BR112015023328A2 - compostos de piridazinona e métodos para o tratamento de fibrose cística - Google Patents

compostos de piridazinona e métodos para o tratamento de fibrose cística

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Publication number
BR112015023328A2
BR112015023328A2 BR112015023328A BR112015023328A BR112015023328A2 BR 112015023328 A2 BR112015023328 A2 BR 112015023328A2 BR 112015023328 A BR112015023328 A BR 112015023328A BR 112015023328 A BR112015023328 A BR 112015023328A BR 112015023328 A2 BR112015023328 A2 BR 112015023328A2
Authority
BR
Brazil
Prior art keywords
methods
cystic fibrosis
treating cystic
pyridazinone compounds
pyridazinone
Prior art date
Application number
BR112015023328A
Other languages
English (en)
Inventor
Kolodziej Andrew
M Cole Bridget
Handley Karen
A Nugent Richard
Original Assignee
Flatley Discovery Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flatley Discovery Lab filed Critical Flatley Discovery Lab
Publication of BR112015023328A2 publication Critical patent/BR112015023328A2/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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BR112015023328A 2013-03-13 2014-03-13 compostos de piridazinona e métodos para o tratamento de fibrose cística BR112015023328A2 (pt)

Applications Claiming Priority (2)

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US201361778870P 2013-03-13 2013-03-13
PCT/US2014/026623 WO2014160440A1 (en) 2013-03-13 2014-03-13 Pyridazinone compounds and methods for the treatment of cystic fibrosis

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US (8) US9783529B2 (pt)
EP (1) EP2968323A4 (pt)
JP (1) JP6545148B2 (pt)
KR (1) KR101943490B1 (pt)
CN (1) CN105307655B (pt)
AU (1) AU2014243818B2 (pt)
BR (1) BR112015023328A2 (pt)
CA (2) CA3044766A1 (pt)
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WO (1) WO2014160440A1 (pt)

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US9783529B2 (en) * 2013-03-13 2017-10-10 Flatley Discovery Lab, Llc Pyridazinone compounds and methods for the treatment of cystic fibrosis
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