EA199900421A1 - Бензонафтиридины в качестве бронхиальных терапевтических средств - Google Patents

Бензонафтиридины в качестве бронхиальных терапевтических средств

Info

Publication number
EA199900421A1
EA199900421A1 EA199900421A EA199900421A EA199900421A1 EA 199900421 A1 EA199900421 A1 EA 199900421A1 EA 199900421 A EA199900421 A EA 199900421A EA 199900421 A EA199900421 A EA 199900421A EA 199900421 A1 EA199900421 A1 EA 199900421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
petrophydridine
therapeutic tools
bronchial therapeutic
bronchial
compounds
Prior art date
Application number
EA199900421A
Other languages
English (en)
Other versions
EA001551B1 (ru
Inventor
Биате Гуттерер
Германн Амшлер
Вольф-Рюдигер Ульрих
Томас Мартин
Томас Бэр
Армин Хатцельманн
Карл Зандерс
Рольф Беуме
Хильдегард Босс
Дитрих Хэфнер
Ханс-Петер Клей
Карл-Йозеф Гёбель
Original Assignee
Бык Гюльден Ломберг Хемише Фабрик Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бык Гюльден Ломберг Хемише Фабрик Гмбх filed Critical Бык Гюльден Ломберг Хемише Фабрик Гмбх
Publication of EA199900421A1 publication Critical patent/EA199900421A1/ru
Publication of EA001551B1 publication Critical patent/EA001551B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

В заявке описаны соединения формулы (I)в которой R1, R2, R3 и R4 имеют значения, указанные в описании. Эти соединения являются новыми эффективными средствами терапии бронхиальных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900421A 1996-11-11 1997-11-05 Бензонафтиридины в качестве бронхиальных терапевтических средств EA001551B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Publications (2)

Publication Number Publication Date
EA199900421A1 true EA199900421A1 (ru) 1999-10-28
EA001551B1 EA001551B1 (ru) 2001-04-23

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900421A EA001551B1 (ru) 1996-11-11 1997-11-05 Бензонафтиридины в качестве бронхиальных терапевтических средств

Country Status (31)

Country Link
US (1) US6008215A (ru)
EP (1) EP0937074B1 (ru)
JP (1) JP4223075B2 (ru)
KR (1) KR100484045B1 (ru)
CN (1) CN1090188C (ru)
AT (1) ATE234300T1 (ru)
AU (1) AU733129B2 (ru)
BG (1) BG63695B1 (ru)
BR (1) BR9713338B1 (ru)
CA (1) CA2270964C (ru)
CY (1) CY2476B1 (ru)
CZ (1) CZ288752B6 (ru)
DE (1) DE69719778T2 (ru)
DK (1) DK0937074T3 (ru)
EA (1) EA001551B1 (ru)
EE (1) EE03829B1 (ru)
ES (1) ES2195189T3 (ru)
GE (1) GEP20012390B (ru)
HK (1) HK1022151A1 (ru)
HU (1) HU226981B1 (ru)
ID (1) ID22042A (ru)
IL (1) IL129054A (ru)
NO (1) NO312764B1 (ru)
NZ (1) NZ334976A (ru)
PL (1) PL189641B1 (ru)
PT (1) PT937074E (ru)
RS (1) RS49607B (ru)
SI (1) SI0937074T1 (ru)
SK (1) SK283269B6 (ru)
TR (1) TR199900856T2 (ru)
WO (1) WO1998021208A1 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002513793A (ja) 1998-05-05 2002-05-14 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規ｎ−オキシド
SI1109810T1 (en) * 1998-08-31 2004-12-31 Altana Pharma Ag Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
KR100720906B1 (ko) * 1999-01-15 2007-05-25 알타나 파마 아게 Ｐｄｅ-ｉｖ 억제 활성을 갖는 페닐페난트리딘
JP2003502278A (ja) 1999-01-15 2003-01-21 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のｎ−オキシド
US6534518B1 (en) 1999-01-15 2003-03-18 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity
EP1147087B1 (en) 1999-01-15 2005-05-11 ALTANA Pharma AG Phenanthridine-n-oxides with pde-iv inhibiting activity
ATE447952T1 (de) * 1999-08-21 2009-11-15 Nycomed Gmbh Synergistische kombination von pumafentrine und salmeterol
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
DK1377574T3 (da) * 2001-02-21 2005-04-25 Altana Pharma Ag 6-phenylbenzonaphtyridiner
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
CA2495603A1 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Benzonaphthyridines with pde 3/4 inhibiting activity
AU2003264132B2 (en) * 2002-09-04 2009-11-19 Takeda Gmbh Novel benzonaphthyridines
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
BRPI0508321B1 (pt) 2004-03-03 2018-02-06 Takeda Gmbh Hidróxi-6-heteroarilfenantridinas, seu uso e composições farmacêuticas que as compreende
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
WO2005087745A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
WO2005090345A1 (en) * 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
AU2005281703B2 (en) * 2004-09-08 2011-11-17 Takeda Gmbh Novel 3-thia-10-aza-phenanthrene derivatives
JP5009799B2 (ja) * 2004-09-08 2012-08-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−オキサ−１０−アザ−フェナントレン
ATE450524T1 (de) 2005-03-02 2009-12-15 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimethoxypyridin-3-yl)-9- ethoxy-8-methoxy-1,2,3,4,4a,10b- hexahydrophenanthridin-2-ol hydrochloridsalz
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
ES2528316T3 (es) * 2006-09-01 2015-02-06 Senhwa Biosciences, Inc. Moduladores de la serina-treonina proteína quinasa y de PARP
CN104016980B (zh) 2008-04-23 2016-12-07 里格尔药品股份有限公司 用于治疗代谢障碍的甲酰胺化合物
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
EP0937074B1 (en) 2003-03-12
ES2195189T3 (es) 2003-12-01
ID22042A (id) 1999-08-26
EE9900105A (et) 1999-10-15
US6008215A (en) 1999-12-28
EA001551B1 (ru) 2001-04-23
SK283269B6 (sk) 2003-04-01
PL189641B1 (pl) 2005-09-30
KR100484045B1 (ko) 2005-04-20
JP2001503442A (ja) 2001-03-13
AU733129B2 (en) 2001-05-10
PT937074E (pt) 2003-07-31
YU19499A (sh) 2001-09-28
NO312764B1 (no) 2002-07-01
TR199900856T2 (xx) 1999-07-21
KR20000053100A (ko) 2000-08-25
BG63695B1 (bg) 2002-09-30
NO992282D0 (no) 1999-05-11
PL333429A1 (en) 1999-12-06
NZ334976A (en) 2000-10-27
BG103310A (en) 2000-05-31
CZ288752B6 (cs) 2001-08-15
WO1998021208A1 (en) 1998-05-22
CA2270964A1 (en) 1998-05-22
DE69719778D1 (de) 2003-04-17
HUP0000426A2 (hu) 2001-02-28
CA2270964C (en) 2007-07-31
CY2476B1 (en) 2005-05-03
BR9713338A (pt) 2000-05-09
HUP0000426A3 (en) 2001-04-28
ATE234300T1 (de) 2003-03-15
IL129054A (en) 2002-07-25
RS49607B (sr) 2007-06-04
CZ167599A3 (cs) 1999-11-17
IL129054A0 (en) 2000-02-17
HU226981B1 (hu) 2010-04-28
NO992282L (no) 1999-05-11
EE03829B1 (et) 2002-08-15
JP4223075B2 (ja) 2009-02-12
HK1022151A1 (en) 2000-07-28
DK0937074T3 (da) 2003-06-23
SK62399A3 (en) 1999-10-08
BR9713338B1 (pt) 2009-12-01
DE69719778T2 (de) 2004-02-05
EP0937074A1 (en) 1999-08-25
CN1090188C (zh) 2002-09-04
CN1236367A (zh) 1999-11-24
AU5317098A (en) 1998-06-03
SI0937074T1 (en) 2003-08-31
GEP20012390B (en) 2001-03-25

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Designated state(s): AM AZ KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU