EA200500856A1 - Новые химические соединения - Google Patents
Новые химические соединенияInfo
- Publication number
- EA200500856A1 EA200500856A1 EA200500856A EA200500856A EA200500856A1 EA 200500856 A1 EA200500856 A1 EA 200500856A1 EA 200500856 A EA200500856 A EA 200500856A EA 200500856 A EA200500856 A EA 200500856A EA 200500856 A1 EA200500856 A1 EA 200500856A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- chemical compounds
- new chemical
- hyak3 proteins
- instability
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Данное изобретение относится к вновь идентифицированным соединениям для ингбирования Hyak3-белков и к способам лечения заболеваний, связанных с неустойчивостью или изменчивой активностью Hyak3-белков.Отчет о международном поиске был опубликован 2004.10.21.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42838402P | 2002-11-22 | 2002-11-22 | |
PCT/US2003/037658 WO2004047760A2 (en) | 2002-11-22 | 2003-11-18 | Novel chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500856A1 true EA200500856A1 (ru) | 2005-10-27 |
EA008865B1 EA008865B1 (ru) | 2007-08-31 |
Family
ID=32393394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500856A EA008865B1 (ru) | 2002-11-22 | 2003-11-18 | Производные 2-имино-4-оксотиазолидина |
Country Status (31)
Country | Link |
---|---|
US (1) | US7767701B2 (ru) |
EP (1) | EP1567112B1 (ru) |
JP (1) | JP2006509765A (ru) |
KR (1) | KR20050085115A (ru) |
CN (1) | CN100579978C (ru) |
AP (1) | AP1967A (ru) |
AR (1) | AR045407A1 (ru) |
AT (1) | ATE411302T1 (ru) |
AU (1) | AU2003298693B2 (ru) |
BR (1) | BR0316502A (ru) |
CA (1) | CA2507256A1 (ru) |
CY (1) | CY1108655T1 (ru) |
DE (1) | DE60324178D1 (ru) |
DK (1) | DK1567112T3 (ru) |
EA (1) | EA008865B1 (ru) |
EC (1) | ECSP055808A (ru) |
ES (1) | ES2315566T3 (ru) |
HK (1) | HK1083443A1 (ru) |
IS (1) | IS2659B (ru) |
MA (1) | MA27701A1 (ru) |
MX (1) | MXPA05005406A (ru) |
MY (1) | MY140132A (ru) |
NO (1) | NO20052928L (ru) |
NZ (1) | NZ539873A (ru) |
OA (1) | OA12963A (ru) |
PL (1) | PL377564A1 (ru) |
PT (1) | PT1567112E (ru) |
SI (1) | SI1567112T1 (ru) |
TW (1) | TWI309648B (ru) |
UA (1) | UA80572C2 (ru) |
WO (1) | WO2004047760A2 (ru) |
Families Citing this family (36)
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IL162721A0 (en) | 2002-01-22 | 2005-11-20 | Warner Lambert Co | 2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones |
AU2004255934B2 (en) * | 2003-07-11 | 2010-02-25 | Warner-Lambert Company Llc | Isethionate salt of a selective CDK4 inhibitor |
ES2328146T3 (es) * | 2003-07-28 | 2009-11-10 | Merck Serono Sa | 2-imino-4-(tio)oxo-5-policiclovinilazolinas para su uso como inhibidores de p13 quinasas. |
USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
DE602004029493D1 (de) | 2003-11-21 | 2010-11-18 | Actelion Pharmaceuticals Ltd | 5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel |
JP2007523957A (ja) * | 2004-02-25 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化学化合物 |
AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
DE602005012273D1 (de) * | 2004-07-01 | 2009-02-26 | Hoffmann La Roche | Chinolinthiazolinone mit cdk-1 antiproliferativer wirkung |
WO2006002829A1 (en) * | 2004-07-01 | 2006-01-12 | F. Hoffmann-La Roche Ag | Thiazolinone unsubstituted quinolines |
US7253285B2 (en) * | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
US7241893B2 (en) * | 2004-09-17 | 2007-07-10 | Hoffman-La Roche Inc. | Thiazolinone 2-substituted quinolines |
WO2006040318A2 (en) * | 2004-10-12 | 2006-04-20 | Applied Research Systems Ars Holding N.V. | Pi3 kinase gamma inhibitors for the treatment of anaemia |
CA2582986A1 (en) * | 2004-10-14 | 2006-04-20 | Shaoqing Chen | Novel azaindole thiazolinones as anti-cancer agents |
EP1802614A1 (en) | 2004-10-14 | 2007-07-04 | F. Hoffmann-Roche AG | Quinazolinylmethylenethiazolinones as cdk1 inhibitors |
CA2583192A1 (en) * | 2004-10-14 | 2006-04-20 | F. Hoffmann-La Roche Ag | 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity |
US7304074B2 (en) * | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
TW200716132A (en) * | 2005-05-03 | 2007-05-01 | Smithkline Beecham Corp | Novel chemical compounds |
JP2008545690A (ja) * | 2005-05-23 | 2008-12-18 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
PE20070083A1 (es) * | 2005-06-08 | 2007-01-27 | Smithkline Beecham Corp | (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona |
JP2008543769A (ja) * | 2005-06-08 | 2008-12-04 | スミスクライン・ビーチャム・コーポレイション | (5z)−5−(6−キノキサリニルメチリデン)−2−[(2,4,6−トリクロロフェニル)アミノ]−1,3−チアゾール−4(5h)−オン |
TW200745066A (en) | 2005-09-16 | 2007-12-16 | Torrent Pharmaceuticals Ltd | Novel PTP1B inhibitors |
JP2009514984A (ja) * | 2005-11-08 | 2009-04-09 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
US20100216801A1 (en) * | 2006-03-02 | 2010-08-26 | Dashyant Dhanak | Thiazolones for use as pi3 kinase inhibitors |
EP1993535A4 (en) * | 2006-03-02 | 2011-04-20 | Glaxosmithkline Llc | THIAZOLONE AS A PI3 KINASE INHIBITOR |
KR100752757B1 (ko) * | 2006-04-05 | 2007-08-29 | 한국과학기술연구원 | 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물 |
WO2007127212A2 (en) * | 2006-04-25 | 2007-11-08 | The Cleveland Clinic Foundation | Anti-viral agents that activate rnase l |
EP2094676B1 (en) * | 2006-11-23 | 2013-04-10 | Actelion Pharmaceuticals Ltd. | New process for the preparation of 2-iminothiazolidin-4-one derivatives |
US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
US20100286041A1 (en) * | 2007-03-22 | 2010-11-11 | Smithkline Beecham Corporation | (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one |
CN101274918A (zh) * | 2007-03-30 | 2008-10-01 | 中国科学院上海药物研究所 | 一类取代五元杂环化合物,其制备方法和医学用途 |
WO2010122979A1 (ja) | 2009-04-20 | 2010-10-28 | Sbiバイオテック株式会社 | チアゾリジノン誘導体 |
EP2881397B1 (en) * | 2012-07-30 | 2020-09-02 | Kyoto University | Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor |
SI2885266T1 (sl) | 2012-08-17 | 2020-10-30 | Actelion Pharmaceuticals Ltd | Postopek za pripravo (2Z,5Z)-5-(3-kloro-4-((R)-2,3-dihidroksipropoksi) benziliden)-2-(propilimino)-3-(O-tolil)tiazolidin-4-on in v omenjenem postopku uporabljena vmesna spojina |
RU2521390C1 (ru) * | 2013-03-14 | 2014-06-27 | Общество с ограниченной ответственностью "Тиацен" | Производное роданина и средство для профилактики опухолевых заболеваний |
AU2015265865B2 (en) * | 2014-05-28 | 2020-05-07 | Universitat Bern | Thiazolidinone compounds and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation |
CN104370852B (zh) * | 2014-11-26 | 2016-04-20 | 山东大学 | 一种噻唑烷酮类化合物及其在制备治疗铁紊乱相关疾病药物中的应用 |
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-
2003
- 2003-11-18 WO PCT/US2003/037658 patent/WO2004047760A2/en active Application Filing
- 2003-11-18 JP JP2004555721A patent/JP2006509765A/ja not_active Ceased
- 2003-11-18 AP AP2005003304A patent/AP1967A/xx active
- 2003-11-18 AU AU2003298693A patent/AU2003298693B2/en not_active Ceased
- 2003-11-18 ES ES03796448T patent/ES2315566T3/es not_active Expired - Lifetime
- 2003-11-18 DE DE60324178T patent/DE60324178D1/de not_active Expired - Lifetime
- 2003-11-18 MX MXPA05005406A patent/MXPA05005406A/es active IP Right Grant
- 2003-11-18 EP EP03796448A patent/EP1567112B1/en not_active Expired - Lifetime
- 2003-11-18 CN CN200380109119A patent/CN100579978C/zh not_active Expired - Fee Related
- 2003-11-18 OA OA1200500154A patent/OA12963A/en unknown
- 2003-11-18 CA CA002507256A patent/CA2507256A1/en not_active Abandoned
- 2003-11-18 AT AT03796448T patent/ATE411302T1/de active
- 2003-11-18 PL PL377564A patent/PL377564A1/pl not_active Application Discontinuation
- 2003-11-18 NZ NZ539873A patent/NZ539873A/en not_active IP Right Cessation
- 2003-11-18 PT PT03796448T patent/PT1567112E/pt unknown
- 2003-11-18 US US10/535,690 patent/US7767701B2/en not_active Expired - Fee Related
- 2003-11-18 UA UAA200504788A patent/UA80572C2/uk unknown
- 2003-11-18 EA EA200500856A patent/EA008865B1/ru not_active IP Right Cessation
- 2003-11-18 BR BR0316502-7A patent/BR0316502A/pt not_active IP Right Cessation
- 2003-11-18 SI SI200331463T patent/SI1567112T1/sl unknown
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