UY26155A1 - Aril y heteroaril pirazinonas policiclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación. - Google Patents
Aril y heteroaril pirazinonas policiclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación.Info
- Publication number
- UY26155A1 UY26155A1 UY26155A UY26155A UY26155A1 UY 26155 A1 UY26155 A1 UY 26155A1 UY 26155 A UY26155 A UY 26155A UY 26155 A UY26155 A UY 26155A UY 26155 A1 UY26155 A1 UY 26155A1
- Authority
- UY
- Uruguay
- Prior art keywords
- useful
- pirazinones
- polyclic
- heteroaril
- aril
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se relaciona con compuestos de pirazinonas arílicas y heteroarílicas útiles para inhibir las proteasas de serina de la cascada de coagulación y con compuestos, composiciones y métodos para terapias anticoagulantes para tratar y prevenir distintos desórdenes trombóticos, incluyendo enfermedades coronarias y cerebrovasculares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13495899P | 1999-05-19 | 1999-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY26155A1 true UY26155A1 (es) | 2000-12-29 |
Family
ID=22465803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY26155A UY26155A1 (es) | 1999-05-19 | 2000-05-19 | Aril y heteroaril pirazinonas policiclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación. |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1202975B1 (es) |
JP (1) | JP2002544264A (es) |
KR (1) | KR20010113971A (es) |
CN (1) | CN1351595A (es) |
AR (1) | AR029752A1 (es) |
AT (1) | ATE292629T1 (es) |
AU (1) | AU775229B2 (es) |
BR (1) | BR0011295A (es) |
CA (1) | CA2372617A1 (es) |
CZ (1) | CZ20014115A3 (es) |
DE (1) | DE60019296T2 (es) |
EA (1) | EA005031B1 (es) |
ES (1) | ES2240100T3 (es) |
HU (1) | HUP0202191A3 (es) |
IL (1) | IL146245A0 (es) |
MX (1) | MXPA01011807A (es) |
NO (1) | NO20015605L (es) |
NZ (1) | NZ514876A (es) |
PE (1) | PE20010290A1 (es) |
PL (1) | PL352368A1 (es) |
SK (1) | SK15872001A3 (es) |
UY (1) | UY26155A1 (es) |
WO (1) | WO2000069834A1 (es) |
ZA (2) | ZA200109341B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA58636C2 (uk) | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
WO2001038323A1 (en) | 1999-11-23 | 2001-05-31 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
US6506754B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Non-covalent thrombin inhibitors |
AU2001255399A1 (en) * | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Pyridine and pyrazine derivatives as thrombin inhibitors |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
US7243153B2 (en) | 2001-06-26 | 2007-07-10 | Eastman Kodak Company | System and method for managing images over a communication network |
CA2462647A1 (en) * | 2001-10-03 | 2003-04-10 | Michael S. South | 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade |
MXPA04003170A (es) * | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion. |
MXPA04003169A (es) * | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Profarmacos de compuestos policiclicos sustituidos utiles para inhibicion selectiva de la cascada de coagulacion. |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
EP1526131A1 (en) * | 2003-10-22 | 2005-04-27 | Graffinity Pharmaceuticals Aktiengesellschaft | Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors |
US7905872B2 (en) * | 2004-06-04 | 2011-03-15 | The Procter & Gamble Company | Absorbent articles comprising a slow recovery stretch laminate |
US9017305B2 (en) | 2010-11-12 | 2015-04-28 | The Procter Gamble Company | Elastomeric compositions that resist force loss and disintegration |
US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
BR112022001054A2 (pt) | 2019-08-21 | 2022-03-15 | Kalvista Pharmaceuticals Ltd | Inibidores enzimáticos |
IL293550A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
US20210179612A1 (en) * | 2019-12-04 | 2021-06-17 | Omeros Corporation | Masp-2 inhibitors and methods of use |
AU2020397894A1 (en) | 2019-12-04 | 2022-06-30 | Omeros Corporation | MASP-2 inhibitors and methods of use |
EP4069676A1 (en) | 2019-12-04 | 2022-10-12 | Omeros Corporation | Masp-2 inhibitors and methods of use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997001338A1 (en) * | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Pyridinone-thrombin inhibitors |
PL329441A1 (en) * | 1996-04-23 | 1999-03-29 | Merck & Co Inc | Pyrasinone-type thrombin inhibitors |
EP0969840A4 (en) * | 1997-03-24 | 2001-02-28 | Merck & Co Inc | THROMBIN INHIBITORS |
CA2301520A1 (en) * | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
CA2329914A1 (en) * | 1998-05-19 | 1999-11-25 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
AU742178B2 (en) * | 1998-05-26 | 2001-12-20 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
CN1224629C (zh) * | 1998-06-11 | 2005-10-26 | 三维药物公司 | 吡嗪酮蛋白酶抑制剂 |
-
2000
- 2000-05-18 IL IL14624500A patent/IL146245A0/xx unknown
- 2000-05-18 NZ NZ514876A patent/NZ514876A/en not_active Application Discontinuation
- 2000-05-18 BR BR0011295-0A patent/BR0011295A/pt not_active IP Right Cessation
- 2000-05-18 HU HU0202191A patent/HUP0202191A3/hu unknown
- 2000-05-18 DE DE60019296T patent/DE60019296T2/de not_active Expired - Fee Related
- 2000-05-18 EA EA200101212A patent/EA005031B1/ru not_active IP Right Cessation
- 2000-05-18 EP EP00931916A patent/EP1202975B1/en not_active Expired - Lifetime
- 2000-05-18 WO PCT/US2000/008225 patent/WO2000069834A1/en not_active Application Discontinuation
- 2000-05-18 AT AT00931916T patent/ATE292629T1/de not_active IP Right Cessation
- 2000-05-18 SK SK1587-2001A patent/SK15872001A3/sk unknown
- 2000-05-18 PL PL00352368A patent/PL352368A1/xx not_active Application Discontinuation
- 2000-05-18 CZ CZ20014115A patent/CZ20014115A3/cs unknown
- 2000-05-18 CN CN00807726A patent/CN1351595A/zh active Pending
- 2000-05-18 JP JP2000618251A patent/JP2002544264A/ja active Pending
- 2000-05-18 ES ES00931916T patent/ES2240100T3/es not_active Expired - Lifetime
- 2000-05-18 AU AU49723/00A patent/AU775229B2/en not_active Ceased
- 2000-05-18 KR KR1020017014752A patent/KR20010113971A/ko not_active Application Discontinuation
- 2000-05-18 CA CA002372617A patent/CA2372617A1/en not_active Abandoned
- 2000-05-18 MX MXPA01011807A patent/MXPA01011807A/es unknown
- 2000-05-19 AR ARP000102447A patent/AR029752A1/es unknown
- 2000-05-19 UY UY26155A patent/UY26155A1/es not_active Application Discontinuation
- 2000-06-15 PE PE2000000593A patent/PE20010290A1/es not_active Application Discontinuation
-
2001
- 2001-11-13 ZA ZA200109341A patent/ZA200109341B/xx unknown
- 2001-11-16 NO NO20015605A patent/NO20015605L/no not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA200400455A patent/ZA200400455B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES2240100T3 (es) | 2005-10-16 |
EP1202975A1 (en) | 2002-05-08 |
EA005031B1 (ru) | 2004-10-28 |
PL352368A1 (en) | 2003-08-25 |
DE60019296T2 (de) | 2006-03-09 |
EA200101212A1 (ru) | 2002-06-27 |
EP1202975B1 (en) | 2005-04-06 |
WO2000069834A1 (en) | 2000-11-23 |
ZA200109341B (en) | 2004-05-26 |
KR20010113971A (ko) | 2001-12-28 |
ATE292629T1 (de) | 2005-04-15 |
AU775229B2 (en) | 2004-07-22 |
PE20010290A1 (es) | 2001-03-07 |
CN1351595A (zh) | 2002-05-29 |
SK15872001A3 (sk) | 2002-10-08 |
JP2002544264A (ja) | 2002-12-24 |
BR0011295A (pt) | 2002-05-28 |
CZ20014115A3 (cs) | 2002-05-15 |
NZ514876A (en) | 2005-03-24 |
HUP0202191A3 (en) | 2003-02-28 |
ZA200400455B (en) | 2004-09-29 |
NO20015605L (no) | 2002-01-18 |
CA2372617A1 (en) | 2000-11-23 |
IL146245A0 (en) | 2002-07-25 |
DE60019296D1 (de) | 2005-05-12 |
HUP0202191A2 (hu) | 2002-12-28 |
AR029752A1 (es) | 2003-07-16 |
AU4972300A (en) | 2000-12-05 |
MXPA01011807A (es) | 2003-09-04 |
NO20015605D0 (no) | 2001-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY26155A1 (es) | Aril y heteroaril pirazinonas policiclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación. | |
UY26156A1 (es) | Aril y heteroaril pirimidonas policíclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación | |
UY26154A1 (es) | Aril y heteroaril piridonas policíclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación | |
BR0011273A (pt) | Uracilas de heteroarila e arila policìclica substituìdas como agentes anti-coagulantes | |
AP1744A (en) | Inhibitors of factor XA and other serine proteases involved in the coagulation cascade | |
WO2002042272A3 (en) | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade | |
DE60107687D1 (de) | Cyclpentanoindole, mischungen derartige verbindungen enthaltend und behandlungsmethoden | |
EA200801530A1 (ru) | Аналоги арилпропионамида, арилакриламида, арилпропинамида или арилметилмочевины в качестве фактор xia ингибиторов | |
NO20030845D0 (no) | Utvalgte fusjonerte pyrrolokarbazoler | |
EA200500856A1 (ru) | Новые химические соединения | |
ATE520662T1 (de) | Sechsgliedrige heterocyclene als serinprotease- inhibitoren | |
NO990708L (no) | Bisykliske pyrimidinderivater og deres anvendelse som antikoagulanter | |
NO20050091L (no) | Fremgangsmater for fremstilling av fibrinogen | |
DK1315506T3 (da) | Phospholipidderivater af valproinsyre og blandinger deraf | |
ATE367380T1 (de) | Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate | |
DE602004031759D1 (de) | 1,2,3-triazolamidderivate als inhibitoren der cytokinproduktion | |
HRP20050899A2 (en) | Novel phosphonic acid compounds as inhibitors of serine proteases | |
BR0213126A (pt) | Compostos heterocìclicos insaturados de 6 membros úteis para inibição seletiva da cascata de coagulação | |
PT1268463E (pt) | 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao | |
DE60329326D1 (de) | Tace inhibitoren | |
ES2147973T3 (es) | Estirenos alquilatados como profarmacos de inhibidores de cox-2. | |
BR0213099A (pt) | Compostos policìclicos de 5 membros substituìdos úteis para inibição seletiva da cascata de coagulação | |
RS33304A (en) | Phosphonic and compounds as inhibitors of serine proteases | |
WO2001079155A3 (en) | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade | |
WO2001077079A3 (en) | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20100111 |