EA200001224A1 - Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола - Google Patents

Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола

Info

Publication number
EA200001224A1
EA200001224A1 EA200001224A EA200001224A EA200001224A1 EA 200001224 A1 EA200001224 A1 EA 200001224A1 EA 200001224 A EA200001224 A EA 200001224A EA 200001224 A EA200001224 A EA 200001224A EA 200001224 A1 EA200001224 A1 EA 200001224A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diola
purin
tetrahydrofuran
derivatives
compounds
Prior art date
Application number
EA200001224A
Other languages
English (en)
Inventor
Дейвид Джордж Аллен
Чуен Чен
Ричард Питер Чарлз Казинз
Брайан Кокс
Джоанна Виктория Джиден
Хедер Хоббз
Сузанн Элейн Килинг
Элисон Джудит Редгрейв
Томас Дейвис Роупер IV
Шиппинг Ксай
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9813538.7A external-priority patent/GB9813538D0/en
Priority claimed from GBGB9909482.3A external-priority patent/GB9909482D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200001224A1 publication Critical patent/EA200001224A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Abstract

Согласно изобретению предложены новые соединения формулы (I), где R, Rи Rявляются такими, как определено в описании изобретения, способы их получения, содержащие эти соединения препараты и их применение в терапии для лечения воспалительных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001224A 1998-06-23 1999-06-23 Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола EA200001224A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9813538.7A GB9813538D0 (en) 1998-06-23 1998-06-23 Chemical compounds
GBGB9909482.3A GB9909482D0 (en) 1999-04-23 1999-04-23 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives
PCT/EP1999/004269 WO1999067265A1 (en) 1998-06-23 1999-06-23 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives

Publications (1)

Publication Number Publication Date
EA200001224A1 true EA200001224A1 (ru) 2001-08-27

Family

ID=26313917

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001224A EA200001224A1 (ru) 1998-06-23 1999-06-23 Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола

Country Status (27)

Country Link
US (1) US6495528B1 (ru)
EP (1) EP1090022B1 (ru)
JP (1) JP3933870B2 (ru)
KR (1) KR20010071591A (ru)
CN (1) CN1313861A (ru)
AP (1) AP2000002016A0 (ru)
AT (1) ATE246701T1 (ru)
AU (1) AU750462B2 (ru)
BR (1) BR9911482A (ru)
CA (1) CA2335809A1 (ru)
CZ (1) CZ20004868A3 (ru)
DE (1) DE69910213T2 (ru)
EA (1) EA200001224A1 (ru)
EE (1) EE200000768A (ru)
ES (1) ES2204139T3 (ru)
HR (1) HRP20000894A2 (ru)
HU (1) HUP0103025A3 (ru)
ID (1) ID29609A (ru)
IL (1) IL140396A0 (ru)
IS (1) IS5779A (ru)
NO (1) NO20006548L (ru)
NZ (1) NZ509030A (ru)
PL (1) PL345062A1 (ru)
SK (1) SK19542000A3 (ru)
TR (1) TR200100410T2 (ru)
WO (1) WO1999067265A1 (ru)
YU (1) YU81100A (ru)

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Also Published As

Publication number Publication date
JP3933870B2 (ja) 2007-06-20
NZ509030A (en) 2003-07-25
ATE246701T1 (de) 2003-08-15
EP1090022A1 (en) 2001-04-11
HUP0103025A3 (en) 2002-04-29
IS5779A (is) 2000-12-19
EP1090022B1 (en) 2003-08-06
AP2000002016A0 (en) 2000-12-31
IL140396A0 (en) 2002-02-10
SK19542000A3 (sk) 2001-09-11
AU750462B2 (en) 2002-07-18
NO20006548L (no) 2001-02-22
NO20006548D0 (no) 2000-12-21
ID29609A (id) 2001-09-06
WO1999067265A1 (en) 1999-12-29
HUP0103025A2 (hu) 2001-12-28
DE69910213T2 (de) 2004-07-01
TR200100410T2 (tr) 2001-06-21
US6495528B1 (en) 2002-12-17
DE69910213D1 (de) 2003-09-11
CZ20004868A3 (cs) 2001-08-15
EE200000768A (et) 2002-04-15
AU4774499A (en) 2000-01-10
BR9911482A (pt) 2002-01-22
YU81100A (sh) 2003-10-31
CA2335809A1 (en) 1999-12-29
JP2002518512A (ja) 2002-06-25
ES2204139T3 (es) 2004-04-16
KR20010071591A (ko) 2001-07-28
PL345062A1 (en) 2001-11-19
CN1313861A (zh) 2001-09-19
HRP20000894A2 (en) 2001-12-31

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