ja) | 1996-10-24 | 2001-02-27 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害剤 |
US6080738A (en) | 1996-10-25 | 2000-06-27 | Yoshitomi Pharmaceuticals Industries, Ltd. | Heterocyclic amide compounds and medicinal uses thereof |
JP2001508796A (ja) | 1997-01-22 | 2001-07-03 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
EP0969840A4 (en) | 1997-03-24 | 2001-02-28 | Merck & Co Inc | THROMBIN INHIBITORS |
US5866573A (en) * | 1997-04-21 | 1999-02-02 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
PT979240E (pt) | 1997-05-02 | 2004-08-31 | Akzo Nobel Nv | Inibidores de serina-protease |
IL133627A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
IL133621A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
JP2001514227A (ja) | 1997-09-05 | 2001-09-11 | メルク エンド カムパニー インコーポレーテッド | ピラジノン系トロンビン阻害薬 |
AU1605699A (en) | 1997-11-26 | 1999-06-15 | Corvas International, Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii) |
JP2001524467A (ja) | 1997-11-26 | 2001-12-04 | 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド | ヘテロアリールアミノグアニジンおよびアルコキシグアニジンおよびプロテアーゼインヒビターとしてのこれらの使用 |
ATE232536T1 (de) | 1998-01-20 | 2003-02-15 | Warner Lambert Co | N-(2-(5-benzyloxycarbonyl-amino-6-oxo-2-(4- |
WO1999043660A1 (en) | 1998-02-26 | 1999-09-02 | Neurogen Corporation | Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands |
GB9806102D0 (en) | 1998-03-20 | 1998-05-20 | Merck Sharp & Dohme | Therapeutic agents |
JP2002515434A (ja) | 1998-05-19 | 2002-05-28 | メルク エンド カムパニー インコーポレーテッド | ピラジノン系トロンビン阻害薬 |
CA2333040A1 (en) | 1998-05-26 | 1999-12-02 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
EP1135151A4 (en) | 1998-06-03 | 2002-01-02 | Cortech Inc | ALPHA-KETO OXADIAZOLE CONTAINING PEPTOIDS AND NON-PEPTOIDS AS SERINE PROTEASE INHIBITORS |
IL139867A0 (en) | 1998-06-11 | 2002-02-10 | Dimensional Pharm Inc | Pyrazinone derivatives and pharmaceutical compositions containing the same |
DE69912379T2 (de) * | 1998-08-14 | 2004-05-06 | Pfizer Inc. | Antithrombosemittel |
CA2343109A1 (en) | 1998-09-28 | 2000-04-06 | Merck & Co., Inc. | Thrombin inhibitors |
AU752186B2 (en) | 1998-10-30 | 2002-09-12 | Merck & Co., Inc. | Thrombin inhibitors |
CA2348734A1 (en) | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
DE19851421A1 (de) | 1998-11-07 | 2000-05-11 | Boehringer Ingelheim Pharma | Neue Pyrimidine, deren Herstellung und Verwendung |
FR2786482B1 (fr) | 1998-11-27 | 2002-08-09 | Synthelabo | Nouveaux derives de 2-pyridone, leur preparation et leur application en therapeutique |
AU3127900A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
AU771740B2 (en) | 1999-05-19 | 2004-04-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
HUP0201242A3 (en) | 1999-05-19 | 2003-02-28 | Pharmacia Corp St Louis | Substituted polycyclic aryl and heteroaryl pyrimidinone and triazinone derivatives useful as anticoagulants and pharmaceutical compositions containing them |
KR20010113970A (ko) | 1999-05-19 | 2001-12-28 | 추후보정 | 응고 캐스케이드의 선택적 억제에 유용한 치환 폴리시클릭아릴 및 헤테로아릴 피리돈 |
US6875791B2 (en) | 2000-04-05 | 2005-04-05 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
-
2001
- 2001-04-04 US US10/240,818 patent/US6875791B2/en not_active Expired - Fee Related
- 2001-04-04 CA CA002405561A patent/CA2405561A1/en not_active Abandoned
- 2001-04-04 ES ES01923149T patent/ES2236211T3/es not_active Expired - Lifetime
- 2001-04-04 AT AT01923149T patent/ATE289299T1/de not_active IP Right Cessation
- 2001-04-04 JP JP2001575571A patent/JP2004505014A/ja not_active Withdrawn
- 2001-04-04 PT PT01923149T patent/PT1268463E/pt unknown
- 2001-04-04 AU AU2001249870A patent/AU2001249870A1/en not_active Abandoned
- 2001-04-04 US US09/826,432 patent/US20020022604A1/en not_active Abandoned
- 2001-04-04 WO PCT/US2001/011013 patent/WO2001077097A2/en active IP Right Grant
- 2001-04-04 DE DE60108948T patent/DE60108948T2/de not_active Expired - Fee Related
- 2001-04-04 EP EP01923149A patent/EP1268463B1/en not_active Expired - Lifetime
-
2003
- 2003-05-14 US US10/438,077 patent/US6916847B2/en not_active Expired - Fee Related
-
2005
- 2005-03-04 US US11/072,595 patent/US20050165021A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040006227A1 (en) | 2004-01-08 |
DE60108948T2 (de) | 2005-11-03 |
EP1268463B1 (en) | 2005-02-16 |
US6875791B2 (en) | 2005-04-05 |
US20050165021A1 (en) | 2005-07-28 |
CA2405561A1 (en) | 2001-10-18 |
US20030216451A1 (en) | 2003-11-20 |
DE60108948D1 (de) | 2005-03-24 |
US20020022604A1 (en) | 2002-02-21 |
WO2001077097A2 (en) | 2001-10-18 |
WO2001077097A3 (en) | 2002-07-04 |
ATE289299T1 (de) | 2005-03-15 |
JP2004505014A (ja) | 2004-02-19 |
AU2001249870A1 (en) | 2001-10-23 |
EP1268463A2 (en) | 2003-01-02 |
US6916847B2 (en) | 2005-07-12 |
ES2236211T3 (es) | 2005-07-16 |
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