DK2970383T3 - Fremgangsmåde til behandling af fibrose - Google Patents

Fremgangsmåde til behandling af fibrose Download PDF

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Publication number
DK2970383T3
DK2970383T3 DK14762435.7T DK14762435T DK2970383T3 DK 2970383 T3 DK2970383 T3 DK 2970383T3 DK 14762435 T DK14762435 T DK 14762435T DK 2970383 T3 DK2970383 T3 DK 2970383T3
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Denmark
Prior art keywords
treating fibrosis
fibrosis
treating
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DK14762435.7T
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English (en)
Inventor
Sreerama Shetty
Steven Idell
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Univ Texas
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Publication of DK2970383T3 publication Critical patent/DK2970383T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK14762435.7T 2013-03-15 2014-03-17 Fremgangsmåde til behandling af fibrose DK2970383T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361800117P 2013-03-15 2013-03-15
PCT/US2014/030147 WO2014145389A1 (en) 2013-03-15 2014-03-17 Inhibition of pulmonary fibrosis with nutlin-3a and peptides

Publications (1)

Publication Number Publication Date
DK2970383T3 true DK2970383T3 (da) 2021-07-05

Family

ID=51537978

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14762435.7T DK2970383T3 (da) 2013-03-15 2014-03-17 Fremgangsmåde til behandling af fibrose

Country Status (12)

Country Link
US (7) US9630990B2 (da)
EP (2) EP3929207A1 (da)
JP (4) JP6603207B2 (da)
KR (3) KR102588702B1 (da)
CN (3) CN117679487A (da)
AU (3) AU2014233055B2 (da)
CA (1) CA2904870C (da)
DK (1) DK2970383T3 (da)
ES (1) ES2875853T3 (da)
HK (1) HK1218924A1 (da)
PT (1) PT2970383T (da)
WO (1) WO2014145389A1 (da)

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CN112996530A (zh) * 2018-09-10 2021-06-18 得克萨斯州大学系统董事会 小窝蛋白-1肽的干粉制剂及其使用方法
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JP2023509666A (ja) * 2019-12-31 2023-03-09 シァメン・ユニヴァーシティ 分子の細胞内送達用の多量体化送達システム
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Also Published As

Publication number Publication date
CA2904870A1 (en) 2014-09-18
US20180086791A1 (en) 2018-03-29
US20220098239A1 (en) 2022-03-31
AU2014233055A1 (en) 2015-10-01
US20230100467A1 (en) 2023-03-30
KR102268883B1 (ko) 2021-06-28
HK1218924A1 (zh) 2017-03-17
WO2014145389A1 (en) 2014-09-18
CN105263948A (zh) 2016-01-20
US20170253632A1 (en) 2017-09-07
JP6603207B2 (ja) 2019-11-06
CN105263948B (zh) 2019-06-04
EP2970383A4 (en) 2016-12-21
US20200165298A1 (en) 2020-05-28
EP2970383A1 (en) 2016-01-20
CA2904870C (en) 2022-08-23
JP6975690B2 (ja) 2021-12-01
KR20210076190A (ko) 2021-06-23
JP7378833B2 (ja) 2023-11-14
EP2970383B1 (en) 2021-04-21
AU2014233055B2 (en) 2018-08-09
JP2021178856A (ja) 2021-11-18
AU2020203192A1 (en) 2020-06-04
KR20150128731A (ko) 2015-11-18
AU2018205157A1 (en) 2018-08-02
US11780879B2 (en) 2023-10-10
PT2970383T (pt) 2021-06-03
CN110201144B (zh) 2024-01-02
US9630990B2 (en) 2017-04-25
KR102588702B1 (ko) 2023-10-16
CN110201144A (zh) 2019-09-06
JP2023178440A (ja) 2023-12-14
BR112015023287A2 (pt) 2019-11-19
JP2018158952A (ja) 2018-10-11
US11161875B2 (en) 2021-11-02
EP3929207A1 (en) 2021-12-29
CN117679487A (zh) 2024-03-12
JP2016522159A (ja) 2016-07-28
US20160272678A1 (en) 2016-09-22
ES2875853T3 (es) 2021-11-11
US10377796B2 (en) 2019-08-13
US20240059736A1 (en) 2024-02-22
KR20230148263A (ko) 2023-10-24

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