BR0011295A - Aril e heteroaril pirazinonas policìclicas substituìdas úteis para inibição seletiva de cascata de coagulação - Google Patents

Aril e heteroaril pirazinonas policìclicas substituìdas úteis para inibição seletiva de cascata de coagulação

Info

Publication number
BR0011295A
BR0011295A BR0011295-0A BR0011295A BR0011295A BR 0011295 A BR0011295 A BR 0011295A BR 0011295 A BR0011295 A BR 0011295A BR 0011295 A BR0011295 A BR 0011295A
Authority
BR
Brazil
Prior art keywords
useful
coagulation cascade
selective inhibition
aryl
pyrazinones
Prior art date
Application number
BR0011295-0A
Other languages
English (en)
Inventor
Michael S South
John J Parlow
Dann E Jones
Brenda Case
Tom Dice
Richard Lindmark
Michael J Hayes
Melvin L Rueppel
Rick Fenton
Gary W Franklin
Horng-Chih Huang
Wei Huang
Carrie Kusturin
Scott A Long
William L Neumann
David B Reitz
John I Trujillo
Ching-Cheng Wang
Rhonda Wood
Quingping Zeng
Matthew W Mahoney
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0011295A publication Critical patent/BR0011295A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Abstract

Patente de Invenção: "ARIL E HETEROARIL PIRAZINONAS POLICìCLICAS SUBSTITUìDAS úTEIS PARA INIBIçãO SELETIVA DE CASCATA DE COAGULAçãO". A invenção refere-se a compostos aril e heteroaril pirazinona policíclicos substituídos úteis como inibidores de serina proteases da cascata de coagulação e a compostos, composições e processos para a terapia anticoagulante para o tratamento e prevenção de uma variedade de condições trombóticas incluindo doenças da artéria coronária e cerebrovasculares.
BR0011295-0A 1999-05-19 2000-05-18 Aril e heteroaril pirazinonas policìclicas substituìdas úteis para inibição seletiva de cascata de coagulação BR0011295A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13495899P 1999-05-19 1999-05-19
PCT/US2000/008225 WO2000069834A1 (en) 1999-05-19 2000-05-18 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

Publications (1)

Publication Number Publication Date
BR0011295A true BR0011295A (pt) 2002-05-28

Family

ID=22465803

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011295-0A BR0011295A (pt) 1999-05-19 2000-05-18 Aril e heteroaril pirazinonas policìclicas substituìdas úteis para inibição seletiva de cascata de coagulação

Country Status (24)

Country Link
EP (1) EP1202975B1 (pt)
JP (1) JP2002544264A (pt)
KR (1) KR20010113971A (pt)
CN (1) CN1351595A (pt)
AR (1) AR029752A1 (pt)
AT (1) ATE292629T1 (pt)
AU (1) AU775229B2 (pt)
BR (1) BR0011295A (pt)
CA (1) CA2372617A1 (pt)
CZ (1) CZ20014115A3 (pt)
DE (1) DE60019296T2 (pt)
EA (1) EA005031B1 (pt)
ES (1) ES2240100T3 (pt)
HU (1) HUP0202191A3 (pt)
IL (1) IL146245A0 (pt)
MX (1) MXPA01011807A (pt)
NO (1) NO20015605L (pt)
NZ (1) NZ514876A (pt)
PE (1) PE20010290A1 (pt)
PL (1) PL352368A1 (pt)
SK (1) SK15872001A3 (pt)
UY (1) UY26155A1 (pt)
WO (1) WO2000069834A1 (pt)
ZA (2) ZA200109341B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA58636C2 (uk) 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
WO2001038323A1 (en) 1999-11-23 2001-05-31 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO2001079195A2 (en) * 2000-04-14 2001-10-25 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
US6506754B1 (en) 2000-04-14 2003-01-14 Corvas International, Inc. Non-covalent thrombin inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7243153B2 (en) 2001-06-26 2007-07-10 Eastman Kodak Company System and method for managing images over a communication network
CA2462601A1 (en) * 2001-10-03 2003-04-10 Pharmacia Corporation Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
CA2462647A1 (en) * 2001-10-03 2003-04-10 Michael S. South 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) * 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
EP1526131A1 (en) * 2003-10-22 2005-04-27 Graffinity Pharmaceuticals Aktiengesellschaft Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors
US7905872B2 (en) * 2004-06-04 2011-03-15 The Procter & Gamble Company Absorbent articles comprising a slow recovery stretch laminate
US9017305B2 (en) 2010-11-12 2015-04-28 The Procter Gamble Company Elastomeric compositions that resist force loss and disintegration
US11584714B2 (en) 2018-05-29 2023-02-21 Omeros Corporation MASP-2 inhibitors and methods of use
CA3147564A1 (en) 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors
CN115052862A (zh) 2019-12-04 2022-09-13 奥默罗斯公司 Masp-2抑制剂和使用方法
JP2023504543A (ja) 2019-12-04 2023-02-03 オメロス コーポレーション Ｍａｓｐ－２阻害剤および使用方法
IL293588A (en) * 2019-12-04 2022-08-01 Omeros Corp 2-masp inhibitor compounds, preparations containing them and their uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11508558A (ja) * 1995-06-27 1999-07-27 メルク エンド カンパニー インコーポレーテッド ピリジノン トロンビン阻害剤
CZ340898A3 (cs) * 1996-04-23 1999-02-17 Merck And Co., Inc. Sloučenina, způsob její výroby a farmaceutický prostředek
JP2001518932A (ja) * 1997-03-24 2001-10-16 メルク エンド カンパニー インコーポレーテッド トロンビン阻害薬
CA2301520A1 (en) * 1997-09-05 1999-03-11 Merck & Co., Inc. Pyrazinone thrombin inhibitors
JP2002515434A (ja) * 1998-05-19 2002-05-28 メルク エンド カムパニー インコーポレーテッド ピラジノン系トロンビン阻害薬
AU742178B2 (en) * 1998-05-26 2001-12-20 Merck & Co., Inc. Imidazopyridine thrombin inhibitors
DE69942159D1 (de) * 1998-06-11 2010-04-29 Ortho Mcneil Pharm Inc Pyrazine Protease Inhibitore

Also Published As

Publication number Publication date
CN1351595A (zh) 2002-05-29
AR029752A1 (es) 2003-07-16
PE20010290A1 (es) 2001-03-07
NO20015605D0 (no) 2001-11-16
KR20010113971A (ko) 2001-12-28
MXPA01011807A (es) 2003-09-04
HUP0202191A3 (en) 2003-02-28
EA200101212A1 (ru) 2002-06-27
IL146245A0 (en) 2002-07-25
DE60019296T2 (de) 2006-03-09
ES2240100T3 (es) 2005-10-16
UY26155A1 (es) 2000-12-29
PL352368A1 (en) 2003-08-25
WO2000069834A1 (en) 2000-11-23
EA005031B1 (ru) 2004-10-28
CZ20014115A3 (cs) 2002-05-15
ATE292629T1 (de) 2005-04-15
HUP0202191A2 (hu) 2002-12-28
EP1202975B1 (en) 2005-04-06
SK15872001A3 (sk) 2002-10-08
ZA200400455B (en) 2004-09-29
CA2372617A1 (en) 2000-11-23
AU775229B2 (en) 2004-07-22
NZ514876A (en) 2005-03-24
NO20015605L (no) 2002-01-18
DE60019296D1 (de) 2005-05-12
JP2002544264A (ja) 2002-12-24
EP1202975A1 (en) 2002-05-08
ZA200109341B (en) 2004-05-26
AU4972300A (en) 2000-12-05

Similar Documents

Publication Publication Date Title
BR0011295A (pt) Aril e heteroaril pirazinonas policìclicas substituìdas úteis para inibição seletiva de cascata de coagulação
BR0010758A (pt) Aril e heteroaril pirimidinonas policìclicas substituìdas úteis como anti coagulantes
BR0011273A (pt) Uracilas de heteroarila e arila policìclica substituìdas como agentes anti-coagulantes
UY26154A1 (es) Aril y heteroaril piridonas policíclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación
AP1744A (en) Inhibitors of factor XA and other serine proteases involved in the coagulation cascade
ATE361288T1 (de) N-(3,-dimethylindolin-6-yl)ä2-ä(4-
ATE277929T1 (de) Immunsuppressive wirkungen von pteridinderivaten
ATE227306T1 (de) Thrombin-inhibitoren als anticoagulierende mittel
DE602004030222D1 (de) 2-oxo-1,3,5-perhydrotriazapinderivate, die sich zur behandlung von hyperproliferativen, angiogenen und entzündlichen erkrankungen eignen
ATE440087T1 (de) 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
ATE444960T1 (de) Polyhydroxystilbene und -stilbenoxide als antipsoriasismittel und proteinkinasehemmer
MXPA03011484A (es) Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades.
DE69905476T2 (de) Phosphonsaürederivate als ptp-1b-inhibitoren
ATE432278T1 (de) Verbindungen zur behandlung von krankheiten
ATE367380T1 (de) Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate
BR0008292A (pt) Derivados de mevinolina
PT1268463E (pt) 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao
ES2182035T3 (es) Derivados del bisarilciclobuteno como inhibidores de ciclooxigenasa.
ATE229514T1 (de) Macrocyclische verbindungen als metallproteaseinhibitoren
DE60018704D1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
BR0213099A (pt) Compostos policìclicos de 5 membros substituìdos úteis para inibição seletiva da cascata de coagulação
WO2001079155A3 (en) Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2001077079A3 (en) Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
ATE346036T1 (de) Antiangiogene substanz zur behandlung von krebs, arthritis und netzhauterkrankungen
WO2004100973A3 (en) Pharmaceutical compositions of antithrombin iii for the treatment of retroviral diseases.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.