DE60202669D1 - 6-phenylbenzonaphthyidine - Google Patents

6-phenylbenzonaphthyidine

Info

Publication number
DE60202669D1
DE60202669D1 DE60202669T DE60202669T DE60202669D1 DE 60202669 D1 DE60202669 D1 DE 60202669D1 DE 60202669 T DE60202669 T DE 60202669T DE 60202669 T DE60202669 T DE 60202669T DE 60202669 D1 DE60202669 D1 DE 60202669D1
Authority
DE
Germany
Prior art keywords
phenylbenzonaphthyidine
pde3
inhibitors
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60202669T
Other languages
English (en)
Other versions
DE60202669T2 (de
Inventor
Dieter Flockerzi
Beate Schmidt
Gerhard Grundler
Armin Hatzelmann
Rolf Beume
Daniela Bundschuh
Hans-Peter Kley
Ruediger Nave
Karl Zech
Felix Reutter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of DE60202669D1 publication Critical patent/DE60202669D1/de
Application granted granted Critical
Publication of DE60202669T2 publication Critical patent/DE60202669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE60202669T 2001-02-21 2002-02-21 6-phenylbenzonaphthyidine Expired - Lifetime DE60202669T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01104086 2001-02-21
EP01104086 2001-02-21
PCT/EP2002/001819 WO2002066476A1 (en) 2001-02-21 2002-02-21 6-phenylbenzonaphthyridines

Publications (2)

Publication Number Publication Date
DE60202669D1 true DE60202669D1 (de) 2005-02-24
DE60202669T2 DE60202669T2 (de) 2005-09-15

Family

ID=8176545

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202669T Expired - Lifetime DE60202669T2 (de) 2001-02-21 2002-02-21 6-phenylbenzonaphthyidine

Country Status (12)

Country Link
US (1) US6936622B2 (de)
EP (1) EP1377574B1 (de)
JP (1) JP4248245B2 (de)
AT (1) ATE287403T1 (de)
AU (1) AU2002253045B2 (de)
CA (1) CA2438717C (de)
DE (1) DE60202669T2 (de)
DK (1) DK1377574T3 (de)
ES (1) ES2236504T3 (de)
PT (1) PT1377574E (de)
SI (1) SI1377574T1 (de)
WO (1) WO2002066476A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2495603A1 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Benzonaphthyridines with pde 3/4 inhibiting activity
RS20050116A (en) * 2002-08-17 2007-11-15 Altana Pharma Ag., Novel phenanthridines
JP4587295B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての３−ヒドロキシ−６−フェニルフェナントリジン
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
PL373989A1 (en) * 2002-09-04 2005-09-19 Altana Pharma Ag Novel benzonaphthyridines
US7585872B2 (en) 2004-02-18 2009-09-08 Nycomed Gmbh Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors
DK2589599T3 (da) 2004-03-03 2014-10-06 Takeda Gmbh Hidtil ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som PDE4-inhibitorer
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
BRPI0508481A (pt) * 2004-03-10 2007-07-31 Altana Pharma Ag hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4
JP2007529471A (ja) 2004-03-17 2007-10-25 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のｎ−（アルコキシアルキル）カルバモイル置換された６−フェニル−ベンゾナフチリジン誘導体及びｐｄｅ３／４インヒビターとしてのそれらの使用
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
WO2018069210A1 (en) 2016-10-10 2018-04-19 Takeda Gmbh Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69719778T2 (de) * 1996-11-11 2004-02-05 Altana Pharma Ag Benzonaphthyridine als bronchialtherapeutika
WO1998040382A1 (en) 1997-03-07 1998-09-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
EP0988302B1 (de) 1997-06-03 2003-02-19 ALTANA Pharma AG Benzonaphthyridine
EP1075477B1 (de) * 1998-05-05 2003-03-12 ALTANA Pharma AG Neue Benzonaphtyridin-N-oxide
AU5970199A (en) * 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
AU2002253045B2 (en) 2007-07-12
WO2002066476A1 (en) 2002-08-29
ES2236504T3 (es) 2005-07-16
WO2002066476A9 (en) 2003-10-30
CA2438717A1 (en) 2002-08-29
DK1377574T3 (da) 2005-04-25
US6936622B2 (en) 2005-08-30
SI1377574T1 (de) 2005-08-31
JP4248245B2 (ja) 2009-04-02
EP1377574B1 (de) 2005-01-19
ATE287403T1 (de) 2005-02-15
JP2004526712A (ja) 2004-09-02
PT1377574E (pt) 2005-05-31
US20040097537A1 (en) 2004-05-20
EP1377574A1 (de) 2004-01-07
CA2438717C (en) 2011-08-30
DE60202669T2 (de) 2005-09-15

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ALTANA PHARMA AG, 78467 KONSTANZ, DE

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NYCOMED GMBH, 78467 KONSTANZ, DE