EE03968B1 - Ftalasinoonid - Google Patents

Ftalasinoonid

Info

Publication number
EE03968B1
EE03968B1 EEP199900274A EEP9900274A EE03968B1 EE 03968 B1 EE03968 B1 EE 03968B1 EE P199900274 A EEP199900274 A EE P199900274A EE P9900274 A EEP9900274 A EE P9900274A EE 03968 B1 EE03968 B1 EE 03968B1
Authority
EE
Estonia
Prior art keywords
pct
date jul
sec
pub
phthalazinones
Prior art date
Application number
EEP199900274A
Other languages
English (en)
Inventor
Johanna Van Der Laan Ivonne
Van Der Mey Margaretha
Timmerman Hendrik
Hatzelmann Armin
Boss Hildegard
H�fner Dietrich
Beume Rolf
Kley Hans-Peter
Jan Sterk Geert
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9900274A publication Critical patent/EE9900274A/et
Publication of EE03968B1 publication Critical patent/EE03968B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP199900274A 1997-01-15 1998-01-12 Ftalasinoonid EE03968B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100488 1997-01-15
PCT/EP1998/000124 WO1998031674A1 (en) 1997-01-15 1998-01-12 Phthalazinones

Publications (2)

Publication Number Publication Date
EE9900274A EE9900274A (et) 2000-02-15
EE03968B1 true EE03968B1 (et) 2003-02-17

Family

ID=8226366

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900274A EE03968B1 (et) 1997-01-15 1998-01-12 Ftalasinoonid

Country Status (27)

Country Link
US (1) US6103718A (et)
EP (1) EP0971901B1 (et)
JP (1) JP2001508078A (et)
KR (1) KR20000070150A (et)
CN (1) CN1127487C (et)
AT (1) ATE233247T1 (et)
AU (1) AU735934B2 (et)
BR (1) BR9806752A (et)
CA (1) CA2276455C (et)
CY (1) CY2446B1 (et)
CZ (1) CZ293815B6 (et)
DE (1) DE69811645T2 (et)
DK (1) DK0971901T3 (et)
EA (1) EA002764B1 (et)
EE (1) EE03968B1 (et)
ES (1) ES2193508T3 (et)
HK (1) HK1024692A1 (et)
HU (1) HUP0001541A3 (et)
IL (1) IL130659A (et)
NO (1) NO313137B1 (et)
NZ (1) NZ336573A (et)
PL (1) PL189418B1 (et)
PT (1) PT971901E (et)
SI (1) SI0971901T1 (et)
SK (1) SK283270B6 (et)
TR (1) TR199901653T2 (et)
WO (1) WO1998031674A1 (et)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070056B1 (en) * 1998-03-14 2004-06-30 ALTANA Pharma AG Phthalazinone pde iii/iv inhibitors
DE60026855T2 (de) 1999-08-21 2006-12-07 Altana Pharma Ag Synergistische kombination von roflumilast und salmeterol
AU7654200A (en) * 1999-09-14 2001-04-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
JP2003512466A (ja) * 1999-10-25 2003-04-02 アルタナ ファルマ アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのテトラヒドロチオピランフタラジノン誘導体
WO2001030766A1 (en) * 1999-10-25 2001-05-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pde 4 inhibitors
JP2003535850A (ja) 2000-06-05 2003-12-02 アルタナ ファルマ アクチエンゲゼルシャフト β−２−アドレナリン受容体として効果的な化合物並びにＰＤＥ４−インヒビター
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
US7868015B2 (en) * 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
CZ20032491A3 (cs) 2001-02-15 2004-01-14 Altana Pharma Ag Ftalazinonpiperidinové deriváty
BR0209076A (pt) 2001-04-25 2004-08-10 Altana Pharma Ag Derivados de piperazino e seu uso como inibidor de pde4
EP1385848A2 (en) * 2001-04-25 2004-02-04 ALTANA Pharma AG Phtalazinones derivatives useful as pde4/7 inhibitors
BR0307780A (pt) 2002-02-19 2004-12-28 Ono Pharmaceutical Co Compostos derivados de piridazina fundida e medicamentos contendo os compostos como o ingrediente ativo
WO2004018449A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
US20060166995A1 (en) * 2002-08-10 2006-07-27 Altana Pharma Ag Piperidine-n-oxide-derivatives
MXPA05001354A (es) * 2002-08-10 2005-04-28 Altana Pharma Ag Piperidina-ftalazonas sustituidas por pirrolidinodiona como inhibidores pde4.
WO2004018451A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
WO2004098633A1 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising a pde-4 inhibitor and a tnf alpha antagonist
US7365215B2 (en) * 2003-07-14 2008-04-29 Ube Industries, Ltd. Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same
WO2005075437A1 (en) * 2004-02-04 2005-08-18 Altana Pharma Ag Pyridazinone derivatives and their use as pde4 inhibitors
JP4778449B2 (ja) * 2004-02-04 2011-09-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体
CA2605383A1 (en) * 2005-04-21 2006-11-02 Nippon Shinyaku Co., Ltd. Phthalazinone derivative and pharmaceutical comprising the same
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2402330B1 (en) * 2007-05-16 2013-06-26 Takeda GmbH Pyrazolone-derivatives as PDE4 inhibitors
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN103582644B (zh) * 2011-06-17 2016-07-20 塔科达有限责任公司 酞嗪酮-吡咯并嘧啶羧酰胺衍生物
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
CN105307655B (zh) 2013-03-13 2019-05-03 弗拉特利发现实验室有限责任公司 哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
US20150050626A1 (en) * 2013-03-15 2015-02-19 Dart Neuroscience, Llc Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
DE69332762T2 (de) * 1992-12-02 2003-08-14 Pfizer Inc., New York Cathecoldiether als selektive pde iv hemmungsmittel
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
NZ290952A (en) * 1994-08-09 1998-05-27 Eisai Co Ltd Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups

Also Published As

Publication number Publication date
CN1127487C (zh) 2003-11-12
PL334561A1 (en) 2000-03-13
EP0971901B1 (en) 2003-02-26
WO1998031674A1 (en) 1998-07-23
NO313137B1 (no) 2002-08-19
CN1249749A (zh) 2000-04-05
CZ253399A3 (cs) 2000-05-17
AU735934B2 (en) 2001-07-19
CA2276455C (en) 2006-10-31
PT971901E (pt) 2003-07-31
SK283270B6 (sk) 2003-04-01
US6103718A (en) 2000-08-15
KR20000070150A (ko) 2000-11-25
SI0971901T1 (en) 2003-10-31
IL130659A0 (en) 2000-06-01
IL130659A (en) 2002-07-25
CA2276455A1 (en) 1998-07-23
PL189418B1 (pl) 2005-08-31
ES2193508T3 (es) 2003-11-01
NZ336573A (en) 2000-10-27
AU5862998A (en) 1998-08-07
HK1024692A1 (en) 2000-10-20
ATE233247T1 (de) 2003-03-15
NO993301D0 (no) 1999-07-02
EA199900620A1 (ru) 2000-04-24
HUP0001541A3 (en) 2001-11-28
TR199901653T2 (xx) 1999-10-21
CY2446B1 (en) 2004-11-12
BR9806752A (pt) 2000-03-14
DE69811645D1 (de) 2003-04-03
HUP0001541A2 (hu) 2001-05-28
CZ293815B6 (cs) 2004-08-18
DK0971901T3 (da) 2003-06-10
NO993301L (no) 1999-09-10
EE9900274A (et) 2000-02-15
SK95199A3 (en) 1999-12-10
EP0971901A1 (en) 2000-01-19
DE69811645T2 (de) 2003-12-04
JP2001508078A (ja) 2001-06-19
EA002764B1 (ru) 2002-08-29

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090112