EA199900620A1 - Фталазиноны - Google Patents

Фталазиноны

Info

Publication number
EA199900620A1
EA199900620A1 EA199900620A EA199900620A EA199900620A1 EA 199900620 A1 EA199900620 A1 EA 199900620A1 EA 199900620 A EA199900620 A EA 199900620A EA 199900620 A EA199900620 A EA 199900620A EA 199900620 A1 EA199900620 A1 EA 199900620A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
phthalasins
international
application
formula
Prior art date
Application number
EA199900620A
Other languages
English (en)
Other versions
EA002764B1 (ru
Inventor
Дер Мей Маргарета Ван
Дер Лаан Ивонне Иоханна Ван
Хендрик Тиммерман
Армин Хатцельманн
Хильдегард Босс
Дитрих Хафнер
Рольф Бойме
Ханс-Петер Клей
Original Assignee
Бык Гульден Ломберг Хемише Фабрик Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бык Гульден Ломберг Хемише Фабрик Гмбх filed Critical Бык Гульден Ломберг Хемише Фабрик Гмбх
Publication of EA199900620A1 publication Critical patent/EA199900620A1/ru
Publication of EA002764B1 publication Critical patent/EA002764B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Abstract

В заявке описаны соединения формулы Iв которых R1, R2, R3, R4 и R5 имеют значения, указанные в описании. Эти соединения являются новыми эффективными средствами для лечения заболеваний дыхательных путей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900620A 1997-01-15 1998-01-12 Фталазиноны EA002764B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100488 1997-01-15
PCT/EP1998/000124 WO1998031674A1 (en) 1997-01-15 1998-01-12 Phthalazinones

Publications (2)

Publication Number Publication Date
EA199900620A1 true EA199900620A1 (ru) 2000-04-24
EA002764B1 EA002764B1 (ru) 2002-08-29

Family

ID=8226366

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900620A EA002764B1 (ru) 1997-01-15 1998-01-12 Фталазиноны

Country Status (27)

Country Link
US (1) US6103718A (ru)
EP (1) EP0971901B1 (ru)
JP (1) JP2001508078A (ru)
KR (1) KR20000070150A (ru)
CN (1) CN1127487C (ru)
AT (1) ATE233247T1 (ru)
AU (1) AU735934B2 (ru)
BR (1) BR9806752A (ru)
CA (1) CA2276455C (ru)
CY (1) CY2446B1 (ru)
CZ (1) CZ293815B6 (ru)
DE (1) DE69811645T2 (ru)
DK (1) DK0971901T3 (ru)
EA (1) EA002764B1 (ru)
EE (1) EE03968B1 (ru)
ES (1) ES2193508T3 (ru)
HK (1) HK1024692A1 (ru)
HU (1) HUP0001541A3 (ru)
IL (1) IL130659A (ru)
NO (1) NO313137B1 (ru)
NZ (1) NZ336573A (ru)
PL (1) PL189418B1 (ru)
PT (1) PT971901E (ru)
SI (1) SI0971901T1 (ru)
SK (1) SK283270B6 (ru)
TR (1) TR199901653T2 (ru)
WO (1) WO1998031674A1 (ru)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69918422T2 (de) * 1998-03-14 2005-08-11 Altana Pharma Ag Phthalazinone als PDE3/4 Inhibitoren
DK1212089T3 (da) 1999-08-21 2006-07-24 Altana Pharma Ag Synergistisk kombination af Roflumilast og Salmeterol
WO2001019818A1 (en) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
JP2003512459A (ja) * 1999-10-25 2003-04-02 アルタナ ファルマ アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのフタラジノン誘導体
EA005856B1 (ru) * 1999-10-25 2005-06-30 Алтана Фарма Аг Тетрагидротиопиранфталазиноновые производные в качестве ингибиторов pde4
CA2411351A1 (en) * 2000-06-05 2001-12-13 Altana Pharma Ag Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors
US7868015B2 (en) * 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
EA200300836A1 (ru) * 2001-02-15 2004-02-26 Алтана Фарма Аг Производные фталазинон-пиперидина в качестве ингибиторов pde4
CA2445233A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Phthalazinones derivatives useful as pde4/7 inhibitors
CA2445236A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor
ATE507207T1 (de) 2002-02-19 2011-05-15 Ono Pharmaceutical Co Kondensierte pyridazinderivat-verbindungen und die verbindungen als wirkstoff enthaltende arzneimittel
WO2004018449A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
ES2286491T3 (es) * 2002-08-10 2007-12-01 Nycomed Gmbh Piperidina-ftalazonas sustituidas con pirrolidinadiona, como agentes inhibidores de la pde4.
AU2003260371A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-n-oxide-derivatives
WO2004098633A1 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising a pde-4 inhibitor and a tnf alpha antagonist
EP1661894A4 (en) * 2003-07-14 2007-02-28 Ube Industries PROCESS FOR THE PRODUCTION OF 4-AMINOTETRAHYDROPYRANES AND SALTS THEREOF HAVING ACIDS, INTERMEDIATES THEREFOR, AND PROCESS FOR THE PRODUCTION THEREOF
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
ES2304692T3 (es) * 2004-02-04 2008-10-16 Nycomed Gmbh Derivados de 2-(piperidin-4-il)-4,5-dihidro-2h-piridazin-3-ona como inhibidores de pde4.
JPWO2006115221A1 (ja) * 2005-04-21 2008-12-18 日本新薬株式会社 フタラジノン誘導体及びその医薬
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
BRPI0811214A2 (pt) * 2007-05-16 2014-10-29 Nycomed Gmbh Derivados de pirazolona
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
BR112013031791A2 (pt) * 2011-06-17 2017-01-31 Takeda Gmbh derivados de ftalazinona-pirrolopirimidinacarboxamida
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
BR112015023328A2 (pt) 2013-03-13 2017-07-18 Flatley Discovery Lab compostos de piridazinona e métodos para o tratamento de fibrose cística
US20150050626A1 (en) * 2013-03-15 2015-02-19 Dart Neuroscience, Llc Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
PT672031E (pt) * 1992-12-02 2003-06-30 Pfizer Dieteres de catecol como inibidores selectivos de pde iv
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
AU705229B2 (en) * 1994-08-09 1999-05-20 Eisai R&D Management Co., Ltd. Fused pyridazine compound

Also Published As

Publication number Publication date
PL189418B1 (pl) 2005-08-31
NO993301L (no) 1999-09-10
CY2446B1 (en) 2004-11-12
BR9806752A (pt) 2000-03-14
CA2276455C (en) 2006-10-31
DE69811645D1 (de) 2003-04-03
NO993301D0 (no) 1999-07-02
JP2001508078A (ja) 2001-06-19
CN1249749A (zh) 2000-04-05
EP0971901A1 (en) 2000-01-19
EE03968B1 (et) 2003-02-17
HUP0001541A3 (en) 2001-11-28
CZ293815B6 (cs) 2004-08-18
SK283270B6 (sk) 2003-04-01
US6103718A (en) 2000-08-15
EA002764B1 (ru) 2002-08-29
ES2193508T3 (es) 2003-11-01
NZ336573A (en) 2000-10-27
SK95199A3 (en) 1999-12-10
TR199901653T2 (xx) 1999-10-21
AU735934B2 (en) 2001-07-19
NO313137B1 (no) 2002-08-19
EE9900274A (et) 2000-02-15
DK0971901T3 (da) 2003-06-10
CA2276455A1 (en) 1998-07-23
PT971901E (pt) 2003-07-31
CZ253399A3 (cs) 2000-05-17
HUP0001541A2 (hu) 2001-05-28
HK1024692A1 (en) 2000-10-20
PL334561A1 (en) 2000-03-13
WO1998031674A1 (en) 1998-07-23
CN1127487C (zh) 2003-11-12
DE69811645T2 (de) 2003-12-04
ATE233247T1 (de) 2003-03-15
AU5862998A (en) 1998-08-07
IL130659A (en) 2002-07-25
KR20000070150A (ko) 2000-11-25
EP0971901B1 (en) 2003-02-26
IL130659A0 (en) 2000-06-01
SI0971901T1 (en) 2003-10-31

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU