HK1022151A1 - Benzonaphthyridines as bronchial therapeutics - Google Patents

Benzonaphthyridines as bronchial therapeutics

Info

Publication number
HK1022151A1
HK1022151A1 HK00101112A HK00101112A HK1022151A1 HK 1022151 A1 HK1022151 A1 HK 1022151A1 HK 00101112 A HK00101112 A HK 00101112A HK 00101112 A HK00101112 A HK 00101112A HK 1022151 A1 HK1022151 A1 HK 1022151A1
Authority
HK
Hong Kong
Prior art keywords
pct
benzonaphthyridines
bronchial therapeutics
date
sec
Prior art date
Application number
HK00101112A
Other languages
English (en)
Inventor
Beate Schmidt
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Thomas Baer
Armin Hatzelmann
Karl Sanders
Rolf Beume
Hildegard Boss
Dietrich Haefner
Hans-Peter Kley
Karl-Josef Goebel
Dieter Flockerzi
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of HK1022151A1 publication Critical patent/HK1022151A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK00101112A 1996-11-11 2000-02-24 Benzonaphthyridines as bronchial therapeutics HK1022151A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Publications (1)

Publication Number Publication Date
HK1022151A1 true HK1022151A1 (en) 2000-07-28

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00101112A HK1022151A1 (en) 1996-11-11 2000-02-24 Benzonaphthyridines as bronchial therapeutics

Country Status (31)

Country Link
US (1) US6008215A (xx)
EP (1) EP0937074B1 (xx)
JP (1) JP4223075B2 (xx)
KR (1) KR100484045B1 (xx)
CN (1) CN1090188C (xx)
AT (1) ATE234300T1 (xx)
AU (1) AU733129B2 (xx)
BG (1) BG63695B1 (xx)
BR (1) BR9713338B1 (xx)
CA (1) CA2270964C (xx)
CY (1) CY2476B1 (xx)
CZ (1) CZ288752B6 (xx)
DE (1) DE69719778T2 (xx)
DK (1) DK0937074T3 (xx)
EA (1) EA001551B1 (xx)
EE (1) EE03829B1 (xx)
ES (1) ES2195189T3 (xx)
GE (1) GEP20012390B (xx)
HK (1) HK1022151A1 (xx)
HU (1) HU226981B1 (xx)
ID (1) ID22042A (xx)
IL (1) IL129054A (xx)
NO (1) NO312764B1 (xx)
NZ (1) NZ334976A (xx)
PL (1) PL189641B1 (xx)
PT (1) PT937074E (xx)
RS (1) RS49607B (xx)
SI (1) SI0937074T1 (xx)
SK (1) SK283269B6 (xx)
TR (1) TR199900856T2 (xx)
WO (1) WO1998021208A1 (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1075477E (pt) 1998-05-05 2003-07-31 Altana Pharma Ag Novos n-oxidos de benzonaftiridina
ES2224745T3 (es) 1998-08-31 2005-03-01 Altana Pharma Ag N-oxidos de benzonaftiridina con actividad inhibidora de pde3 y pde4.
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
JP2002534506A (ja) * 1999-01-15 2002-10-15 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ−ｉｖ抑制作用を有する多重に置換された６−フェニルフェナントリジン
BR0007527B1 (pt) * 1999-01-15 2011-12-27 fenilfenantridinas com atividade inibitària de pde-iv, seu uso, bem como medicamento compreendendo as mesmas.
DK1147103T3 (da) 1999-01-15 2005-08-29 Altana Pharma Ag Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet
ES2242594T3 (es) * 1999-01-15 2005-11-16 Altana Pharma Ag N-oxidos de fenantridinas con una acitvidad inhidora de pde-iv.
KR100701904B1 (ko) 1999-08-21 2007-04-02 알타나 파마 아게 Ｐｄｅ 억제제 및 베타 2 아드레날린수용체 작동제의상승적 조합
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
PT1377574E (pt) * 2001-02-21 2005-05-31 Byk Gulden Lomberg Chem Fab 6-fenilbenzonaftiridinas
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
US20060113968A1 (en) * 2002-08-17 2006-06-01 Altana Pharma Ag Novel benzonaphthyridines
EP1537109B1 (en) * 2002-09-04 2007-04-18 ALTANA Pharma AG Novel benzonaphthyridines
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
ES2427256T3 (es) 2004-03-03 2013-10-30 Takeda Gmbh Nuevas hidroxi-6-heteroaril-fenantridinas y su uso como agentes inhibidores de la PDE4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
KR20060130697A (ko) * 2004-03-10 2006-12-19 알타나 파마 아게 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
CA2559200A1 (en) * 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
ES2365926T3 (es) * 2004-09-08 2011-10-13 Nycomed Gmbh 3-oxa-10-aza-fenantrenos como inhibidores de pde4 o pde3/4.
CA2579000C (en) * 2004-09-08 2013-02-05 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
NZ560268A (en) 2005-03-02 2010-12-24 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
JP2009512676A (ja) 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
CA2661842C (en) * 2006-09-01 2017-08-22 Cylene Pharmaceuticals, Inc. Tricyclic heteroaryl compounds and their use as serine-threonine protein kinases and parp modulators
US8314107B2 (en) 2008-04-23 2012-11-20 Rigel Pharmaceuticals, Inc. Carboxamide compounds and methods for using the same
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
NZ334976A (en) 2000-10-27
JP4223075B2 (ja) 2009-02-12
DK0937074T3 (da) 2003-06-23
EA001551B1 (ru) 2001-04-23
IL129054A (en) 2002-07-25
ES2195189T3 (es) 2003-12-01
EP0937074A1 (en) 1999-08-25
NO992282D0 (no) 1999-05-11
ATE234300T1 (de) 2003-03-15
ID22042A (id) 1999-08-26
SK283269B6 (sk) 2003-04-01
AU5317098A (en) 1998-06-03
EA199900421A1 (ru) 1999-10-28
EE9900105A (et) 1999-10-15
KR100484045B1 (ko) 2005-04-20
GEP20012390B (en) 2001-03-25
HUP0000426A3 (en) 2001-04-28
PL189641B1 (pl) 2005-09-30
CY2476B1 (en) 2005-05-03
CN1090188C (zh) 2002-09-04
TR199900856T2 (xx) 1999-07-21
BG103310A (en) 2000-05-31
CZ167599A3 (cs) 1999-11-17
EE03829B1 (et) 2002-08-15
BG63695B1 (bg) 2002-09-30
CA2270964C (en) 2007-07-31
CZ288752B6 (cs) 2001-08-15
BR9713338A (pt) 2000-05-09
YU19499A (sh) 2001-09-28
JP2001503442A (ja) 2001-03-13
DE69719778T2 (de) 2004-02-05
KR20000053100A (ko) 2000-08-25
HU226981B1 (hu) 2010-04-28
SI0937074T1 (en) 2003-08-31
US6008215A (en) 1999-12-28
IL129054A0 (en) 2000-02-17
BR9713338B1 (pt) 2009-12-01
CA2270964A1 (en) 1998-05-22
CN1236367A (zh) 1999-11-24
DE69719778D1 (de) 2003-04-17
NO312764B1 (no) 2002-07-01
NO992282L (no) 1999-05-11
PT937074E (pt) 2003-07-31
AU733129B2 (en) 2001-05-10
SK62399A3 (en) 1999-10-08
WO1998021208A1 (en) 1998-05-22
PL333429A1 (en) 1999-12-06
EP0937074B1 (en) 2003-03-12
RS49607B (sr) 2007-06-04
HUP0000426A2 (hu) 2001-02-28

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20151105