RU2421464C2 - Человеческие антитела к il-13 и их терапевтическое применение - Google Patents

Человеческие антитела к il-13 и их терапевтическое применение Download PDF

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RU2421464C2
RU2421464C2 RU2008119689/10A RU2008119689A RU2421464C2 RU 2421464 C2 RU2421464 C2 RU 2421464C2 RU 2008119689/10 A RU2008119689/10 A RU 2008119689/10A RU 2008119689 A RU2008119689 A RU 2008119689A RU 2421464 C2 RU2421464 C2 RU 2421464C2
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Джой БУХЛЕР (US)
Джой БУХЛЕР
Эмма Мишелл КАМПБЕЛЛ (GB)
Эмма Мишелл КАМПБЕЛЛ
София ПАРВИН (GB)
София Парвин
Гунарс ВАЛКИРС (US)
Гунарс ВАЛКИРС
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Abstract

Настоящее изобретение относится к иммунологии и биотехнологии. Предложены варианты антител к IL-13, каждое из которых содержит, соответственно, три CDR тяжелой и три CDR легкой цепи. Описана фармацевтическая композиция на основе антител для лечения астмы. Использование изобретения может найти дальнейшее применение в терапии В-клеточных расстройств, опосредованных IL-13. 2 н. и 9 з.п. ф-лы, 6 табл.

Description

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Claims (11)

1. Выделенный антигенсвязывающий участок антитела к IL-13 или его функционально активный фрагмент, содержащий H-CDR1-, H-CDR2- и Н-CDR3- и L-CDR1-, L-CDR2- и L-CDR3-, участки которого имеют аминокислотные последовательности, выбранные вместе из (I) - (III):
(I) SEQ ID NO: 6, SEQ ID NО: 8, SEQ ID NO: 9 и SEQ ID NO: 16, SEQ ID NO: 19, SEQ ID NO: 20;
(II) SEQ ID NO: 7, SEQ ID NО: 8, SEQ ID NO: 10 и SEQ ID NO: 17, SEQ ID NО: 19, SEQ ID NO: 21; и
(III) SEQ ID NO: 7, SEQ ID NО: 8, SEQ ID NO: 10 и SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 22.
2. Выделенное человеческое или гуманизированное антитело к IL13, содержащее выделенный антигенсвязывающий участок по п.1.
3. Антитело по п.2, которое содержит по меньшей мере один антигенсвязывающий центр, включающий домен тяжелой цепи, который имеет аминокислотную последовательность, выбранную из любой SEQ ID NO: 23, 27, 31 и 35.
4. Антитело по п.3, которое содержит по меньшей мере один антигенсвязывающий центр, включающий домен легкой цепи, который имеет аминокислотную последовательность, выбранную из любой SEQ ID NO: 25, 29, 33 и 37.
5. Антитело к IL13 по п.3, которое содержит по меньшей мере один антигенсвязывающий центр, включающий домен легкой цепи, имеющий аминокислотную последовательность, выбранную из любой SEQ ID NO: 25, 29, 33 и 37.
6. Антитело к IL13 по п.4, содержащее вариабельную область тяжелой цепи, которая имеет последовательность SEQ ID NO: 23, и вариабельную область легкой цепи, которая имеет последовательность SEQ ID NO: 25.
7. Антитело к IL13 по п.4, содержащее вариабельную область тяжелой цепи, которая имеет последовательность SEQ ID NO: 27, и вариабельную область легкой цепи, которая имеет последовательность SEQ ID NO: 29.
8. Антитело к IL13 по п.4, содержащее вариабельную область тяжелой цепи, которая имеет последовательность SEQ ID NO: 31, и вариабельную область легкой цепи, которая имеет последовательность SEQ ID NO: 33.
9. Антитело к IL13 по п.4, содержащее вариабельную область тяжелой цепи, которая имеет последовательность SEQ ID NO: 35, и вариабельную область легкой цепи, которая имеет последовательность SEQ ID NO: 37.
10. Антитело к IL13 по одному из пп.2-9, представляющее IgG1 или IgG4.
11. Фармацевтическая композиция, предназначенная для лечения нарушения или состояния, которое ассоциировано с присутствием клеточного рецептора IL-13-мишени, такого как астма, содержащая антитело или его функционально активный фрагмент по одному из пп.2-10 и фармацевтически приемлемый носитель или эксципиент.
RU2008119689/10A 2005-10-21 2006-10-19 Человеческие антитела к il-13 и их терапевтическое применение RU2421464C2 (ru)

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